{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:44:37Z","timestamp":1772585077980,"version":"3.50.1"},"reference-count":90,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"5","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"DOI":"10.1167\/tvst.12.5.18","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T14:31:41Z","timestamp":1684247501000},"page":"18","source":"Crossref","is-referenced-by-count":13,"title":["How Modifications of Corneal Cross-Linking Protocols Influence Corneal Resistance to Enzymatic Digestion and Treatment Depth"],"prefix":"10.1167","volume":"12","author":[{"given":"Malwina","family":"Kowalska","sequence":"first","affiliation":[{"name":"Section of Epidemiology, Vetsuisse Faculty, University of Zurich, Switzerland"},{"name":"Ophthalmology Section, Equine Department, Vetsuisse Faculty, University of Zurich, Switzerland"},{"name":"Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Mischi","sequence":"additional","affiliation":[{"name":"Ophthalmology Section, Equine Department, Vetsuisse Faculty, University of Zurich, Switzerland"},{"name":"Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szymon","family":"Stoma","sequence":"additional","affiliation":[{"name":"Image and Data Analysis Group (IDA), Scientific Center for Optical Electron Microscopy (ScopeM), Swiss Federal Institute of Technology (ETH), Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon F.","family":"N\u00f8rrelykke","sequence":"additional","affiliation":[{"name":"Image and Data Analysis Group (IDA), Scientific Center for Optical Electron Microscopy (ScopeM), Swiss Federal Institute of Technology (ETH), Zurich, Switzerland"},{"name":"Department of Systems Biology, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Hartnack","sequence":"additional","affiliation":[{"name":"Section of Epidemiology, Vetsuisse Faculty, University of Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon A.","family":"Pot","sequence":"additional","affiliation":[{"name":"Ophthalmology Section, Equine Department, Vetsuisse Faculty, University of Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27","published-online":{"date-parts":[[2023,5,16]]},"reference":[{"issue":"6","key":"bib1","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1097\/APO.0000000000000335","article-title":"Corneal cross-linking for keratoconus: Current knowledge and practice and future trends","volume":"9","author":"Chan","year":"2020","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"issue":"4","key":"bib2","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.jtos.2019.08.006","article-title":"Photoactivated chromophore for infectious keratitis \u2013 Corneal cross-linking (PACK-CXL): A systematic review and meta-analysis","volume":"17","author":"Ting","year":"2019","journal-title":"Ocul Surf"},{"issue":"1","key":"bib3","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1097\/ICO.0000000000000644","article-title":"Corneal collagen cross-linking for infectious keratitis: A systematic review and meta-analysis","volume":"35","author":"Papaioannou","year":"2016","journal-title":"Cornea"},{"issue":"4","key":"bib4","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1111\/vop.12090","article-title":"Corneal collagen cross-linking as treatment for infectious and noninfectious corneal melting in cats and dogs: Results of a prospective, nonrandomized, controlled trial","volume":"17","author":"Pot","year":"2014","journal-title":"Vet Ophthalmol"},{"issue":"6","key":"bib6","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1097\/APO.0000000000000332","article-title":"Biochemical markers and alterations in keratoconus","volume":"9","author":"Shetty","year":"2020","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.exer.2019.03.016","article-title":"Matrix metalloproteinases in keratoconus \u2013 Too much of a good thing?","volume":"182","author":"di Martino","year":"2019","journal-title":"Exp Eye Res"},{"issue":"13","key":"bib8","doi-asserted-by":"publisher","first-page":"5372","DOI":"10.1167\/iovs.16-19677","article-title":"Differential molecular expression of extracellular matrix and inflammatory genes at the corneal cone apex drives focal weakening in keratoconus","volume":"57","author":"Pahuja","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib11","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S1096-2867(03)90016-8","article-title":"Bacterial corneal diseases in dogs and cats","volume":"18","author":"Ollivier","year":"2003","journal-title":"Clin Tech Small Anim Pract"},{"issue":"11","key":"bib12","doi-asserted-by":"publisher","first-page":"537","DOI":"10.3390\/microorganisms7110537","article-title":"A pyrrhic victory: The PMN response to ocular bacterial infections","volume":"7","author":"Livingston","year":"2019","journal-title":"Microorganisms"},{"issue":"1","key":"bib13","doi-asserted-by":"publisher","first-page":"2984","DOI":"10.1038\/s41598-019-39876-x","article-title":"Corneal lymphangiogenesis ameliorates corneal inflammation and edema in late stage of bacterial keratitis","volume":"9","author":"Narimatsu","year":"2019","journal-title":"Sci Rep"},{"issue":"2","key":"bib14","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1167\/iovs.08-2390","article-title":"Expression of matrix metalloproteinases during experimental Candida albicans keratitis","volume":"50","author":"Yuan","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib15","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1097\/ICO.0b013e3182541e9a","article-title":"The practical detection of mmp-9 diagnoses ocular surface disease and may help prevent its complications","volume":"32","author":"Kaufman","year":"2013","journal-title":"Cornea"},{"issue":"1","key":"bib16","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/0014-4835(91)90123-V","article-title":"Characterization of the major matrix degrading metalloproteinase of human corneal stroma. Evidence for an enzyme\/inhibitor complex","volume":"52","author":"Brown","year":"1991","journal-title":"Exp Eye Res"},{"issue":"6","key":"bib17","first-page":"711","article-title":"Techniques for stiffening the cornea","volume":"15","author":"Spoerl","year":"1999","journal-title":"J Refract Surg"},{"issue":"5","key":"bib18","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/j.1444-0938.2002.tb03082.x","article-title":"The pathogenesis of bacterial keratitis: Studies with Pseudomonas aeruginosa","volume":"85","author":"Fleiszig","year":"2002","journal-title":"Clin Exp Optom"},{"key":"bib19","first-page":"369094","article-title":"Infectious keratitis: Secreted bacterial proteins that mediate corneal damage","volume":"2013","author":"Marquart","year":"2013","journal-title":"J Ophthalmol"},{"issue":"2","key":"bib20","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1159\/000027291","article-title":"Bacterial corneal ulcer: A multivariate study","volume":"212","author":"Wang","year":"1998","journal-title":"Ophthalmologica"},{"issue":"1","key":"bib21","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/S0002-9394(14)76903-X","article-title":"Epidemiologic characteristics, predisposing factors, and etiologic diagnosis of corneal ulceration in Nepal","volume":"111","author":"Upadhyay","year":"1991","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"bib22","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1111\/j.1442-9071.1994.tb00775.x","article-title":"Suppurative corneal ulceration in Bangladesh. A study of 142 cases examining the microbiological diagnosis, clinical and epidemiological features of bacterial and fungal keratitis","volume":"22","author":"Dunlop","year":"1994","journal-title":"Aust N Z J Ophthalmol"},{"issue":"4","key":"bib23","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1097\/00003226-200405000-00009","article-title":"Trends in the etiology of infectious corneal ulcers at the F. I. Proctor Foundation","volume":"23","author":"Varaprasathan","year":"2004","journal-title":"Cornea"},{"issue":"1","key":"bib24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4103\/2008-322X.156122","article-title":"PACK-CXL: Corneal cross-linking for treatment of infectious keratitis","volume":"10","author":"Tabibian","year":"2015","journal-title":"J Ophthalmic Vis Res"},{"issue":"12","key":"bib25","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1016\/j.jcrs.2007.07.028","article-title":"Corneal collagen crosslinking with riboflavin and ultraviolet A to treat induced keratectasia after laser in situ keratomileusis","volume":"33","author":"Hafezi","year":"2007","journal-title":"J Cataract Refract Surg"},{"issue":"5","key":"bib26","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/S0002-9394(02)02220-1","article-title":"Riboflavin\/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus","volume":"135","author":"Wollensak","year":"2003","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"bib28","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/00003226-200401000-00008","article-title":"Keratocyte apoptosis after corneal collagen cross-linking using riboflavin\/UVA treatment","volume":"23","author":"Wollensak","year":"2004","journal-title":"Cornea"},{"issue":"9","key":"bib29","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1097\/01.ico.0000225720.38748.58","article-title":"Corneal cross-linking-induced stromal demarcation line","volume":"25","author":"Seiler","year":"2006","journal-title":"Cornea"},{"issue":"1","key":"bib30","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.ajo.2013.09.010","article-title":"Correlation of the corneal collagen cross-linking demarcation line using confocal microscopy and anterior segment optical coherence tomography in keratoconic patients","volume":"157","author":"Kymionis","year":"2014","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"bib31","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/vop.12301","article-title":"Penetration depth of corneal cross-linking with riboflavin and UV-A (CXL) in horses and rabbits","volume":"19","author":"Gallhoefer","year":"2016","journal-title":"Vet Ophthalmol"},{"issue":"10","key":"bib32","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1038\/eye.2014.163","article-title":"Pulsed vs continuous light accelerated corneal collagen crosslinking: In vivo qualitative investigation by confocal microscopy and corneal OCT","volume":"28","author":"Mazzotta","year":"2014","journal-title":"Eye (Lond)"},{"issue":"7","key":"bib33","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1097\/ICO.0b013e3181bd9f12","article-title":"Effect of collagen cross-linking in stromal fibril organization in edematous human corneas","volume":"29","author":"Bott\u00f3s","year":"2010","journal-title":"Cornea"},{"issue":"1","key":"bib34","doi-asserted-by":"publisher","first-page":"e52860","DOI":"10.1371\/journal.pone.0052860","article-title":"The effect of riboflavin\/UVA collagen cross-linking therapy on the structure and hydrodynamic behaviour of the ungulate and rabbit corneal stroma","volume":"8","author":"Hayes","year":"2013","journal-title":"PLoS One"},{"issue":"15","key":"bib35","doi-asserted-by":"publisher","first-page":"13011","DOI":"10.1074\/jbc.M110.169813","article-title":"Effects of ultraviolet-A and riboflavin on the interaction of collagen and proteoglycans during corneal cross-linking","volume":"286","author":"Zhang","year":"2011","journal-title":"J Biol Chem"},{"issue":"1","key":"bib36","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1006\/exer.1997.0410","article-title":"Induction of cross-links in corneal tissue","volume":"66","author":"Spoerl","year":"1998","journal-title":"Exp Eye Res"},{"issue":"1","key":"bib37","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1080\/02713680490513182","article-title":"Increased resistance of crosslinked cornea against enzymatic digestion","volume":"29","author":"Spoerl","year":"2004","journal-title":"Curr Eye Res"},{"issue":"9","key":"bib38","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1016\/j.jcrs.2015.10.004","article-title":"Standard versus accelerated riboflavin-ultraviolet corneal collagen crosslinking: Resistance against enzymatic digestion","volume":"41","author":"Aldahlawi","year":"2015","journal-title":"J Cataract Refract Surg"},{"issue":"9","key":"bib39","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1016\/S0886-3350(03)00407-3","article-title":"Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linking","volume":"29","author":"Wollensak","year":"2003","journal-title":"J Cataract Refract Surg"},{"issue":"2","key":"bib40","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s00417-009-1231-2","article-title":"Evaluation of antibacterial efficacy of photo-activated riboflavin using ultraviolet light (UVA)","volume":"248","author":"Makdoumi","year":"2010","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"7","key":"bib41","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1111\/ceo.12723","article-title":"Photodynamic UVA-riboflavin bacterial elimination in antibiotic-resistant bacteria","volume":"44","author":"Makdoumi","year":"2016","journal-title":"Clin Exp Ophthalmol"},{"issue":"7","key":"bib42","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1111\/aos.12301","article-title":"The efficiency of cross-linking methods in eradication of bacteria is influenced by the riboflavin concentration and the irradiation time of ultraviolet light","volume":"92","author":"B\u00e4ckman","year":"2014","journal-title":"Acta Ophthalmol"},{"issue":"8","key":"bib43","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1097\/ICO.0000000000002335","article-title":"High fluence increases the antibacterial efficacy of PACK Cross-Linking","volume":"39","author":"Kling","year":"2020","journal-title":"Cornea"},{"issue":"1","key":"bib44","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s40662-021-00272-0","article-title":"PACK-CXL vs. antimicrobial therapy for bacterial, fungal, and mixed infectious keratitis: A prospective randomized phase 3 trial","volume":"9","author":"Hafezi","year":"2022","journal-title":"Eye Vis (Lond)"},{"issue":"1","key":"bib45","doi-asserted-by":"publisher","first-page":"194","DOI":"10.11124\/JBISRIR-D-19-00148","article-title":"Effectiveness of adjuvant photoactivated chromophore corneal collagen cross-linking versus standard antimicrobial treatment for infectious keratitis: A systematic review protocol","volume":"18","author":"Ting","year":"2020","journal-title":"JBI Evid Synth"},{"issue":"8","key":"bib46","doi-asserted-by":"publisher","first-page":"559","DOI":"10.3928\/1081597X-20180705-01","article-title":"Does PACK-CXL change the prognosis of resistant infectious keratitis?","volume":"34","author":"Zloto","year":"2018","journal-title":"J Refract Surg"},{"issue":"4","key":"bib47","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1097\/ICO.0000000000001498","article-title":"Accelerated corneal cross-linking with photoactivated chromophore for moderate therapy-resistant infectious keratitis","volume":"37","author":"Knyazer","year":"2018","journal-title":"Cornea"},{"issue":"4","key":"bib48","doi-asserted-by":"publisher","first-page":"258","DOI":"10.3928\/1081597X-20200226-02","article-title":"Accelerated corneal cross-linking as an adjunct therapy in the management of presumed bacterial keratitis: A cohort study","volume":"36","author":"Knyazer","year":"2020","journal-title":"J Refract Surg"},{"issue":"3","key":"bib49","first-page":"87","article-title":"Corneal collagen cross-linking in mixed etiology keratitis treatment: A case of successful use","volume":"13","author":"Khripun","year":"2021","journal-title":"Ophthalmol J"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"100499","DOI":"10.1016\/j.ajoc.2019.100499","article-title":"High fluence PACK-CXL as adjuvant treatment for advanced Acanthamoeba keratitis","volume":"15","author":"Nateghi Pettersson","year":"2019","journal-title":"Am J Ophthalmol Case Rep"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.exer.2016.10.014","article-title":"An investigation into corneal enzymatic resistance following epithelium-off and epithelium-on corneal cross-linking protocols","volume":"153","author":"Aldahlawi","year":"2016","journal-title":"Exp Eye Res"},{"issue":"4","key":"bib52","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1167\/iovs.15-18769","article-title":"Enzymatic resistance of corneas crosslinked using riboflavin in conjunction with low energy, high energy, and pulsed UVA irradiation modes","volume":"57","author":"Aldahlawi","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"bib53","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.jcrs.2018.01.036","article-title":"Relationship between initial corneal hydration and stiffening effects of corneal crosslinking treatment","volume":"44","author":"Hatami-Marbini","year":"2018","journal-title":"J Cataract Refract Surg"},{"issue":"6","key":"bib54","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1016\/j.jbiomech.2015.01.038","article-title":"Stiffening effects of riboflavin\/UVA corneal collagen cross-linking is hydration dependent","volume":"48","author":"Hatami-Marbini","year":"2015","journal-title":"J Biomech"},{"issue":"2","key":"bib55","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1167\/iovs.17-22814","article-title":"Effect of UVA\/riboflavin collagen crosslinking on biomechanics of artificially swollen corneas","volume":"59","author":"Hatami-Marbini","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib56","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1167\/iovs.17-22994","article-title":"An investigation of the effects of riboflavin concentration on the efficacy of corneal cross-linking using an enzymatic resistance model in porcine corneas","volume":"59","author":"O'Brart","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"bib57","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1016\/j.jcrs.2015.10.004","article-title":"Standard versus accelerated riboflavin\u2013ultraviolet corneal collagen crosslinking: Resistance against enzymatic digestion","volume":"41","author":"Aldahlawi","year":"2015","journal-title":"J Cataract Refract Surg"},{"issue":"1","key":"bib58","doi-asserted-by":"publisher","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"bib59","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1186\/s12859-021-04344-9","article-title":"CellProfiler 4: Improvements in speed, utility and usability","volume":"22","author":"Stirling","year":"2021","journal-title":"BMC Bioinformatics"},{"issue":"7","key":"bib60","first-page":"S715","article-title":"Immunofluorescence confocal microscopy of porcine corneas following collagen cross-linking treatment with riboflavin and ultraviolet A","volume":"24","author":"Bottos","year":"2008","journal-title":"J Refract Surg"},{"issue":"4","key":"bib61","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1097\/ICO.0b013e3181bdf1cc","article-title":"Immunofluorescence of rabbit corneas after collagen cross-linking treatment with riboflavin and ultraviolet A","volume":"29","author":"Esquenazi","year":"2010","journal-title":"Cornea"},{"issue":"7","key":"bib62","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nature Methods"},{"key":"bib64","doi-asserted-by":"crossref","DOI":"10.21105\/joss.03021","article-title":"seaborn: Statistical data visualization","author":"Waskom","year":"2021","journal-title":"Journal of Open Source Software"},{"issue":"2","key":"bib65","first-page":"333","article-title":"Normal human keratocyte density and corneal thickness measurement by using confocal microscopy in vivo","volume":"42","author":"Patel","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib66","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/00003226-199501000-00002","article-title":"Quantitative assessment of anteroposterior keratocyte density in the normal rabbit cornea","volume":"14","author":"Petroll","year":"1995","journal-title":"Cornea"},{"issue":"6","key":"bib67","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.ajo.2011.05.023","article-title":"Assessment of corneal thickness and keratocyte density in a rabbit model of laser in situ keratomileusis using scanning laser confocal microscopy","volume":"152","author":"Twa","year":"2011","journal-title":"Am J Ophthalmol"},{"issue":"Pt B","key":"bib68","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/978-1-4615-0717-8_116","article-title":"Apoptosis in the cornea in response to epithelial injury: Significance to wound healing and dry eye","volume":"506","author":"Wilson","year":"2002","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"bib69","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1006\/exer.2000.0926","article-title":"Kinetics of keratocyte proliferation in response to epithelial debridement","volume":"72","author":"Zieske","year":"2001","journal-title":"Exp Eye Res"},{"issue":"4","key":"bib71","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1167\/tvst.3.4.5","article-title":"Depth resolved differences after corneal crosslinking with and without epithelial debridement using multimodal imaging","volume":"3","author":"Gupta","year":"2014","journal-title":"Transl Vis Sci Technol"},{"issue":"4","key":"bib72","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1097\/ICO.0000000000000758","article-title":"Cross-linking biomechanical effect in human corneas by same energy, different UV-A fluence: An enzymatic digestion comparative evaluation","volume":"35","author":"Kanellopoulos","year":"2016","journal-title":"Cornea"},{"issue":"9","key":"bib73","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1097\/ICO.0000000000000185","article-title":"UV cross-linking of donor corneas confers resistance to keratolysis","volume":"33","author":"Arafat","year":"2014","journal-title":"Cornea"},{"issue":"6","key":"bib74","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/1740-9713.01462","article-title":"Replication power and regression to the mean","volume":"17","author":"Held","year":"2020","journal-title":"Significance"},{"issue":"6","key":"bib75","doi-asserted-by":"publisher","first-page":"e0179580","DOI":"10.1371\/journal.pone.0179580","article-title":"High-intensity corneal collagen crosslinking with riboflavin and UVA in rat cornea","volume":"12","author":"Zhu","year":"2017","journal-title":"PLoS One"},{"key":"bib76","doi-asserted-by":"publisher","first-page":"3057329","DOI":"10.1155\/2017\/3057329","article-title":"Effect of ultraviolet light irradiation combined with riboflavin on different bacterial pathogens from ocular surface infection","volume":"2017","author":"Shen","year":"2017","journal-title":"J Biophys"},{"issue":"9","key":"bib77","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1097\/ICO.0000000000000916","article-title":"Corneal crosslinking with Rose Bengal and green light: Efficacy and safety evaluation","volume":"35","author":"Zhu","year":"2016","journal-title":"Cornea"},{"issue":"3","key":"bib78","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1097\/ICO.0000000000000324","article-title":"In vivo thermographic analysis of the corneal surface in keratoconic patients undergoing riboflavin\u2013UV-A accelerated cross-linking","volume":"34","author":"Mencucci","year":"2015","journal-title":"Cornea"},{"issue":"7","key":"bib79","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1136\/bjophthalmol-2016-309210","article-title":"Refractive improvements and safety with topography-guided corneal crosslinking for keratoconus: 1-year results","volume":"101","author":"Nordstrom","year":"2017","journal-title":"Br J Ophthalmol"},{"issue":"11","key":"bib82","doi-asserted-by":"publisher","first-page":"4451","DOI":"10.1167\/iovs.18-24795","article-title":"Author Response: The role of riboflavin concentration and oxygen in the efficacy and depth of corneal crosslinking","volume":"59","author":"O'Brart","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib83","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.jcrs.2005.12.092","article-title":"Biomechanical evidence of the distribution of cross-links in corneas treated with riboflavin and ultraviolet A light","volume":"32","author":"Kohlhaas","year":"2006","journal-title":"J Cataract Refract Surg"},{"issue":"15","key":"bib84","doi-asserted-by":"publisher","first-page":"6610","DOI":"10.1167\/iovs.15-18764","article-title":"Corneal resistance to keratolysis after collagen crosslinking with Rose Bengal and green light","volume":"57","author":"Fadlallah","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"bib85","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1083\/jcb.200903097","article-title":"Accuracy and precision in quantitative fluorescence microscopy","volume":"185","author":"Waters","year":"2009","journal-title":"J Cell Biol"},{"issue":"11","key":"bib86","doi-asserted-by":"publisher","first-page":"4449","DOI":"10.1167\/iovs.18-24437","article-title":"The role of riboflavin concentration and oxygen in the efficacy and depth of corneal crosslinking","volume":"59","author":"Lin","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"bib87","doi-asserted-by":"publisher","first-page":"5125","DOI":"10.1167\/iovs.18-25244","article-title":"Influencing factors relating the demarcation line depth and efficacy of corneal crosslinking","volume":"59","author":"Lin","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib88","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3928\/1081597X-20120117-01","article-title":"Absorption of UV-light by riboflavin solutions with different concentration","volume":"28","author":"Schumacher","year":"2012","journal-title":"J Refract Surg"},{"issue":"1","key":"bib89","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1167\/iovs.09-3738","article-title":"Mechanisms of corneal tissue cross-linking in response to treatment with topical riboflavin and long-wavelength ultraviolet radiation (UVA)","volume":"51","author":"McCall","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"bib90","doi-asserted-by":"publisher","first-page":"798","DOI":"10.3928\/1081597X-20160920-03","article-title":"Comparison of corneal riboflavin gradients using dextran and HPMC solutions","volume":"32","author":"Ehmke","year":"2016","journal-title":"J Refract Surg"},{"key":"bib5","first-page":"1","article-title":"Photoactivated Chromophore for Keratitis\u2013Corneal Cross-linking (PACK-CXL): Retrospective, multicenter study in canine and feline patients","volume-title":"Vet. Ophthalmol","author":"Shukla","year":"2023"},{"key":"bib9","first-page":"976","article-title":"Diseases and surgery of the canine cornea and sclera","volume-title":"Veterinary Ophthalmology","author":"Ledbetter","year":"2013"},{"key":"bib10","first-page":"184","article-title":"Cornea and Sclera","volume-title":"Slatter's fundamentals of veterinary ophthalmology","author":"Maggs","year":"2013"},{"key":"bib27","first-page":"13","article-title":"Fundamental Principals of Corneal Collagen Cross-Linking","volume-title":"Corneal Collagen Cross-Linking","author":"Wollensak","year":"2013"},{"key":"bib63","first-page":"2020","author":"Reback"},{"key":"bib70","article-title":"A comparison study of Riboflavin\/UV-A and Rose-Bengal\/Green light cross-linking of the rabbit corneas using optical coherence elastography","volume-title":"Proc. SPIE","author":"Li J","year":"2016"},{"key":"bib80","article-title":"Safety of high-dose, transepithelial, accelerated CXL with supplemental oxygen on human and monkey eyes","volume-title":"International CXL Experts\u2019 Meeting","author":"Nicklin","year":"2018"},{"key":"bib81","first-page":"65","article-title":"In-vitro efficacy of accelerated high-fluence PACK-CXL with riboflavin for bacterial keratitis","volume-title":"International CXL Experts' Meeting","author":"Gilardoni","year":"2019"}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2785622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T21:01:31Z","timestamp":1730235691000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2785622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,16]]},"references-count":90,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.12.5.18","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5,16]]}}}