{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:31:52Z","timestamp":1785529912933,"version":"3.56.0"},"reference-count":47,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"8","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2022,8,18]]},"DOI":"10.1167\/tvst.11.8.18","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T15:31:16Z","timestamp":1660836676000},"page":"18","source":"Crossref","is-referenced-by-count":9,"title":["Inhibitory Effects of 3\u2032,4\u2032-Dihydroxyflavonol in a Mouse Model of Glaucoma Filtration Surgery and TGF\u03b21-Induced Responses in Human Tenon's Fibroblasts"],"prefix":"10.1167","volume":"11","author":[{"given":"Jennifer C.","family":"Fan Gaskin","sequence":"first","affiliation":[{"name":"Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Australia"},{"name":"Glaucoma Investigation and Research Unit, Royal Victorian Eye and Ear Hospital, Melbourne, Australia"},{"name":"Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy C. K.","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manisha H.","family":"Shah","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Australia"},{"name":"Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.","family":"Edgley","sequence":"additional","affiliation":[{"name":"Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitesh M.","family":"Peshavariya","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa C.","family":"Chan","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Australia"},{"name":"Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, Australia"},{"name":"Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"11","key":"bib1","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"issue":"12","key":"bib2","doi-asserted-by":"publisher","first-page":"2532","DOI":"10.1016\/j.ophtha.2013.07.049","article-title":"Trabeculectomy in the 21st century: a multicenter analysis","volume":"120","author":"Kirwan","year":"2013","journal-title":"Ophthalmology"},{"issue":"5\u20136","key":"bib3","doi-asserted-by":"crossref","first-page":"557","DOI":"10.2119\/molmed.2010.00188","article-title":"Validation of the glaucoma filtration surgical mouse model for antifibrotic drug evaluation","volume":"17","author":"Seet","year":"2011","journal-title":"Mol Med"},{"issue":"5","key":"bib4","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.ajo.2011.10.026","article-title":"Treatment outcomes in the Tube Versus Trabeculectomy (TVT) study after five years of follow-up","volume":"153","author":"Gedde","year":"2012","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"bib5","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/S0002-9394(14)70431-3","article-title":"Five-year follow-up of the Fluorouracil Filtering Surgery Study.","volume":"121","author":"The Fluorouracil Filtering Surgery Study Group","year":"1996","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"bib6","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1001\/archopht.116.4.443","article-title":"Late-onset bleb leaks after glaucoma filtering surgery","volume":"116","author":"Greenfield","year":"1998","journal-title":"Arch Ophthalmol"},{"issue":"7","key":"bib7","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/S0161-6420(85)33948-9","article-title":"Complications of surgery in glaucoma. Early and late bacterial endophthalmitis following glaucoma filtering surgery","volume":"92","author":"Katz","year":"1985","journal-title":"Ophthalmology"},{"issue":"3","key":"bib8","doi-asserted-by":"publisher","first-page":"e0024","DOI":"10.5041\/RMMJ.20769172","article-title":"Evolution of glaucoma surgery in the last 25 years","volume":"9","author":"Bar-David","year":"2018","journal-title":"Rambam Maimonides Med J"},{"issue":"4","key":"bib9","doi-asserted-by":"publisher","first-page":"150","DOI":"10.5694\/mja2.v210.4","article-title":"Glaucoma in perspective","volume":"210","author":"Kong","year":"2019","journal-title":"Med J Aust"},{"issue":"9","key":"bib10","first-page":"1975","article-title":"Transforming growth factor-beta1, -beta2, and -beta3 in vivo: effects on normal and mitomycin C-modulated conjunctival scarring","volume":"40","author":"Cordeiro","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.preteyeres.2017.08.001","article-title":"Myofibroblast transdifferentiation: the dark force in ocular wound healing and fibrosis","volume":"60","author":"Shu","year":"2017","journal-title":"Prog Retin Eye Res"},{"issue":"3","key":"bib12","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1172\/JCI31487","article-title":"Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases","volume":"117","author":"Wynn","year":"2007","journal-title":"J Clin Invest"},{"issue":"1","key":"bib13","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1076\/ceyr.27.2.35.15456","article-title":"Effect of growth factors on the activation of human Tenon's capsule fibroblasts","volume":"27","author":"Denk","year":"2003","journal-title":"Curr Eye Res"},{"issue":"10","key":"bib14","doi-asserted-by":"publisher","first-page":"963","DOI":"10.3109\/02713689009069932","article-title":"Transforming growth factor-beta in human aqueous humor","volume":"9","author":"Jampel","year":"1990","journal-title":"Curr Eye Res"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.redox.2015.08.015","article-title":"Redox-fibrosis: impact of TGF\u00df1 on ROS generators, mediators and functional consequences","volume":"6","author":"Richter","year":"2015","journal-title":"Redox Biol"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"9003","DOI":"10.1038\/srep09003","article-title":"Quercetin attenuates lactate production and extracellular matrix secretion in keratoconus","volume":"5","author":"McKay","year":"2015","journal-title":"Sci Rep"},{"issue":"5","key":"bib17","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1093\/ajcn\/79.5.727","article-title":"Polyphenols: food sources and bioavailability","volume":"79","author":"Manach","year":"2004","journal-title":"Am J Clin Nutr"},{"issue":"2","key":"bib18","doi-asserted-by":"publisher","first-page":"292","DOI":"10.3390\/molecules22020292","article-title":"Wine flavonoids in health and disease prevention","volume":"22","author":"Fernandes","year":"2017","journal-title":"Molecules"},{"issue":"6","key":"bib19","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1097\/00005344-200312000-00006","article-title":"3',4'-Dihydroxyflavonol enhances nitric oxide bioavailability and improves vascular function after ischemia and reperfusion injury in the rat","volume":"42","author":"Chan","year":"2003","journal-title":"J Cardiovasc Pharmacol"},{"issue":"6","key":"bib20","doi-asserted-by":"publisher","first-page":"e20813","DOI":"10.1371\/journal.pone.0020813","article-title":"3',4'-Dihydroxyflavonol reduces superoxide and improves nitric oxide function in diabetic rat mesenteric arteries","volume":"6","author":"Leo","year":"2011","journal-title":"PLoS One"},{"issue":"11","key":"bib21","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.3390\/antiox9111126","article-title":"Nox4 facilitates TGF\u00df1-induced fibrotic response in human Tenon's fibroblasts and promotes wound collagen accumulation in murine model of glaucoma filtration surgery","volume":"9","author":"Shah","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1002\/ffj.v32.5","article-title":"Captisol: an efficient carrier and solubilizing agent for essential oils and their components","volume":"32","author":"Kfoury","year":"2017","journal-title":"Flavour Fragr J"},{"issue":"6","key":"bib23","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1097\/00061198-200412000-00005","article-title":"A pilot study of a system for grading of drainage blebs after glaucoma surgery","volume":"13","author":"Wells","year":"2004","journal-title":"J Glaucoma"},{"issue":"9","key":"bib24","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1042\/CS20150103","article-title":"NADPH oxidase 2 plays a role in experimental corneal neovascularization","volume":"130","author":"Chan","year":"2016","journal-title":"Clin Sci (Lond)"},{"issue":"7","key":"bib25","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"issue":"2","key":"bib26","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1016\/j.ijcard.2012.11.067","article-title":"A new anti-fibrotic drug attenuates cardiac remodeling and systolic dysfunction following experimental myocardial infarction","volume":"168","author":"Zhang","year":"2013","journal-title":"Int J Cardiol"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/bs.pbr.2015.04.014","article-title":"Rho kinase inhibitor AMA0526 improves surgical outcome in a rabbit model of glaucoma filtration surgery","volume":"220","author":"Van de Velde","year":"2015","journal-title":"Prog Brain Res"},{"issue":"6","key":"bib28","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1111\/jcmm.2014.18.issue-6","article-title":"Transforming growth factor-\u00df1 requires NADPH oxidase 4 for angiogenesis in vitro and in vivo","volume":"18","author":"Peshavariya","year":"2014","journal-title":"J Cell Mol Med"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"108776","DOI":"10.1016\/j.biopha.2019.108776","article-title":"Epicatechin protective effects on bleomycin-induced pulmonary oxidative stress and fibrosis in mice","volume":"114","author":"Shariati","year":"2019","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"bib30","doi-asserted-by":"publisher","first-page":"4783","DOI":"10.3892\/mmr","article-title":"Arctigenin suppresses fibroblast activity and extracellular matrix deposition in hypertrophic scarring by reducing inflammation and oxidative stress","volume":"22","author":"Jiang","year":"2020","journal-title":"Mol Med Rep"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"108119","DOI":"10.1016\/j.exer.2020.108119","article-title":"Epigallocatechin-3-gallate (EGCG) inhibits myofibroblast transformation of human Tenon's fibroblasts","volume":"197","author":"Lin","year":"2020","journal-title":"Exp Eye Res"},{"issue":"6","key":"bib32","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1167\/iovs.04-0820","article-title":"Prolonged antiscarring effects of ilomastat and MMC after experimental glaucoma filtration surgery","volume":"46","author":"Wong","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib33","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s12013-015-0566-z","article-title":"Bevacizumab inhibits angiogenesis and inflammation in rat filtration surgery model","volume":"73","author":"Cheng","year":"2015","journal-title":"Cell Biochem Biophys"},{"issue":"10","key":"bib34","doi-asserted-by":"publisher","first-page":"e0186740","DOI":"10.1371\/journal.pone.0186740","article-title":"Antioxidants and NOX1\/NOX4 inhibition blocks TGF\u00df1-induced CCN2 and a-SMA expression in dermal and gingival fibroblasts","volume":"12","author":"Murphy-Marshman","year":"2017","journal-title":"PLoS One"},{"issue":"3","key":"bib35","first-page":"75","article-title":"The role of myofibroblasts in wound healing, contraction and its clinical implications in cleft palate repair","volume":"7","author":"Chitturi","year":"2015","journal-title":"J Int Oral Health"},{"issue":"11","key":"bib36","doi-asserted-by":"publisher","first-page":"4895","DOI":"10.1167\/iovs.06-0118","article-title":"Contractility as a prerequisite for TGF-beta-induced myofibroblast transdifferentiation in human Tenon fibroblasts","volume":"47","author":"Meyer-ter-Vehn","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib37","first-page":"e53974","article-title":"Development of an in vitro assay to evaluate contractile function of mesenchymal cells that underwent epithelial-mesenchymal transition","volume":"112","author":"Mikami","year":"2016","journal-title":"J Vis Exp"},{"key":"bib38","first-page":"33","article-title":"The role of the fibroblast in wound contraction and healing","volume":"3","author":"Porter","year":"2007","journal-title":"Wounds UK"},{"issue":"4","key":"bib39","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1159\/000063880","article-title":"Mitomycin C-induced cell death in mouse lens epithelial cells","volume":"34","author":"Park","year":"2002","journal-title":"Ophthalmic Res"},{"issue":"4","key":"bib40","doi-asserted-by":"publisher","first-page":"316","DOI":"10.5935\/0004-2749.20180062","article-title":"Antiscarring effect of intraoperative bevacizumab in experimental glaucoma filtration surgery","volume":"81","author":"Hilgert","year":"2018","journal-title":"Arq Bras Oftalmol"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"8965709","DOI":"10.1155\/2018\/8965709","article-title":"Combined application of bevacizumab and mitomycin C or bevacizumab and 5-fluorouracil in experimental glaucoma filtration surgery","volume":"2018","author":"Zuo","year":"2018","journal-title":"J Ophthalmol"},{"issue":"2","key":"bib42","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/s41419-019-1333-7","article-title":"Flavones hydroxylated at 5, 7, 3' and 4' ameliorate skin fibrosis via inhibiting activin receptor-like kinase 5 kinase activity","volume":"10","author":"Zhang","year":"2019","journal-title":"Cell Death Dis"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.carbpol.2013.08.078","article-title":"Cyclodextrins as encapsulation agents for plant bioactive compounds","volume":"101","author":"Pinho","year":"2014","journal-title":"Carbohydr Polym"},{"issue":"11","key":"bib44","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.3390\/molecules22111975","article-title":"Chitosan\/cyclodextrin\/TPP nanoparticles loaded with quercetin as novel bacterial quorum sensing inhibitors","volume":"22","author":"Thanh Nguyen","year":"2017","journal-title":"Molecules"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"112281","DOI":"10.1016\/j.colsurfb.2021.112281","article-title":"Chitosan\/cyclodextrin surface-adsorbed naringenin-loaded nanocapsules enhance bacterial quorum quenching and anti-biofilm activities","volume":"211","author":"Nguyen","year":"2022","journal-title":"Colloids Surf B Biointerfaces"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"5276130","DOI":"10.1155\/2016\/5276130","article-title":"Role of antioxidants and natural products in inflammation","volume":"2016","author":"Arulselvan","year":"2016","journal-title":"Oxid Med Cell Longev"},{"issue":"8","key":"bib47","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1001\/archopht.1996.01100140151007","article-title":"Endophthalmitis after filtering surgery with mitomycin","volume":"114","author":"Greenfield","year":"1996","journal-title":"Arch Ophthalmol"}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2783579","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T15:31:26Z","timestamp":1660836686000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2783579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,18]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.11.8.18","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8,18]]}}}