{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T19:25:20Z","timestamp":1768073120861,"version":"3.49.0"},"reference-count":23,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"11","license":[{"start":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:00:00Z","timestamp":1699228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2023,11,6]]},"DOI":"10.1167\/tvst.12.11.10","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T16:31:06Z","timestamp":1699288266000},"page":"10","source":"Crossref","is-referenced-by-count":2,"title":["A Novel Riboflavin Formulation for Corneal Delivery Without Damaging Epithelial Cells"],"prefix":"10.1167","volume":"12","author":[{"given":"Yutaka","family":"Yamagata","sequence":"first","affiliation":[{"name":"Analytical Research Laboratory, MEDRx Co. Ltd., Kagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Ide","sequence":"additional","affiliation":[{"name":"Tokyo Vision Eye Clinic Asagaya, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27","reference":[{"issue":"5","key":"bib1","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/S0002-9394(02)02220-1","article-title":"Riboflavin\/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus","volume":"135","author":"Wollensak","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"686630","DOI":"10.3389\/fphar.2021.686630","article-title":"Corneal cross-linking: the evolution of treatment for corneal diseases","volume":"12","author":"Wu","year":"2021","journal-title":"Front Pharmacol"},{"issue":"4","key":"bib3","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1097\/ICO.0b013e3180334f78","article-title":"Safety of UVA-riboflavin cross-linking of the cornea","volume":"26","author":"Spoerl","year":"2007","journal-title":"Cornea"},{"issue":"1","key":"bib4","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1080\/08820538.2017.1353809","article-title":"Corneal collagen cross-linking complications","volume":"33","author":"Evangelista","year":"2018","journal-title":"Semin Ophthalmol"},{"issue":"1\u20132","key":"bib5","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ijpharm.2014.06.007","article-title":"Enhancement in corneal permeability of riboflavin using calcium sequestering compounds","volume":"472","author":"Morrison","year":"2014","journal-title":"Int J Pharm"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ejpb.2021.02.012","article-title":"Enhancement in corneal permeability of riboflavin using cyclodextrin derivates complexes as a previous step to transepithelial cross-linking","volume":"162","author":"Conde Penedo","year":"2021","journal-title":"Eur J Pharm Biopharm"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.jconrel.2020.05.017","article-title":"Design of ocular drug delivery platforms and in vitro \u2013 in vivo evaluation of riboflavin to the cornea by non-interventional (epi-on) technique for keratoconus treatment","volume":"324","author":"Aytekin","year":"2020","journal-title":"J Control Release"},{"issue":"7","key":"bib8","doi-asserted-by":"publisher","first-page":"3337","DOI":"10.1167\/iovs.08-3053","article-title":"NC-1059: a channel-forming peptide that modulates drug delivery across in vitro corneal epithelium","volume":"50","author":"Martin","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"bib9","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1097\/ICO.0000000000001707","article-title":"Corneal cross-linking: current USA status: report from the Cornea Society","volume":"37","author":"Belin","year":"2018","journal-title":"Cornea"},{"issue":"11","key":"bib10","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1136\/bjo.2006.109439","article-title":"Long-term recovery of the human corneal endothelium after toxic injury by benzalkonium chloride","volume":"91","author":"Hughes","year":"2007","journal-title":"Br J Ophthalmol"},{"issue":"9","key":"bib11","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1136\/bjo.2008.138768","article-title":"Conjunctival and corneal reactions in rabbits following short- and repeated exposure to preservative-free tafluprost, commercially available latanoprost and 0.02% benzalkonium chloride","volume":"92","author":"Liang","year":"2008","journal-title":"Br J Ophthalmol"},{"issue":"2","key":"bib12","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1111\/ceo.2004.32.issue-2","article-title":"Corneal epithelial cellular dysfunction from benzalkonium chloride (BAC) in vitro","volume":"32","author":"Cha","year":"2004","journal-title":"Clin Exp Ophthalmol"},{"issue":"4","key":"bib13","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1081\/DDC-120002997","article-title":"Penetration enhancers and ocular bioadhesives: two new avenues for ophthalmic drug delivery","volume":"28","author":"Kaur","year":"2002","journal-title":"Drug Dev Ind Pharm"},{"issue":"28","key":"bib14","doi-asserted-by":"publisher","first-page":"7296","DOI":"10.1073\/pnas.1722338115","article-title":"Ionic liquids for oral insulin delivery","volume":"115","author":"Banerjee","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"bib15","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1002\/adhm.v5.11","article-title":"Choline and geranate deep eutectic solvent as a broad-spectrum antiseptic agent for preventive and therapeutic applications","volume":"5","author":"Zakrewsky","year":"2016","journal-title":"Adv Healthc Mater"},{"issue":"21","key":"bib16","doi-asserted-by":"publisher","first-page":"5179","DOI":"10.3390\/cancers14215179","article-title":"Spermidine\/spermine N1-acetyltransferase 1 (SAT1)\u2014a potential gene target for selective sensitization of glioblastoma cells using an ionizable lipid nanoparticle to deliver siRNA","volume":"14","author":"Yathindranath","year":"2022","journal-title":"Cancers"},{"key":"bib17","first-page":"5531","article-title":"Safety and efficacy of vitamin B2 (riboflavine 5'-phosphate ester monosodium salt) for all animal species when used in water for drinking","volume":"16","author":"Bampidis","year":"2018","journal-title":"EFSA J"},{"issue":"8","key":"bib19","doi-asserted-by":"publisher","first-page":"715","DOI":"10.3109\/02713683.2010.481068","article-title":"Pharmacological modification of the epithelial permeability by benzalkonium chloride in UVA\/riboflavin corneal collagen cross-linking","volume":"35","author":"Kissner","year":"2010","journal-title":"Curr Eye Res"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1136\/bjo.2008.138768","article-title":"Conjunctival and corneal reactions in rabbits following short- and repeated exposure to preservative-free tafluprost, commercially available latanoprost and 0.02% benzalkonium chloride","volume":"92","author":"Liang","year":"2008","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"bib21","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1002\/jps.2600560112","article-title":"Absorption, metabolism, and excretion of riboflavin-5'-phosphate in man","volume":"56","author":"Jusko","year":"1967","journal-title":"J Pharm Sci"},{"issue":"2","key":"bib22","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1177\/2211068214561025","article-title":"TEER measurement techniques for in vitro barrier model system","volume":"20","author":"Srinivasan","year":"2015","journal-title":"J Lab Autom"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"104200","DOI":"10.1016\/j.isci.2022.104200","article-title":"A human cornea-on-a-chip for the study of epithelial wound healing by extracellular vesicles","volume":"25","author":"Yu","year":"2022","journal-title":"iScience"},{"key":"bib18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/B978-0-12-823907-0.00026-1","volume-title":"Material Kinetics: Transport and Rate Phenomenon","author":"Mauro","year":"2021"}],"container-title":["Translational Vision Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2792992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T16:31:10Z","timestamp":1699288270000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2792992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,6]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.12.11.10","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11,6]]}}}