{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:35:06Z","timestamp":1792427706365,"version":"4.5.0"},"reference-count":47,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"10","license":[{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2024,10,16]]},"DOI":"10.1167\/tvst.13.10.25","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T15:30:59Z","timestamp":1729092659000},"page":"25","source":"Crossref","is-referenced-by-count":14,"title":["Multi-Characteristic Opsin Therapy to Functionalize Retina, Attenuate Retinal Degeneration, and Restore Vision in Mouse Models of Retinitis Pigmentosa"],"prefix":"10.1167","volume":"13","author":[{"given":"Subrata","family":"Batabyal","sequence":"first","affiliation":[{"name":"Nanoscope Technologies LLC, Bedford, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanghoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Nanoscope Technologies LLC, Bedford, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Carlson","sequence":"additional","affiliation":[{"name":"Nanoscope Technologies LLC, Bedford, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darryl","family":"Narcisse","sequence":"additional","affiliation":[{"name":"Nanoscope Technologies LLC, Bedford, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kissaou","family":"Tchedre","sequence":"additional","affiliation":[{"name":"Nanoscope Therapeutics, Inc., Dallas, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Dibas","sequence":"additional","affiliation":[{"name":"Nanoscope Technologies LLC, Bedford, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najam A.","family":"Sharif","sequence":"additional","affiliation":[{"name":"Nanoscope Therapeutics, Inc., Dallas, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samarendra","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Nanoscope Technologies LLC, Bedford, TX, USA"},{"name":"Nanoscope Therapeutics, Inc., Dallas, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1016\/S0140-6736(06)69740-7","article-title":"Retinitis pigmentosa","volume":"368","author":"Hartong","year":"2006","journal-title":"Lancet"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/eye.2009.176","article-title":"Relationship between peripheral visual field loss and vision-related quality of life in patients with retinitis pigmentosa","volume":"24","author":"Sugawara","year":"2010","journal-title":"Eye (Lond)"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1001\/archopht.125.2.151","article-title":"Perspective on genes and mutations causing retinitis pigmentosa","volume":"125","author":"Daiger","year":"2007","journal-title":"Arch Ophthalmol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1080\/13816810701199423","article-title":"Attitudes regarding predictive testing for retinitis pigmentosa","volume":"28","author":"Mezer","year":"2007","journal-title":"Ophthalmic Genet"},{"key":"bib5","first-page":"191","article-title":"Degenerative changes in a retina affected with autosomal dominant retinitis pigmentosa","volume":"30","author":"Flannery","year":"1989","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/S0161-6420(97)30291-7","article-title":"Rate of visual field loss in retinitis pigmentosa","volume":"104","author":"Grover","year":"1997","journal-title":"Ophthalmology"},{"key":"bib7","doi-asserted-by":"crossref","first-page":"177ps5","DOI":"10.1126\/scitranslmed.3003101","article-title":"Optogenetics and translational medicine","volume":"5","author":"Chow","year":"2013","journal-title":"Sci Transl Med"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"3916","DOI":"10.1529\/biophysj.108.130187","article-title":"In-depth activation of channelrhodopsin 2-sensitized excitable cells with high spatial resolution using two-photon excitation with a near-infrared laser microbeam","volume":"95","author":"Mohanty","year":"2008","journal-title":"Biophys J"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nmeth.f.321","article-title":"Method of the year 2010 [editorial]","volume":"8","author":"Nature America","year":"2011","journal-title":"Nat Meth"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/nmeth.f.324","article-title":"Optogenetics","volume":"8","author":"Deisseroth","year":"2011","journal-title":"Nat Meth"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1146\/annurev-neuro-061010-113817","article-title":"The Development and application of optogenetics","volume":"34","author":"Fenno","year":"2011","journal-title":"Ann Rev Neurosci"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/nmeth.f.323","article-title":"Optogenetics: controlling cell function with light","volume":"8","author":"Pastrana","year":"2011","journal-title":"Nat Meth"},{"issue":"2","key":"bib13","doi-asserted-by":"publisher","first-page":"e0117746","DOI":"10.1371\/journal.pone.0117746","article-title":"Pain inhibition by optogenetic activation of specific anterior cingulate cortical neurons.","volume":"10","author":"Gu","year":"2015","journal-title":"PLoS One."},{"key":"bib14","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1038\/nn1525","article-title":"Millisecond-timescale, genetically targeted optical control of neural activity","volume":"8","author":"Boyden","year":"2005","journal-title":"Nat Neurosci"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"S143","DOI":"10.1088\/1741-2560\/4\/3\/S02","article-title":"An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology","volume":"4","author":"Aravanis","year":"2007","journal-title":"J Neural Eng"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/nrn2192","article-title":"Circuit-breakers: optical technologies for probing neural signals and systems","volume":"8","author":"Zhang","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"eaao0540","DOI":"10.1126\/scitranslmed.aao0540","article-title":"Optogenetic stimulation of cochlear neurons activates the auditory pathway and restores auditory-driven behavior in deaf adult gerbils","volume":"10","author":"Wrobel","year":"2018","journal-title":"Sci Transl Med"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"12692","DOI":"10.1073\/pnas.1002418107","article-title":"Optical activation of lateral amygdala pyramidal cells instructs associative fear learning","volume":"107","author":"Johansen","year":"2010","journal-title":"Proc Nat Acad Sci USA"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"e17560","DOI":"10.1371\/journal.pone.0017560","article-title":"Functional integration of grafted neural stem cell-derived dopaminergic neurons monitored by optogenetics in an in vitro Parkinson model","volume":"6","author":"T\u00f8nnesen","year":"2011","journal-title":"PLoS One"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"10829","DOI":"10.1523\/JNEUROSCI.2246-11.2011","article-title":"Optogenetic interrogation of dopaminergic modulation of the multiple phases of reward-seeking behavior","volume":"31","author":"Adamantidis","year":"2011","journal-title":"J Neurosci"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"11862","DOI":"10.1523\/JNEUROSCI.3378-08.2008","article-title":"Light-induced rescue of breathing after spinal cord injury","volume":"28","author":"Alilain","year":"2008","journal-title":"J Neurosci"},{"key":"bib22","first-page":"1059","article-title":"Retinal channelrhodopsin-2-mediated activity in vivo evaluated with manganese-enhanced magnetic resonance imaging","volume":"16","author":"Ivanova","year":"2010","journal-title":"J Mol Vis"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/nn.2117","article-title":"Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration","volume":"11","author":"Lagali","year":"2008","journal-title":"Nat Neurosci"},{"issue":"7","key":"bib25","doi-asserted-by":"publisher","first-page":"e3720","DOI":"10.1002\/jgm.3720","article-title":"Safety of intravitreally delivered AAV2 vector-mediated multi-characteristic opsin genetic construct in wild type beagle dogs.","volume":"26","author":"Mohanty","year":"2024","journal-title":"J Gene Med."},{"key":"bib26","doi-asserted-by":"publisher","first-page":"eaax2324","DOI":"10.1126\/scitranslmed.aax2324","article-title":"Depicting brighter possibilities for treating blindness","volume":"11","author":"Sahel","year":"2019","journal-title":"Sci Transl Med"},{"key":"bib27","first-page":"041505","article-title":"Restoring vision in mice with retinal degeneration using multicharacteristic opsin","volume":"4","author":"Wright","year":"2017","journal-title":"Neurophotonics"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"13940","DOI":"10.1073\/pnas.1936192100","article-title":"Channelrhodopsin-2, a directly light-gated cation-selective membrane channel","volume":"100","author":"Nagel","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/nmeth.2836","article-title":"Independent optical excitation of distinct neural populations","volume":"11","author":"Klapoetke","year":"2014","journal-title":"Nat Methods"},{"key":"bib30","first-page":"4","article-title":"WHO Drug Information 2022","volume":"36","author":"World Health Organization","year":"2022","journal-title":"WHO Drug Inf"},{"key":"bib31","first-page":"1064","article-title":"International nonproprietary names for pharmaceutical substances (INN)","volume":"36","author":"World Health Organization","year":"2022","journal-title":"WHO Drug Inf"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"4009","DOI":"10.1038\/s41598-022-07622-5","article-title":"OCT guided micro-focal ERG system with multiple stimulation wavelengths for characterization of ocular health","volume":"12","author":"Carlson","year":"2022","journal-title":"Sci Rep"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/s41434-020-00200-2","article-title":"Sensitization of ON-bipolar cells with ambient light activatable multi-characteristic opsin rescues vision in mice","volume":"28","author":"Batabyal","year":"2021","journal-title":"Gene Ther"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"4611","DOI":"10.1167\/iovs.04-0541","article-title":"Rapid quantification of adult and developing mouse spatial vision using a virtual optomotor system","volume":"45","author":"Prusky","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1017\/S0952523805225166","article-title":"Independent visual threshold measurements in the two eyes of freely moving rats and mice using a virtual-reality optokinetic system","volume":"22","author":"Douglas","year":"2005","journal-title":"Vis Neurosci"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s00441-006-0234-0","article-title":"Ribbon synapses of the retina","volume":"326","author":"tom Dieck","year":"2006","journal-title":"Cell Tissue Res"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"750663","DOI":"10.3389\/fncel.2021.750663","article-title":"Bioluminescent multi-characteristic opsin for simultaneous optical stimulation and continuous monitoring of cortical activities.","volume":"15","author":"Narcisse","year":"2021","journal-title":"Front Cell Neurosci."},{"key":"bib38","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1097\/IAE.0b013e3180592ba6","article-title":"Changes of intraocular pressure after intravitreal injection of bevacizumab (Avastin)","volume":"27","author":"Falkenstein","year":"2007","journal-title":"Retina"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12886-021-02012-3","article-title":"Correlation between intraocular pressure reduction and anterior chamber aqueous flare after micropulse transscleral cyclophotocoagulation","volume":"21","author":"Kimura","year":"2021","journal-title":"BMC Ophthalmol"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/S0042-6989(01)00146-8","article-title":"Retinal degeneration mutants in the mouse","volume":"42","author":"Chang","year":"2002","journal-title":"Vision Res"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/cne.21144","article-title":"Retinal organization in the retinal degeneration 10 (rd10) mutant mouse: a morphological and ERG study","volume":"500","author":"Gargini","year":"2007","journal-title":"J Comp Neurol"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"6051","DOI":"10.1167\/iovs.09-4704","article-title":"PKCa is essential for the proper activation and termination of rod bipolar cell response","volume":"51","author":"Ruether","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.preteyeres.2010.03.005","article-title":"Complexity of retinal cone bipolar cells","volume":"29","author":"Strettoi","year":"2010","journal-title":"Prog Retin Eye Res"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s12038-007-0029-9","article-title":"Age-related decrease in rod bipolar cell density of the human retina: an immunohistochemical study","volume":"32","author":"Aggarwal","year":"2007","journal-title":"J Biosci"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3389\/fnins.2017.00161","article-title":"Present molecular limitations of ON-bipolar cell targeted gene therapy","volume":"11","author":"van Wyk","year":"2017","journal-title":"Front Neurosci"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.omtm.2017.11.007","article-title":"Emerging issues in AAV-mediated in vivo gene therapy","volume":"8","author":"Colella","year":"2018","journal-title":"Mol Ther Methods Clin Dev"},{"key":"bib24","first-page":"758","article-title":"Near-infrared laser-based spatially targeted nano-enhanced optical delivery of therapeutic genes to degenerated retina.","volume-title":"Mol Ther Methods Clin Dev.","author":"Batabyal","year":"2020"},{"key":"bib43","author":"Pan","year":"June 25, 2013"}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2802140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T15:31:03Z","timestamp":1729092663000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2802140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,16]]},"references-count":47,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.13.10.25","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10,16]]}}}