{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:01:16Z","timestamp":1788022876604,"version":"build-2784847793"},"reference-count":53,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"12","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2024,12,11]]},"DOI":"10.1167\/tvst.13.12.12","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T20:39:16Z","timestamp":1733949556000},"page":"12","source":"Crossref","is-referenced-by-count":4,"title":["A New Approach to Retinal Oxygen Extraction Measurement Based on Laser Speckle Flowgraphy and Retinal Oximetry"],"prefix":"10.1167","volume":"13","author":[{"given":"Viktoria","family":"Pai","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Janku","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Lindner","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Graf","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leopold","family":"Schmetterer","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"},{"name":"Singapore Eye Research Institute, Singapore National Eye Centre, Singapore"},{"name":"Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore"},{"name":"SERI-NTU Advanced Ocular Engineering (STANCE), Nanyang Technological University, Singapore"},{"name":"School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Garh\u00f6fer","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doreen","family":"Schmidl","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"10152","DOI":"10.3390\/ijms231710152","article-title":"Retinal oxygen extraction in patients with primary open-angle glaucoma","volume":"23","author":"Garh\u00f6fer","year":"2022","journal-title":"Int J Mol Sci"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.2337\/db22-0219","article-title":"Retinal oxygen metabolism in patients with type 2 diabetes and different stages of diabetic retinopathy","volume":"71","author":"Hommer","year":"2022","journal-title":"Diabetes"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1007\/s00125-017-4309-0","article-title":"Retinal oxygen extraction in individuals with type 1 diabetes with no or mild diabetic retinopathy","volume":"60","author":"Fondi","year":"2017","journal-title":"Diabetologia"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/aos.12294","article-title":"Retinal oxygen metabolism in exudative age-related macular degeneration","volume":"92","author":"Geirsdottir","year":"2014","journal-title":"Acta Ophthalmol"},{"issue":"7","key":"bib5","doi-asserted-by":"publisher","first-page":"e914","DOI":"10.1111\/aos.14419","article-title":"Anatomical and functional changes in the retina in patients with Alzheimer's disease and mild cognitive impairment","volume":"98","author":"Szegedi","year":"2020","journal-title":"Acta Ophthalmol"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3233\/JAD-150457","article-title":"Retinal oximetry imaging in Alzheimer's disease","volume":"49","author":"Einarsdottir","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"761654","DOI":"10.3389\/fnins.2021.761654","article-title":"Retinal oxygen metabolism and haemodynamics in patients with multiple sclerosis and history of optic neuritis","volume":"15","author":"Kallab","year":"2021","journal-title":"Front Neurosci"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2019.04.001","article-title":"Retinal oximetry: metabolic imaging for diseases of the retina and brain","volume":"70","author":"Stef\u00e1nsson","year":"2019","journal-title":"Prog Retin Eye Res"},{"key":"bib9","first-page":"3","article-title":"Current use of the automatic retinal oximetry. Review","volume":"76","author":"H\u00fcbnerov\u00e1","year":"2020","journal-title":"Cesk Slov Oftalmol"},{"issue":"2","key":"bib10","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1167\/tvst.10.2.5","article-title":"Advances in retinal oximetry","volume":"10","author":"Garg","year":"2021","journal-title":"Transl Vis Sci Technol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"15763","DOI":"10.1038\/srep15763","article-title":"Retinal oxygen extraction in humans","volume":"5","author":"Werkmeister","year":"2015","journal-title":"Sci Rep"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"1069449","DOI":"10.3389\/fmed.2022.1069449","article-title":"Methods to measure blood flow and vascular reactivity in the retina","volume":"9","author":"B\u00f6hm","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"3162","DOI":"10.1167\/iovs.18-26234","article-title":"Age-related decline of retinal oxygen extraction in healthy subjects","volume":"60","author":"Bata","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1089\/jop.2020.0131","article-title":"The effect of orally administered low-dose dronabinol on retinal blood flow and oxygen metabolism in healthy subjects","volume":"37","author":"Hommer","year":"2021","journal-title":"J Ocul Pharmacol Ther"},{"issue":"7","key":"bib15","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1167\/tvst.9.7.34","article-title":"Repeatability and reproducibility of total retinal blood flow measurements using bi-directional doppler OCT","volume":"9","author":"Szegedi","year":"2020","journal-title":"Transl Vis Sci Technol"},{"issue":"7","key":"bib16","doi-asserted-by":"publisher","first-page":"e202300567","DOI":"10.1002\/jbio.202300567","article-title":"The retinal oxygen metabolism and hemodynamics as a substitute for biochemical tests to predict nonproliferative diabetic retinopathy","volume":"17","author":"Zhou","year":"2024","journal-title":"J Biophotonics"},{"key":"bib17","first-page":"1171","article-title":"Reproducibility of retinal circulation measurements obtained using laser speckle flowgraphy-NAVI in patients with glaucoma","volume":"5","author":"Aizawa","year":"2011","journal-title":"Clin Ophthalmol"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"3877","DOI":"10.1007\/s10792-021-01954-3","article-title":"Diagnostic performance of laser speckle flowgraphy in glaucoma: a systematic review and meta-analysis","volume":"41","author":"Gu","year":"2021","journal-title":"Int Ophthalmol"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"5417","DOI":"10.1167\/iovs.16-19896","article-title":"Measurements of retinal perfusion using laser speckle flowgraphy and Doppler optical coherence tomography","volume":"57","author":"Luft","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"bib20","doi-asserted-by":"publisher","first-page":"e0207525","DOI":"10.1371\/journal.pone.0207525","article-title":"Evaluation of flicker induced hyperemia in the retina and optic nerve head measured by Laser Speckle Flowgraphy","volume":"13","author":"Fondi","year":"2018","journal-title":"PLoS One"},{"issue":"9","key":"bib21","doi-asserted-by":"publisher","first-page":"e0184772","DOI":"10.1371\/journal.pone.0184772","article-title":"Optic nerve head and retinal blood flow regulation during isometric exercise as assessed with laser speckle flowgraphy","volume":"12","author":"Witkowska","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"bib22","doi-asserted-by":"publisher","first-page":"e181","DOI":"10.1111\/aos.14862","article-title":"Measuring optic nerve head perfusion to monitor glaucoma: a study on structure-function relationships using laser speckle flowgraphy","volume":"100","author":"Calzetti","year":"2022","journal-title":"Acta Ophthalmol"},{"issue":"1","key":"bib23","doi-asserted-by":"publisher","first-page":"13798","DOI":"10.1038\/s41598-024-63435-8","article-title":"Effects of switching from intravitreal injection of aflibercept to faricimab on ocular blood flow in patients with diabetic macular edema","volume":"14","author":"Saima","year":"2024","journal-title":"Sci Rep"},{"issue":"1","key":"bib24","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1186\/s12886-022-02505-9","article-title":"Reduced blood flow by laser speckle flowgraphy after (125)I-plaque brachytherapy for uveal melanoma","volume":"22","author":"Tamplin","year":"2022","journal-title":"BMC Ophthalmol"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s10877-020-00475-1","article-title":"Ocular blood flow by laser speckle flowgraphy to detect cerebral ischemia during carotid endarterectomy","volume":"35","author":"Motoyama","year":"2021","journal-title":"J Clin Monit Comput"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.2147\/OPTH.S213031","article-title":"Correlation between laser speckle flowgraphy and optical coherence tomography angiography measurements in normal and glaucomatous eyes","volume":"13","author":"Kohmoto","year":"2019","journal-title":"Clin Ophthalmol"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"4707","DOI":"10.1167\/iovs.14-14593","article-title":"Retinal oxygen metabolism during normoxia and hyperoxia in healthy subjects","volume":"55","author":"Palkovits","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"bib28","doi-asserted-by":"publisher","first-page":"H1412","DOI":"10.1152\/ajpheart.00479.2014","article-title":"Regulation of retinal oxygen metabolism in humans during graded hypoxia","volume":"307","author":"Palkovits","year":"2014","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"5","key":"bib29","doi-asserted-by":"publisher","first-page":"054015","DOI":"10.1117\/1.2976032","article-title":"Retinal vessel oximetry-calibration, compensation for vessel diameter and fundus pigmentation, and reproducibility","volume":"13","author":"Hammer","year":"2008","journal-title":"J Biomed Opt"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1109\/10.804573","article-title":"In vivo measurement of the oxygen saturation of retinal vessels in healthy volunteers","volume":"46","author":"Schweitzer","year":"1999","journal-title":"IEEE Trans Biomed Eng"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1007\/s004170050236","article-title":"Noninvasive measurement of the Bayliss effect in retinal autoregulation","volume":"237","author":"Blum","year":"1999","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/0002-9394(74)90458-9","article-title":"Mathematic Relationships Between the width of a Retinal Artery and the Widths of its Branches","volume":"77","author":"Parr","year":"1974","journal-title":"Am J Ophthalmol"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.1016\/S0161-6420(99)90525-0","article-title":"Methods for evaluation of retinal microvascular abnormalities associated with hypertension\/sclerosis in the Atherosclerosis Risk in Communities Study","volume":"106","author":"Hubbard","year":"1999","journal-title":"Ophthalmology"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"5343","DOI":"10.1038\/s41598-018-23149-0","article-title":"Laser speckle flowgraphy derived characteristics of optic nerve head perfusion in normal tension glaucoma and healthy individuals: a Pilot study","volume":"8","author":"Mursch-Edlmayr","year":"2018","journal-title":"Sci Rep"},{"issue":"5","key":"bib35","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1167\/tvst.9.5.9","article-title":"Assessment of Choroidal Neovascularization Perfusion: A Pilot Study With Laser Speckle Flowgraphy","volume":"9","author":"Calzetti","year":"2020","journal-title":"Transl Vis Sci Technol"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"220","DOI":"10.3390\/photonics1030220","article-title":"Basic technology and clinical applications of the updated model of laser speckle flowgraphy to ocular diseases","volume":"1","author":"Sugiyama","year":"2014","journal-title":"Photonics"},{"issue":"12","key":"bib37","doi-asserted-by":"publisher","first-page":"e0168190","DOI":"10.1371\/journal.pone.0168190","article-title":"Ocular blood flow measurements in healthy white subjects using laser speckle flowgraphy","volume":"11","author":"Luft","year":"2016","journal-title":"PLoS One"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1111\/j.1755-3768.2009.01586.x","article-title":"Use of laser speckle flowgraphy in ocular blood flow research","volume":"88","author":"Sugiyama","year":"2010","journal-title":"Acta Ophthalmologica"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"3899","DOI":"10.1167\/iovs.14-14116","article-title":"Relative flow volume, a novel blood flow index in the human retina derived from laser speckle flowgraphy","volume":"55","author":"Shiga","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib40","first-page":"9496242","article-title":"Changes in ocular blood flow after ranibizumab intravitreal injection for diabetic macular edema measured using laser speckle flowgraphy","volume":"2020","author":"Toto","year":"2020","journal-title":"Biomed Res Int"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jcm.2016.02.012","article-title":"A guideline of selecting and reporting intraclass correlation coefficients for reliability research","volume":"15","author":"Koo","year":"2016","journal-title":"J Chiropr Med"},{"key":"bib42","first-page":"612","article-title":"Effects of hyperoxia on the oxygen distribution in the intact cat retina","volume":"30","author":"Linsenmeier","year":"1989","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1152\/jappl.1986.61.2.592","article-title":"Regulation of local oxygen tension and blood flow in the inner retina during hyperoxia","volume":"61","author":"Riva","year":"1986","journal-title":"J Appl Physiol"},{"key":"bib44","first-page":"2493","article-title":"The response of rat vitreal oxygen tension to stepwise increases in inspired percentage oxygen","volume":"31","author":"Yu","year":"1990","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"5012","DOI":"10.1167\/iovs.13-11887","article-title":"Inner retinal oxygen delivery and metabolism under normoxia and hypoxia in rat","volume":"54","author":"Wanek","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"bib46","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1167\/iovs.61.6.49","article-title":"Retinal vascular reactivity in type 1 diabetes patients without retinopathy using optical coherence tomography angiography","volume":"61","author":"Sousa","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"2891","DOI":"10.1167\/iovs.16-21389","article-title":"Repeatability and reproducibility of retinal blood flow measurement using a Doppler optical coherence tomography flowmeter in healthy subjects","volume":"58","author":"Tani","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"6633","DOI":"10.1167\/iovs.15-17321","article-title":"Inner retinal oxygen extraction fraction in response to light flicker stimulation in humans","volume":"56","author":"Felder","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib49","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1167\/tvst.11.2.9","article-title":"Retinal oxygen delivery and extraction in ophthalmologically healthy subjects with different blood pressure status","volume":"11","author":"Pappelis","year":"2022","journal-title":"Transl Vis Sci Technol"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"5470","DOI":"10.1364\/BOE.10.005470","article-title":"Optical coherence tomography velocimetry based on decorrelation estimation of phasor pair ratios (DEPPAIR)","volume":"10","author":"Gr\u00e4fe","year":"2019","journal-title":"Biomed Opt Express"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.21037\/atm-20-3246","article-title":"Approaches to quantify optical coherence tomography angiography metrics","volume":"8","author":"Tan","year":"2020","journal-title":"Ann Transl Med"},{"key":"bib52","first-page":"340","article-title":"Retinal oxygen metabolism in patients with mild cognitive impairment","volume":"10","author":"Olafsdottir","year":"2018","journal-title":"Alzheimers Dement"},{"key":"bib53","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1055\/a-1384-0737","article-title":"The oxygen saturation in the retinal vessels of patients with diabetes mellitus\u2014the search for determinants","volume":"239","author":"Stodtmeister","year":"2022","journal-title":"Klin Monbl Augenheilkd"}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2802348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T20:39:20Z","timestamp":1733949560000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2802348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,11]]},"references-count":53,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12,2]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.13.12.12","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12,11]]}}}