{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:31:18Z","timestamp":1785461478173,"version":"3.56.0"},"reference-count":47,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2023,6,1]]},"DOI":"10.1167\/tvst.12.6.1","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T14:31:02Z","timestamp":1685629862000},"page":"1","source":"Crossref","is-referenced-by-count":14,"title":["Metagenome Investigation of Ocular Microbiota of Cataract Patients With and Without Type 2 Diabetes"],"prefix":"10.1167","volume":"12","author":[{"given":"Zheng","family":"Shao","sequence":"first","affiliation":[{"name":"School of Clinical Medicine, Weifang Medical University, Weifang, China"},{"name":"Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaona","family":"Shan","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Qingdao, China"},{"name":"State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Jing","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Qingdao, China"},{"name":"State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weina","family":"Wang","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Qingdao, China"},{"name":"State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, The Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Ren","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Qingdao, China"},{"name":"Qingdao University Medical College, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi Ning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Qingdao, China"},{"name":"State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusen","family":"Huang","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Qingdao, China"},{"name":"State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"643.e7","DOI":"10.1016\/j.cmi.2016.04.008","article-title":"Defining the normal core microbiome of conjunctival microbial communities","volume":"22","author":"Huang","year":"2016","journal-title":"Clin Microbiol Infect"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.immuni.2017.06.014","article-title":"An ocular commensal protects against corneal infection by driving an interleukin-17 response from mucosal ?d t cells","volume":"47","author":"St Leger","year":"2017","journal-title":"Immunity"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"860370","DOI":"10.3389\/fcimb.2022.860370","article-title":"Profiling of the conjunctival bacterial microbiota reveals the feasibility of utilizing a microbiome-based machine learning model to differentially diagnose microbial keratitis and the core components of the conjunctival bacterial interaction network","volume":"12","author":"Ren","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.exer.2013.06.003","article-title":"Characterization of the normal microbiota of the ocular surface","volume":"117","author":"Willcox","year":"2013","journal-title":"Exp Eye Res"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.2337\/db18-0158","article-title":"Restructuring of the gut microbiome by intermittent fasting prevents retinopathy and prolongs survival in db\/db mice","volume":"67","author":"Beli","year":"2018","journal-title":"Diabetes"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1136\/bjophthalmol-2016-309248","article-title":"Propionibacterium acnes as a possible pathogen of granuloma in patients with ocular sarcoidosis","volume":"101","author":"Goto","year":"2017","journal-title":"Br J Ophthalmol"},{"key":"bib7","first-page":"194","article-title":"Conjunctival microbiome changes associated with fungal keratitis: metagenomic analysis","volume":"12","author":"Ge","year":"2019","journal-title":"Int J Ophthalmol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"4774","DOI":"10.1167\/iovs.19-27719","article-title":"Composition and diversity of bacterial community on the ocular surface of patients with Meibomian gland dysfunction","volume":"60","author":"Dong","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"645907","DOI":"10.3389\/fcimb.2021.645907","article-title":"Profiling of diagnostic information of and latent susceptibility to bacterial keratitis from the perspective of ocular bacterial microbiota","volume":"11","author":"Ren","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"bib10","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0039-6257(05)80056-6","article-title":"Antimicrobial prophylaxis for ophthalmic surgery","volume":"39","author":"Starr","year":"1995","journal-title":"Surv Ophthalmol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.2147\/IDR.S252674","article-title":"Intraoperative cefuroxime irrigation prophylaxis for acute-onset endophthalmitis after phacoemulsification surgery","volume":"13","author":"Ma","year":"2020","journal-title":"Infect Drug Resistance"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"109119","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF Diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res Clin Pract"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"107843","DOI":"10.1016\/j.diabres.2019.107843","article-title":"Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition","volume":"157","author":"Saeedi","year":"2019","journal-title":"Diabetes Res Clin Pract"},{"issue":"suppl 1","key":"bib15","first-page":"S27","article-title":"Infections in patients with diabetes mellitus: a review of pathogenesis","volume":"16","author":"Casqueiro","year":"2012","journal-title":"Indian J Endocrinol Metab"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"510","DOI":"10.2337\/diacare.26.2.510","article-title":"Quantifying the risk of infectious diseases for people with diabetes","volume":"26","author":"Shah","year":"2003","journal-title":"Diabetes Care"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/fim.1999.26.issue-3-4","article-title":"Immune dysfunction in patients with diabetes mellitus (DM)","volume":"26","author":"Geerlings","year":"1999","journal-title":"FEMS Immunol Med Microbiol"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"101044","DOI":"10.1016\/j.molmet.2020.101044","article-title":"Diabetes, infection risk and COVID-19","volume":"39","author":"Erener","year":"2020","journal-title":"Mol Metab"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1007\/s00203-020-01818-x","article-title":"Diabetes-associated infections: development of antimicrobial resistance and possible treatment strategies","volume":"202","author":"Akash","year":"2020","journal-title":"Arch Microbiol"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3389\/fcimb.2019.00202","article-title":"How ocular surface microbiota debuts in type 2 diabetes mellitus","volume":"9","author":"Li","year":"2019","journal-title":"Front Cell Infect Microbiol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1038\/nbt.3935","article-title":"Shotgun metagenomics, from sampling to analysis","volume":"35","author":"Quince","year":"2017","journal-title":"Nat Biotechnol"},{"issue":"10","key":"bib22","doi-asserted-by":"publisher","first-page":"R245","DOI":"10.1016\/S1074-5521(98)90108-9","article-title":"Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products","volume":"5","author":"Handelsman","year":"1998","journal-title":"Chem Biol"},{"key":"bib23","first-page":"2114","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics (Oxford, England)"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat Methods"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/1471-2105-11-119","article-title":"Prodigal: prokaryotic gene recognition and translation initiation site identification","volume":"11","author":"Hyatt","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"bib27","first-page":"282","article-title":"Clustering of highly homologous sequences to reduce the size of large protein databases","volume":"17","author":"Li","year":"2001","journal-title":"Bioinformatics (Oxford, England)"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.2147\/OPTH","article-title":"Effect of clinical parameters on the ocular surface microbiome in children and adults","volume":"12","author":"Cavuoto","year":"2018","journal-title":"Clin Ophthalmol"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.survophthal.2021.03.010","article-title":"The ocular microbiome and microbiota and their effects on ocular surface pathophysiology and disorders","volume":"66","author":"Aragona","year":"2021","journal-title":"Surv Ophthalmol"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"123.e9","DOI":"10.1016\/j.cmi.2019.05.011","article-title":"Characterization of fungal microbiota on normal ocular surface of humans.","volume":"26","author":"Wang","year":"2020","journal-title":"Clin Microbiol Infect Dis"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.immuni.2021.12.013","article-title":"Inflammation in obesity, diabetes, and related disorders","volume":"55","author":"Rohm","year":"2022","journal-title":"Immunity"},{"key":"bib32","first-page":"442","article-title":"Type 2 diabetes and its impact on the immune system","volume":"16","author":"Berbudi","year":"2020","journal-title":"Curr Diabetes Rev"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.preteyeres.2014.05.002","article-title":"Emerging role of advanced glycation-end products (AGEs) in the pathobiology of eye diseases","volume":"42","author":"Kandarakis","year":"2014","journal-title":"Prog Retin Eye Res"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.2147\/OPTH","article-title":"Effect of clinical parameters on the ocular surface microbiome in children and adults","volume":"12","author":"Cavuoto","year":"2018","journal-title":"Clin Ophthalmol"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1111\/1574-6976.12005","article-title":"Gram-positive anaerobic cocci \u2013 commensals and opportunistic pathogens","volume":"37","author":"Murphy","year":"2013","journal-title":"FEMS Microbiol Rev"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"19786","DOI":"10.1073\/pnas.1211002109","article-title":"Boraston AB. Bacteria of the human gut microbiome catabolize red seaweed glycans with carbohydrate-active enzyme updates from extrinsic microbes","volume":"109","author":"Hehemann","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"3991","DOI":"10.1128\/JB.183.13.3991-3998.2001","article-title":"Cell wall core galactofuran synthesis is essential for growth of mycobacteria","volume":"183","author":"Pan","year":"2001","journal-title":"J Bacteriol"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"eabb9833","DOI":"10.1126\/sciadv.abb9833","article-title":"Structural basis of trehalose recycling by the ABC transporter LpqY-SugABC","volume":"6","author":"Liu","year":"2020","journal-title":"Sci Adv"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.mib.2015.05.005","article-title":"Metagenomics of extreme environments","volume":"25","author":"Cowan","year":"2015","journal-title":"Curr Opin Microbiol"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"e154944","DOI":"10.1172\/JCI154944","article-title":"Next-generation sequencing: insights to advance clinical investigations of the microbiome","volume":"132","author":"Wensel","year":"2022","journal-title":"J Clin Invest"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1128\/JCM.03060-15","article-title":"Unbiased detection of respiratory viruses by use of RNA sequencing-based metagenomics: a systematic comparison to a commercial PCR panel","volume":"54","author":"Graf","year":"2016","journal-title":"J Clin Microbiol"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/s41576-019-0113-7","article-title":"Clinical metagenomics","volume":"20","author":"Chiu","year":"2019","journal-title":"Nat Rev Genet"},{"key":"bib45","first-page":"13","article-title":"Ocular surface microbiota in diabetic patients with dry eye disease","volume":"62","author":"Zhang","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1080\/02713683.2017.1406528","article-title":"Distribution and diversity of ocular microbial communities in diabetic patients compared with healthy subjects","volume":"43","author":"Ham","year":"2018","journal-title":"Curr Eye Res"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"21527","DOI":"10.1038\/s41598-022-25722-0","article-title":"Ocular surface microbiome in diabetes mellitus","volume":"12","author":"Suwajanakorn","year":"2022","journal-title":"Sci Rep"},{"key":"bib14","first-page":"491","article-title":"Type-2 diabetes mellitus and cardiovascular disease","volume-title":"Future Cardiol","author":"Henning","year":"2018"},{"key":"bib25","first-page":"1674","article-title":"MEGAHIT: an ultra-fast single-node solution for large and complex metagenomics assembly via succinct de Bruijn graph","volume-title":"Bioinformatics","author":"Li","year":"2015"},{"key":"bib36","first-page":"1513","article-title":"Microbiota and diabetes: an evolving relationship","volume-title":"Gut","author":"Tilg","year":"2014"},{"key":"bib38","first-page":"605","article-title":"Sphingomonas and related genera","volume-title":"The Prokaryotes: Volume 7: Proteobacteria: Delta, Epsilon Subclass","author":"Balkwill","year":"2006"}],"container-title":["Translational Vision Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2785668","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T14:31:21Z","timestamp":1685629881000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2785668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,1]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.12.6.1","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6,1]]}}}