{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:58:26Z","timestamp":1757703506555},"reference-count":36,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"7","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2022,7,15]]},"DOI":"10.1167\/tvst.11.7.13","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T13:31:05Z","timestamp":1657891865000},"page":"13","source":"Crossref","is-referenced-by-count":2,"title":["Heritability of Corneal Parameters in Nuclear Families With Keratoconus"],"prefix":"10.1167","volume":"11","author":[{"given":"Yawen","family":"Wang","sequence":"first","affiliation":[{"name":"Henan University People's Hospital, Henan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyan","family":"Xu","sequence":"additional","affiliation":[{"name":"Henan University People's Hospital, Henan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou 450003, China"},{"name":"Henan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, People's Hospital of Zhengzhou University, Henan University People's Hospital, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaopei","family":"Wang","sequence":"additional","affiliation":[{"name":"Xinxiang Medical University, Henan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaili","family":"Yang","sequence":"additional","affiliation":[{"name":"Henan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, People's Hospital of Zhengzhou University, Henan University People's Hospital, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwei","family":"Gu","sequence":"additional","affiliation":[{"name":"Henan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, People's Hospital of Zhengzhou University, Henan University People's Hospital, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Fan","sequence":"additional","affiliation":[{"name":"Henan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, People's Hospital of Zhengzhou University, Henan University People's Hospital, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan University People's Hospital, Henan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Henan Eye Hospital & Henan Eye Institution, Zhengzhou, 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Guo","sequence":"additional","affiliation":[{"name":"Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Henan Eye Hospital & Henan Eye Institution, Zhengzhou, 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenjiu","family":"Pang","sequence":"additional","affiliation":[{"name":"Henan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, People's Hospital of Zhengzhou University, Henan University People's Hospital, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengwei","family":"Ren","sequence":"additional","affiliation":[{"name":"Henan University People's Hospital, Henan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou 450003, China"},{"name":"Henan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, People's Hospital of Zhengzhou University, Henan University People's Hospital, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Henan University People's Hospital, Henan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou 450003, China"},{"name":"Henan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, People's Hospital of Zhengzhou University, Henan University People's Hospital, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"108328","DOI":"10.1016\/j.exer.2020.108328","article-title":"Genetics vs chronic corneal mechanical trauma in the etiology of keratoconus","volume":"202","author":"Rabinowitz","year":"2021","journal-title":"Exp Eye Res"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1097\/ICO.0000000000000408","article-title":"Global consensus on keratoconus and ectatic diseases","volume":"34","author":"Gomes","year":"2015","journal-title":"Cornea"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1097\/ICO.0000000000002150","article-title":"The prevalence and risk factors for keratoconus: a systematic review and meta-analysis","volume":"39","author":"Hashemi","year":"2020","journal-title":"Cornea"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1146\/vision.2020.6.issue-1","article-title":"Genetic and environmental risk factors for keratoconus","volume":"6","author":"Lucas","year":"2020","journal-title":"Annu Rev Vis Sci"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.1097\/ICO.0000000000002219","article-title":"Obstructive sleep apnea-hypopnea syndrome and keratoconus: an epiphenomenon related to sleep position?","volume":"39","author":"Gatinel","year":"2020","journal-title":"Cornea"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1007\/s00417-020-04771-z","article-title":"Incorrect sleeping position and eye rubbing in patients with unilateral or highly asymmetric keratoconus: a case-control study","volume":"258","author":"Mazharian","year":"2020","journal-title":"Graefes Arch Clin Exp Ophthal"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"e482","DOI":"10.1111\/aos.2012.90.issue-6","article-title":"Keratoconus in 18 pairs of twins","volume":"90","author":"Tuft","year":"2012","journal-title":"Acta Ophthalmol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s42003-021-01784-0","article-title":"A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus","volume":"4","author":"Hardcastle","year":"2021","journal-title":"Commun Biol"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1167\/iovs.08-2173","article-title":"Localization of a gene for keratoconus to a 5.6-Mb interval on 13q32","volume":"50","author":"Gajecka","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1007\/s10792-019-01111-x","article-title":"Association of KIF26B and COL4A4 gene polymorphisms with the risk of keratoconus in a sample of Iranian population","volume":"39","author":"Sargazi","year":"2019","journal-title":"Int Ophthalmol"},{"key":"bib11","doi-asserted-by":"crossref","first-page":"266","DOI":"10.4103\/jovr.jovr_116_17","article-title":"Analysis of VSX1 variations in Brazilian subjects with keratoconus","volume":"13","author":"da Silva","year":"2018","journal-title":"J Ophthalmic Vis Res"},{"key":"bib12","first-page":"270","article-title":"Whole mitochondrial genome analysis in Chinese patients with keratoconus","volume":"27","author":"Xu","year":"2021","journal-title":"Mol Vis"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.mito.2017.05.009","article-title":"Mitochondrial dysfunction and oxidative stress in corneal disease","volume":"36","author":"Vallabh","year":"2017","journal-title":"Mitochondrion"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1167\/iovs.18-25916","article-title":"Multiple differentially methylated regions specific to keratoconus explain known keratoconus linkage loci","volume":"60","author":"Kabza","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nrg2322","article-title":"Heritability in the genomics era\u2013concepts and misconceptions","volume":"9","author":"Visscher","year":"2008","journal-title":"Nat Rev Genet"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.survophthal.2010.07.003","article-title":"The heritability of ocular traits","volume":"55","author":"Sanfilippo","year":"2010","journal-title":"Surv Ophthalmol"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"3805","DOI":"10.1002\/(ISSN)1097-0258","article-title":"Non-parametric bootstrap confidence intervals for the intraclass correlation coefficient","volume":"22","author":"Ukoumunne","year":"2003","journal-title":"Stat Med"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"e562","DOI":"10.1111\/aos.12389","article-title":"Segregation analysis suggests that keratoconus is a complex non-mendelian disease","volume":"92","author":"Kriszt","year":"2014","journal-title":"Acta Ophthalmol"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1080\/13816810.2017.1393831","article-title":"A new perspective on the genetics of keratoconus: why have we not been more successful?","volume":"39","author":"Valgaeren","year":"2018","journal-title":"Ophthalmic Genet"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1176\/appi.ajp.160.4.636","article-title":"The endophenotype concept in psychiatry: etymology and strategic intentions","volume":"160","author":"Gottesman","year":"2003","journal-title":"Am J of Psychiatry"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1136\/bjo.2009.162735","article-title":"The genetics of central corneal thickness","volume":"94","author":"Dimasi","year":"2010","journal-title":"Br J Ophthalmol"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1186\/s12864-021-07860-3","article-title":"Mendelian randomization analysis identified genes pleiotropically associated with central corneal thickness","volume":"22","author":"Yang","year":"2021","journal-title":"BMC Genomics"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.clae.2015.01.008","article-title":"Characteristics and associations of keratoconus patients","volume":"38","author":"Naderan","year":"2015","journal-title":"Contact Lens Anterior Eye"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1097\/ICL.0000000000000589","article-title":"Heritability of corneal curvature and Pentacam Topometric indices: a population-based study","volume":"45","author":"Heydarian","year":"2019","journal-title":"Eye Contact Lens"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1136\/bjophthalmol-2019-314640","article-title":"Heritability of pachymetric indices using Pentacam Scheimflug imaging","volume":"104","author":"Hashemi","year":"2020","journal-title":"Br J Ophthalmol"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1038\/s42003-020-01137-3","article-title":"Keratoconus-susceptibility gene identification by corneal thickness genome-wide association study and artificial intelligence IBM Watson","volume":"3","author":"Hosoda","year":"2020","journal-title":"Commun Biol"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1038\/s41467-018-03646-6","article-title":"Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases","volume":"9","author":"Iglesias","year":"2018","journal-title":"Nat Commun"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"8359","DOI":"10.1167\/iovs.14-15043","article-title":"High heritability of posterior corneal tomography, as measured by Scheimpflug imaging, in a twin study","volume":"55","author":"Mahroo","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"4303","DOI":"10.1167\/iovs.08-1934","article-title":"Heritability of central corneal thickness in Chinese: the Guangzhou Twin Eye Study","volume":"49","author":"Zheng","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"3718","DOI":"10.1167\/iovs.04-1497","article-title":"Central corneal thickness is highly heritable: the twin eye studies","volume":"46","author":"Toh","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"4087","DOI":"10.1167\/iovs.08-3271","article-title":"Heritability of central corneal thickness in nuclear families","volume":"50","author":"Landers","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"e55573","DOI":"10.1371\/journal.pone.0055573","article-title":"The heritability of glaucoma-related traits corneal hysteresis, central corneal thickness, intraocular pressure, and choroidal blood flow pulsatility","volume":"8","author":"Freeman","year":"2013","journal-title":"PloS One"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"5035","DOI":"10.1093\/hmg\/ddw172","article-title":"Genome-wide association study identifies WNT7B as a novel locus for central corneal thickness in Latinos","volume":"25","author":"Gao","year":"2016","journal-title":"Human Mol Genet"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/ng.2506","article-title":"Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus","volume":"45","author":"Lu","year":"2013","journal-title":"Nat Genet"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"132","DOI":"10.3109\/13816810.2015.1005317","article-title":"Evaluating the association between keratoconus and reported genetic loci in a Han Chinese population","volume":"36","author":"Hao","year":"2015","journal-title":"Ophthalmic Genet"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/ceo.2009.37.issue-1","article-title":"An introduction to understanding elevation-based topography: how elevation data are displayed - a review","volume":"37","author":"Belin","year":"2009","journal-title":"Clin Exp Ophthalmol"}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2783487","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T13:31:09Z","timestamp":1657891869000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2783487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,15]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7,8]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.11.7.13","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7,15]]}}}