{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:31Z","timestamp":1791928891134,"version":"4.3.4"},"reference-count":55,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"8","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,7,6]]},"DOI":"10.1167\/iovs.67.8.11","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T12:39:00Z","timestamp":1783341540000},"page":"11","source":"Crossref","is-referenced-by-count":0,"title":["Dual-Hit Myopia Mechanism Unveiled by Multi-Omics:\n                    <i>Opn1mw<\/i>\n                    Deficiency Primed the Retina for Exaggerated Response to Environmental Defocus"],"prefix":"10.1167","volume":"67","author":[{"given":"Lin","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Zhongshan Hospital Affiliated to Fudan University, Shanghai, China"},{"name":"Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianglian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Zhongshan Hospital Affiliated to Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyu","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Zhongshan Hospital Affiliated to Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Ma","sequence":"additional","affiliation":[{"name":"The Fifth Clinical College of Medical, Xinxiang Medical University, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayue","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Zhongshan Hospital Affiliated to Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehui","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Zhongshan Hospital Affiliated to Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhong","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Zhongshan Hospital Affiliated to Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhui","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Zhongshan Hospital Affiliated to Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunmei","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Zhongshan Hospital Affiliated to Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.exer.2019.04.020","article-title":"Monochromatic and white light and the regulation of eye growth","volume":"184","author":"Rucker","year":"2019","journal-title":"Exp Eye Res"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"110155","DOI":"10.1016\/j.exer.2024.110155","article-title":"Monochromatic light effects on refractive error, cone cell density and retinoic acid signaling in dorsal and ventral retina in guinea pigs","volume":"249","author":"Zou","year":"2024","journal-title":"Exp Eye Res"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1167\/iovs.62.1.21","article-title":"Short wavelength (blue) light is protective for lens-induced myopia in guinea pigs potentially through a retinoic acid-related mechanism","volume":"62","author":"Yu","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"108669","DOI":"10.1016\/j.exer.2021.108669","article-title":"Contribution of M-opsin-based color vision to refractive development in mice","volume":"209","author":"Ji","year":"2021","journal-title":"Exp Eye Res"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"109208","DOI":"10.1016\/j.exer.2022.109208","article-title":"Retinal neurodegeneration in a mouse model of green-light-induced myopia","volume":"223","author":"Ji","year":"2022","journal-title":"Exp Eye Res"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"6490","DOI":"10.1167\/iovs.15-17025","article-title":"Effects of long-wavelength lighting on refractive development in infant rhesus monkeys","volume":"56","author":"Smith","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"113459","DOI":"10.1016\/j.isci.2025.113459","article-title":"Non-invasive low-level red-light therapy for axial length control in pediatric extreme myopia","volume":"28","author":"Tian","year":"2025","journal-title":"iScience"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1146\/annurev-vision-102122-102059","article-title":"Insights into myopia from mouse models","volume":"10","author":"Mazade","year":"2024","journal-title":"Annu Rev Vis Sci"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.exer.2018.12.021","article-title":"Lack of cone mediated retinal function increases susceptibility to form-deprivation myopia in mice","volume":"180","author":"Chakraborty","year":"2019","journal-title":"Exp Eye Res"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1167\/iovs.07-0643","article-title":"High susceptibility to experimental myopia in a mouse model with a retinal on pathway defect","volume":"49","author":"Pardue","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3390\/ijms24010219","article-title":"Mice lacking Gpr179 with complete congenital stationary night blindness are a good model for myopia","volume":"24","author":"Wilmet","year":"2022","journal-title":"Int J Mol Sci"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"108866","DOI":"10.1016\/j.exer.2021.108866","article-title":"Melanopsin modulates refractive development and myopia","volume":"214","author":"Chakraborty","year":"2022","journal-title":"Exp Eye Res"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"e2018840118","DOI":"10.1073\/pnas.2018840118","article-title":"Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice","volume":"118","author":"Jiang","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1167\/iovs.64.4.29","article-title":"Unique haplotypes in OPN1LW as a common cause of high myopia with or without protanopia: a potential window into myopic mechanism","volume":"64","author":"Wang","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1167\/iovs.16-21405","article-title":"Myopia and late-onset progressive cone dystrophy associate to LVAVA\/MVAVA exon 3 interchange haplotypes of opsin genes on chromosome X","volume":"58","author":"Orosz","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"942","DOI":"10.3390\/genes13060942","article-title":"Insight from OPN1LW gene haplotypes into the cause and prevention of myopia","volume":"13","author":"Neitz","year":"2022","journal-title":"Genes (Basel)"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"8231","DOI":"10.1523\/JNEUROSCI.1196-23.2023","article-title":"The role of retinal dopamine D1 receptors in ocular growth and myopia development in mice","volume":"43","author":"Shu","year":"2023","journal-title":"J Neurosci"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1167\/iovs.64.13.15","article-title":"Integrative transcriptome and proteome analyses elucidate the mechanism of lens-induced myopia in mice","volume":"64","author":"Ji","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib19","first-page":"99","article-title":"Measurement of refractive state and deprivation myopia in two strains of mice","volume":"81","author":"Schaeffel","year":"2004","journal-title":"Optom Vis Sci"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.jgg.2021.07.007","article-title":"EVenn: easy to create repeatable and editable Venn diagrams and Venn networks online","volume":"48","author":"Chen","year":"2021","journal-title":"J Genet Genomics"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"8986","DOI":"10.1038\/s41598-023-36141-0","article-title":"The causal mutation in ARR3 gene for high myopia and progressive color vision defect","volume":"13","author":"Gu","year":"2023","journal-title":"Sci Rep"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"109086","DOI":"10.1016\/j.exer.2022.109086","article-title":"Impact of cone abundancy ratios and light spectra on emmetropization in chickens","volume":"219","author":"Gisbert","year":"2022","journal-title":"Exp Eye Res"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"4441","DOI":"10.1167\/iovs.17-21574","article-title":"Dopamine receptor subtypes mediate opposing effects on form deprivation myopia in pigmented guinea pigs","volume":"59","author":"Zhang","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"7508","DOI":"10.1167\/iovs.14-14294","article-title":"Effects of dopaminergic agents on progression of naturally occurring myopia in albino guinea pigs (Cavia porcellus)","volume":"55","author":"Jiang","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1167\/iovs.61.2.13","article-title":"Short- wavelength (violet) light protects mice from myopia through cone signaling","volume":"61","author":"Strickland","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"14895","DOI":"10.1038\/s41598-020-71806-0","article-title":"A role of color vision in emmetropization in C57BL\/6J mice","volume":"10","author":"Yang","year":"2020","journal-title":"Sci Rep"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"113944","DOI":"10.1016\/j.expneurol.2021.113944","article-title":"FGF binding protein 3 is required for spinal cord motor neuron development and regeneration in zebrafish","volume":"348","author":"Xu","year":"2022","journal-title":"Exp Neurol"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"109849","DOI":"10.1016\/j.exer.2024.109849","article-title":"Characterization of lncRNA and mRNA profiles in ciliary body in experimental myopia","volume":"241","author":"Wu","year":"2024","journal-title":"Exp Eye Res"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"26462","DOI":"10.1021\/acs.jafc.4c09346","article-title":"Excessive supplement of l-arginine induces myopia via orchestrating the MEK-ERK-NO signaling pathway","volume":"72","author":"Bao","year":"2024","journal-title":"J Agric Food Chem"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"e2104689118","DOI":"10.1073\/pnas.2104689118","article-title":"Dietary omega-3 polyunsaturated fatty acids are protective for myopia","volume":"118","author":"Pan","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.ajo.2024.08.041","article-title":"Omega-3 polyunsaturated fatty acids as a protective factor for myopia","volume":"268","author":"Xue","year":"2024","journal-title":"Am J Ophthalmol"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1136\/bjo-2024-326872","article-title":"Dietary omega-3 polyunsaturated fatty acids as a protective factor of myopia: the Hong Kong Children Eye Study","volume":"110","author":"Zhang","year":"2025","journal-title":"Br J Ophthalmol"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1167\/iovs.65.11.29","article-title":"Administration of nicotine can inhibit myopic growth in animal models","volume":"65","author":"Thomson","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.ebiom.2016.12.007","article-title":"Violet light exposure can be a preventive strategy against myopia progression","volume":"15","author":"Torii","year":"2017","journal-title":"EBioMedicine"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"101410","DOI":"10.1016\/j.preteyeres.2025.101410","article-title":"Interventions to reduce incidence and progression of myopia in children and adults","volume":"109","author":"Yam","year":"2025","journal-title":"Prog Retin Eye Res"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"eabm9027","DOI":"10.1126\/sciadv.abm9027","article-title":"The role of ipRGCs in ocular growth and myopia development","volume":"8","author":"Liu","year":"2022","journal-title":"Sci Adv"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1167\/iovs.62.1.28","article-title":"Ambient light regulates retinal dopamine signaling and myopia susceptibility","volume":"62","author":"Landis","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1167\/iovs.66.12.52","article-title":"Methylphenidate inhibits the development of myopia by altering dopamine and norepinephrine reuptake","volume":"66","author":"Karouta","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"14181","DOI":"10.1073\/pnas.0803893105","article-title":"Intraretinal signaling by ganglion cell photoreceptors to dopaminergic amacrine neurons","volume":"105","author":"Zhang","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"7920","DOI":"10.1038\/s41598-017-08172-x","article-title":"Mapping physiological inputs from multiple photoreceptor systems to dopaminergic amacrine cells in the mouse retina","volume":"7","author":"Zhao","year":"2017","journal-title":"Sci Rep"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1167\/iovs.63.1.24","article-title":"Retinal dopamine D2 receptors participate in the development of myopia in mice","volume":"63","author":"Huang","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.preteyeres.2017.06.003","article-title":"Dopamine signaling and myopia development: what are the key challenges","volume":"61","author":"Zhou","year":"2017","journal-title":"Prog Retin Eye Res"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1002\/cne.23932","article-title":"Dopamine D1 receptor expression is bipolar cell type-specific in the mouse retina","volume":"524","author":"Farshi","year":"2016","journal-title":"J Comp Neurol"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s13024-020-00363-x","article-title":"PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency","volume":"15","author":"Pirooznia","year":"2020","journal-title":"Mol Neurodegener"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"e70900","DOI":"10.1096\/fj.202501454RR","article-title":"Dopaminergic neuron-specific Tfam knockout links inter-organelle miscommunication to early-onset parkinsonism","volume":"39","author":"Shen","year":"2025","journal-title":"FASEB J"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"4499219","DOI":"10.1155\/2022\/4499219","article-title":"Dopamine D2 receptor signaling attenuates acinar cell necroptosis in acute pancreatitis through the cathepsin B\/TFAM\/ROS pathway","volume":"2022","author":"Wu","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"104554","DOI":"10.1016\/j.archger.2021.104554","article-title":"Age-related biochemical dysfunction in 6-OHDA model rats subject to induced-endurance exercise","volume":"98","author":"Rezaee","year":"2022","journal-title":"Arch Gerontol Geriatr"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"113707","DOI":"10.1016\/j.expneurol.2021.113707","article-title":"Progressive parkinsonism due to mitochondrial impairment: lessons from the MitoPark mouse model","volume":"341","author":"Beckstead","year":"2021","journal-title":"Exp Neurol"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.nbd.2010.05.017","article-title":"Genetic zebrafish models of neurodegenerative diseases","volume":"40","author":"Bandmann","year":"2010","journal-title":"Neurobiol Dis"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1038\/s42003-023-05543-1","article-title":"SMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy","volume":"6","author":"Valsecchi","year":"2023","journal-title":"Commun Biol"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"2242","DOI":"10.1523\/JNEUROSCI.1802-22.2022","article-title":"Inducible CRISPR epigenome systems mimic cocaine induced bidirectional regulation of Nab2 and Egr3","volume":"43","author":"Choi","year":"2023","journal-title":"J Neurosci"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1007\/s00213-023-06374-y","article-title":"Effects of chronic methamphetamine exposure on rewarding behavior and neurodegeneration markers in adult mice","volume":"240","author":"Davis","year":"2023","journal-title":"Psychopharmacology (Berl)"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1167\/iovs.63.2.2","article-title":"Association between color vision deficiency and myopia in Chinese children over a five-year period","volume":"63","author":"Gan","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"11581","DOI":"10.1038\/s41598-023-38569-w","article-title":"Factors associated with myopia in 19-year-old adult men in Korea between 2014 and 2020","volume":"13","author":"Gwon","year":"2023","journal-title":"Sci Rep"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1167\/iovs.66.13.22","article-title":"IMI-myopia genetics report","volume":"66","author":"Voogelaar","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.8.11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:13Z","timestamp":1791927133000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.8.11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,6]]},"references-count":55,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.8.11","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,6]]}}}