{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:55:34Z","timestamp":1789707334795,"version":"4.0.1"},"reference-count":29,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"4","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2021,4,21]]},"DOI":"10.1167\/tvst.10.4.18","type":"journal-article","created":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T09:41:11Z","timestamp":1618652471000},"page":"18","source":"Crossref","is-referenced-by-count":34,"title":["The ROCK Inhibitor Ripasudil Shows an Endothelial Protective Effect in Patients With Low Corneal Endothelial Cell Density After Cataract Surgery"],"prefix":"10.1167","volume":"10","author":[{"given":"Hisataka","family":"Fujimoto","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinao","family":"Setoguchi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Kiryu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","first-page":"101","article-title":"Use of Rho kinase inhibitors in ophthalmology: a review of the literature","volume":"7","author":"Moshirfar","year":"2018","journal-title":"Med Hypothesis Discov Innov Ophthalmol J"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1358\/dof.2013.038.02.1924778","article-title":"Rho kinase inhibitors for the treatment of glaucoma","volume":"38","author":"Novack","year":"2013","journal-title":"Drugs Future"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2013.05.002","article-title":"Rho-associated kinase inhibitors: a novel glaucoma therapy","volume":"37","author":"Inoue","year":"2013","journal-title":"Prog Retin Eye Res"},{"key":"bib4","doi-asserted-by":"crossref","first-page":"2646904","DOI":"10.1155\/2017\/2646904","article-title":"Application of rho kinase inhibitors for the treatment of corneal endothelial diseases","volume":"2017","author":"Okumura","year":"2017","journal-title":"J Ophthalmol"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s40135-019-00197-x","article-title":"New insights into corneal endothelial regeneration","volume":"7","author":"Jafri","year":"2019","journal-title":"Curr Ophthalmol Rep"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/bjophthalmol-2017-310378","article-title":"ROCK inhibitors for the treatment of ocular diseases","volume":"102","author":"Nourinia","year":"2017","journal-title":"Br J Ophthalmol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1056\/NEJMoa1712770","article-title":"Injection of cultured cells with a ROCK inhibitor for bullous keratopathy","volume":"378","author":"Kinoshita","year":"2018","journal-title":"N Engl J Med"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"6067","DOI":"10.1167\/iovs.15-17595","article-title":"Effect of the Rho kinase inhibitor Y-27632 on corneal endothelial wound healing","volume":"56","author":"Okumura","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.ajpath.2012.03.033","article-title":"ROCK inhibitor converts corneal endothelial cells into a phenotype capable of regenerating in vivo endothelial tissue","volume":"181","author":"Okumura","year":"2012","journal-title":"Am J Pathol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"3680","DOI":"10.1167\/iovs.08-2634","article-title":"Enhancement on primate corneal endothelial cell survival in vitro by a rock inhibitor","volume":"50","author":"Okumura","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1080\/02713683.2019.1700529","article-title":"Regeneration of the corneal endothelium","volume":"45","author":"Okumura","year":"2020","journal-title":"Curr Eye Res"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-016-0001-8","article-title":"Rho kinase inhibitor enables cell-based therapy for corneal endothelial dysfunction","volume":"6","author":"Okumura","year":"2016","journal-title":"Sci Rep"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"2992","DOI":"10.1167\/iovs.03-1174","article-title":"Cultured human corneal endothelial cell transplantation with a collagen sheet in a rabbit model","volume":"45","author":"Mimura","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib14","doi-asserted-by":"publisher","first-page":"90","DOI":"10.22336\/rjo","article-title":"Pseudophakic bullous keratopathy","volume":"61","author":"Pricopie","year":"2017","journal-title":"Rom J Ophthalmol"},{"issue":"Suppl 11","key":"bib15","doi-asserted-by":"publisher","first-page":"S25","DOI":"10.1097\/ICO.0000000000000240","article-title":"New therapeutic modality for corneal endothelial disease using Rho-associated kinase inhibitor eye drops","volume":"33","author":"Koizumi","year":"2014","journal-title":"Cornea"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1167\/iovs.15-18586","article-title":"Effect of the rho-associated kinase inhibitor eye drop (Ripasudil) on corneal endothelial wound healing","volume":"57","author":"Okumura","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1097\/ICO.0000000000001209","article-title":"Descemetorhexis without grafting for Fuchs endothelial dystrophy-supplementation with topical ripasudil","volume":"36","author":"Moloney","year":"2017","journal-title":"Cornea"},{"issue":"3","key":"bib18","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1097\/ICO.0000000000002437","article-title":"Descemet stripping only supplemented with topical ripasudil for Fuchs endothelial dystrophy 12-month outcomes of the Sydney Eye Hospital Study","volume":"40","author":"Moloney","year":"2021","journal-title":"Cornea"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1186\/s12886-020-01490-1","article-title":"Safety and efficacy of ripasudil in Japanese patients with glaucoma or ocular hypertension: 12-month interim analysis of ROCK-J, a post-marketing surveillance study","volume":"20","author":"Tanihara","year":"2020","journal-title":"BMC Ophthalmol"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.2147\/OPTH.S216907","article-title":"Ripasudil hydrochloride hydrate in the treatment of glaucoma: safety, efficacy, and patient selection","volume":"14","author":"Kusuhara","year":"2020","journal-title":"Clin Ophthalmol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.jcrs.2011.10.027","article-title":"Reliability and repeatability of swept-source Fourier-domain optical coherence tomography and Scheimpflug imaging in keratoconus","volume":"38","author":"Szalai","year":"2012","journal-title":"J Cataract Refract Surg"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1136\/bjo.2010.194571","article-title":"Enhancement of corneal endothelium wound healing by Rho-associated kinase (ROCK) inhibitor eye drops","volume":"95","author":"Okumura","year":"2011","journal-title":"Br J Ophthalmol"},{"issue":"8","key":"bib23","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1097\/ICO.0b013e318285475d","article-title":"Rho-associated kinase inhibitor eye drop treatment as a possible medical treatment for Fuchs corneal dystrophy","volume":"32","author":"Koizumi","year":"2013","journal-title":"Cornea"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"2523","DOI":"10.1002\/stem.v30.11","article-title":"Revisited microanatomy of the corneal endothelial periphery: New evidence for continuous centripetal migration of endothelial cells in humans","volume":"30","author":"He","year":"2012","journal-title":"Stem Cells"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"5090","DOI":"10.1167\/iovs.14-14249","article-title":"Quantitative regional differences in corneal endothelial abnormalities in the central and peripheral zones in Fuchs\u2019 endothelial corneal dystrophy","volume":"55","author":"Fujimoto","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.ophtha.2010.03.001","article-title":"One hundred years of Fuchs\u2019 dystrophy","volume":"117","author":"Jun","year":"2010","journal-title":"Ophthalmology"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1007\/BF02147776","article-title":"Cellular membrane activity in the corneal endothelium of the intact eye","volume":"24","author":"Maurice","year":"1968","journal-title":"Experientia"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/S0161-6420(00)00087-7","article-title":"Keratopathy in pseudoexfoliation syndrome as a cause of corneal endothelial decompensation: a clinicopathologic study","volume":"107","author":"Naumann","year":"2000","journal-title":"Ophthalmology"},{"key":"bib29","first-page":"444","article-title":"Wound-healing of corneal endothelium in monkey: an autoradiographic study","volume":"27","author":"Matsubara","year":"1983","journal-title":"Jpn J Ophthalmol"}],"container-title":["Translational Vision Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2772488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T18:43:23Z","timestamp":1619117003000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2772488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,21]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.10.4.18","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4,21]]}}}