{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:02:24Z","timestamp":1791928944638,"version":"4.3.4"},"reference-count":77,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"5","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,5,18]]},"DOI":"10.1167\/iovs.67.5.39","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:30:41Z","timestamp":1779114641000},"page":"39","source":"Crossref","is-referenced-by-count":0,"title":["Sexual Dimorphism Is Associated With Corneal Nerve and Epithelial Alterations and Tear-Film Defects in Pax6 Haploinsufficiency Mouse Model"],"prefix":"10.1167","volume":"67","author":[{"given":"Marjolaine","family":"Willems","sequence":"first","affiliation":[{"name":"Institute for Neurosciences of Montpellier, University of Montpellier, INSERM, Montpellier, France"},{"name":"Department of Clinical Genetics, Arnaud de Villeneuve Hospital, University Hospital of Montpellier, Montpellier, France"},{"name":"OPHTARA Rare Disease Competence Center, University Hospital of Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lissa","family":"Girard","sequence":"additional","affiliation":[{"name":"Institute for Neurosciences of Montpellier, University of Montpellier, INSERM, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nad\u00e8ge","family":"Feret","sequence":"additional","affiliation":[{"name":"Institute for Neurosciences of Montpellier, University of Montpellier, INSERM, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Touchet","sequence":"additional","affiliation":[{"name":"Institute for Neurosciences of Montpellier, University of Montpellier, INSERM, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Vialaret","sequence":"additional","affiliation":[{"name":"Institute for Neurosciences of Montpellier, University of Montpellier, INSERM, Montpellier, France"},{"name":"IRMB-PPC, University of Montpellier, University Hospital of Montpellier, INSERM CNRS, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Kindermans","sequence":"additional","affiliation":[{"name":"Institute for Neurosciences of Montpellier, University of Montpellier, INSERM, Montpellier, France"},{"name":"IRMB-PPC, University of Montpellier, University Hospital of Montpellier, INSERM CNRS, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Fichter","sequence":"additional","affiliation":[{"name":"Institute for Neurosciences of Montpellier, University of Montpellier, INSERM, Montpellier, France"},{"name":"IRMB-PPC, University of Montpellier, University Hospital of Montpellier, INSERM CNRS, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Hirtz","sequence":"additional","affiliation":[{"name":"Institute for Neurosciences of Montpellier, University of Montpellier, INSERM, Montpellier, France"},{"name":"IRMB-PPC, University of Montpellier, University Hospital of Montpellier, INSERM CNRS, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Bremond-Gignac","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Necker Enfants Malades, APHP, Paris, INSERM UMRS 1138, T17, Centre de Reference Maladies Rares OPHTARA Rare Disease Reference Center, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Daien","sequence":"additional","affiliation":[{"name":"Institute for Neurosciences of Montpellier, University of Montpellier, INSERM, Montpellier, France"},{"name":"OPHTARA Rare Disease Competence Center, University Hospital of Montpellier, Montpellier, France"},{"name":"Department of Ophthalmology, Gui de Chauliac Hospital, University Hospital of Montpellier, Montpellier, France"},{"name":"The Save Sight Institute, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Delettre","sequence":"additional","affiliation":[{"name":"Institute for Neurosciences of Montpellier, University of Montpellier, INSERM, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Pequignot","sequence":"additional","affiliation":[{"name":"Institute for Neurosciences of Montpellier, University of Montpellier, INSERM, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Michon","sequence":"additional","affiliation":[{"name":"Institute for Neurosciences of Montpellier, University of Montpellier, INSERM, Montpellier, France"},{"name":"Department of Ophthalmology, Gui de Chauliac Hospital, University Hospital of Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"7","key":"bib1","doi-asserted-by":"publisher","first-page":"2280","DOI":"10.4103\/ijo.IJO_2255_21","article-title":"Clinical and molecular aspects of congenital aniridia - a review of current concepts","volume":"70","author":"Tibrewal","year":"2022","journal-title":"Indian J Ophthalmol"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"101133","DOI":"10.1016\/j.preteyeres.2022.101133","article-title":"Congenital aniridia beyond black eyes: from phenotype and novel genetic mechanisms to innovative therapeutic approaches","volume":"95","author":"Daruich","year":"2023","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"bib3","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.jtos.2019.11.002","article-title":"Early phenotypic features of aniridia-associated keratopathy and association with PAX6 coding mutations","volume":"18","author":"Lagali","year":"2020","journal-title":"Ocul Surf"},{"issue":"1","key":"bib4","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1136\/bjo-2021-320774","article-title":"Early ocular surface and tear film status in congenital aniridia indicates a supportive treatment window","volume":"108","author":"Fries","year":"2023","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"bib5","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.jtos.2017.07.001","article-title":"Clinical and morphological manifestations of aniridia-associated keratopathy on anterior segment optical coherence tomography and in vivo confocal microscopy","volume":"15","author":"Voskresenskaya","year":"2017","journal-title":"Ocul Surf"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/bs.pmbts.2015.04.001","article-title":"Chapter Two - Overview of the cornea: structure, function, and development","volume":"134","author":"Eghrari","year":"2015","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"8","key":"bib7","doi-asserted-by":"publisher","first-page":"3648","DOI":"10.1167\/iovs.08-2941","article-title":"Dimensions and morphology of the cornea in three strains of mice","volume":"50","author":"Henriksson","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib8","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.celrep.2017.12.040","article-title":"Corneal-committed cells restore the stem cell pool and tissue boundary following injury","volume":"22","author":"Nasser","year":"2018","journal-title":"Cell Rep"},{"issue":"2","key":"bib9","doi-asserted-by":"publisher","first-page":"190","DOI":"10.4103\/ijo.IJO_646_17","article-title":"Anatomy of cornea and ocular surface","volume":"66","author":"Sridhar","year":"2018","journal-title":"Indian J Ophthalmol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"100877","DOI":"10.1016\/j.preteyeres.2020.100877","article-title":"Plasmacytoid dendritic cells in the eye","volume":"80","author":"Jamali","year":"2021","journal-title":"Prog Retin Eye Res"},{"issue":"4","key":"bib11","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.it.2017.11.007","article-title":"When clarity is crucial: regulating ocular surface immunity","volume":"39","author":"Foulsham","year":"2018","journal-title":"Trends Immunol"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"620284","DOI":"10.3389\/fimmu.2021.620284","article-title":"Resident innate immune cells in the cornea","volume":"12","author":"Liu","year":"2021","journal-title":"Front Immunol"},{"issue":"15","key":"bib13","doi-asserted-by":"publisher","first-page":"4972","DOI":"10.1167\/iovs.19-28519","article-title":"Comparative anatomy of the mammalian corneal subbasal nerve plexus","volume":"60","author":"Marfurt","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib14","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S0014-4835(03)00050-2","article-title":"Corneal nerves: structure, contents and function","volume":"76","author":"M\u00fcller","year":"2003","journal-title":"Exp Eye Res"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.exer.2013.07.015","article-title":"Tears as a source of biomarkers for ocular and systemic diseases","volume":"117","author":"von Thun","year":"2013","journal-title":"Exp Eye Res"},{"issue":"1","key":"bib16","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1097\/00004397-197301310-00005","article-title":"Chemical composition of the aqueous phase","volume":"13","author":"Iwata","year":"1973","journal-title":"Int Ophthalmol Clin"},{"issue":"3","key":"bib17","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/S1542-0124(12)70613-4","article-title":"Growth factors in the tear film: role in tissue maintenance, wound healing, and ocular pathology","volume":"5","author":"Klenkler","year":"2007","journal-title":"Ocul Surf"},{"issue":"5","key":"bib18","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1097\/01.ICL.0000152487.16012.40","article-title":"Central corneal thickness in patients with congenital aniridia","volume":"31","author":"Whitson","year":"2005","journal-title":"Eye Contact Lens"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.jtos.2021.09.001","article-title":"Pathophysiology of aniridia-associated keratopathy: developmental aspects and unanswered questions","volume":"22","author":"Latta","year":"2021","journal-title":"Ocul Surf"},{"issue":"4","key":"bib20","doi-asserted-by":"publisher","first-page":"e0125631","DOI":"10.1371\/journal.pone.0125631","article-title":"A comparison of some organizational characteristics of the mouse central retina and the human macula","volume":"10","author":"Volland","year":"2015","journal-title":"PLoS One"},{"issue":"23","key":"bib21","doi-asserted-by":"publisher","first-page":"16661","DOI":"10.3390\/ijms242316661","article-title":"Animal models in eye research: focus on corneal pathologies","volume":"24","author":"Loiseau","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"12","key":"bib22","doi-asserted-by":"publisher","first-page":"4119","DOI":"10.4103\/ijo.IJO_316_22","article-title":"PAX6 disease models for aniridia","volume":"70","author":"Abdolkarimi","year":"2022","journal-title":"Indian J Ophthalmol"},{"issue":"12","key":"bib23","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1242\/dev.127.12.2563","article-title":"FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development","volume":"127","author":"Makarenkova","year":"2000","journal-title":"Development"},{"issue":"3","key":"bib24","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1167\/iovs.09-4023","article-title":"Cytoskeletal and cell adhesion defects in wounded and Pax6+\/- corneal epithelia","volume":"51","author":"Ou","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib25","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1002\/path.2371","article-title":"Chronic wound state exacerbated by oxidative stress in Pax6+\/- aniridia-related keratopathy","volume":"215","author":"Ou","year":"2008","journal-title":"J Pathol"},{"issue":"5","key":"bib26","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1167\/iovs.05-1028","article-title":"Increased apoptosis and abnormal wound-healing responses in the heterozygous Pax6+\/- mouse cornea","volume":"47","author":"Ramaesh","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib27","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1167\/iovs.08-2812","article-title":"Control of patterns of corneal innervation by Pax6","volume":"50","author":"Leiper","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib28","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1749-8104-4-19","article-title":"Normal ventral telencephalic expression of Pax6 is required for normal development of thalamocortical axons in embryonic mice","volume":"4","author":"Simpson","year":"2009","journal-title":"Neural Dev"},{"issue":"4","key":"bib29","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1002\/stem.2767","article-title":"Bmi1+ progenitor cell dynamics in murine cornea during homeostasis and wound healing","volume":"36","author":"Kalha","year":"2018","journal-title":"Stem Cells"},{"issue":"202","key":"bib30","first-page":"66182","article-title":"Three strategies to induce neurotrophic keratitis and nerve regeneration in murine cornea","author":"Meneux","year":"2023","journal-title":"J Vis Exp"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.omtm.2022.08.006","article-title":"AAV2\/9-mediated gene transfer into murine lacrimal gland leads to a long-term targeted tear film modification","volume":"27","author":"Gautier","year":"2022","journal-title":"Mol Ther Methods Clin Dev"},{"issue":"5","key":"bib32","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1093\/bioinformatics\/btn025","article-title":"SOAP: short oligonucleotide alignment program","volume":"24","author":"Li","year":"2008","journal-title":"Bioinformatics"},{"issue":"4","key":"bib33","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat Methods"},{"issue":"12","key":"bib34","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1387\/ijdb.041860jz","article-title":"Corneal development associated with eyelid opening","volume":"48","author":"Zieske","year":"2004","journal-title":"Int J Dev Biol"},{"issue":"1","key":"bib36","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.jtos.2017.11.003","article-title":"Stage-related central corneal epithelial transformation in congenital aniridia-associated keratopathy","volume":"16","author":"Lagali","year":"2018","journal-title":"Ocul Surf"},{"issue":"2","key":"bib37","doi-asserted-by":"publisher","first-page":"e183965","DOI":"10.1172\/jci.insight.183965","article-title":"A human-like model of aniridia-associated keratopathy for mechanistic and therapeutic studies","volume":"10","author":"Javidjam","year":"2024","journal-title":"JCI Insight"},{"issue":"3","key":"bib38","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1002\/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9","article-title":"The Ki-67 protein: from the known and the unknown","volume":"182","author":"Scholzen","year":"2000","journal-title":"J Cell Physiol"},{"issue":"11","key":"bib39","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1242\/jcs.00441","article-title":"Requirement for Pax6 in corneal morphogenesis: a role in adhesion","volume":"116","author":"Davis","year":"2003","journal-title":"J Cell Sci"},{"issue":"39","key":"bib40","doi-asserted-by":"publisher","first-page":"65064","DOI":"10.18632\/oncotarget.17775","article-title":"The value of phosphohistone H3 as a proliferation marker for evaluating invasive breast cancers: A comparative study with Ki67","volume":"8","author":"Kim","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"bib41","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.brainresrev.2006.08.002","article-title":"BrdU immunohistochemistry for studying adult neurogenesis: paradigms, pitfalls, limitations, and validation","volume":"53","author":"Taupin","year":"2007","journal-title":"Brain Res Rev"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"620284","DOI":"10.3389\/fimmu.2021.620284","article-title":"Resident innate immune cells in the cornea","volume":"12","author":"Liu","year":"2021","journal-title":"Front Immunol"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"100877","DOI":"10.1016\/j.preteyeres.2020.100877","article-title":"Plasmacytoid dendritic cells in the eye","volume":"80","author":"Jamali","year":"2021","journal-title":"Prog Retin Eye Res"},{"issue":"4","key":"bib44","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.it.2017.11.007","article-title":"When clarity is crucial: regulating ocular surface immunity","volume":"39","author":"Foulsham","year":"2018","journal-title":"Trends Immunol"},{"issue":"5","key":"bib45","doi-asserted-by":"publisher","first-page":"e37175","DOI":"10.1371\/journal.pone.0037175","article-title":"Distinct roles for neuropilin1 and neuropilin2 during mouse corneal innervation.","volume":"7","author":"McKenna","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"bib46","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1167\/iovs.03-1118","article-title":"Corneal development, limbal stem cell function, and corneal epithelial cell migration in the Pax6+\/- mouse","volume":"45","author":"Collinson","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib47","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0012-1606(02)00095-7","article-title":"The roles of Pax6 in the cornea, retina, and olfactory epithelium of the developing mouse embryo","volume":"255","author":"Collinson","year":"2003","journal-title":"Dev Biol"},{"issue":"1","key":"bib48","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1167\/iovs.10-5902","article-title":"Innervation of the mouse cornea during development","volume":"52","author":"McKenna","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib49","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.exer.2010.07.007","article-title":"Mapping the entire human corneal nerve architecture","volume":"91","author":"He","year":"2010","journal-title":"Exp Eye Res"},{"issue":"3","key":"bib50","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.jtos.2017.05.002","article-title":"TFOS DEWS II pain and sensation report","volume":"15","author":"Belmonte","year":"2017","journal-title":"Ocul Surf"},{"issue":"3","key":"bib51","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1080\/02713683.2019.1675175","article-title":"Corneal cells: fine-tuning nerve regeneration","volume":"45","author":"Kowtharapu","year":"2020","journal-title":"Curr Eye Res"},{"issue":"10","key":"bib52","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1124\/dmd.122.001072","article-title":"Challenges and opportunities in P450 research on the eye","volume":"51","author":"Pikuleva","year":"2023","journal-title":"Drug Metab Dispos"},{"issue":"2","key":"bib53","doi-asserted-by":"publisher","first-page":"224","DOI":"10.3390\/cells11020224","article-title":"Sex hormones, growth hormone, and the cornea","volume":"11","author":"McKay","year":"2022","journal-title":"Cells"},{"issue":"19","key":"bib54","doi-asserted-by":"publisher","first-page":"2930","DOI":"10.3390\/cells11192930","article-title":"Cytochrome P450 1B1: a key regulator of ocular iron homeostasis and oxidative stress","volume":"11","author":"Song","year":"2022","journal-title":"Cells"},{"issue":"5","key":"bib55","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/j.survophthal.2023.04.003","article-title":"Future directions in managing aniridia-associated keratopathy","volume":"68","author":"van Velthoven","year":"2023","journal-title":"Surv Ophthalmol"},{"issue":"8","key":"bib56","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/s41419-020-02848-5","article-title":"PAX6, modified by SUMOylation, plays a protective role in corneal endothelial injury","volume":"11","author":"Yu","year":"2020","journal-title":"Cell Death Dis"},{"issue":"1","key":"bib57","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1128\/MCB.24.1.245-257.2004","article-title":"Transcription factors Pax6 and AP-2alpha interact to coordinate corneal epithelial repair by controlling expression of matrix metalloproteinase gelatinase B","volume":"24","author":"Sivak","year":"2004","journal-title":"Mol Cell Biol"},{"issue":"1","key":"bib58","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.ydbio.2010.04.032","article-title":"Developmental guidance of embryonic corneal innervation: roles of Semaphorin3A and Slit2","volume":"344","author":"Kubilus","year":"2010","journal-title":"Dev Biol"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.preteyeres.2015.07.002","article-title":"Progress in corneal wound healing","volume":"49","author":"Ljubimov","year":"2015","journal-title":"Prog Retin Eye Res"},{"issue":"6","key":"bib60","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1080\/02713683.2024.2320779","article-title":"Examination of subbasal nerve plexus and central corneal stromal microstructure in subjects with congenital aniridia, using in vivo confocal laser scanning microscopy","volume":"49","author":"Csorba","year":"2024","journal-title":"Curr Eye Res"},{"issue":"7","key":"bib61","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/j.stem.2021.02.024","article-title":"Exploring the human lacrimal gland using organoids and single-cell sequencing","volume":"28","author":"Bannier-H\u00e9laou\u00ebt","year":"2021","journal-title":"Cell Stem Cell"},{"issue":"5","key":"bib62","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1002\/dvdy.23925","article-title":"The corneal epithelium and lens develop independently from a common pool of precursors","volume":"242","author":"Collomb","year":"2013","journal-title":"Dev Dyn"},{"issue":"1\u20136","key":"bib63","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0022-4731(89)90089-7","article-title":"Hormonal influence on the secretory immune system of the eye: Endocrine impact on the lacrimal gland accumulation and secretion of IgA and IgG","volume":"34","author":"Sullivan","year":"1989","journal-title":"J Steroid Biochem"},{"issue":"1","key":"bib64","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.exer.2005.04.014","article-title":"Influence of sex on gene expression in the mouse lacrimal gland","volume":"82","author":"Richards","year":"2006","journal-title":"Exp Eye Res"},{"issue":"6","key":"bib65","doi-asserted-by":"publisher","first-page":"5609","DOI":"10.3390\/ijms24065609","article-title":"Expression of androgen and estrogen receptors in the human lacrimal gland","volume":"24","author":"Hat","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"1","key":"bib66","doi-asserted-by":"publisher","first-page":"6965","DOI":"10.1038\/s41598-017-06022-4","article-title":"Serotonin hormonally regulates lacrimal gland secretory function via the serotonin type 3a receptor","volume":"7","author":"Imada","year":"2017","journal-title":"Sci Rep"},{"issue":"8-9","key":"bib67","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1387\/ijdb.041866ac","article-title":"Regulation of gene expression by Pax6 in ocular cells: a case of tissue-preferred expression of crystallins in lens","volume":"48","author":"Cvekl","year":"2004","journal-title":"Int J Dev Biol"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.exer.2016.11.005","article-title":"PAX6 regulates human corneal epithelium cell identity","volume":"154","author":"Kitazawa","year":"2017","journal-title":"Exp Eye Res"},{"issue":"12","key":"bib69","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1167\/iovs.65.12.40","article-title":"PAX6-WNK2 axis governs corneal epithelial homeostasis","volume":"65","author":"Zhu","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib70","doi-asserted-by":"publisher","first-page":"e0146433","DOI":"10.1371\/journal.pone.0146433","article-title":"ALDH3A1 plays a functional role in maintenance of corneal epithelial homeostasis","volume":"11","author":"Koppaka","year":"2016","journal-title":"PLoS One"},{"issue":"30","key":"bib71","doi-asserted-by":"publisher","first-page":"27998","DOI":"10.1074\/jbc.M503698200","article-title":"Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells","volume":"280","author":"Pappa","year":"2005","journal-title":"J Biol Chem"},{"issue":"6","key":"bib72","doi-asserted-by":"publisher","first-page":"5845","DOI":"10.3390\/ijms24065845","article-title":"Investigating the functional roles of aldehyde dehydrogenase 3A1 in human corneal epithelial cells","volume":"24","author":"Voulgaridou","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"4","key":"bib73","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1080\/02713683.2025.2449915","article-title":"Expression of PAX6 and keratocyte-characteristic markers in human limbal stromal cells of congenital aniridia and healthy subjects, in vitro","volume":"50","author":"Li","year":"2025","journal-title":"Curr Eye Res"},{"issue":"1","key":"bib74","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1749-8104-4-19","article-title":"Normal ventral telencephalic expression of Pax6 is required for normal development of thalamocortical axons in embryonic mice","volume":"4","author":"Simpson","year":"2009","journal-title":"Neural Dev"},{"issue":"24","key":"bib75","doi-asserted-by":"publisher","first-page":"5080","DOI":"10.1093\/nar\/23.24.5080","article-title":"A cre -transgenic mouse strain for the ubiquitous deletion of loxP -flanked gene segments including deletion in germ cells","volume":"23","author":"Schwenk","year":"1995","journal-title":"Nucl Acids Res"},{"issue":"5","key":"bib76","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1002\/ajmg.a.32209","article-title":"Genetic analysis of chromosome 11p13 and the PAX6 gene in a series of 125 cases referred with aniridia","volume":"146A","author":"Robinson","year":"2008","journal-title":"Am J Med Genet A"},{"key":"bib77","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.jtos.2021.09.001","article-title":"Pathophysiology of aniridia-associated keratopathy: developmental aspects and unanswered questions","volume":"22","author":"Latta","year":"2021","journal-title":"Ocul Surf"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.5.39","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:19Z","timestamp":1791927139000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.5.39"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,18]]},"references-count":77,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.5.39","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,18]]}}}