{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:33:04Z","timestamp":1780511584168,"version":"3.54.1"},"reference-count":76,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"7","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2023,7,18]]},"DOI":"10.1167\/tvst.12.7.17","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T15:56:29Z","timestamp":1689695789000},"page":"17","source":"Crossref","is-referenced-by-count":5,"title":["Regulatable Complement Inhibition of the Alternative Pathway Mitigates Wet Age-Related Macular Degeneration Pathology in a Mouse Model"],"prefix":"10.1167","volume":"12","author":[{"given":"Nathaniel B.","family":"Parsons","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balasubramaniam","family":"Annamalai","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e4rbel","family":"Rohrer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Medical University of South Carolina, Charleston, SC, USA"},{"name":"Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA"},{"name":"Ralph H. Johnson VA Medical Center, Division of Research, Charleston, SC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s40662-016-0063-5","article-title":"Epidemiology of age-related macular degeneration (AMD): associations with cardiovascular disease phenotypes and lipid factors","volume":"3","author":"Pennington","year":"2016","journal-title":"Eye Vis (Lond)"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1016\/j.ophtha.2009.03.046","article-title":"Age-related macular degeneration and risk of coronary heart disease and stroke: the Cardiovascular Health Study","volume":"116","author":"Sun","year":"2009","journal-title":"Ophthalmology"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/ng1750","article-title":"Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration","volume":"38","author":"Gold","year":"2006","journal-title":"Nat Genet"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1038\/ng.2741","article-title":"Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration","volume":"45","author":"Seddon","year":"2013","journal-title":"Nat Genet"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1126\/science.1109557","article-title":"Complement factor H polymorphism in age-related macular degeneration","volume":"308","author":"Klein","year":"2005","journal-title":"Science"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"4487","DOI":"10.1007\/s00018-021-03796-9","article-title":"The complement system in age-related macular degeneration","volume":"78","author":"Armento","year":"2021","journal-title":"Cell Mol Life Sci"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.tips.2022.02.006","article-title":"Targeting complement in neurodegeneration: challenges, risks, and strategies","volume":"43","author":"Zelek","year":"2022","journal-title":"Trends Pharmacol Sci"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1111\/j.1582-4934.2008.00350.x","article-title":"The alternative complement pathway revisited","volume":"12","author":"Harboe","year":"2008","journal-title":"J Cell Mol Med"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.tips.2022.01.004","article-title":"Compstatins: the dawn of clinical C3-targeted complement inhibition","volume":"43","author":"Lamers","year":"2022","journal-title":"Trends Pharmacol Sci"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.3390\/biomedicines10081884","article-title":"Targeting the complement cascade for treatment of dry age-related macular degeneration","volume":"10","author":"Patel","year":"2022","journal-title":"Biomedicines"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"15001","DOI":"10.1038\/sigtrans.2015.1","article-title":"Human IgG1 antibodies suppress angiogenesis in a target-independent manner","volume":"1","author":"Bogdanovich","year":"2016","journal-title":"Signal Transduct Target Ther"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.preteyeres.2017.09.001","article-title":"Complement factor H in AMD: bridging genetic associations and pathobiology","volume":"62","author":"Toomey","year":"2018","journal-title":"Prog Retin Eye Res"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1080\/02713680802546658","article-title":"C5a, but not C3a, increases VEGF secretion in ARPE-19 human retinal pigment epithelial cells","volume":"34","author":"Cortright","year":"2009","journal-title":"Curr Eye Res"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"3056","DOI":"10.1167\/iovs.08-2222","article-title":"A targeted inhibitor of the alternative complement pathway reduces angiogenesis in a mouse model of age-related macular degeneration","volume":"50","author":"Rohrer","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.molimm.2019.02.001","article-title":"Inhibition of the alternative complement pathway accelerates repair processes in the murine model of choroidal neovascularization","volume":"108","author":"Parsons","year":"2019","journal-title":"Mol Immunol"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.molimm.2019.07.030","article-title":"Compendium of current complement therapeutics","volume":"114","author":"Zelek","year":"2019","journal-title":"Mol Immunol"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1042\/BST0381342","article-title":"Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology","volume":"38","author":"Clark","year":"2010","journal-title":"Biochem Soc Trans"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1172\/JCI17348","article-title":"Complement receptor 2-mediated targeting of complement inhibitors to sites of complement activation","volume":"111","author":"Song","year":"2003","journal-title":"J Clin Invest"},{"key":"bib19","article-title":"Targeting complement factor H for treatment of diseases","volume":"114","author":"Gilkeson","year":"2010"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"14534","DOI":"10.1074\/jbc.M114.564674","article-title":"Smoke exposure causes endoplasmic reticulum stress and lipid accumulation in retinal pigment epithelium through oxidative stress and complement activation","volume":"289","author":"Kunchithapautham","year":"2014","journal-title":"J Biol Chem"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"12753","DOI":"10.1074\/jbc.M112.421891","article-title":"Oxidative stress sensitizes retinal pigmented epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner","volume":"288","author":"Joseph","year":"2013","journal-title":"J Biol Chem"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1167\/iovs.15-18471","article-title":"A targeted inhibitor of the alternative complement pathway accelerates recovery from smoke-induced ocular injury","volume":"57","author":"Woodell","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1089\/jop.2011.0212","article-title":"Systemic human CR2-targeted complement alternative pathway inhibitor ameliorates mouse laser-induced choroidal neovascularization","volume":"28","author":"Rohrer","year":"2012","journal-title":"J Ocul Pharmacol Ther"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1167\/tvst.7.2.3","article-title":"Encapsulated cell technology-based delivery of a complement inhibitor reduces choroidal neovascularization in a mouse model","volume":"7","author":"Annamalai","year":"2018","journal-title":"Transl Vis Sci Technol"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.omtm.2017.11.003","article-title":"Delivery of CR2-fH using AAV vector therapy as treatment strategy in the mouse model of choroidal neovascularization","volume":"9","author":"Schnabolk","year":"2018","journal-title":"Mol Ther Methods Clin Dev"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.molmed.2008.11.003","article-title":"Ocular gene therapy: current progress and future prospects","volume":"15","author":"Colella","year":"2009","journal-title":"Trends Mol Med"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.visres.2007.08.009","article-title":"Comparative analysis of in vivo and in vitro AAV vector transduction in the neonatal mouse retina: effects of serotype and site of administration","volume":"48","author":"Pang","year":"2008","journal-title":"Vision Res"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1007\/s00281-021-00892-7","article-title":"Tipping the balance: intricate roles of the complement system in disease and therapy","volume":"43","author":"Pouw","year":"2021","journal-title":"Semin Immunopathol"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.4049\/jimmunol.1501886","article-title":"Complement component 3 is regulated by TWIST1 and mediates epithelial-mesenchymal transition","volume":"196","author":"Cho","year":"2016","journal-title":"J Immunol"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1007\/s10162-008-0123-1","article-title":"Occupational noise, smoking, and a high body mass index are risk factors for age-related hearing impairment and moderate alcohol consumption is protective: a European population-based multicenter study","volume":"9","author":"Fransen","year":"2008","journal-title":"J Assoc Res Otolaryngol"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"548","DOI":"10.3390\/antiox8110548","article-title":"Oxidative stress increases endogenous complement-dependent inflammatory and angiogenic responses in retinal pigment epithelial cells independently of exogenous complement sources","volume":"8","author":"Trakkides","year":"2019","journal-title":"Antioxidants (Basel)"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"e0136523","DOI":"10.1371\/journal.pone.0136523","article-title":"Trans-corneal subretinal injection in mice and its effect on the function and morphology of the retina","volume":"10","author":"Qi","year":"2015","journal-title":"PLoS One"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1167\/iovs.62.4.11","article-title":"Subretinal rather than intravitreal adeno-associated virus-mediated delivery of a complement alternative pathway inhibitor is effective in a mouse model of RPE damage","volume":"62","author":"Annamalai","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib34","article-title":"Encapsulated cell technology for the delivery of biologics to the mouse eye","volume":"157","author":"Belhaj","year":"2020","journal-title":"J Vis Exp"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"e67894","DOI":"10.1371\/journal.pone.0067894","article-title":"Alternative complement pathway deficiency ameliorates chronic smoke-induced functional and morphological ocular injury","volume":"8","author":"Woodell","year":"2013","journal-title":"PLoS ONE"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1096\/fsb2.v28.5","article-title":"Progressive dysfunction of the retinal pigment epithelium and retina due to increased VEGF-A levels","volume":"28","author":"Ablonczy","year":"2014","journal-title":"FASEB J"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"14814","DOI":"10.1074\/jbc.M117.795674","article-title":"The exocyst is required for photoreceptor ciliogenesis and retinal development","volume":"292","author":"Lobo","year":"2017","journal-title":"J Biol Chem"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1167\/iovs.07-1194","article-title":"Effects of an anti-VEGF-A monoclonal antibody on laser-induced choroidal neovascularization in mice: optimizing methods to quantify vascular changes","volume":"49","author":"Campa","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"e11359","DOI":"10.1016\/j.heliyon.2022.e11359","article-title":"Evaluation of a connexin-based peptide for the treatment of age-related macular degeneration","volume":"8","author":"Obert","year":"2022","journal-title":"Heliyon"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"6525","DOI":"10.1167\/iovs.14-15067","article-title":"Reliability of the mouse model of choroidal neovascularization induced by laser photocoagulation","volume":"55","author":"Poor","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1136\/bjophthalmol-2013-304515","article-title":"Evidence of early ultrastructural photoreceptor abnormalities in light-induced retinal degeneration using spectral domain optical coherence tomography","volume":"98","author":"Aziz","year":"2014","journal-title":"Br J Ophthalmol"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"3880","DOI":"10.1167\/iovs.10-6266","article-title":"In vivo evaluation of laser-induced choroidal neovascularization using spectral-domain optical coherence tomography","volume":"52","author":"Giani","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"2218","DOI":"10.1172\/JCI65861","article-title":"Detection of complement activation using monoclonal antibodies against C3d","volume":"123","author":"Thurman","year":"2013","journal-title":"J Clin Invest"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"16939","DOI":"10.1074\/jbc.M808166200","article-title":"Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury","volume":"284","author":"Thurman","year":"2009","journal-title":"J Biol Chem"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"4278","DOI":"10.1167\/iovs.07-1622","article-title":"AAV-mediated gene therapy for retinal degeneration in the rd10 mouse containing a recessive PDEbeta mutation","volume":"49","author":"Pang","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"e19078","DOI":"10.1371\/journal.pone.0019078","article-title":"A non membrane-targeted human soluble CD59 attenuates choroidal neovascularization in a model of age related macular degeneration","volume":"6","author":"Cashman","year":"2011","journal-title":"PLoS ONE"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1016\/j.ymthe.2006.03.005","article-title":"Safety of recombinant adeno-associated virus type 2-RPE65 vector delivered by ocular subretinal injection","volume":"13","author":"Jacobson","year":"2006","journal-title":"Mol Ther"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.molimm.2010.12.016","article-title":"The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization","volume":"48","author":"Rohrer","year":"2011","journal-title":"Mol Immunol"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3389\/fnagi.2018.00015","article-title":"The complement system is critical in maintaining retinal integrity during aging","volume":"10","author":"Mukai","year":"2018","journal-title":"Front Aging Neurosci"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1007\/s00109-018-1683-0","article-title":"Cell-specific gene therapy driven by an optimized hypoxia-regulated vector reduces choroidal neovascularization","volume":"96","author":"Biswal","year":"2018","journal-title":"J Mol Med"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.omtn.2019.01.012","article-title":"Suppression of choroidal neovascularization by AAV-based dual-acting antiangiogenic gene therapy","volume":"16","author":"Askou","year":"2019","journal-title":"Mol Ther Nucleic Acids"},{"key":"bib52","doi-asserted-by":"crossref","first-page":"e709","DOI":"10.1111\/aos.14372","article-title":"Relationships among retinal\/choroidal thickness, retinal microvascular network and visual field in high myopia","volume":"98","author":"Wu","year":"2020","journal-title":"Acta Ophthalmol"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1097\/IAE.0000000000003194","article-title":"Retinal fluid and thickness as measures of disease activity in neovascular age-related macular degeneration","volume":"41","author":"Kaiser","year":"2021","journal-title":"Retina"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1167\/iovs.61.14.11","article-title":"Systemic inflammation by collagen-induced arthritis affects the progression of age-related macular degeneration differently in two mouse models of the disease","volume":"61","author":"Schnabolk","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/978-3-319-75402-4","article-title":"Inflammation-induced photoreceptor cell death","volume":"1074","author":"Sene","year":"2018","journal-title":"Adv Exp Med Biol"},{"issue":"suppl 1","key":"bib56","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000328206","article-title":"Apoptosis and other cell death mechanisms after retinal detachment: implications for photoreceptor rescue","volume":"226","author":"Lo","year":"2011","journal-title":"Ophthalmologica"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"297ra116","DOI":"10.1126\/scitranslmed.aab1482","article-title":"Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury","volume":"7","author":"Sweigard","year":"2015","journal-title":"Sci Transl Med"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"4717","DOI":"10.3390\/jcm11164717","article-title":"Subretinal injection techniques for retinal disease: a review","volume":"11","author":"Irigoyen","year":"2022","journal-title":"J Clin Med"},{"key":"bib59","doi-asserted-by":"crossref","first-page":"E517","DOI":"10.1073\/pnas.1218933110","article-title":"Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement","volume":"110","author":"Cideciyan","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1093\/hmg\/ddn075","article-title":"C3 R102G polymorphism increases risk of age-related macular degeneration","volume":"17","author":"Spencer","year":"2008","journal-title":"Hum Mol Genet"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3109\/13816810.2013.766217","article-title":"Complement factor B polymorphism and the phenotype of early age-related macular degeneration","volume":"35","author":"Mantel","year":"2014","journal-title":"Ophthalmic Genet"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1097\/IAE.0b013e318240a540","article-title":"The ARMS2 A69S variant and bilateral advanced age-related macular degeneration","volume":"32","author":"Schwartz","year":"2012","journal-title":"Retina"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"108583","DOI":"10.1016\/j.exer.2021.108583","article-title":"Natural immunoglobulin M-based delivery of a complement alternative pathway inhibitor in mouse models of retinal degeneration","volume":"207","author":"Annamalai B","year":"2020","journal-title":"Exp Eye Res"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3389\/fimmu.2014.00402","article-title":"Complement, c1q, and c1q-related molecules regulate macrophage polarization","volume":"5","author":"Bohlson","year":"2014","journal-title":"Front Immunol"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.ophtha.2020.08.027","article-title":"C5 inhibitor avacincaptad pegol for geographic atrophy due to age-related macular degeneration: a randomized pivotal phase 2\/3 trial","volume":"128","author":"Jaffe","year":"2021","journal-title":"Ophthalmology"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"dev201047","DOI":"10.1242\/dev.201047","article-title":"Microglia refine developing retinal astrocytic and vascular networks through the complement C3\/C3aR axis","volume":"150","author":"Gnanaguru","year":"2023","journal-title":"Development"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"16229","DOI":"10.1074\/jbc.M110.204701","article-title":"Polyethylene glycol (PEG)-induced mouse model of choroidal neovascularization","volume":"286","author":"Lyzogubov","year":"2011","journal-title":"J Biol Chem"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"11769","DOI":"10.1021\/acsnano.2c04543","article-title":"Anti-PEG antibodies boosted in humans by SARS-CoV-2 lipid nanoparticle mRNA vaccine","volume":"16","author":"Ju","year":"2022","journal-title":"ACS Nano"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"380","DOI":"10.3389\/fncel.2014.00380","article-title":"Versatility of the complement system in neuroinflammation, neurodegeneration and brain homeostasis","volume":"8","author":"Orsini","year":"2014","journal-title":"Front Cell Neurosci"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1167\/iovs.61.6.18","article-title":"Rare genetic variants in complement factor I lead to low FI plasma levels resulting in increased risk of age-related macular degeneration","volume":"61","author":"Hallam","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib74","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1097\/ICU.0000000000000850","article-title":"Complications of intravitreal injections: 2022","volume":"33","author":"Patel","year":"2022","journal-title":"Curr Opin Ophthalmol"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1159\/000520171","article-title":"Development of macular atrophy in patients with wet age-related macular degeneration receiving anti-VEGF treatment","volume":"245","author":"Foss","year":"2022","journal-title":"Ophthalmologica"},{"key":"bib76","doi-asserted-by":"publisher","first-page":"11763","DOI":"10.1038\/s41598-018-29726-7","article-title":"Development of an inducible anti-VEGF rAAV gene therapy strategy for the treatment of wet AMD","volume":"8","author":"Reid","year":"2018","journal-title":"Sci Rep"},{"key":"bib69","article-title":"Clinical trial of gene therapy for the treatment of Leber congenital amaurosis (LCA) (OPTIRPE65) (NCT02781480)","year":"2021"},{"key":"bib72","article-title":"Interim results from a first-in-human phase I\/II Gene Therapy Study (FOCUS) of GT005, an investigational AAV2 vector encoding complement factor I (CFI), in patients with Geographic Atrophy (GA), retina society"},{"key":"bib73","author":"Hemera Biosciences","year":"2022"}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2791317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T15:56:35Z","timestamp":1689695795000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2791317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,18]]},"references-count":76,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7,3]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.12.7.17","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7,18]]}}}