{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:02:54Z","timestamp":1792519374544,"version":"4.5.0"},"reference-count":74,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"9","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2022,9,22]]},"DOI":"10.1167\/tvst.11.9.17","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T11:01:44Z","timestamp":1663844504000},"page":"17","source":"Crossref","is-referenced-by-count":5,"title":["Biological Correlations and Confounders for Quantification of Retinal Ganglion Cells by Optical Coherence Tomography Based on Studies of Outbred Mice"],"prefix":"10.1167","volume":"11","author":[{"given":"Adam","family":"Hedberg-Buenz","sequence":"first","affiliation":[{"name":"VA Center for the Prevention and Treatment of Visual Loss, Iowa City VA Health Care System, Iowa City, IA, USA"},{"name":"Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kacie J.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carly J.","family":"van der Heide","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiang","family":"Deng","sequence":"additional","affiliation":[{"name":"VA Center for the Prevention and Treatment of Visual Loss, Iowa City VA Health Care System, Iowa City, IA, USA"},{"name":"Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungmoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana A.","family":"Soukup","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Kettelson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Pellack","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Mercer","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona K.","family":"Garvin","sequence":"additional","affiliation":[{"name":"VA Center for the Prevention and Treatment of Visual Loss, Iowa City VA Health Care System, Iowa City, IA, USA"},{"name":"Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Abramoff","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA, USA"},{"name":"Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA"},{"name":"Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Anderson","sequence":"additional","affiliation":[{"name":"VA Center for the Prevention and Treatment of Visual Loss, Iowa City VA Health Care System, Iowa City, IA, USA"},{"name":"Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA"},{"name":"Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The pathophysiology and treatment of glaucoma: a review","volume":"311","author":"Weinreb","year":"2014","journal-title":"JAMA"},{"key":"bib2","doi-asserted-by":"crossref","first-page":"E2655","DOI":"10.1073\/pnas.1522014113","article-title":"Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus","volume":"113","author":"Sohn","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"241","DOI":"10.2217\/nmt.14.19","article-title":"Retinal manifestations of Alzheimer's disease","volume":"4","author":"Dehabadi","year":"2014","journal-title":"Neurodegener Dis Manag"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.msard.2018.11.010","article-title":"Sequential phases of RGC axonal and somatic injury in EAE mice examined using DTI and OCT","volume":"27","author":"Nishioka","year":"2019","journal-title":"Mult Scler Relat Disord"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1016\/j.ophtha.2011.11.032","article-title":"Ganglion cell loss in relation to visual disability in multiple sclerosis","volume":"119","author":"Walter","year":"2012","journal-title":"Ophthalmology"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"8330","DOI":"10.1167\/iovs.14-15468","article-title":"Early detection of subclinical visual damage after blast-mediated TBI enables prevention of chronic visual deficit by treatment with P7C3-S243","volume":"55","author":"Dutca","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"3440","DOI":"10.1167\/iovs.12-11522","article-title":"Retinal ganglion cell damage in an experimental rodent model of blast-mediated traumatic brain injury","volume":"54","author":"Mohan","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"11774","DOI":"10.1038\/s41598-021-90412-2","article-title":"Axonopathy precedes cell death in ocular damage mediated by blast exposure","volume":"11","author":"Boehme","year":"2021","journal-title":"Sci Rep"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1167\/iovs.62.7.13","article-title":"The retinal ganglion cell response to blast-mediated traumatic brain injury is genetic background dependent","volume":"62","author":"Harper","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/S1350-9462(02)00012-5","article-title":"Retinal ganglion cell disorders: types and treatments","volume":"21","author":"Levin","year":"2002","journal-title":"Prog Retin Eye Res"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1001\/archophthalmol.2012.669","article-title":"Distribution of damage to the entire retinal ganglion cell pathway: quantified using spectral-domain optical coherence tomography analysis in patients with glaucoma","volume":"130","author":"Lee","year":"2012","journal-title":"Arch Ophthalmol"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.jfo.2019.03.001","article-title":"Glaucoma progression analysis by spectral-domain optical coherence tomography (SD-OCT)","volume":"42","author":"Renard","year":"2019","journal-title":"J Fr Ophtalmol"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"S57","DOI":"10.1016\/j.ophtha.2017.07.015","article-title":"Detecting structural progression in glaucoma with optical coherence tomography","volume":"124","author":"Tatham","year":"2017","journal-title":"Ophthalmology"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1097\/ICU.0000000000000452","article-title":"New developments in optical coherence tomography imaging for glaucoma","volume":"29","author":"Mwanza","year":"2018","journal-title":"Curr Opin Ophthalmol"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1097\/ICU.0000000000000418","article-title":"The use of optical coherence tomography in neuro-ophthalmology","volume":"28","author":"Chan","year":"2017","journal-title":"Curr Opin Ophthalmol"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.exer.2015.06.001","article-title":"In vivo imaging methods to assess glaucomatous optic neuropathy","volume":"141","author":"Fortune","year":"2015","journal-title":"Exp Eye Res"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1097\/WNO.0000000000000422","article-title":"Avoiding clinical misinterpretation and artifacts of optical coherence tomography analysis of the optic nerve, retinal nerve fiber layer, and ganglion cell layer","volume":"36","author":"Chen","year":"2016","journal-title":"J Neuroophthalmol"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/eye.2016.295","article-title":"Assessing retinal ganglion cell damage","volume":"31","author":"Smith","year":"2017","journal-title":"Eye (London, England)"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"3733","DOI":"10.1167\/iovs.12-9814","article-title":"Microbead-induced ocular hypertensive mouse model for screening and testing of aqueous production suppressants for glaucoma","volume":"53","author":"Yang","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.exer.2013.05.009","article-title":"Thickness mapping of the inner retina by spectral-domain optical coherence tomography in an N-methyl-D-aspartate-induced retinal damage model","volume":"113","author":"Ohno","year":"2013","journal-title":"Exp Eye Res"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"5226","DOI":"10.1167\/iovs.10-6307","article-title":"Structural correlation between the nerve fiber layer and retinal ganglion cell loss in mice with targeted disruption of the Brn3b gene","volume":"52","author":"Camp","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3389\/fncel.2020.00109","article-title":"Longitudinal morphological and functional assessment of RGC neurodegeneration after optic nerve crush in mouse","volume":"14","author":"Li","year":"2020","journal-title":"Front Cell Neurosci"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"7193","DOI":"10.1523\/JNEUROSCI.16-22-07193.1996","article-title":"Genetic and environmental control of variation in retinal ganglion cell number in mice","volume":"16","author":"Williams","year":"1996","journal-title":"J Neurosci"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1523\/JNEUROSCI.18-01-00138.1998","article-title":"Natural variation in neuron number in mice is linked to a major quantitative trait locus on Chr 11","volume":"18","author":"Williams","year":"1998","journal-title":"J Neurosci"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"9948","DOI":"10.1523\/JNEUROSCI.18-23-09948.1998","article-title":"Cell production and cell death in the generation of variation in neuron number","volume":"18","author":"Strom","year":"1998","journal-title":"J Neurosci"},{"key":"bib26","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ng1104-1133","article-title":"The Collaborative Cross, a community resource for the genetic analysis of complex traits","volume":"36","author":"Churchill","year":"2004","journal-title":"Nat Genet"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"e0132804","DOI":"10.1371\/journal.pone.0132804","article-title":"Ketamine\/xylazine-induced corneal damage in mice","volume":"10","author":"Koehn","year":"2015","journal-title":"PLoS One"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"2440","DOI":"10.1167\/iovs.04-1174","article-title":"Reproducibility of retinal nerve fiber thickness measurements using the stratus OCT in normal and glaucomatous eyes","volume":"46","author":"Budenz","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"6519","DOI":"10.1167\/iovs.10-5662","article-title":"Reproducibility of spectral-domain optical coherence tomography total retinal thickness measurements in mice","volume":"51","author":"Gabriele","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1109\/RBME.2010.2084567","article-title":"Retinal imaging and image analysis","volume":"3","author":"Abr\u00e0moff","year":"2010","journal-title":"IEEE Rev Biomed Eng"},{"key":"bib31","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1167\/tvst.3.5.8","article-title":"Automated 3D segmentation of intraretinal surfaces in SD-OCT volumes in normal and diabetic mice","volume":"3","author":"Antony","year":"2014","journal-title":"Trans Vis Sci & Technol"},{"key":"bib32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1167\/tvst.4.4.9","article-title":"Quantitative analysis of mouse retinal layers using automated segmentation of spectral domain optical coherence tomography images","volume":"4","author":"Dysli","year":"2015","journal-title":"Transl Vis Sci Technol"},{"key":"bib33","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1136\/bjo.2004.059824","article-title":"A new quality assessment parameter for optical coherence tomography","volume":"90","author":"Stein","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"bib34","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1167\/iovs.11-8755","article-title":"Signal quality assessment of retinal optical coherence tomography images","volume":"53","author":"Huang","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib35","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.exer.2015.07.020","article-title":"RetFM-J, an ImageJ-based module for automated counting and quantifying features of nuclei in retinal whole-mounts","volume":"146","author":"Hedberg-Buenz","year":"2016","journal-title":"Exp Eye Res"},{"key":"bib36","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1167\/iovs.10-5993","article-title":"Anterior segment dysgenesis and early-onset glaucoma in nee mice with mutation of Sh3pxd2b","volume":"52","author":"Mao","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib37","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.exer.2015.09.011","article-title":"Quantitative measurement of retinal ganglion cell populations via histology-based random forest classification","volume":"146","author":"Hedberg-Buenz","year":"2016","journal-title":"Exp Eye Res"},{"key":"bib38","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"bib39","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.exer.2015.09.011","article-title":"Quantitative measurement of retinal ganglion cell populations via histology-based random forest classification","volume":"146","author":"Hedberg-Buenz","year":"2016","journal-title":"Exp Eye Res"},{"key":"bib40","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1167\/iovs.08-2791","article-title":"Lyst mutation in mice recapitulates iris defects of human exfoliation syndrome","volume":"50","author":"Trantow","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib42","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1167\/tvst.10.14.22","article-title":"AxonDeep: Automated Optic Nerve Axon Segmentation in Mice With Deep Learning","volume":"10","author":"Deng","year":"2021","journal-title":"Transl Vis Sci Technol"},{"key":"bib43","first-page":"5604","article-title":"Correlation of retinal ganglion cell metrics made in vivo using SD-OCT versus ex vivo using quantitative histology in Diversity Outbred mice","volume":"60","author":"Anderson","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib44","doi-asserted-by":"crossref","first-page":"4566","DOI":"10.1073\/pnas.0407357102","article-title":"High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma","volume":"102","author":"Anderson","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib46","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.1167\/iovs.02-1101","article-title":"Quantitative analysis of retinal ganglion cell (RGC) loss in aging DBA\/2NNia glaucomatous mice: comparison with RGC loss in aging C57\/BL6 mice","volume":"44","author":"Danias","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib47","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1017\/S0952523805224070","article-title":"Regularity and packing of the horizontal cell mosaic in different strains of mice","volume":"22","author":"Raven","year":"2005","journal-title":"Vis Neurosci"},{"key":"bib48","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.neurobiolaging.2017.09.021","article-title":"The aging rat retina: from function to anatomy","volume":"61","author":"Nadal-Nicol\u00e1s","year":"2018","journal-title":"Neurobiol Aging"},{"key":"bib49","doi-asserted-by":"crossref","first-page":"16033","DOI":"10.1523\/JNEUROSCI.3580-11.2011","article-title":"Age-related alterations in neurons of the mouse retina","volume":"31","author":"Samuel","year":"2011","journal-title":"J Neurosci"},{"key":"bib50","first-page":"1387","article-title":"Evaluation of the percentage of ganglion cells in the ganglion cell layer of the rodent retina","volume":"19","author":"Schlamp","year":"2013","journal-title":"Mol Vis"},{"key":"bib51","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1167\/iovs.19-27113","article-title":"Reversibility of Retinal Ganglion Cell Dysfunction From Chronic IOP Elevation","volume":"60","author":"Zhao","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib52","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.exer.2017.08.012","article-title":"Norrin treatment improves ganglion cell survival in an oxygen-induced retinopathy model of retinal ischemia","volume":"164","author":"Dailey","year":"2017","journal-title":"Exp Eye Res"},{"key":"bib53","doi-asserted-by":"crossref","first-page":"4692","DOI":"10.1167\/iovs.16-19535","article-title":"Quantitative and topographical analysis of the losses of cone photoreceptors and retinal ganglion cells under taurine depletion","volume":"57","author":"Hadj-Sa\u00efd","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib54","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1167\/iovs.18-25999","article-title":"Hybrid compound SA-2 is neuroprotective in animal models of retinal ganglion cell death","volume":"60","author":"Stankowska","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib55","doi-asserted-by":"crossref","first-page":"5981","DOI":"10.1167\/iovs.13-12419","article-title":"Optical coherence tomography study of experimental anterior ischemic optic neuropathy and histologic confirmation","volume":"54","author":"Ho","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib56","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1002\/cne.23521","article-title":"The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina","volume":"522","author":"Rodriguez","year":"2014","journal-title":"J Comp Neurol"},{"key":"bib57","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1016\/j.ophtha.2014.06.047","article-title":"Relationship between ganglion cell layer thickness and estimated retinal ganglion cell counts in the glaucomatous macula","volume":"121","author":"Zhang","year":"2014","journal-title":"Ophthalmology"},{"key":"bib58","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1016\/j.ophtha.2014.06.047","article-title":"Relationship between ganglion cell layer thickness and estimated retinal ganglion cell counts in the glaucomatous macula","volume":"121","author":"Zhang","year":"2014","journal-title":"Ophthalmology"},{"key":"bib59","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1471-2202-8-19","article-title":"Dominant inheritance of retinal ganglion cell resistance to optic nerve crush in mice","volume":"8","author":"Li","year":"2007","journal-title":"BMC Neurosci"},{"key":"bib60","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.exer.2011.01.006","article-title":"Lack of neuroprotection against experimental glaucoma in c-Jun N-terminal kinase 3 knockout mice","volume":"92","author":"Quigley","year":"2011","journal-title":"Exp Eye Res"},{"key":"bib61","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1471-2202-8-19","article-title":"Dominant inheritance of retinal ganglion cell resistance to optic nerve crush in mice","volume":"8","author":"Li","year":"2007","journal-title":"BMC Neurosci"},{"key":"bib62","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/ilar.52.1.24","article-title":"The collaborative cross: a recombinant inbred mouse population for the systems genetic era","volume":"52","author":"Threadgill","year":"2011","journal-title":"ILAR"},{"key":"bib63","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.tig.2019.04.003","article-title":"High-diversity mouse populations for complex traits","volume":"35","author":"Saul","year":"2019","journal-title":"Trends Genet"},{"key":"bib64","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00335-012-9414-2","article-title":"The Diversity Outbred mouse population","volume":"23","author":"Churchill","year":"2012","journal-title":"Mamm Genome"},{"key":"bib65","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s12920-019-0560-1","article-title":"Analysis of genetic networks regulating refractive eye development in collaborative cross progenitor strain mice reveals new genes and pathways underlying human myopia","volume":"12","author":"Tkatchenko","year":"2019","journal-title":"BMC Med Genomics"},{"key":"bib66","doi-asserted-by":"crossref","first-page":"e1356956","DOI":"10.1080\/19420889.2017.1356956","article-title":"Nicotinamide treatment robustly protects from inherited mouse glaucoma","volume":"11","author":"Williams","year":"2018","journal-title":"Commun Integr Biol"},{"key":"bib67","doi-asserted-by":"crossref","first-page":"R58","DOI":"10.1093\/hmg\/ddx180","article-title":"Genetic modifiers as relevant biological variables of eye disorders","volume":"26","author":"Meyer","year":"2017","journal-title":"Hum Mol Genet"},{"key":"bib68","first-page":"707","article-title":"Retinal gene expression responses to aging are sexually divergent","volume":"23","author":"Du","year":"2017","journal-title":"Mol Vis"},{"key":"bib69","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.1167\/iovs.08-3267","article-title":"Brn3a as a marker of retinal ganglion cells: qualitative and quantitative time course studies in naive and optic nerve-injured retinas","volume":"50","author":"Nadal-Nicolas","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib70","doi-asserted-by":"crossref","first-page":"e110612","DOI":"10.1371\/journal.pone.0110612","article-title":"Comparative evaluation of methods for estimating retinal ganglion cell loss in retinal sections and wholemounts","volume":"9","author":"Mead","year":"2014","journal-title":"PLoS One"},{"key":"bib71","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.exer.2011.02.008","article-title":"Axotomy-induced retinal ganglion cell death in adult mice: quantitative and topographic time course analyses","volume":"92","author":"Galindo-Romero","year":"2011","journal-title":"Exp Eye Res"},{"key":"bib72","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1038\/s41467-018-05134-3","article-title":"Single cell transcriptome profiling of retinal ganglion cells identifies cellular subtypes","volume":"9","author":"Rheaume","year":"2018","journal-title":"Nat Commun"},{"key":"bib73","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.neuron.2019.11.006","article-title":"Single-cell profiles of retinal ganglion cells differing in resilience to injury reveal neuroprotective genes","volume":"104","author":"Tran","year":"2019","journal-title":"Neuron"},{"key":"bib74","doi-asserted-by":"crossref","first-page":"108774","DOI":"10.1016\/j.exer.2021.108774","article-title":"Quantification and image-derived phenotyping of retinal ganglion cell nuclei in the nee mouse model of congenital glaucoma","volume":"212","author":"van der Heide","year":"2021","journal-title":"Exp Eye Res"},{"key":"bib41","doi-asserted-by":"crossref","DOI":"10.1201\/9781420041606","volume-title":"Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods","author":"Smith","year":"2001"},{"key":"bib45","first-page":"22","article-title":"AxonDeep: Automated Optic Nerve Axon Segmentation in Mice with Deep Learning","volume-title":"Transl Vis Sci Technol","author":"Deng","year":"2021"}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2783667","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T11:02:26Z","timestamp":1663844546000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2783667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,22]]},"references-count":74,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.11.9.17","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9,22]]}}}