{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:02:48Z","timestamp":1791928968036,"version":"4.3.4"},"reference-count":20,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"5","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,5,27]]},"DOI":"10.1167\/iovs.67.5.66","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:30:37Z","timestamp":1779888637000},"page":"66","source":"Crossref","is-referenced-by-count":2,"title":["Perivascular Macrophages Are Associated With Permissive Sites of Immune Cell Extravasation in Retinal Venules"],"prefix":"10.1167","volume":"67","author":[{"given":"Colin A.","family":"Lemire","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrita","family":"Rajesh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritvik","family":"Viniak","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy A.","family":"Lavine","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States"},{"name":"https:\/\/orcid.org\/0000-0002-0884-1336"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"5997","DOI":"10.1167\/iovs.09-3515","article-title":"Scavenger function of resident autofluorescent perivascular macrophages and their contribution to the maintenance of the blood\u2013retinal barrier","volume":"50","author":"Mendes-Jorge","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1186\/s12974-022-02562-3","article-title":"Macrophages in close proximity to the vitreoretinal interface are potential biomarkers of inflammation during retinal vascular disease","volume":"19","author":"Rajesh","year":"2022","journal-title":"J Neuroinflammation"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"e180904","DOI":"10.1172\/JCI180904","article-title":"Retinal perivascular macrophages regulate immune cell infiltration during neuroinflammation in mouse models of ocular disease","volume":"134","author":"Sterling","year":"2024","journal-title":"J Clin Invest"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1084\/jem.20051210","article-title":"Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils","volume":"203","author":"Wang","year":"2006","journal-title":"J Exp Med"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1161\/ATVBAHA.109.187450","article-title":"Monocytes and neutrophils exhibit both distinct and common mechanisms in penetrating the vascular basement membrane in vivo","volume":"29","author":"Voisin","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"482","DOI":"10.2353\/ajpath.2010.090510","article-title":"Venular basement membranes ubiquitously express matrix protein low-expression regions","volume":"176","author":"Voisin","year":"2010","journal-title":"Am J Pathol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"5059","DOI":"10.1167\/iovs.19-28165","article-title":"Monocyte-derived macrophages are necessary for beta-adrenergic receptor-driven choroidal neovascularization inhibition","volume":"60","author":"Droho","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"108204","DOI":"10.1016\/j.exer.2020.108204","article-title":"Spectacle: an interactive resource for ocular single-cell RNA sequencing data analysis","volume":"200","author":"Voigt","year":"2020","journal-title":"Exp Eye Res"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.bbrc.2009.01.135","article-title":"Presence of a-smooth muscle actin-positive endothelial cells in the luminal surface of adult aorta","volume":"380","author":"Azuma","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"e60547","DOI":"10.7554\/eLife.60547","article-title":"Label-free imaging of immune cell dynamics in the living retina using adaptive optics","volume":"9","author":"Joseph","year":"2020","journal-title":"eLife"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"6409","DOI":"10.1038\/s41467-022-34087-x","article-title":"Divergent regulation of basement membrane trafficking by human macrophages and cancer cells","volume":"13","author":"Bahr","year":"2022","journal-title":"Nat Commun"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1002\/glia.10031","article-title":"Juxtavascular microglia migrate along brain microvessels following activation during early postnatal development","volume":"37","author":"Grossmann","year":"2002","journal-title":"Glia"},{"key":"bib13","first-page":"473","article-title":"Multimodal analysis of ocular inflammation using endotoxin-induced uveitis","volume":"9","author":"Chu","year":"2016","journal-title":"Dis Model Mech"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1076\/ocii.8.4.221.6461","article-title":"Cytokine gene expression in different strains of mice with endotoxin-induced uveitis (EIU)","volume":"8","author":"Shen","year":"2000","journal-title":"Ocul Immunol Inflamm"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1111\/jnc.13002","article-title":"Sigma receptor 1 activation attenuates release of inflammatory cytokines MIP1?, MIP2, MIP3a, and IL12 (p40\/p70) by retinal M\u00fcller glial cells","volume":"132","author":"Shanmugam","year":"2015","journal-title":"J Neurochem"},{"key":"bib16","first-page":"408","article-title":"Epigallocatechin-3-gallate attenuates lipopolysaccharide-induced inflammation in human retinal endothelial cells","volume":"7","author":"Zhang","year":"2014","journal-title":"Int J Ophthalmol"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1016\/j.immuni.2018.09.018","article-title":"Distinct compartmentalization of the chemokines CXCL1 and CXCL2 and the atypical receptor ACKR1 determine discrete stages of neutrophil diapedesis","volume":"49","author":"Girbl","year":"2018","journal-title":"Immunity"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.2174\/1381612821666150316122928","article-title":"Mouse models of autoimmune uveitis","volume":"21","author":"Klaska","year":"2015","journal-title":"Curr Pharm Des"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"103417","DOI":"10.1016\/j.jaut.2025.103417","article-title":"Preventing the antigen-presenting function of retinal microglia blocks autoimmune neuroinflammation by dendritic cell-primed CD4+ T cells","volume":"153","author":"Shirahama","year":"2025","journal-title":"J Autoimmun"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"9989","DOI":"10.1073\/pnas.1820387116","article-title":"Retinal microglia initiate neuroinflammation in ocular autoimmunity","volume":"116","author":"Okunuki","year":"2019","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.5.66","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:23Z","timestamp":1791927143000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.5.66"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,27]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.5.66","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,27]]}}}