{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:02:22Z","timestamp":1791928942392,"version":"4.3.4"},"reference-count":53,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"8","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,7,9]]},"DOI":"10.1167\/iovs.67.8.14","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T12:42:03Z","timestamp":1783341723000},"page":"14","source":"Crossref","is-referenced-by-count":0,"title":["Sensory Eye Dominance Remains Stable Across Binocular Combination and Rivalry in Normal and Anisometropic Amblyopic Vision"],"prefix":"10.1167","volume":"67","author":[{"given":"Wenjing","family":"Wang","sequence":"first","affiliation":[{"name":"School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China"},{"name":"National Clinical Research Center for Ocular Disease, Wenzhou, Zhejiang, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiya","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China"},{"name":"National Clinical Research Center for Ocular Disease, Wenzhou, Zhejiang, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqiu","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China"},{"name":"National Clinical Research Center for Ocular Disease, Wenzhou, Zhejiang, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Ningbo Eye Hospital, Wenzhou Medical University, Ningbo, Zhejiang, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.preteyeres.2012.11.001","article-title":"Amblyopia and binocular vision","volume":"33","author":"Birch","year":"2013","journal-title":"Prog Retin Eye Res"},{"issue":"6","key":"bib2","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/j.1444-0938.2005.tb05102.x","article-title":"Amblyopia: prevalence, natural history, functional effects and treatment","volume":"88","author":"Webber","year":"2005","journal-title":"Clin Exp Optom"},{"issue":"4","key":"bib3","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/S0959-4388(99)80072-5","article-title":"Neural mechanisms underlying amblyopia","volume":"9","author":"Kiorpes","year":"1999","journal-title":"Curr Opin Neurobiol"},{"issue":"9","key":"bib4","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/0042-6989(77)90009-8","article-title":"The threshold contrast sensitivity function in strabismic amblyopia: evidence for a two type classification","volume":"17","author":"Hess","year":"1977","journal-title":"Vision Res"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.visres.2020.07.014","article-title":"Rethinking amblyopia 2020","volume":"176","author":"Levi","year":"2020","journal-title":"Vision Res"},{"issue":"6","key":"bib6","doi-asserted-by":"publisher","first-page":"10.1167\/11.6.4","DOI":"10.1167\/11.6.4","article-title":"Deficient binocular combination reveals mechanisms of anisometropic amblyopia: signal attenuation and interocular inhibition","volume":"11","author":"Huang","year":"2011","journal-title":"J Vis"},{"issue":"4","key":"bib7","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1111\/j.1475-1313.1993.tb00490.x","article-title":"TNO stereopsis test as an aid to the prevention of amblyopia","volume":"13","author":"Walraven","year":"1993","journal-title":"Ophthalmic Physiol Opt"},{"issue":"8","key":"bib8","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1167\/iovs.61.8.7","article-title":"Binocular imbalance in amblyopia depends on spatial frequency in binocular combination","volume":"61","author":"Mao","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib9","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1167\/iovs.15-18253","article-title":"Deficient binocular combination of second-order stimuli in amblyopia","volume":"57","author":"Zhou","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"17181","DOI":"10.1038\/srep17181","article-title":"Spatial-frequency dependent binocular imbalance in amblyopia","volume":"5","author":"Kwon","year":"2015","journal-title":"Sci Rep"},{"issue":"4","key":"bib12","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1073\/pnas.0509629103","article-title":"A gain-control theory of binocular combination","volume":"103","author":"Ding","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"bib13","doi-asserted-by":"publisher","first-page":"e15075","DOI":"10.1371\/journal.pone.0015075","article-title":"Contrast and phase combination in binocular vision","volume":"5","author":"Huang","year":"2010","journal-title":"PLoS One"},{"issue":"13","key":"bib14","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1167\/14.13.24","article-title":"Linear binocular combination of responses to contrast modulation: contrast-weighted summation in first- and second-order vision","volume":"14","author":"Zhou","year":"2014","journal-title":"J Vis"},{"issue":"3","key":"bib15","first-page":"168","article-title":"Sensory eye dominance","volume":"72","author":"Ooi","year":"2001","journal-title":"Optometry"},{"issue":"1","key":"bib16","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/nrn701","article-title":"Visual competition","volume":"3","author":"Blake","year":"2002","journal-title":"Nat Rev Neurosci"},{"issue":"6","key":"bib17","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1093\/cercor\/8.6.553","article-title":"A neural model of binocular integration and rivalry based on the coordination of action-potential timing in primary visual cortex","volume":"8","author":"Lumer","year":"1998","journal-title":"Cereb Cortex"},{"issue":"11","key":"bib18","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.tics.2006.09.003","article-title":"Neural bases of binocular rivalry","volume":"10","author":"Tong","year":"2006","journal-title":"Trends Cogn Sci"},{"issue":"12","key":"bib19","doi-asserted-by":"publisher","first-page":"5140","DOI":"10.1167\/iovs.18-24342","article-title":"On sensory eye dominance revealed by binocular integrative and binocular competitive stimuli","volume":"59","author":"Han","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib20","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1002\/pchj.437","article-title":"Effect of physiological aging on binocular vision","volume":"10","author":"Yan","year":"2021","journal-title":"Psych J"},{"issue":"11","key":"bib21","doi-asserted-by":"publisher","first-page":"160534","DOI":"10.1098\/rsos.160534","article-title":"Binocular combination of stimulus orientation","volume":"3","author":"Yehezkel","year":"2016","journal-title":"R Soc Open Sci"},{"issue":"3","key":"bib22","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1113\/jphysiol.1959.sp006308","article-title":"Receptive fields of single neurones in the cat's striate cortex","volume":"148","author":"Hubel","year":"1959","journal-title":"J Physiol"},{"issue":"1","key":"bib23","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1113\/jphysiol.1962.sp006837","article-title":"Receptive fields, binocular interaction and functional architecture in the cat's visual cortex","volume":"160","author":"Hubel","year":"1962","journal-title":"J Physiol"},{"issue":"6571","key":"bib24","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/380249a0","article-title":"Orientation selectivity of thalamic input to simple cells of cat visual cortex","volume":"380","author":"Ferster","year":"1996","journal-title":"Nature"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1146\/annurev-vision-111815-114456","article-title":"Mechanisms of orientation selectivity in the primary visual cortex","volume":"2","author":"Priebe","year":"2016","journal-title":"Annu Rev Vis Sci"},{"issue":"3","key":"bib26","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1113\/jphysiol.1972.sp010006","article-title":"A second neural mechanism of binocular depth discrimination","volume":"226","author":"Blakemore","year":"1972","journal-title":"J Physiol"},{"issue":"18","key":"bib27","doi-asserted-by":"publisher","first-page":"7293","DOI":"10.1523\/JNEUROSCI.21-18-07293.2001","article-title":"Responses of macaque V1 neurons to binocular orientation differences","volume":"21","author":"Bridge","year":"2001","journal-title":"J Neurosci"},{"issue":"2","key":"bib28","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1068\/p020123","article-title":"The dependence of monocular rivalry on orientation","volume":"2","author":"Campbell","year":"1973","journal-title":"Perception"},{"issue":"11","key":"bib29","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/0042-6989(80)90084-X","article-title":"Angular selectivity of monocular rivalry: experiment and computer simulation","volume":"20","author":"Georgeson","year":"1980","journal-title":"Vision Res"},{"issue":"5","key":"bib30","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1167\/iovs.63.5.3","article-title":"Psychophysical reverse correlation revealed broader orientation tuning and prolonged reaction time in amblyopia","volume":"63","author":"Zhu","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3389\/fnhum.2019.00106","article-title":"The binocular balance at high spatial frequencies as revealed by the binocular orientation combination task","volume":"13","author":"Wang","year":"2019","journal-title":"Front Hum Neurosci"},{"issue":"2","key":"bib32","doi-asserted-by":"publisher","first-page":"519","DOI":"10.2466\/pms.99.2.519-524","article-title":"Correlations among handedness, eyedness, monocular shifts from binocular focal point, and nonverbal intelligence in university mathematics students","volume":"99","author":"Dane","year":"2004","journal-title":"Percept Mot Skills"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.3389\/fpsyg.2018.01250","article-title":"Applying the model-comparison approach to test specific research hypotheses in psychophysical research using the Palamedes Toolbox","volume":"9","author":"Prins","year":"2018","journal-title":"Front Psychol"},{"issue":"13","key":"bib34","doi-asserted-by":"publisher","first-page":"5462","DOI":"10.1167\/iovs.18-23954","article-title":"Orientation tuning and contrast dependence of continuous flash suppression in amblyopia and normal vision","volume":"59","author":"Gao","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"14","key":"bib35","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1167\/iovs.61.14.28","article-title":"Interocular suppression as revealed by dichoptic masking is orientation-dependent and imbalanced in amblyopia","volume":"61","author":"Gong","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib36","first-page":"467","article-title":"Contrast sensitivity in anisometropic amblyopia","volume":"21","author":"Bradley","year":"1981","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"bib37","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1016\/0042-6989(78)90014-7","article-title":"Reaction time as a measure of suprathreshold grating detection","volume":"18","author":"Harwerth","year":"1978","journal-title":"Vision Res"},{"issue":"1208","key":"bib38","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1098\/rspb.1983.0012","article-title":"Contrast-coding in amblyopia. I. Differences in the neural basis of human amblyopia","volume":"217","author":"Hess","year":"1983","journal-title":"Proc R Soc Lond B Biol Sci"},{"issue":"5781","key":"bib39","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/287463a0","article-title":"Contrast perception above threshold is only minimally impaired in human amblyopia","volume":"287","author":"Hess","year":"1980","journal-title":"Nature"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.neubiorev.2015.07.002","article-title":"On the use of spatial frequency to isolate contributions from the magnocellular and parvocellular systems and the dorsal and ventral cortical streams","volume":"56","author":"Skottun","year":"2015","journal-title":"Neurosci Biobehav Rev"},{"issue":"3","key":"bib41","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1002\/cne.901580304","article-title":"Sequence regularity and geometry of orientation columns in the monkey striate cortex","volume":"158","author":"Hubel","year":"1974","journal-title":"J Comp Neurol"},{"issue":"1130","key":"bib42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1098\/rspb.1977.0085","article-title":"Ferrier lecture. Functional architecture of macaque monkey visual cortex","volume":"198","author":"Hubel","year":"1977","journal-title":"Proc R Soc Lond B Biol Sci"},{"issue":"3","key":"bib43","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1113\/jphysiol.1963.sp007079","article-title":"Shape and arrangement of columns in cat's striate cortex","volume":"165","author":"Hubel","year":"1963","journal-title":"J Physiol"},{"issue":"8","key":"bib44","doi-asserted-by":"publisher","first-page":"3115","DOI":"10.1523\/JNEUROSCI.12-08-03115.1992","article-title":"Differential imaging of ocular dominance and orientation selectivity in monkey striate cortex","volume":"12","author":"Blasdel","year":"1992","journal-title":"J Neurosci"},{"issue":"43","key":"bib45","doi-asserted-by":"publisher","first-page":"8527","DOI":"10.1523\/JNEUROSCI.0713-19.2019","article-title":"Humans perceive binocular rivalry and fusion in a tristable dynamic state","volume":"39","author":"Riesen","year":"2019","journal-title":"J Neurosci"},{"issue":"5","key":"bib46","doi-asserted-by":"publisher","first-page":"526","DOI":"10.3758\/BF03201370","article-title":"Computer-aided estimation of psychophysical thresholds by Wetherill tracking","volume":"11","author":"Corwin","year":"1979","journal-title":"Behav Res Methods Instrument"},{"issue":"2","key":"bib47","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1167\/13.2.14","article-title":"Binocular combination in abnormal binocular vision","volume":"13","author":"Ding","year":"2013","journal-title":"J Vis"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"108503","DOI":"10.1016\/j.visres.2024.108503","article-title":"Towards a principled and efficacious approach to the treatment of amblyopia. A review","volume":"226","author":"Hess","year":"2025","journal-title":"Vision Res"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"E012","DOI":"10.1017\/S0952523817000190","article-title":"Classification and diversity of amblyopia","volume":"35","author":"Maurer","year":"2018","journal-title":"Vis Neurosci"},{"issue":"4","key":"bib50","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1167\/iovs.65.4.36","article-title":"Peripheral binocular imbalance in anisometropic and strabismic amblyopia","volume":"65","author":"Wiecek","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1867","key":"bib51","first-page":"20171669","article-title":"Chromatic and achromatic monocular deprivation produce separable changes of eye dominance in adults","volume":"284","author":"Zhou","year":"2017","journal-title":"Proc Biol Sci"},{"issue":"6","key":"bib52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1167\/13.6.1","article-title":"Long-term effects of monocular deprivation revealed with binocular rivalry gratings modulated in luminance and in color","volume":"13","author":"Lunghi","year":"2013","journal-title":"J Vis"},{"issue":"1","key":"bib53","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s40662-022-00303-4","article-title":"The shift in sensory eye dominance from short-term monocular deprivation exhibits no dependence on test spatial frequency","volume":"9","author":"Chen","year":"2022","journal-title":"Eye Vis (Lond)"},{"key":"bib11","first-page":"102727","article-title":"Binocular visual deficits at mid to high spatial frequency in treated amblyopes.","volume-title":"iScience","author":"Chen","year":"2021"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.8.14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:14Z","timestamp":1791927134000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.8.14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,9]]},"references-count":53,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.8.14","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,9]]}}}