{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:02:49Z","timestamp":1791928969825,"version":"4.3.4"},"reference-count":26,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"5","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,5,20]]},"DOI":"10.1167\/iovs.67.5.54","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T13:30:47Z","timestamp":1779283847000},"page":"54","source":"Crossref","is-referenced-by-count":0,"title":["Loss of\n                    <i>Streptococcus pneumoniae iga<\/i>\n                    Causes More Severe Keratitis in Mice"],"prefix":"10.1167","volume":"67","author":[{"given":"Mary A.","family":"Carr","sequence":"first","affiliation":[{"name":"Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva M.","family":"Bengt\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi, United States"},{"name":"Center for Immunology and Microbial Research and the Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Marquart","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi, United States"},{"name":"Center for Immunology and Microbial Research and the Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","first-page":"383","article-title":"IgA subclasses in various secretions and in serum","volume":"47","author":"Delacroix","year":"1982","journal-title":"Immunology"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1128\/iai.26.1.143-149.1979","article-title":"Pathogenic species of the genus Haemophilus and Streptococcus pneumoniae produce immunoglobulin A1 protease","volume":"26","author":"Kilian","year":"1979","journal-title":"Infect Immun"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1086\/323397","article-title":"Cleavage of the hormone human chorionic gonadotropin, by the Type 1 IgA1 protease of Neisseria gonorrhoeae, and its implications","volume":"184","author":"Senior","year":"2001","journal-title":"J Infect Dis"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1080\/21505594.2021.1871822","article-title":"Neisseria meningitidis IgA1-specific serine protease exhibits novel cleavage activity against IgG3","volume":"12","author":"Spoerry","year":"2021","journal-title":"Virulence"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"7359","DOI":"10.1016\/S0021-9258(18)42525-2","article-title":"Concerted evolution of the primate immunoglobulin alpha-gene through gene conversion","volume":"267","author":"Kawamura","year":"1992","journal-title":"J Biol Chem"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1471-2180-3-14","article-title":"The three extra-cellular zinc metalloproteinases of Streptococcus pneumoniae have a different impact on virulence in mice","volume":"3","author":"Chiavolini","year":"2003","journal-title":"BMC Microbiol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"5620","DOI":"10.1128\/IAI.66.12.5620-5629.1998","article-title":"Large-scale identification of virulence genes from Streptococcus pneumoniae","volume":"66","author":"Polissi","year":"1998","journal-title":"Infect Immun"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1097\/ICO.0b013e318093de1f","article-title":"Expression of toll-like receptors in the healthy and herpes simplex virus-infected cornea","volume":"26","author":"Jin","year":"2007","journal-title":"Cornea"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"3337","DOI":"10.4049\/jimmunol.173.5.3337","article-title":"Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium","volume":"173","author":"Ueta","year":"2004","journal-title":"J Immunol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1097\/00029330-200705020-00008","article-title":"Expression profiles and function of Toll-like receptors in human corneal epithelia","volume":"120","author":"Wu","year":"2007","journal-title":"Chin Med J (Engl)"},{"key":"bib11","first-page":"2264","article-title":"Identification of a novel macrophage population in the normal mouse corneal stroma","volume":"43","author":"Brissette-Storkus","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1167\/iovs.02-0838","article-title":"The corneal stroma is endowed with a significant number of resident dendritic cells","volume":"44","author":"Hamrah","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib13","first-page":"1389","article-title":"Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors","volume":"45","author":"Hava","year":"2002","journal-title":"Mol Microbiol"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1159\/000229028","article-title":"Development of a Streptococcus pneumoniae keratitis model in mice","volume":"42","author":"Moore","year":"2009","journal-title":"Ophthalmic Res"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"2661","DOI":"10.1167\/iovs.07-0017","article-title":"Cholesterol as treatment for pneumococcal keratitis: cholesterol-specific inhibition of pneumolysin in the cornea","volume":"48","author":"Marquart","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1128\/IAI.68.2.921-924.2000","article-title":"Evaluation of the virulence of a Streptococcus pneumoniae neuraminidase-deficient mutant in nasopharyngeal colonization and development of otitis media in the chinchilla model","volume":"68","author":"Tong","year":"2000","journal-title":"Infect Immun"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1128\/IAI.01384-06","article-title":"Contributions of pneumolysin, pneumococcal surface protein A (PspA), and PspC to pathogenicity of Streptococcus pneumoniae D39 in a mouse model","volume":"75","author":"Ogunniyi","year":"2007","journal-title":"Infect Immun"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"12994","DOI":"10.1074\/jbc.M511431200","article-title":"Epithelial cells are sensitive detectors of bacterial pore-forming toxins","volume":"281","author":"Ratner","year":"2006","journal-title":"J Biol Chem"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1167\/iovs.02-0656","article-title":"A new topical model of Staphylococcus corneal infection in the mouse","volume":"44","author":"Girgis","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1111\/j.1440-1711.2005.01326.x","article-title":"A Staphylococcus aureus mouse keratitis topical infection model: cytokine balance in different strains of mice","volume":"83","author":"Hume","year":"2005","journal-title":"Immunol Cell Biol"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1097\/ICO.0000000000004056","article-title":"Myeloid-derived suppressor cells enhance wound healing in a murine model of corneal injury","volume":"45","author":"Lee","year":"2026","journal-title":"Cornea"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1111\/cmi.12130","article-title":"Pneumococcal immune evasion: ZmpC inhibits neutrophil influx","volume":"15","author":"Surewaard","year":"2013","journal-title":"Cell Microbiol"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.exer.2018.07.018","article-title":"Demonstration of P-selectin expression and potential function in human corneal epithelial cells","volume":"176","author":"Gillies","year":"2018","journal-title":"Exp Eye Res"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"4083","DOI":"10.1128\/IAI.00297-06","article-title":"Burkholderia cenocepacia ZmpB is a broad-specificity zinc metalloprotease involved in virulence","volume":"74","author":"Kooi","year":"2006","journal-title":"Infect Immun"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/mi.2013.41","article-title":"Pneumococcal IgA1 protease subverts specific protection by human IgA1","volume":"7","author":"Janoff","year":"2014","journal-title":"Mucosal Immunol"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.5.54","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:22Z","timestamp":1791927142000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.5.54"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,20]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.5.54","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,20]]}}}