{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:27:34Z","timestamp":1787315254113,"version":"build-2736575974"},"reference-count":37,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"6","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2023,6,30]]},"DOI":"10.1167\/tvst.12.6.30","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T10:31:04Z","timestamp":1688121064000},"page":"30","source":"Crossref","is-referenced-by-count":4,"title":["Convolutional Neural Network\u2013Based Automated Quality Assessment of OCT and OCT Angiography Image Maps in Individuals With Neurodegenerative Disease"],"prefix":"10.1167","volume":"12","author":[{"given":"Terry","family":"Lee","sequence":"first","affiliation":[{"name":"iMIND Study Group, Duke University School of Medicine, Durham, NC, USA"},{"name":"Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Rivera","sequence":"additional","affiliation":[{"name":"iMIND Study Group, Duke University School of Medicine, Durham, NC, USA"},{"name":"Pratt School of Engineering, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Brune","sequence":"additional","affiliation":[{"name":"iMIND Study Group, Duke University School of Medicine, Durham, NC, USA"},{"name":"Pratt School of Engineering, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Kundu","sequence":"additional","affiliation":[{"name":"iMIND Study Group, Duke University School of Medicine, Durham, NC, USA"},{"name":"Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Haystead","sequence":"additional","affiliation":[{"name":"iMIND Study Group, Duke University School of Medicine, Durham, NC, USA"},{"name":"Pratt School of Engineering, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Winslow","sequence":"additional","affiliation":[{"name":"iMIND Study Group, Duke University School of Medicine, Durham, NC, USA"},{"name":"Pratt School of Engineering, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Kundu","sequence":"additional","affiliation":[{"name":"iMIND Study Group, Duke University School of Medicine, Durham, NC, USA"},{"name":"Pratt School of Engineering, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Ellis","family":"Wisely","sequence":"additional","affiliation":[{"name":"iMIND Study Group, Duke University School of Medicine, Durham, NC, USA"},{"name":"Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cason B.","family":"Robbins","sequence":"additional","affiliation":[{"name":"iMIND Study Group, Duke University School of Medicine, Durham, NC, USA"},{"name":"Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Henao","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, Duke University, Durham, NC, USA"},{"name":"Department of Biostatistics & Bioinformatics, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilraj S.","family":"Grewal","sequence":"additional","affiliation":[{"name":"iMIND Study Group, Duke University School of Medicine, Durham, NC, USA"},{"name":"Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Fekrat","sequence":"additional","affiliation":[{"name":"iMIND Study Group, Duke University School of Medicine, Durham, NC, USA"},{"name":"Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA"},{"name":"Department of Neurology, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"3","key":"bib1","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/alz.v17.3","article-title":"2021 Alzheimer's disease facts and figures","volume":"17","year":"2021","journal-title":"Alzheimers Dement"},{"issue":"1","key":"bib2","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/s41531-018-0058-0","article-title":"Prevalence of Parkinson's disease across North America","volume":"4","author":"Marras","year":"2018","journal-title":"NPJ Parkinsons Dis"},{"issue":"6","key":"bib3","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1111\/joim.2018.284.issue-6","article-title":"Biomarkers for Alzheimer's disease: current status and prospects for the future","volume":"284","author":"Blennow","year":"2018","journal-title":"J Intern Med"},{"issue":"7","key":"bib4","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1038\/jcbfm.2013.58","article-title":"Associations between retinal microvascular changes and dementia, cognitive functioning, and brain imaging abnormalities: a systematic review","volume":"33","author":"Heringa","year":"2013","journal-title":"J Cereb Blood Flow Metab"},{"issue":"1","key":"bib5","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nrneurol.2012.227","article-title":"The retina as a window to the brain - From eye research to CNS disorders","volume":"9","author":"London","year":"2013","journal-title":"Nat Rev Neurol"},{"issue":"7","key":"bib6","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.clineuro.2011.02.014","article-title":"Retinal thickness in patients with mild cognitive impairment and Alzheimer's disease","volume":"113","author":"Kesler","year":"2011","journal-title":"Clin Neurol Neurosurg"},{"issue":"3","key":"bib7","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1136\/bjophthalmol-2020-317659","article-title":"Convolutional neural network to identify symptomatic Alzheimer's disease using multimodal retinal imaging","volume":"106","author":"Wisely","year":"2020","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"bib8","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s40942-019-0197-4","article-title":"The effect of image quality on the reliability of OCT angiography measurements in patients with diabetes","volume":"5","author":"Czak\u00f3","year":"2019","journal-title":"Int J Retina Vitreous"},{"issue":"3","key":"bib9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1167\/tvst.10.3.2","article-title":"Optical coherence tomography angiography quality across three multicenter clinical studies of diabetic retinopathy","volume":"10","author":"Lujan","year":"2021","journal-title":"Transl Vis Sci Technol"},{"issue":"3","key":"bib10","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1097\/IJG.0b013e31817eee20","article-title":"Signal strength is an important determinant of accuracy of nerve fiber layer thickness measurement by optical coherence tomography","volume":"18","author":"Wu","year":"2009","journal-title":"J Glaucoma"},{"issue":"7","key":"bib11","first-page":"712","article-title":"The value of OCT and OCTA as potential biomarkers for preclinical Alzheimer's disease: a review study","volume":"11","author":"L\u00f3pez-Cuenca","year":"2021","journal-title":"Life (Basel)"},{"issue":"7","key":"bib12","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.oret.2022.03.001","article-title":"Longitudinal analysis of the retina and choroid in cognitively normal individuals at higher genetic risk of Alzheimer disease","volume":"6","author":"Ma","year":"2022","journal-title":"Ophthalmol Retina"},{"issue":"6","key":"bib13","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1145\/3065386","article-title":"ImageNet classification with deep convolutional neural networks","volume":"60","author":"Krizhevsky","year":"2017","journal-title":"Commun ACM"},{"issue":"1","key":"bib16","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s40942-017-0068-9","article-title":"Impact of image quality on OCT angiography based quantitative measurements","volume":"3","author":"Al-Sheikh","year":"2017","journal-title":"Int J Retina Vitreous"},{"issue":"3","key":"bib17","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1177\/2474126420953968","article-title":"Repeatability of peripapillary optical coherence tomography angiography parameters in older adults","volume":"5","author":"Robbins","year":"2020","journal-title":"J Vitreoretin Dis"},{"issue":"4","key":"bib18","doi-asserted-by":"publisher","first-page":"100075","DOI":"10.1016\/j.xops.2021.100075","article-title":"Repeatability of peripapillary OCT angiography in neurodegenerative disease","volume":"1","author":"Ma","year":"2021","journal-title":"Ophthalmol Sci"},{"issue":"7","key":"bib19","first-page":"2951","article-title":"Intrasession repeatability of macular optical coherence tomography angiography parameters in neurodegenerative disease","volume":"63","author":"Akrobetu","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"bib20","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1136\/bjophthalmol-2013-303660","article-title":"Relationship between ganglion cell-inner plexiform layer and optic disc\/retinal nerve fibre layer parameters in non-glaucomatous eyes","volume":"97","author":"Tham","year":"2013","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"bib21","doi-asserted-by":"publisher","first-page":"5520","DOI":"10.1038\/s41598-021-84862-x","article-title":"Applicability of optical coherence tomography angiography (OCTA) imaging in Parkinson's disease","volume":"11","author":"Lauermann","year":"2021","journal-title":"Sci Rep"},{"issue":"8","key":"bib22","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1016\/j.ophtha.2007.11.027","article-title":"Relationship between retinal nerve fiber layer measurement and signal strength in optical coherence tomography","volume":"115","author":"Cheung","year":"2008","journal-title":"Ophthalmology"},{"issue":"1","key":"bib23","doi-asserted-by":"crossref","first-page":"12897","DOI":"10.1038\/s41598-018-31321-9","article-title":"The Importance of signal strength in quantitative assessment of retinal vessel density using optical coherence tomography angiography","volume":"8","author":"Bin","year":"2018","journal-title":"Sci Rep"},{"issue":"10","key":"bib24","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.oret.2019.04.029","article-title":"Signal strength reduction effects in OCT angiography","volume":"3","author":"Yu","year":"2019","journal-title":"Ophthalmol Retina"},{"issue":"2","key":"bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1167\/tvst.9.2.35","article-title":"Transfer learning for automated OCTA detection of diabetic retinopathy","volume":"9","author":"Le","year":"2020","journal-title":"Transl Vis Sci Technol"},{"issue":"7","key":"bib26","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1167\/tvst.10.7.23","article-title":"Macular ischemia quantification using deep-learning denoised optical coherence tomography angiography in branch retinal vein occlusion","volume":"10","author":"Yeung","year":"2021","journal-title":"Transl Vis Sci Technol"},{"issue":"8","key":"bib28","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1007\/s00417-019-04338-7","article-title":"Automated OCT angiography image quality assessment using a deep learning algorithm","volume":"257","author":"Lauermann","year":"2019","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"9","key":"bib29","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1038\/eye.2010.72","article-title":"Influence of pupil dilation on retinal nerve fibre layer measurements with spectral domain OCT","volume":"24","author":"Massa","year":"2010","journal-title":"Eye (Lond)"},{"issue":"10","key":"bib30","doi-asserted-by":"publisher","first-page":"e0223452","DOI":"10.1371\/journal.pone.0223452","article-title":"Influence of mydriasis on optical coherence tomography angiography imaging in patients with age-related macular degeneration","volume":"14","author":"Br\u00fccher","year":"2019","journal-title":"PLoS One"},{"issue":"10","key":"bib31","doi-asserted-by":"publisher","first-page":"e0221395","DOI":"10.1371\/journal.pone.0221395","article-title":"OCT-angiography: mydriatic phenylephrine and tropicamide do not influence retinal microvasculature in macula and peripapillary region","volume":"14","author":"Hohberger","year":"2019","journal-title":"PLoS One"},{"issue":"1","key":"bib32","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1186\/s12886-015-0168-y","article-title":"Evaluating the effect of pupil dilation on spectral-domain optical coherence tomography measurements and their quality score","volume":"15","author":"Tanga","year":"2015","journal-title":"BMC Ophthalmol"},{"issue":"12","key":"bib33","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1136\/bjo.2006.113134","article-title":"Effect of pupillary dilatation on glaucoma assessments using optical coherence tomography","volume":"91","author":"Smith","year":"2007","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"bib34","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41746-018-0040-6","article-title":"Pivotal trial of an autonomous AI-based diagnostic system for detection of diabetic retinopathy in primary care offices","volume":"1","author":"Abr\u00e0moff","year":"2018","journal-title":"NPJ Digit Med"},{"issue":"1","key":"bib35","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/aos.13613","article-title":"Validation of automated screening for referable diabetic retinopathy with the IDx-DR device in the Hoorn Diabetes Care System","volume":"96","author":"van der Heijden","year":"2018","journal-title":"Acta Ophthalmol"},{"issue":"9","key":"bib36","doi-asserted-by":"publisher","first-page":"960","DOI":"10.4103\/0301-4738.143949","article-title":"Fundus imaging with a mobile phone: a review of techniques","volume":"62","author":"Shanmugam","year":"2014","journal-title":"Indian J Ophthalmol"},{"issue":"11","key":"bib37","doi-asserted-by":"publisher","first-page":"e030882","DOI":"10.1136\/bmjopen-2019-030882","article-title":"Optical coherence tomography (OCT) in unconscious and systemically unwell patients using a mobile OCT device: a pilot study","volume":"9","author":"Liu","year":"2019","journal-title":"BMJ Open"},{"key":"bib14","author":"Simonyan"},{"key":"bib15","article-title":"PyTorch: an imperative style, high-performance deep learning library","author":"Paszke"},{"key":"bib27","first-page":"13775","article-title":"Deep learning for quality assessment of optical coherence tomography angiography images. Sci Rep","author":"Dhodapkar","year":"2022"}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2791261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T10:31:13Z","timestamp":1688121073000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2791261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,30]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.12.6.30","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6,30]]}}}