{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:58Z","timestamp":1791928918973,"version":"4.3.4"},"reference-count":49,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"6","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"DOI":"10.1167\/iovs.67.6.43","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T13:30:41Z","timestamp":1782135041000},"page":"43","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of Histostructural Modifications in the Ocular Surface of Patients With Chronic Glaucoma"],"prefix":"10.1167","volume":"67","author":[{"given":"Olimpia","family":"Ortiz-Arrabal","sequence":"first","affiliation":[{"name":"Tissue Engineering Group, Department of Histology, Faculty of Medicine, University of Granada, Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Francisco","family":"Ramos-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Granada, Spain"},{"name":"Division of Ophthalmology, University Hospital Virgen de las Nieves, Granada, Spain"},{"name":"Instituto Oftalmol\u00f3gico de Granada, Granada, Spain"},{"name":"Department of Surgery and Specialties, Faculty of Medicina, University of Granada, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Ortiz-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Granada, Spain"},{"name":"Division of Ophthalmology, University Hospital Virgen de las Nieves, Granada, Spain"},{"name":"Department of Surgery and Specialties, Faculty of Medicina, University of Granada, Granada, Spain"},{"name":"Department of Ophthalmology, Vithas Granada Hospital, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Bermejo-Casares","sequence":"additional","affiliation":[{"name":"Tissue Engineering Group, Department of Histology, Faculty of Medicine, University of Granada, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"S\u00e1nchez-Porras","sequence":"additional","affiliation":[{"name":"Tissue Engineering Group, Department of Histology, Faculty of Medicine, University of Granada, Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Alaminos","sequence":"additional","affiliation":[{"name":"Tissue Engineering Group, Department of Histology, Faculty of Medicine, University of Granada, Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"issue":"13","key":"bib1","first-page":"225","article-title":"The diagnosis and treatment of glaucoma","volume":"117","author":"Schuster","year":"2020","journal-title":"Dtsch Arzteblatt Int"},{"issue":"3","key":"bib2","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.mcna.2021.01.004","article-title":"Glaucoma","volume":"105","author":"Kang","year":"2021","journal-title":"Med Clin North Am"},{"issue":"2","key":"bib3","doi-asserted-by":"publisher","first-page":"906","DOI":"10.3390\/ijms25020906","article-title":"Glaucoma animal models beyond chronic IOP increase","volume":"25","author":"Tsai","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"2","key":"bib5","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1001\/jama.2020.21899","article-title":"Glaucoma in adults\u2014screening, diagnosis, and management: a review","volume":"325","author":"Stein","year":"2021","journal-title":"JAMA"},{"issue":"2","key":"bib6","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1111\/ceo.13989","article-title":"Medical therapy for glaucoma: a review","volume":"50","author":"Casson","year":"2022","journal-title":"Clin Exp Ophthalmol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"431","DOI":"10.2147\/PPA.S176412","article-title":"Investigation of medication adherence and reasons for poor adherence in patients on long-term glaucoma treatment regimes","volume":"13","author":"McClelland","year":"2019","journal-title":"Patient Prefer Adherence"},{"issue":"6","key":"bib8","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.mayocpiqo.2022.09.007","article-title":"Updates on the diagnosis and management of glaucoma","volume":"6","author":"Wagner","year":"2022","journal-title":"Mayo Clin Proc Innov Qual Outcomes"},{"issue":"2","key":"bib9","first-page":"CD005655","article-title":"Peripheral iridotomy for pigmentary glaucoma","volume":"2","author":"Michelessi","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"issue":"9","key":"bib10","doi-asserted-by":"publisher","first-page":"5258","DOI":"10.1167\/iovs.12-9705","article-title":"Quantitative mapping of collagen fiber orientation in non-glaucoma and glaucoma posterior human sclerae","volume":"53","author":"Pijanka","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib11","first-page":"623","article-title":"Alterations in proteome of human sclera associated with primary open-angle glaucoma involve proteins participating in regulation of the extracellular matrix","volume":"26","author":"Iomdina","year":"2020","journal-title":"Mol Vis"},{"issue":"9","key":"bib12","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1136\/bjo.71.9.706","article-title":"Iris atrophy with hypoperfusion and microneovascularisation","volume":"71","author":"Brooks","year":"1987","journal-title":"Br J Ophthalmol"},{"issue":"9","key":"bib13","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1016\/S0161-6420(95)30873-1","article-title":"A histopathologic study of iris changes in pseudoexfoliation syndrome","volume":"102","author":"Asano","year":"1995","journal-title":"Ophthalmology"},{"issue":"4","key":"bib14","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1034\/j.1600-0420.2000.078004437.x","article-title":"Iris indocyanine green angiography in pseudoexfoliation syndrome and capsular glaucoma","volume":"78","author":"Parodi","year":"2000","journal-title":"Acta Ophthalmol Scand"},{"issue":"6","key":"bib15","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1111\/aos.15082","article-title":"Ultrasound biomicroscopy of the anterior segment in patients with primary congenital glaucoma: a review of the literature","volume":"100","author":"Janssens","year":"2022","journal-title":"Acta Ophthalmol (Copenh)"},{"issue":"11","key":"bib16","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.oftal.2013.04.013","article-title":"[The effects of ocular hypotensive drugs on the cornea: an in vivo analysis with confocal microscopy]","volume":"88","author":"Fern\u00e1ndez Jim\u00e9nez-Ortiz","year":"2013","journal-title":"Arch Soc Espanola Oftalmol"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"566473","DOI":"10.2147\/OPTH.S566473","article-title":"A comparison of vessel density in primary open-angle glaucoma and normal-tension glaucoma patients using OCT angiography","volume":"20","author":"Zehavi-Dorin","year":"2026","journal-title":"Clin Ophthalmol"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/978-1-0716-4510-9","article-title":"Histological and histochemical methods for the evaluation of tissue engineered skin substitutes","volume":"2922","author":"Campos","year":"2025","journal-title":"Methods Mol Biol"},{"issue":"6","key":"bib20","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1080\/03008207.2025.2522860","article-title":"A gene expression and a histostructural analysis of the palmar fascia of patients affected by Dupuytren's disease","volume":"66","author":"Gal\u00e1n Novella","year":"2025","journal-title":"Connect Tissue Res"},{"issue":"1","key":"bib21","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s00418-018-1701-x","article-title":"Characterization of the human ridged and non-ridged skin: a comprehensive histological, histochemical and immunohistochemical analysis","volume":"151","author":"Vela-Romera","year":"2019","journal-title":"Histochem Cell Biol"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"596","DOI":"10.3389\/fbioe.2020.00596","article-title":"Evaluation of fibrin-agarose tissue-like hydrogels biocompatibility for tissue engineering applications","volume":"8","author":"Campos","year":"2020","journal-title":"Front Bioeng Biotechnol"},{"issue":"9","key":"bib24","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1369\/0022155416659249","article-title":"Comparison of picrosirius red staining with second harmonic generation imaging for the quantification of clinically relevant collagen fiber features in histopathology samples","volume":"64","author":"Drifka","year":"2016","journal-title":"J Histochem Cytochem"},{"issue":"4","key":"bib25","doi-asserted-by":"publisher","first-page":"221","DOI":"10.3109\/08820530009037873","article-title":"The relationship between structural and functional alterations in glaucoma: a review","volume":"15","author":"Johnson","year":"2000","journal-title":"Semin Ophthalmol"},{"issue":"1","key":"bib26","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1159\/000545948","article-title":"Evaluation of the iris vessel density for primary glaucoma diagnosis using anterior segment optical coherence tomography","volume":"68","author":"Li","year":"2025","journal-title":"Ophthalmic Res"},{"issue":"3","key":"bib27","doi-asserted-by":"publisher","first-page":"101825","DOI":"10.1016\/j.clae.2023.101825","article-title":"Scleral thinning causes, diagnosis, and management: a narrative review","volume":"46","author":"Bulloch","year":"2023","journal-title":"Contact Lens Anterior Eye"},{"issue":"2","key":"bib28","doi-asserted-by":"publisher","first-page":"174","DOI":"10.4103\/IJO.IJO_1392_23","article-title":"Scleral collagen cross linkage in progressive myopia","volume":"72","author":"Yasir","year":"2024","journal-title":"Indian J Ophthalmol"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"100773","DOI":"10.1016\/j.preteyeres.2019.100773","article-title":"Scleral structure and biomechanics","volume":"74","author":"Boote","year":"2020","journal-title":"Prog Retin Eye Res"},{"issue":"7","key":"bib30","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.3390\/biom11071018","article-title":"Molecular basis for mechanical properties of ECMs: proposed role of fibrillar collagen and proteoglycans in tissue biomechanics","volume":"11","author":"Silver","year":"2021","journal-title":"Biomolecules"},{"issue":"9","key":"bib31","doi-asserted-by":"publisher","first-page":"e7028","DOI":"10.1371\/journal.pone.0007028","article-title":"Decorin core protein (decoron) shape complements collagen fibril surface structure and mediates its binding","volume":"4","author":"Orgel","year":"2009","journal-title":"PLoS One"},{"issue":"12","key":"bib32","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1002\/jemt.24398","article-title":"Histological characterization of the human masticatory oral mucosa. A histochemical and immunohistochemical study","volume":"86","author":"Ib\u00e1\u00f1ez-Cort\u00e9s","year":"2023","journal-title":"Microsc Res Tech"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"29","DOI":"10.2147\/CCID.S143015","article-title":"Calcium hydroxylapatite treatment of human skin: evidence of collagen turnover through picrosirius red staining and circularly polarized microscopy","volume":"11","author":"Zerbinati","year":"2018","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"10","key":"bib34","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1369\/0022155414545787","article-title":"Picrosirius red staining: a useful tool to appraise collagen networks in normal and pathological tissues","volume":"62","author":"Lattouf","year":"2014","journal-title":"J Histochem Cytochem"},{"issue":"10","key":"bib35","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1369\/00221554211046777","article-title":"Picrosirius red staining: revisiting its application to the qualitative and quantitative assessment of collagen type I and type III in tendon","volume":"69","author":"L\u00f3pez De Padilla","year":"2021","journal-title":"J Histochem Cytochem"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"107169","DOI":"10.1016\/j.jmbbm.2025.107169","article-title":"Regional quantification of glycosaminoglycans and their association with collagen fibril ultrastructure in the sclera following enzymatic degradation","volume":"172","author":"Kazaili","year":"2025","journal-title":"J Mech Behav Biomed Mater"},{"issue":"5","key":"bib37","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1007\/s00417-021-05523-3","article-title":"The anterior scleral thickness in eyes with primary open-angle glaucoma","volume":"260","author":"Yan","year":"2022","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"5","key":"bib39","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/0002-9394(75)90283-4","article-title":"The histopathology of pigmentary dispersion syndrome with glaucoma","volume":"80","author":"Kupfer","year":"1975","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"bib40","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1679\/aohc.65.109","article-title":"Collagen fibers, reticular fibers and elastic fibers. A comprehensive understanding from a morphological viewpoint","volume":"65","author":"Ushiki","year":"2002","journal-title":"Arch Histol Cytol"},{"issue":"6","key":"bib41","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1111\/j.1755-3768.1993.tb08595.x","article-title":"Morphology of iris vasculopathy in exfoliation glaucoma","volume":"71","author":"Konstas","year":"1993","journal-title":"Acta Ophthalmol (Copenh)"},{"issue":"8","key":"bib42","first-page":"2098","article-title":"Iridial vasculature and pericyte morphology in different types of glaucoma","volume":"58","author":"S","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib43","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/j.1755-3768.2007.01167.x","article-title":"Endothelial dysfunction in glaucoma","volume":"87","author":"Resch","year":"2009","journal-title":"Acta Ophthalmol"},{"issue":"4","key":"bib44","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1097\/00061198-200408000-00013","article-title":"Response of retinal vessel diameters to flicker stimulation in patients with early open angle glaucoma","volume":"13","author":"Garh\u00f6fer","year":"2004","journal-title":"J Glaucoma"},{"issue":"3","key":"bib45","doi-asserted-by":"publisher","first-page":"H985","DOI":"10.1152\/ajpheart.00292.2006","article-title":"Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture)","volume":"291","author":"F\u00e9l\u00e9tou","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"113164","DOI":"10.1016\/j.jbiomech.2026.113164","article-title":"Mechanotransduction in trabecular meshwork cells: Rho\/ROCK-dependent responses to substrate stiffness","volume":"198","author":"Du","year":"2026","journal-title":"J Biomech"},{"issue":"5","key":"bib47","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.3390\/cells9051076","article-title":"Structure and function of human matrix metalloproteinases","volume":"9","author":"Laronha","year":"2020","journal-title":"Cells"},{"issue":"3","key":"bib48","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/S0161-6420(99)90116-1","article-title":"Ocular surface inflammatory changes induced by topical antiglaucoma drugs: human and animal studies","volume":"106","author":"Baudouin","year":"1999","journal-title":"Ophthalmology"},{"issue":"10","key":"bib49","doi-asserted-by":"publisher","first-page":"7385","DOI":"10.1167\/iovs.10-6532","article-title":"Proteomic profiling of inflammatory signaling molecules in the tears of patients on chronic glaucoma medication","volume":"52","author":"Wong","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib4","volume-title":"Shields\u2019 Textbook of Glaucoma","author":"Allingham","year":"2012"},{"key":"bib18","volume-title":"Clinical Decisions in Glaucoma","author":"Hodapp","year":"1993"},{"key":"bib22","volume-title":"Histological and Histochemical Methods: Theory and Practice","author":"Kiernan","year":"2015","edition":"5th ed"},{"key":"bib38","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-030-45756-3","volume-title":"The Iris: Understanding the Essentials","author":"Moazed","year":"2020"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.6.43","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:19Z","timestamp":1791927139000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.6.43"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,22]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.6.43","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,22]]}}}