{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T03:24:07Z","timestamp":1774581847518,"version":"3.50.1"},"reference-count":41,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"2","license":[{"start":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:00:00Z","timestamp":1613088000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2021,2,12]]},"DOI":"10.1167\/tvst.10.2.18","type":"journal-article","created":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T01:41:19Z","timestamp":1613180479000},"page":"18","source":"Crossref","is-referenced-by-count":11,"title":["Correction for the Influence of Cataract on Macular Pigment Measurement by Autofluorescence Technique Using Deep Learning"],"prefix":"10.1167","volume":"10","author":[{"given":"Akira","family":"Obana","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Seirei Hamamatsu General Hospital, Hamamatsu City, Shizuoka, Japan"},{"name":"Department of Medical Spectroscopy, Institute for Medical Photonics Research, Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kibo","family":"Ote","sequence":"additional","affiliation":[{"name":"Central Research Laboratory, Hamamatsu Photonics K.K., Hamamatsu, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Central Research Laboratory, Hamamatsu Photonics K.K., Hamamatsu, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Asaoka","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seirei Hamamatsu General Hospital, Hamamatsu City, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Gohto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seirei Hamamatsu General Hospital, Hamamatsu City, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigetoshi","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of Medical Spectroscopy, Institute for Medical Photonics Research, Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenao","family":"Yamada","sequence":"additional","affiliation":[{"name":"Central Research Laboratory, Hamamatsu Photonics K.K., Hamamatsu, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27","reference":[{"key":"bib1","first-page":"2033","article-title":"Stereochemistry of the human macular carotenoids","volume":"34","author":"Bone","year":"1993","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1006\/abbi.2000.2171","article-title":"Lutein, zeaxanthin, and the macular pigment","volume":"385","author":"Landrum","year":"2001","journal-title":"Arch Biochem Biophys"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"7871","DOI":"10.1167\/iovs.12-10690","article-title":"The impact of macular pigment augmentation on visual performance using different carotenoid formulations","volume":"53","author":"Loughman","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"2290","DOI":"10.1016\/j.ophtha.2012.06.014","article-title":"Effect of lutein and zeaxanthin on macular pigment and visual function in patients with early age-related macular degeneration","volume":"119","author":"Ma","year":"2012","journal-title":"Ophthalmology"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"7406","DOI":"10.1167\/iovs.10-6699","article-title":"Macular pigment and visual performance in glare: benefits for photostress recovery, disability glare, and visual discomfort","volume":"52","author":"Stringham","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"3429","DOI":"10.1167\/iovs.16-19520","article-title":"Enrichment of Macular Pigment Enhances Contrast Sensitivity in Subjects Free of Retinal Disease: Central Retinal Enrichment Supplementation Trials - Report 1","volume":"57","author":"Nolan","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1146\/annurev.nutr.23.011702.073307","article-title":"Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye","volume":"23","author":"Krinsky","year":"2003","journal-title":"Annu Rev Nutr"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.mam.2005.10.001","article-title":"Carotenoid actions and their relation to health and disease","volume":"26","author":"Krinsky","year":"2005","journal-title":"Mol Aspects Med"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0014-5793(97)01355-0","article-title":"Comparative mechanisms and rates of free radical scavenging by carotenoid antioxidants","volume":"418","author":"Mortensen","year":"1997","journal-title":"FEBS Lett"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/S1529-1839(04)70049-4","article-title":"Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial)","volume":"75","author":"Richer","year":"2004","journal-title":"Optometry"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.ophtha.2007.03.083","article-title":"Dietary antioxidants and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study","volume":"115","author":"Tan","year":"2008","journal-title":"Ophthalmology"},{"key":"bib12","first-page":"439","article-title":"Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population","volume":"42","author":"Beatty","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1016\/S0161-6420(02)01173-9","article-title":"Resonance Raman measurement of macular carotenoids in normal subjects and in age-related macular degeneration patients","volume":"109","author":"Bernstein","year":"2002","journal-title":"Ophthalmology"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1097\/ICU.0b013e32833866ee","article-title":"Nutritional supplements for age-related macular degeneration","volume":"21","author":"Krishnadev","year":"2010","journal-title":"Curr Opin Ophthalmol"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"216","DOI":"10.5301\/ejo.5000069","article-title":"Carotenoids in Age-related Maculopathy Italian Study (CARMIS): two-year results of a randomized study","volume":"22","author":"Piermarocchi","year":"2012","journal-title":"Eur J Ophthalmol"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s00417-010-1577-5","article-title":"Measuring macular pigment optical density in vivo: a review of techniques","volume":"249","author":"Howells","year":"2011","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.exer.2013.08.014","article-title":"Concordance of macular pigment measurements obtained using customized heterochromatic flicker photometry, dual-wavelength autofluorescence, and single-wavelength reflectance","volume":"116","author":"Dennison","year":"2013","journal-title":"Exp Eye Res"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1167\/iovs.13-13470","article-title":"The spatial profile of macular pigment in subjects from a Singapore Chinese population","volume":"55","author":"Neelam","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s00417-013-2471-8","article-title":"The macular pigment optical density spatial profile and increasing age","volume":"252","author":"Beirne","year":"2014","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.exer.2017.12.015","article-title":"Reliability of a two-wavelength autofluorescence technique by Heidelberg Spectralis to measure macular pigment optical density in Asian subjects","volume":"168","author":"Obana","year":"2018","journal-title":"Exp Eye Res"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"061714","DOI":"10.1117\/1.3526358","article-title":"Simple and objective method for routine detection of the macular pigment xanthophyll","volume":"15","author":"Schweitzer","year":"2010","journal-title":"J Biomed Opt"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1364\/JOSAA.18.001212","article-title":"Macular pigment density measured by autofluorescence spectrometry: comparison with reflectometry and heterochromatic flicker photometry","volume":"18","author":"Delori","year":"2001","journal-title":"J Opt Soc Am A Opt Image Sci Vis"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.abb.2004.05.016","article-title":"Autofluorescence method to measure macular pigment optical densities fluorometry and autofluorescence imaging","volume":"430","author":"Delori","year":"2004","journal-title":"Arch Biochem Biophys"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1364\/JOSAA.19.001172","article-title":"In vivo resonant Raman measurement of macular carotenoid pigments in the young and the aging human retina","volume":"19","author":"Gellermann","year":"2002","journal-title":"J Opt Soc Am A Opt Image Sci Vis"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1364\/JOSAA.25.000947","article-title":"Resonance Raman imaging of macular pigment distributions in the human retina","volume":"25","author":"Sharifzadeh","year":"2008","journal-title":"J Opt Soc Am A Opt Image Sci Vis"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"4034","DOI":"10.1167\/iovs.13-11891","article-title":"Blue-light reflectance imaging of macular pigment in infants and children","volume":"54","author":"Bernstein","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1167\/tvst.7.4.3","article-title":"Optical Detection of Macular Pigment Formation in Premature Infants","volume":"7","author":"Sasano","year":"2018","journal-title":"Transl Vis Sci Technol"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1167\/tvst.8.6.41","article-title":"Standardizing the Assessment of Macular Pigment Using a Dual-Wavelength Autofluorescence Technique","volume":"8","author":"Green-Gomez","year":"2019","journal-title":"Transl Vis Sci Technol"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"96010","DOI":"10.1117\/1.JBO.19.9.096010","article-title":"Autofluorescence imaging of macular pigment: influence and correction of ocular media opacities","volume":"19","author":"Sharifzadeh","year":"2014","journal-title":"J Biomed Opt"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"2552","DOI":"10.1167\/iovs.16-19141","article-title":"The Impact of Cataract, and Its Surgical Removal, on Measures of Macular Pigment Using the Heidelberg Spectralis HRA+OCT MultiColor Device","volume":"57","author":"Akuffo","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"3011","DOI":"10.1167\/iovs.17-23699","article-title":"Grade of Cataract and Its Influence on Measurement of Macular Pigment Optical Density Using Autofluorescence Imaging","volume":"59","author":"Obana","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1097\/IAE.0000000000000893","article-title":"Reproducibility of Macular Pigment Optical Density Measurement by Two-Wavelength Autofluorescence in a Clinical Setting","volume":"36","author":"You","year":"2016","journal-title":"Retina"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.jml.2007.12.005","article-title":"Mixed-effects modeling with crossed random effects for subjects and items","volume":"59","author":"Baayen","year":"2008","journal-title":"J Mem Lang"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting Linear Mixed-Effects Models Usinglme4","volume":"67","author":"Bates","year":"2015","journal-title":"J Stat Softw"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1076\/opep.9.2.83.1523","article-title":"A simplified cataract grading system","volume":"9","author":"Thylefors","year":"2002","journal-title":"Ophthalmic Epidemiol"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s11263-015-0816-y","article-title":"ImageNet Large Scale Visual Recognition Challenge","volume":"115","author":"Russakovsky","year":"2015","journal-title":"Int J Comput Vis"},{"key":"bib39","first-page":"1097","article-title":"ImageNet Classification with Deep Convolutional Neural Networks","volume":"1","author":"Krizhevsky","year":"2012","journal-title":"Adv Neural Inf Process Syst"},{"key":"bib33","article-title":"Very deep convolutional networks for large-scale image recognition","author":"Simonyan","year":"2015"},{"key":"bib38","article-title":"Transfer Learning for Action Unit Recognition","author":"Lim","year":"2018"},{"key":"bib40","first-page":"1","article-title":"Going deeper with convolutions","volume-title":"Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition","author":"Szegedy","year":"2015"},{"key":"bib41","article-title":"Deep Residual Learning for Image Recognition","author":"He","year":"2015"}],"container-title":["Translational Vision Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2772277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T01:41:26Z","timestamp":1613180486000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2772277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,12]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2,5]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.10.2.18","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2,12]]}}}