{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:54Z","timestamp":1791928914791,"version":"4.3.4"},"reference-count":22,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"5","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,5,14]]},"DOI":"10.1167\/iovs.67.5.31","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T13:30:52Z","timestamp":1778765452000},"page":"31","source":"Crossref","is-referenced-by-count":0,"title":["Spectrally Resolved Fundus Autofluorescence as a Biomarker of Retinal Metabolic Integrity in Intermediate and Atrophic AMD"],"prefix":"10.1167","volume":"67","author":[{"given":"Stela","family":"Vujosevic","sequence":"first","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy"},{"name":"Eye Clinic, IRCCS MultiMedica, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Zanzottera","sequence":"additional","affiliation":[{"name":"Eye Hospital, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Brotto","sequence":"additional","affiliation":[{"name":"Eye Clinic, IRCCS MultiMedica, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Piccoli","sequence":"additional","affiliation":[{"name":"Eye Clinic, IRCCS MultiMedica, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Alovisi","sequence":"additional","affiliation":[{"name":"Eye Hospital, Oftalmico di Torino, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanda","family":"Bucceri","sequence":"additional","affiliation":[{"name":"Eye Clinic, IRCCS MultiMedica, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Rui","sequence":"additional","affiliation":[{"name":"CenterVue S.p.A, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enea","family":"Poletti","sequence":"additional","affiliation":[{"name":"CenterVue S.p.A, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Brambilla","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, Azienda Ospedaliero Universitaria Maggiore della Carita, Novara, Piemonte, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Coppola","sequence":"additional","affiliation":[{"name":"Eye Hospital, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Nucci","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Chakravarthy","sequence":"additional","affiliation":[{"name":"Center for Public Health, Queen's University of Belfast, Belfast, Northern Ireland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","article-title":"Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis","volume":"2","author":"Wong","year":"2014","journal-title":"Lancet Glob Health"},{"issue":"12","key":"bib2","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1001\/jamaophthalmol.2022.4401","article-title":"Prevalence of age-related macular degeneration in the US in 2019","volume":"140","author":"Rein","year":"2022","journal-title":"JAMA Ophthalmol"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1016\/S0140-6736(23)01520-9","article-title":"Pegcetacoplan for the treatment of geographic atrophy secondary to age-related macular degeneration (OAKS and DERBY): two multicentre, randomised, double-masked, sham-controlled, phase 3 trials","volume":"402","author":"Heier","year":"2023","journal-title":"Lancet"},{"issue":"6","key":"bib4","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/S0197-2456(99)00031-8","article-title":"The Age-Related Eye Disease Study (AREDS): design implications. AREDS Report No. 1","volume":"20","author":"Age-Related Eye Disease Study Research Group","year":"1999","journal-title":"Control Clin Trials"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.ophtha.2012.10.036","article-title":"Clinical classification of age-related macular degeneration","volume":"120","author":"Ferris","year":"2013","journal-title":"Ophthalmology"},{"issue":"6","key":"bib6","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1038\/s41433-024-03568-2","article-title":"Validating candidate endpoints for intermediate age-related macular degeneration trials in a multi-centre setting-lessons from the MACUSTAR study","volume":"39","author":"Terheyden","year":"2025","journal-title":"Eye (Lond)"},{"issue":"4","key":"bib7","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.ophtha.2017.09.028","article-title":"Consensus definition for atrophy associated with age-related macular degeneration on OCT: Classification of Atrophy Report 3","volume":"125","author":"Sadda","year":"2018","journal-title":"Ophthalmology"},{"issue":"3","key":"bib8","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.ophtha.2019.09.035","article-title":"Incomplete retinal pigment epithelial and outer retinal atrophy in age-related macular degeneration: Classification of Atrophy Meeting Report 4","volume":"127","author":"Guymer","year":"2020","journal-title":"Ophthalmology"},{"issue":"1","key":"bib9","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.survophthal.2008.10.004","article-title":"Fundus autofluorescence and progression of age-related macular degeneration","volume":"54","author":"Schmitz-Valckenberg","year":"2009","journal-title":"Surv Ophthalmol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"100893","DOI":"10.1016\/j.preteyeres.2020.100893","article-title":"Fundus autofluorescence imaging","volume":"81","author":"Schmitz-Valckenberg","year":"2021","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"bib11","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1167\/iovs.18-25755","article-title":"Spectrally resolved fundus autofluorescence in ABCA4-related retinopathy","volume":"60","author":"Dysli","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib12","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3390\/jcm10010048","article-title":"Quantitative color fundus autofluorescence in patients with diabetes mellitus","volume":"10","author":"Vujosevic","year":"2021","journal-title":"J Clin Med"},{"issue":"2","key":"bib13","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1167\/tvst.10.2.33","article-title":"Color fundus autofluorescence to determine activity of macular neovascularization in age-related macular degeneration","volume":"10","author":"Vujosevic","year":"2021","journal-title":"Transl Vis Sci Technol"},{"issue":"6","key":"bib14","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1136\/bjophthalmol-2017-310881","article-title":"Green emission fluorophores in eyes with atrophic age-related macular degeneration: a colour fundus autofluorescence pilot study","volume":"102","author":"Borrelli","year":"2018","journal-title":"Br J Ophthalmol"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1136\/bjophthalmol-2018-311849","article-title":"Comparison of short-wavelength blue-light autofluorescence and conventional blue-light autofluorescence in geographic atrophy","volume":"103","author":"Borrelli","year":"2018","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"bib17","doi-asserted-by":"publisher","first-page":"14337","DOI":"10.1038\/s41598-022-18048-4","article-title":"Spectrally resolved autofluorescence imaging in posterior uveitis","volume":"12","author":"Wintergerst","year":"2022","journal-title":"Sci Rep"},{"issue":"12","key":"bib18","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.1016\/j.ophtha.2014.06.034","article-title":"Optical coherence tomography-defined changes preceding the development of drusen-associated atrophy in age-related macular degeneration","volume":"121","author":"Wu","year":"2014","journal-title":"Ophthalmology"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.oret.2019.12.011","article-title":"Prospective longitudinal evaluation of nascent geographic atrophy in age-related macular degeneration","volume":"4","author":"Wu","year":"2020","journal-title":"Ophthalmol Retina"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"3519","DOI":"10.1167\/iovs.17-21696","article-title":"Optical coherence tomography features preceding the onset of advanced age-related macular degeneration","volume":"58","author":"Ferrara","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1159\/000510887","article-title":"Can the onset of atrophic age-related macular degeneration be an acceptable endpoint for preventative trials?","volume":"243","author":"Wu","year":"2020","journal-title":"Ophthalmologica"},{"issue":"2","key":"bib22","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.ophtha.2022.09.004","article-title":"Incomplete retinal pigment epithelial and outer retinal atrophy: longitudinal evaluation in age-related macular degeneration","volume":"130","author":"Wu","year":"2023","journal-title":"Ophthalmology"},{"key":"bib16","article-title":"EIDON Family user manual","author":"Centervue"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.5.31","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:17Z","timestamp":1791927137000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.5.31"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,14]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.5.31","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,14]]}}}