{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:02:44Z","timestamp":1791928964557,"version":"4.3.4"},"reference-count":38,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"6","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,6,25]]},"DOI":"10.1167\/iovs.67.6.50","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T13:32:12Z","timestamp":1782394332000},"page":"50","source":"Crossref","is-referenced-by-count":0,"title":["In Vivo Evaluation of Peripapillary Scleral Architecture in Myopia and Glaucoma Using Polarization-Sensitive Optical Coherence Tomography"],"prefix":"10.1167","volume":"67","author":[{"given":"Kaho","family":"Akiyama","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichiro","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asahi","family":"Konagai","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yamanari","sequence":"additional","affiliation":[{"name":"Tomey Corporation, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiaki","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Tomey Corporation, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Honjo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitomi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"101156","DOI":"10.1016\/j.preteyeres.2022.101156","article-title":"Myopia: histology, clinical features, and potential implications for the etiology of axial elongation","volume":"96","author":"Jonas","year":"2023","journal-title":"Prog Retin Eye Res"},{"issue":"6","key":"bib2","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/j.ajo.2011.05.006","article-title":"Histology of the parapapillary region in high myopia","volume":"152","author":"Jonas","year":"2011","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"bib3","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1167\/iovs.61.4.49","article-title":"The complications of myopia: a review and meta-analysis","volume":"61","author":"Haarman","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"13","key":"bib4","doi-asserted-by":"publisher","first-page":"5897","DOI":"10.1167\/iovs.17-21942","article-title":"Intraocular pressure and glaucomatous optic neuropathy in high myopia","volume":"58","author":"Jonas","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"bib5","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1016\/j.ophtha.2006.03.059","article-title":"Risk factors for open-angle glaucoma in a Japanese population: the Tajimi Study","volume":"113","author":"Suzuki","year":"2006","journal-title":"Ophthalmology"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"108188","DOI":"10.1016\/j.exer.2020.108188","article-title":"Role of radially aligned scleral collagen fibers in optic nerve head biomechanics","volume":"199","author":"Hua","year":"2020","journal-title":"Exp Eye Res"},{"issue":"1","key":"bib7","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.preteyeres.2004.06.001","article-title":"The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage","volume":"24","author":"Burgoyne","year":"2005","journal-title":"Prog Retin Eye Res"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"100773","DOI":"10.1016\/j.preteyeres.2019.100773","article-title":"Scleral structure and biomechanics","volume":"74","author":"Boote","year":"2020","journal-title":"Prog Retin Eye Res"},{"issue":"2","key":"bib9","doi-asserted-by":"publisher","first-page":"e0118648","DOI":"10.1371\/journal.pone.0118648","article-title":"Depth-dependent changes in collagen organization in the human peripapillary sclera","volume":"10","author":"Pijanka","year":"2015","journal-title":"PLoS One"},{"issue":"13","key":"bib10","doi-asserted-by":"publisher","first-page":"9684","DOI":"10.1167\/iovs.11-7894","article-title":"Quantitative mapping of scleral fiber orientation in normal rat eyes","volume":"52","author":"Girard","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"bib11","doi-asserted-by":"publisher","first-page":"4763","DOI":"10.1167\/iovs.18-25025","article-title":"Radial and circumferential collagen fibers are a feature of the peripapillary sclera of human, monkey, pig, cow, goat, and sheep","volume":"59","author":"Gogola","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"bib12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1167\/tvst.9.11.21","article-title":"In vivo 3D determination of peripapillary scleral and retinal layer architecture using polarization-sensitive optical coherence tomography","volume":"9","author":"Willemse","year":"2020","journal-title":"Transl Vis Sci Technol"},{"issue":"4","key":"bib13","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1001\/jamaophthalmol.2024.0002","article-title":"Polarization-sensitive oct imaging of scleral abnormalities in eyes with high myopia and dome-shaped macula","volume":"142","author":"Ohno-Matsui","year":"2024","journal-title":"JAMA Ophthalmol"},{"issue":"6","key":"bib14","doi-asserted-by":"publisher","first-page":"100117","DOI":"10.1016\/j.apjo.2024.100117","article-title":"Visualization of the scleral structure changes at various stages of eyes with myopic maculopathy using polarization-sensitive OCT","volume":"13","author":"Sugisawa","year":"2024","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"issue":"1","key":"bib15","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1167\/iovs.67.1.13","article-title":"Possible extension of inner scleral fibers into the peripapillary sclera detected by polarization-sensitive OCT","volume":"67","author":"Xiong","year":"2026","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib16","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/j.ajo.2015.01.022","article-title":"International photographic classification and grading system for myopic maculopathy","volume":"159","author":"Ohno-Matsui","year":"2015","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"bib18","doi-asserted-by":"publisher","first-page":"19513","DOI":"10.1038\/s41598-020-76397-4","article-title":"Melanin concentration and depolarization metrics measurement by polarization-sensitive optical coherence tomography","volume":"10","author":"Yamanari","year":"2020","journal-title":"Sci Rep"},{"issue":"5","key":"bib19","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1364\/BOE.10.002318","article-title":"Parallel detection of Jones-matrix elements in polarization-sensitive optical coherence tomography","volume":"10","author":"Yamanari","year":"2019","journal-title":"Biomed Opt Express"},{"issue":"9","key":"bib20","doi-asserted-by":"publisher","first-page":"3551","DOI":"10.1364\/BOE.7.003551","article-title":"Estimation of Jones matrix, birefringence and entropy using Cloude-Pottier decomposition in polarization-sensitive optical coherence tomography","volume":"7","author":"Yamanari","year":"2016","journal-title":"Biomed Opt Express"},{"issue":"6","key":"bib21","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/BF00175988","article-title":"Improvements on Littmann's method of determining the size of retinal features by fundus photography","volume":"232","author":"Bennett","year":"1994","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"1","key":"bib22","doi-asserted-by":"publisher","first-page":"18874","DOI":"10.1038\/s41598-024-69864-9","article-title":"Effect of magnification error and axial length on circumpapillary capillary density and retinal nerve fiber layer thickness","volume":"14","author":"Akiyama","year":"2024","journal-title":"Sci Rep"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.ajo.2023.01.003","article-title":"Deep optic nerve head structures associated with increasing axial length in healthy myopic eyes of moderate axial length","volume":"249","author":"Saito","year":"2023","journal-title":"Am J Ophthalmol"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.ajo.2024.01.023","article-title":"OCT optic nerve head morphology in myopia IV: neural canal scleral flange remodeling in highly myopic eyes","volume":"261","author":"Jiravarnsirikul","year":"2024","journal-title":"Am J Ophthalmol"},{"issue":"5","key":"bib25","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1007\/s10237-012-0455-y","article-title":"Scleral anisotropy and its effects on the mechanical response of the optic nerve head","volume":"12","author":"Coudrillier","year":"2013","journal-title":"Biomech Model Mechanobiol"},{"issue":"1","key":"bib26","doi-asserted-by":"publisher","first-page":"e29692","DOI":"10.1371\/journal.pone.0029692","article-title":"Scleral thickness in human eyes","volume":"7","author":"Vurgese","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"bib27","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.exer.2009.11.001","article-title":"Dimensions of the human sclera: thickness measurement and regional changes with axial length","volume":"90","author":"Norman","year":"2010","journal-title":"Exp Eye Res"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"110048","DOI":"10.1016\/j.exer.2024.110048","article-title":"Polarization-sensitive optical coherence tomography and scleral collagen fiber orientation in osteogenesis imperfecta","volume":"247","author":"Verdonk","year":"2024","journal-title":"Exp Eye Res"},{"issue":"9","key":"bib29","doi-asserted-by":"publisher","first-page":"3759","DOI":"10.1167\/iovs.17-21842","article-title":"Variation in the three-dimensional histomorphometry of the normal human optic nerve head with age and race: lamina cribrosa and peripapillary scleral thickness and position","volume":"58","author":"Girkin","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"bib30","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1016\/j.ophtha.2014.03.035","article-title":"Proposed classification of posterior staphylomas based on analyses of eye shape by three-dimensional magnetic resonance imaging and wide-field fundus imaging","volume":"121","author":"Ohno-Matsui","year":"2014","journal-title":"Ophthalmology"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"101020","DOI":"10.1016\/j.preteyeres.2021.101020","article-title":"Tilted disc syndrome (TDS): new hypotheses for posterior segment complications and their implications in other retinal diseases","volume":"88","author":"Cohen","year":"2022","journal-title":"Prog Retin Eye Res"},{"issue":"3","key":"bib32","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1167\/iovs.14-15742","article-title":"Peripapillary choroidal thickness in young Asians with high myopia","volume":"56","author":"Gupta","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"bib33","doi-asserted-by":"publisher","first-page":"4045","DOI":"10.1167\/iovs.15-16521","article-title":"Peripapillary choroidal thickness in adult Chinese: The Beijing Eye Study","volume":"56","author":"Jiang","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib34","doi-asserted-by":"publisher","first-page":"4607","DOI":"10.1038\/s41598-020-61485-2","article-title":"Parapapillary atrophy and changes in the optic nerve head and posterior pole in high myopia","volume":"10","author":"Sung","year":"2020","journal-title":"Sci Rep"},{"issue":"6","key":"bib35","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1167\/iovs.64.6.5","article-title":"IMI-nonpathological human ocular tissue changes with axial myopia","volume":"64","author":"Jonas","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib36","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1167\/iovs.07-1429","article-title":"Lamina cribrosa and peripapillary sclera histomorphometry in normal and advanced glaucomatous Chinese eyes with various axial length","volume":"50","author":"Ren","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"bib37","doi-asserted-by":"publisher","first-page":"e0131396","DOI":"10.1371\/journal.pone.0131396","article-title":"Glaucoma-related changes in the mechanical properties and collagen micro-architecture of the human sclera","volume":"10","author":"Coudrillier","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"bib38","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.survophthal.2024.12.003","article-title":"Evaluating glaucoma in myopic eyes: challenges and opportunities","volume":"70","author":"Jiravarnsirikul","year":"2025","journal-title":"Surv Ophthalmol"},{"key":"bib17","first-page":"121","volume-title":"Automated Static Perimetry","author":"Anderson","year":"1999","edition":"2nd ed."}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.6.50","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:21Z","timestamp":1791927141000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.6.50"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.6.50","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,25]]}}}