{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T05:18:46Z","timestamp":1783660726609,"version":"3.55.0"},"reference-count":34,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"4","license":[{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2021,4,14]]},"DOI":"10.1167\/tvst.10.4.11","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T19:56:18Z","timestamp":1618602978000},"page":"11","source":"Crossref","is-referenced-by-count":31,"title":["Validation of a Novel Automated Algorithm to Measure Drusen Volume and Area Using Swept Source Optical Coherence Tomography Angiography"],"prefix":"10.1167","volume":"10","author":[{"given":"Xiaoshuang","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA"},{"name":"Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxi","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"de Sisternes","sequence":"additional","affiliation":[{"name":"Research and Development, Carl Zeiss Meditec, Inc., Dublin, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary K.","family":"Durbin","sequence":"additional","affiliation":[{"name":"Research and Development, Carl Zeiss Meditec, Inc., Dublin, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Feuer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Rosenfeld","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Gregori","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"4","key":"bib1","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1167\/iovs.18-24882","article-title":"Soft drusen in age-related macular degeneration: biology and targeting via the oil spill strategies","volume":"59","author":"Curcio","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"bib2","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1097\/IAE.0000000000002893","article-title":"Abundance and multimodal visibility of soft drusen in early age-related macular degeneration: a clinicopathologic correlation","volume":"40","author":"Chen","year":"2020","journal-title":"Retina"},{"issue":"1","key":"bib3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0039-6257(99)00072-7","article-title":"Drusen in age-related macular degeneration: pathogenesis, natural course, and laser photocoagulation-induced regression","volume":"44","author":"Abdelsalam","year":"1999","journal-title":"Surv Ophthalmol"},{"issue":"12","key":"bib4","doi-asserted-by":"publisher","first-page":"6715","DOI":"10.1167\/iovs.10-5288","article-title":"Performance of drusen detection by spectral-domain optical coherence tomography","volume":"51","author":"Schlanitz","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib5","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/S0002-9394(14)75576-X","article-title":"Drusen as risk factors in age-related macular disease","volume":"109","author":"Pauleikhoff","year":"1990","journal-title":"Am J Ophthalmol"},{"issue":"10","key":"bib6","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1001\/archopht.1990.01070120090035","article-title":"Relationship of drusen and abnormalities of the retinal pigment epithelium to the prognosis of neovascular macular degeneration. The Macular Photocoagulation Study Group","volume":"108","author":"Bressler","year":"1990","journal-title":"Arch Ophthalmol"},{"issue":"11","key":"bib7","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1001\/archopht.123.11.1484","article-title":"The Age-Related Eye Disease Study severity scale for age-related macular degeneration: AREDS Report No. 17","volume":"123","author":"Davis","year":"2005","journal-title":"Arch Ophthalmol"},{"issue":"4","key":"bib8","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1001\/archopht.121.4.519","article-title":"The risk and natural course of age-related maculopathy: follow-up at 6 1\/2 years in the Rotterdam study","volume":"121","author":"van Leeuwen","year":"2003","journal-title":"Arch Ophthalmol"},{"issue":"5","key":"bib9","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1001\/archopht.121.5.658","article-title":"Risk of age-related macular degeneration in eyes with macular drusen or hyperpigmentation: the Blue Mountains Eye Study cohort","volume":"121","author":"Wang","year":"2003","journal-title":"Arch Ophthalmol"},{"issue":"2","key":"bib10","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.ophtha.2006.10.040","article-title":"Fifteen-year cumulative incidence of age-related macular degeneration: the Beaver Dam Eye Study","volume":"114","author":"Klein","year":"2007","journal-title":"Ophthalmology"},{"issue":"4","key":"bib11","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.ophtha.2012.10.036","article-title":"Clinical classification of age-related macular degeneration","volume":"120","author":"Ferris","year":"2013","journal-title":"Ophthalmology"},{"issue":"7","key":"bib12","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.ophtha.2010.11.013","article-title":"Spectral domain optical coherence tomography imaging of drusen in nonexudative age-related macular degeneration","volume":"118","author":"Gregori","year":"2011","journal-title":"Ophthalmology"},{"issue":"8","key":"bib13","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1097\/IAE.0b013e318285cbd2","article-title":"Spectral-domain optical coherence tomography imaging of drusenoid pigment epithelial detachments","volume":"33","author":"Alexandre de Amorim Garcia Filho","year":"2013","journal-title":"Retina"},{"issue":"1","key":"bib14","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1097\/IAE.0b013e31829d0015","article-title":"Drusen measurements comparison by fundus photograph manual delineation versus optical coherence tomography retinal pigment epithelial segmentation automated analysis","volume":"34","author":"Diniz","year":"2014","journal-title":"Retina"},{"issue":"11","key":"bib15","doi-asserted-by":"publisher","first-page":"7662","DOI":"10.1167\/iovs.14-15273","article-title":"Change in drusen area over time compared using spectral-domain optical coherence tomography and color fundus imaging","volume":"55","author":"Gregori","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib16","doi-asserted-by":"publisher","first-page":"2429","DOI":"10.1167\/iovs.12-11569","article-title":"Comparison of drusen area detected by spectral domain optical coherence tomography and color fundus imaging","volume":"54","author":"Yehoshua","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"bib17","doi-asserted-by":"publisher","first-page":"2434","DOI":"10.1016\/j.ophtha.2011.05.008","article-title":"Natural history of drusen morphology in age-related macular degeneration using spectral domain optical coherence tomography","volume":"118","author":"Yehoshua","year":"2011","journal-title":"Ophthalmology"},{"issue":"1","key":"bib18","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1167\/iovs.11-7640","article-title":"Validated automatic segmentation of AMD pathology including drusen and geographic atrophy in SD-OCT images","volume":"53","author":"Chiu","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"bib19","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1016\/j.media.2013.06.003","article-title":"Automated drusen segmentation and quantification in SD-OCT images","volume":"17","author":"Chen","year":"2013","journal-title":"Med Image Anal"},{"issue":"10","key":"bib20","doi-asserted-by":"publisher","first-page":"4875","DOI":"10.1167\/iovs.09-4962","article-title":"Quantitative comparison of drusen segmented on SD-OCT versus drusen delineated on color fundus photographs","volume":"51","author":"Jain","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib21","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.ajo.2011.08.031","article-title":"Quantitative imaging of retinal pigment epithelial detachments using spectral-domain optical coherence tomography","volume":"153","author":"Penha","year":"2012","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"bib22","doi-asserted-by":"publisher","first-page":"204","DOI":"10.3928\/23258160-20130313-12","article-title":"Increasing volume of a retinal pigmented epithelial detachment as a predictor of submacular hemorrhage during anti-VEGF therapy","volume":"44","author":"de Amorim Garcia Filho","year":"2013","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"issue":"3","key":"bib23","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1097\/IAE.0b013e31827d2657","article-title":"Quantitative changes in retinal pigment epithelial detachments as a predictor for retreatment with anti-VEGF therapy","volume":"33","author":"Penha","year":"2013","journal-title":"Retina"},{"issue":"2","key":"bib24","doi-asserted-by":"publisher","first-page":"304","DOI":"10.3390\/jcm4020304","article-title":"Association of OCT derived drusen measurements with AMD associated-genotypic SNPs in Amish population","volume":"4","author":"Chavali","year":"2015","journal-title":"J Clin Med"},{"issue":"1","key":"bib25","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3928\/23258160-20131217-01","article-title":"Change in drusen volume as a novel clinical trial endpoint for the study of complement inhibition in age-related macular degeneration","volume":"45","author":"Garcia Filho","year":"2014","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"issue":"5","key":"bib26","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.ophtha.2016.01.034","article-title":"Anatomic clinical trial endpoints for nonexudative age-related macular degeneration","volume":"123","author":"Schaal","year":"2016","journal-title":"Ophthalmology"},{"issue":"13","key":"bib27","doi-asserted-by":"publisher","first-page":"8319","DOI":"10.1167\/iovs.12-10582","article-title":"Accuracy and reproducibility of automated drusen segmentation in eyes with non-neovascular age-related macular degeneration","volume":"53","author":"Nittala","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib29","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1167\/tvst.6.1.12","article-title":"Individual drusen segmentation and repeatability and reproducibility of their automated quantification in optical coherence tomography images","volume":"6","author":"de Sisternes","year":"2017","journal-title":"Transl Vis Sci Technol"},{"issue":"4","key":"bib30","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1007\/s10278-017-0038-7","article-title":"Automated segmentation and quantification of drusen in fundus and optical coherence tomography images for detection of ARMD","volume":"31","author":"Khalid","year":"2018","journal-title":"J Digit Imaging"},{"issue":"1","key":"bib31","doi-asserted-by":"publisher","first-page":"9541","DOI":"10.1038\/s41598-020-66355-5","article-title":"Automated retinal layer segmentation using graph-based algorithm incorporating deep-learning-derived information","volume":"10","author":"Mishra","year":"2020","journal-title":"Sci Rep"},{"issue":"7","key":"bib32","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1001\/jamaophthalmol.2020.1376","article-title":"Characterization of drusen and hyperreflective foci as biomarkers for disease progression in age-related macular degeneration using artificial intelligence in optical coherence tomography","volume":"138","author":"Waldstein","year":"2020","journal-title":"JAMA Ophthalmol"},{"issue":"1","key":"bib33","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1364\/BOE.398222","article-title":"OCT-OCTA segmentation: combining structural and blood flow information to segment Bruch's membrane","volume":"12","author":"Schottenhamml","year":"2021","journal-title":"Biomed Opt Express"},{"issue":"6 Suppl","key":"bib34","doi-asserted-by":"publisher","first-page":"S32","DOI":"10.3928\/15428877-20121001-06","article-title":"Automated detection of the foveal center improves SD-OCT measurements of central retinal thickness","volume":"43","author":"Wang","year":"2012","journal-title":"Ophthalmic Surg Lasers Imaging"},{"key":"bib28","volume-title":"The Design and Analysis of Clinical Experiments","author":"Fleiss","year":"1986"}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2772474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T06:57:23Z","timestamp":1698908243000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2772474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,14]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.10.4.11","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4,14]]}}}