{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T17:26:42Z","timestamp":1780939602828,"version":"3.54.1"},"reference-count":38,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"14","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2021,12,6]]},"DOI":"10.1167\/tvst.10.14.5","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T14:30:47Z","timestamp":1638801047000},"page":"5","source":"Crossref","is-referenced-by-count":16,"title":["Controlled Release of Multiple Therapeutics From Silicone Hydrogel Contact Lenses for Post-Cataract\/Post-Refractive Surgery and Uveitis Treatment"],"prefix":"10.1167","volume":"10","author":[{"given":"Stephen A.","family":"DiPasquale","sequence":"first","affiliation":[{"name":"Biomimetic & Biohybrid Materials, Biomedical Devices, and Drug Delivery Laboratories, Department of Biomedical Engineering, Rowan University, Glassboro, NJ 08028, USA"},{"name":"OcuMedic, Inc. Mullica Hill, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biaggio","family":"Uricoli","sequence":"additional","affiliation":[{"name":"Biomimetic & Biohybrid Materials, Biomedical Devices, and Drug Delivery Laboratories, Department of Biomedical Engineering, Rowan University, Glassboro, NJ 08028, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"DiCerbo","sequence":"additional","affiliation":[{"name":"Biomimetic & Biohybrid Materials, Biomedical Devices, and Drug Delivery Laboratories, Department of Biomedical Engineering, Rowan University, Glassboro, NJ 08028, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thea L.","family":"Brown","sequence":"additional","affiliation":[{"name":"Biomimetic & Biohybrid Materials, Biomedical Devices, and Drug Delivery Laboratories, Department of Biomedical Engineering, Rowan University, Glassboro, NJ 08028, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Byrne","sequence":"additional","affiliation":[{"name":"Biomimetic & Biohybrid Materials, Biomedical Devices, and Drug Delivery Laboratories, Department of Biomedical Engineering, Rowan University, Glassboro, NJ 08028, USA"},{"name":"OcuMedic, Inc. Mullica Hill, NJ, USA"},{"name":"Department of Chemical Engineering, Rowan University, Glassboro, NJ 08028, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib2","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/S2214-109X(20)30488-5","article-title":"The Lancet Global Health Commission on global eye health: vision beyond 2020","volume":"9","author":"Burton","year":"2021","journal-title":"Lancet Glob Health"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"47","DOI":"10.5497\/wjp.v2.i2.47","article-title":"Ocular drug delivery systems: an overview","volume":"2","author":"Patel","year":"2013","journal-title":"World J Pharmacol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.survophthal.2003.12.009","article-title":"Determinants of eye drop size","volume":"49","author":"Van Santvliet","year":"2004","journal-title":"Surv Ophthalmol"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1586\/erd.09.4","article-title":"Drug delivery systems for the eye","volume":"6","author":"Kearns","year":"2009","journal-title":"Expert Rev Med Devices"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/clpt.2008.297","article-title":"Ophthalmic drug delivery: development and regulatory considerations","volume":"85","author":"Novack","year":"2009","journal-title":"Clin Pharmacol Ther"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1007\/s13346-016-0339-2","article-title":"A comprehensive insight on ocular pharmacokinetics","volume":"6","author":"Agrahari","year":"2016","journal-title":"Drug Deliv Transl Res"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/j.addr.2006.07.027","article-title":"Challenges and obstacles of ocular pharmacokinetics and drug delivery","volume":"58","author":"Urtti","year":"2006","journal-title":"Adv Drug Deliv Rev"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/185117a0","article-title":"Hydrophilic gels for biological use","volume":"185","author":"Wichterle","year":"1960","journal-title":"Nature"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/0002-9394(73)91015-5","article-title":"Ocular penetration of pilocarpine in primates","volume":"75","author":"Asseff","year":"1973","journal-title":"Am J Ophthalmol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1136\/bjo.58.7.674","article-title":"Management of acute glaucoma with pilocarpine-soaked hydrophilic lens","volume":"58","author":"Hillman","year":"1974","journal-title":"Br J Ophthalmol"},{"key":"bib12","first-page":"79","article-title":"Pilocarpine delivery by hydrophilic lens in the management of acute glaucoma","volume":"95","author":"Hillman","year":"1975","journal-title":"Trans Ophthalmol Soc UK"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/0002-9394(72)90062-1","article-title":"Pilocarpine therapy with soft contact lenses","volume":"73","author":"Podos","year":"1972","journal-title":"Am J Ophthalmol"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.jcis.2007.06.054","article-title":"Timolol transport from microemulsions trapped in HEMA gels","volume":"315","author":"Li","year":"2007","journal-title":"J Colloid Interface Sci"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.clae.2013.09.008","article-title":"Preparation, characterization and antimicrobial study of a hydrogel (soft contact lens) material impregnated with silver nanoparticles","volume":"37","author":"Bazzaz","year":"2014","journal-title":"Cont Lens Anterior Eye"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"110885","DOI":"10.1016\/j.msec.2020.110885","article-title":"Multiple drug delivery from the drug-implants-laden silicone contact lens: Addressing the issue of burst drug release","volume":"112","author":"Desai","year":"2020","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s10856-016-5724-3","article-title":"Extended release of ketotifen from silica shell nanoparticle-laden hydrogel contact lenses: in vitro and in vivo evaluation","volume":"27","author":"Maulvi","year":"2016","journal-title":"J Mater Sci Mater Med"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.actbio.2019.01.004","article-title":"Effect of gold nanoparticles on timolol uptake and its release kinetics from contact lenses: in vitro and in vivo evaluation","volume":"86","author":"Maulvi","year":"2019","journal-title":"Acta Biomater"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1016\/j.biomaterials.2008.10.032","article-title":"Surfactant-laden soft contact lenses for extended delivery of ophthalmic drugs","volume":"30","author":"Kapoor","year":"2009","journal-title":"Biomaterials"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"2998","DOI":"10.1021\/nn5002968","article-title":"Diamond nanogel-embedded contact lenses mediate lysozyme-dependent therapeutic release","volume":"8","author":"Kim","year":"2014","journal-title":"ACS Nano"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"4032","DOI":"10.1016\/j.biomaterials.2010.01.113","article-title":"Extended delivery of hydrophilic drugs from silicone-hydrogel contact lenses containing vitamin E diffusion barriers","volume":"31","author":"Peng","year":"2010","journal-title":"Biomaterials"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.jconrel.2010.07.119","article-title":"Extended release of dexamethasone from silicone-hydrogel contact lenses containing vitamin E","volume":"148","author":"Kim","year":"2010","journal-title":"J Control Rel"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S0168-3659(02)00213-4","article-title":"Timolol uptake and release by imprinted soft contact lenses made of N, N-diethylacrylamide and methacrylic acid","volume":"83","author":"Hiratani","year":"2002","journal-title":"J Control Rel"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.ejpb.2017.10.016","article-title":"Epalrestat-loaded silicone hydrogels as contact lenses to address diabetic-eye complications","volume":"122","author":"Alvarez-Rivera","year":"2018","journal-title":"Eur J Pharm Biopharm"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s40123-018-0138-6","article-title":"The Routine Use of Intracameral Antibiotics to Prevent Endophthalmitis After Cataract Surgery: How Good is the Evidence?","volume":"7","author":"George","year":"2018","journal-title":"Ophthalmol Ther"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/aos.2015.93.issue-4","article-title":"Antibiotic prevention of postcataract endophthalmitis: a systematic review and meta-analysis","volume":"93","author":"Kessel","year":"2015","journal-title":"Acta Ophthalmol"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.ejpb.2012.01.015","article-title":"In vitro controlled release of an anti-inflammatory from daily disposable therapeutic contact lenses under physiological ocular tear flow","volume":"81","author":"Tieppo","year":"2012","journal-title":"Eur J Pharm Biopharm"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.biomaterials.2006.09.007","article-title":"Biomimetic hydrogels for enhanced loading and extended release of ocular therapeutics","volume":"28","author":"Venkatesh","year":"2007","journal-title":"Biomaterials"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1007\/s11095-008-9818-6","article-title":"Controlled release of high molecular weight hyaluronic Acid from molecularly imprinted hydrogel contact lenses","volume":"26","author":"Ali","year":"2009","journal-title":"Pharm Res"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"5698","DOI":"10.1016\/j.biomaterials.2011.04.044","article-title":"Extended release of high molecular weight hydroxypropyl methylcellulose from molecularly imprinted, extended wear silicone hydrogel contact lenses","volume":"32","author":"White","year":"2011","journal-title":"Biomaterials"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/j.ejpb.2008.01.036","article-title":"Transport and structural analysis of molecular imprinted hydrogels for controlled drug delivery","volume":"69","author":"Venkatesh","year":"2008","journal-title":"Eur J Pharm Biopharm"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1097\/OPX.0000000000000849","article-title":"Controlled release of multiple therapeutics from silicone hydrogel contact lenses","volume":"93","author":"White","year":"2016","journal-title":"Optom Vis Sci"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.jconrel.2011.09.087","article-title":"Sustained in vivo release from imprinted therapeutic contact lenses","volume":"157","author":"Tieppo","year":"2012","journal-title":"J Control Rel"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.jconrel.2007.09.006","article-title":"Zero-order therapeutic release from imprinted hydrogel contact lenses within in vitro physiological ocular tear flow","volume":"124","author":"Ali","year":"2007","journal-title":"J Control Rel"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/clpt.2008.297","article-title":"Ophthalmic drug delivery: development and regulatory considerations","volume":"85","author":"Novack","year":"2009","journal-title":"Clin Pharmacol Ther"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1097\/OPX.0b013e3182691454","article-title":"Measuring the modulus of silicone hydrogel contact lenses","volume":"89","author":"Horst","year":"2012","journal-title":"Optom Vis Sci"},{"key":"bib37","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/jbm.a.31260","article-title":"In vitro water wettability of silicone hydrogel contact lenses determined using the sessile drop and captive bubble techniques","volume":"83","author":"Maldonado-Codina","year":"2007","journal-title":"J Biomed Mater Res A"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/S1542-0124(12)70262-8","article-title":"Silicone hydrogel contact lenses and the ocular surface","volume":"4","author":"Stapleton","year":"2006","journal-title":"Ocul Surf"},{"key":"bib1","volume-title":"World report on vision","year":"2019"}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2778139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T14:30:54Z","timestamp":1638801054000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2778139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,6]]},"references-count":38,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2021,12,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.10.14.5","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12,6]]}}}