{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T07:09:14Z","timestamp":1778310554758,"version":"3.51.4"},"reference-count":81,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"8","license":[{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2022,8,19]]},"DOI":"10.1167\/tvst.11.8.20","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T15:31:00Z","timestamp":1660923060000},"page":"20","source":"Crossref","is-referenced-by-count":7,"title":["Sustained Release of Tacrolimus From a Topical Drug Delivery System Promotes Corneal Reinnervation"],"prefix":"10.1167","volume":"11","author":[{"given":"Simeon C.","family":"Daeschler","sequence":"first","affiliation":[{"name":"Neurosciences & Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaveh","family":"Mirmoeini","sequence":"additional","affiliation":[{"name":"Neurosciences & Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tessa","family":"Gordon","sequence":"additional","affiliation":[{"name":"Neurosciences & Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada"},{"name":"Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katelyn","family":"Chan","sequence":"additional","affiliation":[{"name":"Neurosciences & Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada"},{"name":"Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Zhang","sequence":"additional","affiliation":[{"name":"Neurosciences & Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada"},{"name":"Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asim","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Science, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantin","family":"Feinberg","sequence":"additional","affiliation":[{"name":"Neurosciences & Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada"},{"name":"Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory H.","family":"Borschel","sequence":"additional","affiliation":[{"name":"Neurosciences & Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada"},{"name":"Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"},{"name":"Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Ophthalmology and Vision Science, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27","reference":[{"key":"bib1","first-page":"476","article-title":"Ultrastructural organization of human corneal nerves","volume":"37","author":"M\u00fcller","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S0014-4835(03)00050-2","article-title":"Corneal nerves: structure, contents and function","volume":"76","author":"Muller","year":"2003","journal-title":"Exp Eye Res"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/0092-8674(89)90958-6","article-title":"Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells","volume":"57","author":"Cotsarelis","year":"1989","journal-title":"Cell"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1002\/stem.794","article-title":"Limbal epithelial stem cells: role of the niche microenvironment","volume":"30","author":"Ordonez","year":"2012","journal-title":"Stem Cells"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.celrep.2017.12.040","article-title":"Corneal-committed cells restore the stem cell pool and tissue boundary following injury","volume":"22","author":"Nasser","year":"2018","journal-title":"Cell Rep"},{"key":"bib6","first-page":"1442","article-title":"The X, Y, Z hypothesis of corneal epithelial maintenance","volume":"24","author":"Thoft","year":"1983","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/stem.1769","article-title":"Tracing the fate of limbal epithelial progenitor cells in the murine cornea","volume":"33","author":"Di Girolamo","year":"2015","journal-title":"Stem Cells"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1242\/jcs.111.19.2867","article-title":"Strategies of epithelial repair: modulation of stem cell and transit amplifying cell proliferation","volume":"111","author":"Lehrer","year":"1998","journal-title":"J Cell Sci"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.preteyeres.2018.04.003","article-title":"Neurotrophic keratopathy","volume":"66","author":"Dua","year":"2018","journal-title":"Prog Retin Eye Res"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1167\/iovs.11-8438","article-title":"Dependence of corneal stem\/progenitor cells on ocular surface innervation","volume":"53","author":"Ueno","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/0014-4886(80)90154-5","article-title":"Sensory denervation of the rabbit cornea affects epithelial properties","volume":"69","author":"Beuerman","year":"1980","journal-title":"Exp Neurol"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"203","DOI":"10.3109\/02713689408995778","article-title":"Epithelial wound healing in the denervated cornea","volume":"13","author":"Araki","year":"1994","journal-title":"Curr Eye Res"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"4345","DOI":"10.1167\/iovs.18-24843","article-title":"Corneal neurotization improves ocular surface health in a novel rat model of neurotrophic keratopathy and corneal neurotization","volume":"59","author":"Catapano","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1038\/sj.eye.6700616","article-title":"Neurotrophic keratitis","volume":"17","author":"Bonini","year":"2003","journal-title":"Eye (Lond)"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s00347-004-1140-z","article-title":"[Neurotrophic keratitis]","volume":"102","author":"Cursiefen","year":"2005","journal-title":"Ophthalmologe"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s40265-020-01289-w","article-title":"Cenegermin: a review in neurotrophic keratitis","volume":"80","author":"Deeks","year":"2020","journal-title":"Drugs"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1016\/j.ophtha.2018.02.022","article-title":"Phase II randomized, double-masked, vehicle-controlled trial of recombinant human nerve growth factor for neurotrophic keratitis","volume":"125","author":"Bonini","year":"2018","journal-title":"Ophthalmology"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1056\/NEJM199804233381702","article-title":"Topical treatment with nerve growth factor for corneal neurotrophic ulcers","volume":"338","author":"Lambiase","year":"1998","journal-title":"N Engl J Med"},{"key":"bib21","first-page":"1724","article-title":"Treatment of neurotrophic keratopathy with minimally invasive corneal neurotisation: long-term clinical outcomes and evidence of corneal reinnervation","volume":"103","author":"Catapano","year":"2019","journal-title":"Br J Ophthalmol"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1097\/ICO.0000000000001315","article-title":"In vivo confocal microscopy reveals corneal reinnervation after treatment of neurotrophic keratopathy with corneal neurotization","volume":"37","author":"Fung","year":"2018","journal-title":"Cornea"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1001\/jamaophthalmol.2014.2316","article-title":"Restoration of corneal sensation with regional nerve transfers and nerve grafts: a new approach to a difficult problem","volume":"132","author":"Elbaz","year":"2014","journal-title":"JAMA Ophthalmol"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1097\/PRS.0b013e3181904d3a","article-title":"Corneal neurotization: a novel solution to neurotrophic keratopathy","volume":"123","author":"Terzis","year":"2009","journal-title":"Plast Reconstr Surg"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1002\/stem.2921","article-title":"The role of nerve growth factor in maintaining proliferative capacity, colony-forming efficiency, and the limbal stem cell phenotype","volume":"37","author":"Kolli","year":"2019","journal-title":"Stem Cells"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"3880","DOI":"10.1167\/iovs.12-10816","article-title":"Nerve growth factor promotes corneal epithelial migration by enhancing expression of matrix metalloprotease-9","volume":"54","author":"Blanco-Mezquita","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.ophtha.2019.08.020","article-title":"Topical recombinant human nerve growth factor (cenegermin) for neurotrophic keratopathy: a multicenter randomized vehicle-controlled pivotal trial","volume":"127","author":"Pflugfelder","year":"2020","journal-title":"Ophthalmology"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1097\/ICO.0000000000001549","article-title":"Corneal neurotization with a great auricular nerve graft: effective reinnervation demonstrated by in vivo confocal microscopy","volume":"37","author":"Benkhatar","year":"2018","journal-title":"Cornea"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1097\/ACI.0000000000000560","article-title":"Topical tacrolimus for allergic eye diseases","volume":"19","author":"Erdinest","year":"2019","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1136\/bjophthalmol-2013-303639","article-title":"Topical 0.03% tacrolimus preventing rejection in high-risk corneal transplantation: a cohort study","volume":"97","author":"Magalhaes","year":"2013","journal-title":"Br J Ophthalmol"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s40662-017-0072-z","article-title":"Topical tacrolimus in anterior segment inflammatory disorders","volume":"4","author":"Shoughy","year":"2017","journal-title":"Eye Vis (Lond)"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"3191","DOI":"10.1073\/pnas.91.8.3191","article-title":"Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia","volume":"91","author":"Lyons","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib33","first-page":"1202","article-title":"Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506","volume":"289","author":"Gold","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S0304-3940(97)00960-9","article-title":"The immunosuppressant FK506 increases GAP-43 mRNA levels in axotomized sensory neurons","volume":"241","author":"Gold","year":"1998","journal-title":"Neurosci Lett"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/nm0497-421","article-title":"Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A","volume":"3","author":"Steiner","year":"1997","journal-title":"Nat Med"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1002\/mus.v60.5","article-title":"Comparing electrical stimulation and tacrolimus (FK506) to enhance treating nerve injuries","volume":"60","author":"Jo","year":"2019","journal-title":"Muscle Nerve"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1097\/01.PRS.0000091167.27303.18","article-title":"Dose-dependent effects of FK506 on neuroregeneration in a rat model","volume":"112","author":"Yang","year":"2003","journal-title":"Plast Reconstr Surg"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"259","DOI":"10.2133\/dmpk.13.259","article-title":"Absorption, distribution, metabolism and excretion of tacrolimus (FK506) in the rat","volume":"13","author":"Iwasaki","year":"1998","journal-title":"Drug Metab Pharmacokinet"},{"key":"bib39","first-page":"287","article-title":"The immunosuppressant FK506 increases functional recovery and nerve regeneration following peripheral nerve injury","volume":"6","author":"Gold","year":"1994","journal-title":"Restor Neurol Neurosci"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1006\/exnr.2002.7878","article-title":"FK506 increases peripheral nerve regeneration after chronic axotomy but not after chronic Schwann cell denervation","volume":"175","author":"Sulaiman","year":"2002","journal-title":"Exp Neurol"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"114204","DOI":"10.1016\/j.bcp.2020.114204","article-title":"Proof that the high molecular weight immunophilin FKBP52 mediates the in vivo neuroregenerative effect of the macrolide FK506","volume":"182","author":"Daneri-Becerra","year":"2020","journal-title":"Biochem Pharmacol"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1111\/j.1476-5381.2011.01783.x","article-title":"The neuroregenerative mechanism mediated by the Hsp90-binding immunophilin FKBP52 resembles the early steps of neuronal differentiation","volume":"166","author":"Quint\u00e1","year":"2012","journal-title":"Br J Pharmacol"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.neuron.2009.09.025","article-title":"Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening","volume":"64","author":"Shim","year":"2009","journal-title":"Neuron"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1002\/mus.v26:3","article-title":"Bimodal dose-dependence of FK506 on the rate of axonal regeneration in mouse peripheral nerve","volume":"26","author":"Udina","year":"2002","journal-title":"Muscle Nerve"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"7509","DOI":"10.1523\/JNEUROSCI.15-11-07509.1995","article-title":"The immunosuppressant FK506 increases the rate of axonal regeneration in rat sciatic nerve","volume":"15","author":"Gold","year":"1995","journal-title":"J Neurosci"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"113680","DOI":"10.1016\/j.expneurol.2021.113680","article-title":"Local FK506 drug delivery enhances nerve regeneration through fresh, unprocessed peripheral nerve allografts","volume":"341","author":"Zuo","year":"2021","journal-title":"Exp Neurol"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.actbio.2019.05.058","article-title":"Local delivery of FK506 to injured peripheral nerve enhances axon regeneration after surgical nerve repair in rats","volume":"96","author":"Tajdaran","year":"2019","journal-title":"Acta Biomater"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1002\/bit.25598","article-title":"A novel polymeric drug delivery system for localized and sustained release of tacrolimus (FK506)","volume":"112","author":"Tajdaran","year":"2015","journal-title":"Biotechnol Bioeng"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"3655","DOI":"10.1083\/jcb.201705085","article-title":"A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria","volume":"216","author":"Feinberg","year":"2017","journal-title":"J Cell Biol"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"e3000411","DOI":"10.1371\/journal.pbio.3000411","article-title":"Reporting animal research: explanation and elaboration for the ARRIVE guidelines 2.0","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1002\/jbm.a.v106.5","article-title":"Influence of ciprofloxacin-based additives on the hydrolysis of nanofiber polyurethane membranes","volume":"106","author":"Wright","year":"2018","journal-title":"J Biomed Mater Res A"},{"key":"bib52","article-title":"A biodegradable, tacrolimus-releasing nerve wrap promotes peripheral nerve regeneration","author":"Daeschler","year":"2021","journal-title":"bioRxiv"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/s41596-020-00414-z","article-title":"Antigen retrieval and clearing for whole-organ immunofluorescence by FLASH","volume":"16","author":"Messal","year":"2021","journal-title":"Nat Protoc"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"4516","DOI":"10.1073\/pnas.74.10.4516","article-title":"Local control of neurite development by nerve growth factor","volume":"74","author":"Campenot","year":"1977","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"4205","DOI":"10.1111\/bph.v174.23","article-title":"Principles of pharmacology in the eye","volume":"174","author":"Awwad","year":"2017","journal-title":"Br J Pharmacol"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1136\/bjo.2008.156828","article-title":"Turnover rate of tear-film lipid layer determined by fluorophotometry","volume":"93","author":"Mochizuki","year":"2009","journal-title":"Br J Ophthalmol"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s10072-016-2769-5","article-title":"Long-term efficacy and side effects of low-dose tacrolimus for the treatment of myasthenia gravis","volume":"38","author":"Tao","year":"2017","journal-title":"Neurol Sci"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/aor.v44.2","article-title":"Tacrolimus: 20 years of use in adult kidney transplantation. What we should know about its nephrotoxicity","volume":"44","author":"Bentata","year":"2020","journal-title":"Artif Organs"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1034\/j.1399-0012.2003.00028.x","article-title":"Neuropsychologic side-effects of tacrolimus in pediatric renal transplantation","volume":"17","author":"Kemper","year":"2003","journal-title":"Clin Transplant"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"327.e5","DOI":"10.1016\/j.genhosppsych.2012.07.010","article-title":"Tacrolimus-induced paranoid delusions and fugue-like state","volume":"35","author":"Krishna","year":"2013","journal-title":"Gen Hosp Psychiatry"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.exer.2015.06.008","article-title":"Combined 3DISCO clearing method, retrograde tracer and ultramicroscopy to map corneal neurons in a whole adult mouse trigeminal ganglion","volume":"139","author":"Launay","year":"2015","journal-title":"Exp Eye Res"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.exer.2009.12.010","article-title":"Anatomy of the human corneal innervation","volume":"90","author":"Marfurt","year":"2010","journal-title":"Exp Eye Res"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1136\/bjo.2009.173799","article-title":"Architecture and distribution of human corneal nerves","volume":"94","author":"Al-Aqaba","year":"2010","journal-title":"Br J Ophthalmol"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1097\/ICU.0b013e3283543b61","article-title":"Nerve growth factor therapy for corneal disease","volume":"23","author":"Lambiase","year":"2012","journal-title":"Curr Opin Ophthalmol"},{"key":"bib65","first-page":"1063","article-title":"Nerve growth factor promotes corneal healing: structural, biochemical, and molecular analyses of rat and human corneas","volume":"41","author":"Lambiase","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1016\/S0028-3908(97)00160-3","article-title":"Comparative effects of FK-506, rapamycin and cyclosporin A, on the in vitro differentiation of dorsal root ganglia explants and septal cholinergic neurons","volume":"36","author":"Carreau","year":"1997","journal-title":"Neuropharmacology"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.jhsa.2020.03.018","article-title":"Systemic and local FK506 (tacrolimus) and its application in peripheral nerve surgery","volume":"45","author":"Zuo","year":"2020","journal-title":"J Hand Surg Am"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1002\/(ISSN)1097-4598","article-title":"A small dose of the immunosuppressive agent FK506 (tacrolimus) protects peripheral nerve from ischemic fiber degeneration","volume":"24","author":"Kihara","year":"2001","journal-title":"Muscle Nerve"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1016\/j.drudis.2019.03.005","article-title":"Drug delivery systems and novel formulations to improve treatment of rare corneal disease","volume":"24","author":"Jimenez","year":"2019","journal-title":"Drug Discov Today"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"9156","DOI":"10.3748\/wjg.v19.i48.9156","article-title":"Pharmacogenetic considerations for optimizing tacrolimus dosing in liver and kidney transplant patients","volume":"19","author":"Provenzani","year":"2013","journal-title":"World J Gastroenterol"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1046\/j.1365-2125.1999.00007.x","article-title":"Tacrolimus whole blood concentrations correlate closely to side-effects in renal transplant recipients","volume":"48","author":"B\u00f6ttiger","year":"1999","journal-title":"Br J Clin Pharmacol"},{"key":"bib72","first-page":"429","article-title":"Alteration of epithelial paracellular permeability during corneal epithelial wound healing","volume":"31","author":"Huang","year":"1990","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib73","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/J.JHSB.2006.01.003","article-title":"The first Belgian hand transplantation\u201337 month term results","volume":"31","author":"Schuind","year":"2006","journal-title":"J Hand Surg Br"},{"key":"bib74","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1016\/S0041-1345(00)02656-7","article-title":"Peripheral nerve regeneration in human hand transplantation","volume":"33","author":"Owen","year":"2001","journal-title":"Transplant Proc"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.anplas.2005.02.001","article-title":"[First case in the world of autoreplantation of a limb associated with oral administration of an immunosupressant agent (FK 506-tacrolimus)]","volume":"50","author":"Martin","year":"2005","journal-title":"Ann Chir Plast Esthet"},{"key":"bib76","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1136\/bjophthalmol-2017-310436","article-title":"Safety profile and efficacy of tacrolimus in the treatment of birdshot retinochoroiditis: a retrospective case series review","volume":"102","author":"Islam","year":"2018","journal-title":"Br J Ophthalmol"},{"key":"bib77","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1097\/ICO.0000000000001298","article-title":"Tacrolimus eye drops as adjunct therapy in severe corneal endothelial rejection refractory to corticosteroids","volume":"36","author":"Ghaffari","year":"2017","journal-title":"Cornea"},{"key":"bib78","doi-asserted-by":"crossref","first-page":"643","DOI":"10.2147\/OPTH.S99157","article-title":"Efficacy and safety of low-dose topical tacrolimus in vernal keratoconjunctivitis","volume":"10","author":"Shoughy","year":"2016","journal-title":"Clin Ophthalmol"},{"key":"bib79","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.jaad.2020.03.075","article-title":"No evidence of increased cancer incidence in children using topical tacrolimus for atopic dermatitis","volume":"83","author":"Paller","year":"2020","journal-title":"J Am Acad Dermatol"},{"key":"bib80","first-page":"CD009864","article-title":"Topical tacrolimus for atopic dermatitis","volume":"2015","author":"Martins","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"bib81","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.ejps.2018.04.038","article-title":"Preclinical characterization and clinical evaluation of tacrolimus eye drops","volume":"120","author":"Luaces-Rodr\u00edguez","year":"2018","journal-title":"Eur J Pharm Sci"},{"key":"bib15","article-title":"Neurotrophic keratopathy ORPHA:137596","author":"Institut national de la sant\u00e9 et de la recherche m\u00e9dicale"},{"key":"bib19","article-title":"Drug approval package: OXERVATE (cenegermin-bkbj)","author":"U.S. Food and Drug Administration"}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2783583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T15:31:13Z","timestamp":1660923073000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2783583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,19]]},"references-count":81,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.11.8.20","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8,19]]}}}