{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T04:51:05Z","timestamp":1777783865124,"version":"3.51.4"},"reference-count":28,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"3","license":[{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2021,3,25]]},"DOI":"10.1167\/tvst.10.3.29","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T16:51:23Z","timestamp":1616691083000},"page":"29","source":"Crossref","is-referenced-by-count":21,"title":["Longitudinal Higher-Order OCT Assessment of Quantitative Fluid Dynamics and the Total Retinal Fluid Index in Neovascular AMD"],"prefix":"10.1167","volume":"10","author":[{"given":"Justis P.","family":"Ehlers","sequence":"first","affiliation":[{"name":"The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cleveland Clinic, Cleveland, OH, USA"},{"name":"Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Clark","sequence":"additional","affiliation":[{"name":"Formerly Novartis Pharmaceuticals, East Hanover, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuro","family":"Uchida","sequence":"additional","affiliation":[{"name":"The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cleveland Clinic, Cleveland, OH, USA"},{"name":"Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cleveland Clinic, Cleveland, OH, USA"},{"name":"Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Babiuch","sequence":"additional","affiliation":[{"name":"The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cleveland Clinic, Cleveland, OH, USA"},{"name":"Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine E.","family":"Talcott","sequence":"additional","affiliation":[{"name":"The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cleveland Clinic, Cleveland, OH, USA"},{"name":"Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leina","family":"Lunasco","sequence":"additional","affiliation":[{"name":"The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cleveland Clinic, Cleveland, OH, USA"},{"name":"Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuy K.","family":"Le","sequence":"additional","affiliation":[{"name":"The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cleveland Clinic, Cleveland, OH, USA"},{"name":"Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyi","family":"Meng","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceuticals, East Hanover, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Hu","sequence":"additional","affiliation":[{"name":"The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cleveland Clinic, Cleveland, OH, USA"},{"name":"Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie","family":"Reese","sequence":"additional","affiliation":[{"name":"The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cleveland Clinic, Cleveland, OH, USA"},{"name":"Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil K.","family":"Srivastava","sequence":"additional","affiliation":[{"name":"The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cleveland Clinic, Cleveland, OH, USA"},{"name":"Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27","reference":[{"issue":"1","key":"bib1","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ophtha.2018.07.028","article-title":"Safety and efficacy of anti-vascular endothelial growth factor therapies for neovascular age-related macular degeneration: a report by the American Academy of Ophthalmology","volume":"126","author":"Bakri","year":"2019","journal-title":"Ophthalmology"},{"issue":"2-a Suppl","key":"bib2","first-page":"S3","article-title":"Optimizing anti-VEGF treatment outcomes for patients with neovascular age-related macular degeneration","volume":"24","author":"Wykoff","year":"2018","journal-title":"J Manag Care Spec Pharm"},{"issue":"11","key":"bib3","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.2217\/cer-2018-0058","article-title":"The economic and humanistic burden of patients in receipt of current available therapies for nAMD","volume":"7","author":"Jaffe","year":"2018","journal-title":"J Comp Eff Res"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12886-016-0207-3","article-title":"The role of sub-retinal fluid in determining treatment outcomes in patients with neovascular age-related macular degeneration-a Phase IV randomised clinical trial with ranibizumab: the FLUID study","volume":"16","author":"Arnold","year":"2016","journal-title":"BMC Ophthalmol"},{"issue":"4","key":"bib5","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1364\/BOE.9.001545","article-title":"Deep learning approach for the detection and quantification of intraretinal cystoid fluid in multivendor optical coherence tomography","volume":"9","author":"Venhuizen","year":"2018","journal-title":"Biomed Opt Express"},{"issue":"3","key":"bib6","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.ajo.2014.05.014","article-title":"Anti-VEGF treatment patterns for neovascular age-related macular degeneration among Medicare beneficiaries","volume":"158","author":"Lad","year":"2014","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"bib7","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.oret.2019.05.017","article-title":"Visual acuity outcomes and anti-vascular endothelial growth factor therapy intensity in neovascular age-related macular degeneration patients: a real-world analysis of 49 485 eyes","volume":"4","author":"Ciulla","year":"2020","journal-title":"Ophthalmol Retina"},{"issue":"12","key":"bib8","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1016\/j.oret.2019.06.010","article-title":"Higher-order assessment of OCT in diabetic macular edema from the VISTA study: ellipsoid zone dynamics and the retinal fluid index","volume":"3","author":"Ehlers","year":"2019","journal-title":"Ophthalmol Retina"},{"issue":"3","key":"bib9","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1136\/bjophthalmol-2015-307105","article-title":"Volumetric ellipsoid zone mapping for enhanced visualisation of outer retinal integrity with optical coherence tomography","volume":"100","author":"Itoh","year":"2016","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"bib10","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1167\/iovs.12-10246","article-title":"A novel segmentation algorithm for volumetric analysis of macular hole boundaries identified with optical coherence tomography","volume":"54","author":"Xu","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"bib11","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1038\/eye.2017.61","article-title":"Supervised learning and dimension reduction techniques for quantification of retinal fluid in optical coherence tomography images","volume":"31","author":"Breger","year":"2017","journal-title":"Eye (Lond)"},{"issue":"8","key":"bib12","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1016\/j.ophtha.2016.04.005","article-title":"Automated identification of lesion activity in neovascular age-related macular degeneration","volume":"123","author":"Chakravarthy","year":"2016","journal-title":"Ophthalmology"},{"issue":"7","key":"bib13","doi-asserted-by":"publisher","first-page":"3366","DOI":"10.1167\/iovs.08-2691","article-title":"Quantitative subanalysis of cystoid spaces and outer nuclear layer using optical coherence tomography in age-related macular degeneration","volume":"50","author":"Kashani","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"bib14","doi-asserted-by":"publisher","first-page":"76015","DOI":"10.1117\/1.JBO.21.7.076015","article-title":"Length-adaptive graph search for automatic segmentation of pathological features in optical coherence tomography images","volume":"21","author":"Keller","year":"2016","journal-title":"J Biomed Opt"},{"issue":"7","key":"bib15","doi-asserted-by":"publisher","first-page":"3440","DOI":"10.1364\/BOE.8.003440","article-title":"Deep-learning based, automated segmentation of macular edema in optical coherence tomography","volume":"8","author":"Lee","year":"2017","journal-title":"Biomed Opt Express"},{"issue":"9","key":"bib16","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1016\/j.ophtha.2017.03.057","article-title":"Brolucizumab versus aflibercept in participants with neovascular age-related macular degeneration: a randomized trial","volume":"124","author":"Dugel","year":"2017","journal-title":"Ophthalmology"},{"issue":"1","key":"bib17","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.ophtha.2019.04.017","article-title":"HAWK and HARRIER: phase 3, multicenter, randomized, double-masked trials of brolucizumab for neovascular age-related macular degeneration","volume":"127","author":"Dugel","year":"2020","journal-title":"Ophthalmology"},{"issue":"10","key":"bib18","doi-asserted-by":"publisher","first-page":"e0203324","DOI":"10.1371\/journal.pone.0203324","article-title":"Assessment of inner and outer retinal layer metrics on the Cirrus HD-OCT platform in normal eyes","volume":"13","author":"Arepalli","year":"2018","journal-title":"PLoS One"},{"issue":"4","key":"bib19","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.oret.2016.12.004","article-title":"Randomized trial of treat-and-extend versus monthly dosing for neovascular age-related macular degeneration: 2-year results of the TREX-AMD study","volume":"1","author":"Wykoff","year":"2017","journal-title":"Ophthalmol Retina"},{"issue":"1","key":"bib20","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ophtha.2017.07.014","article-title":"Treat-and-extend versus monthly regimen in neovascular age-related macular degeneration: results with ranibizumab from the TREND study","volume":"125","author":"Silva","year":"2018","journal-title":"Ophthalmology"},{"issue":"5","key":"bib21","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1016\/j.ophtha.2012.10.014","article-title":"Twelve-month efficacy and safety of 0.5 mg or 2.0 mg ranibizumab in patients with subfoveal neovascular age-related macular degeneration","volume":"120","author":"Busbee","year":"2013","journal-title":"Ophthalmology"},{"issue":"1","key":"bib22","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.ophtha.2014.07.041","article-title":"Comparison of ranibizumab and bevacizumab for neovascular age-related macular degeneration according to LUCAS treat-and-extend protocol","volume":"122","author":"Berg","year":"2015","journal-title":"Ophthalmology"},{"issue":"1","key":"bib23","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1097\/IAE.0b013e318263cedf","article-title":"Anatomical measures as predictors of visual outcomes in ranibizumab-treated eyes with neovascular age-related macular degeneration","volume":"33","author":"Brown","year":"2013","journal-title":"Retina"},{"issue":"7","key":"bib24","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1097\/IAE.0000000000000902","article-title":"Implication of recurrent or retained fluid on optical coherence tomography for visual acuity during active treatment of neovascular age-related macular degeneration with a treat and extend protocol","volume":"36","author":"Wickremasinghe","year":"2016","journal-title":"Retina"},{"issue":"6","key":"bib25","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/j.ophtha.2019.01.013","article-title":"Canadian treat-and-extend analysis trial with ranibizumab in patients with neovascular age-related macular disease: one-year results of the randomized Canadian Treat-and-Extend Analysis Trial With Ranibizumab study","volume":"126","author":"Kertes","year":"2019","journal-title":"Ophthalmology"},{"issue":"9","key":"bib26","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1016\/j.ophtha.2013.01.073","article-title":"Macular morphology and visual acuity in the Comparison of Age-related Macular Degeneration Treatments Trials","volume":"120","author":"Jaffe","year":"2013","journal-title":"Ophthalmology"},{"issue":"4","key":"bib27","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/j.ophtha.2015.12.002","article-title":"Macular morphology and visual acuity in the second year of the Comparison of Age-related Macular Degeneration Treatments Trials","volume":"123","author":"Sharma","year":"2016","journal-title":"Ophthalmology"},{"issue":"6","key":"bib28","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1016\/j.ophtha.2013.12.029","article-title":"Morphologic parameters relevant for visual outcome during anti-angiogenic therapy of neovascular age-related macular degeneration","volume":"121","author":"Simader","year":"2014","journal-title":"Ophthalmology"}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2772428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T16:51:27Z","timestamp":1616691087000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2772428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,25]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.10.3.29","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3,25]]}}}