{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T09:27:22Z","timestamp":1778318842845,"version":"3.51.4"},"reference-count":44,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"5","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2024,5,22]]},"DOI":"10.1167\/tvst.13.5.19","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T15:31:11Z","timestamp":1716391871000},"page":"19","source":"Crossref","is-referenced-by-count":9,"title":["Design and Biocompatibility of a Novel, Flexible Artificial Cornea"],"prefix":"10.1167","volume":"13","author":[{"given":"Gavin","family":"Li","sequence":"first","affiliation":[{"name":"The Ocular Surface Disease Clinic, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA"},{"name":"Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J.","family":"Aldave","sequence":"additional","affiliation":[{"name":"Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Amescua","sequence":"additional","affiliation":[{"name":"Bascom Palmer Eye Institute, University of Miami-Miller School of Medicine, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn A.","family":"Colby","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology at New York University Grossman School of Medicine, New York University, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria S.","family":"Cortina","sequence":"additional","affiliation":[{"name":"Illinois Eye and Ear Infirmary, University of Illinois, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"de la Cruz","sequence":"additional","affiliation":[{"name":"Illinois Eye and Ear Infirmary, University of Illinois, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Marie A.","family":"Parel","sequence":"additional","affiliation":[{"name":"Bascom Palmer Eye Institute, University of Miami-Miller School of Medicine, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas B.","family":"Schmiedel","sequence":"additional","affiliation":[{"name":"Innovation Center of Excellence, W. L. Gore & Associates, Inc., Newark, DE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esen Karamursel","family":"Akpek","sequence":"additional","affiliation":[{"name":"The Ocular Surface Disease Clinic, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27","reference":[{"issue":"7","key":"bib1","doi-asserted-by":"publisher","first-page":"e0271736","DOI":"10.1371\/journal.pone.0271736","article-title":"Blindness and visual impairment and their causes in India: results of a nationally representative survey","volume":"17","author":"Vashist","year":"2022","journal-title":"PLoS One"},{"issue":"9","key":"bib2","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1097\/ICO.0000000000002374","article-title":"Corneal blindness in Asia: a systematic review and meta-analysis to identify challenges and opportunities","volume":"39","author":"Tran","year":"2020","journal-title":"Cornea"},{"issue":"2","key":"bib4","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1001\/jamaophthalmol.2015.4776","article-title":"Global survey of corneal transplantation and eye banking","volume":"134","author":"Gain","year":"2016","journal-title":"JAMA Ophthalmol"},{"issue":"8","key":"bib5","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1136\/bjophthalmol-2020-316705","article-title":"Corneal graft failure: an update","volume":"105","author":"Alio","year":"2021","journal-title":"Br J Ophthalmol"},{"issue":"5","key":"bib8","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1177\/1120672118762224","article-title":"Corneal transplantation trends in France from 2004 to 2015: a 12-year review","volume":"28","author":"Bigan","year":"2018","journal-title":"Eur J Ophthalmol"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.ajo.2018.01.018","article-title":"Trends in corneal transplantation from 2001 to 2016 in Germany: a report of the DOG-Section Cornea and its Keratoplasty Registry","volume":"188","author":"Flockerzi","year":"2018","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"bib10","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.jcjo.2018.02.023","article-title":"New trends in corneal transplants at the University of Toronto","volume":"53","author":"Chan","year":"2018","journal-title":"Can J Ophthalmol"},{"issue":"8","key":"bib11","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1001\/jamaophthalmol.2018.1515","article-title":"Differential survival of penetrating and lamellar transplants in management of failed corneal grafts","volume":"136","author":"Aboshiha","year":"2018","journal-title":"JAMA Ophthalmol"},{"issue":"5","key":"bib12","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1097\/ICO.0b013e3181c29705","article-title":"Extended long-term results of penetrating keratoplasty for keratoconus","volume":"29","author":"Fukuoka","year":"2010","journal-title":"Cornea"},{"issue":"1","key":"bib13","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.ophtha.2015.09.028","article-title":"Boston type 1 keratoprosthesis versus repeat donor keratoplasty for corneal graft failure: a systematic review and meta-analysis","volume":"123","author":"Ahmad","year":"2016","journal-title":"Ophthalmology"},{"issue":"9","key":"bib14","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.1007\/s00417-022-05646-1","article-title":"The treatment of end-stage corneal disease: penetrating keratoplasty compared with Boston type 1 keratoprosthesis","volume":"260","author":"Bonneau","year":"2022","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib15","first-page":"T3","article-title":"Donor corneal transplantation vs Boston type 1 keratoprosthesis in patients with previous graft failures: a retrospective single center study (an American Ophthalmological Society thesis)","volume":"113","author":"Akpek","year":"2015","journal-title":"Trans Am Ophthalmol Soc"},{"issue":"7","key":"bib16","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1016\/j.ophtha.2015.03.025","article-title":"Boston keratoprosthesis: outcomes and complications: a report by the American Academy of Ophthalmology","volume":"122","author":"Lee","year":"2015","journal-title":"Ophthalmology"},{"issue":"1","key":"bib18","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/ICO.0000000000001405","article-title":"Long-term visual outcomes, complications, and retention of the Boston type I keratoprosthesis","volume":"37","author":"Aravena","year":"2018","journal-title":"Cornea"},{"issue":"10","key":"bib19","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1016\/j.jfo.2023.07.014","article-title":"Long-term visual outcomes of Boston type I keratoprosthesis in Canada","volume":"46","author":"Aoun","year":"2023","journal-title":"J Fr Ophtalmol"},{"issue":"6","key":"bib20","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1136\/bjophthalmol-2019-315617","article-title":"Long-term outcomes of Boston keratoprosthesis type I: the Chinese People's Liberation Army General Hospital experience","volume":"106","author":"Wang","year":"2022","journal-title":"Br J Ophthalmol"},{"issue":"2","key":"bib21","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1097\/IIO.0b013e31827ab3d3","article-title":"The international use of the Boston type I keratoprosthesis","volume":"53","author":"Kim","year":"2013","journal-title":"Int Ophthalmol Clin"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"S35","DOI":"10.1097\/ICO.0000000000000567","article-title":"Corneal transplantation in the developing world: lessons learned and meeting the challenge","volume":"34","author":"Pineda","year":"2015","journal-title":"Cornea"},{"issue":"8","key":"bib23","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1167\/tvst.12.8.9","article-title":"Twelve-month clinical and histopathological performance of a novel synthetic cornea device in rabbit model","volume":"12","author":"Akpek","year":"2023","journal-title":"Transl Vis Sci Technol"},{"issue":"6","key":"bib24","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1097\/ICO.0000000000002266","article-title":"Short-term clinical outcomes of a novel corneal prosthetic device in a rabbit model","volume":"39","author":"Akpek","year":"2020","journal-title":"Cornea"},{"issue":"4","key":"bib25","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1111\/opo.2015.35.issue-4","article-title":"Repeatability of a novel corneal indentation device for corneal biomechanical measurement","volume":"35","author":"Lam","year":"2015","journal-title":"Ophthalmic Physiol Opt"},{"issue":"7","key":"bib26","doi-asserted-by":"publisher","first-page":"4324","DOI":"10.1167\/iovs.09-4798","article-title":"Age-related differences in the elasticity of the human cornea","volume":"52","author":"Knox Cartwright","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"5410143","DOI":"10.1155\/2017\/5410143","article-title":"Estimation of the corneal Young's modulus in vivo based on a fluid-filled spherical-shell model with Scheimpflug imaging","volume":"2017","author":"Shih","year":"2017","journal-title":"J Ophthalmol"},{"issue":"9","key":"bib28","first-page":"901","article-title":"Ocular surface temperature","volume":"8","author":"Efron","year":"1989","journal-title":"Curr Eye Res"},{"issue":"6","key":"bib29","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1097\/01.ico.0000121703.74077.ea","article-title":"In vitro drug-induced spoliation of a keratoprosthetic hydrogel","volume":"23","author":"Chirila","year":"2004","journal-title":"Cornea"},{"issue":"2","key":"bib30","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/eye.2015.252","article-title":"What is light? The visible spectrum and beyond","volume":"30","author":"Sliney","year":"2016","journal-title":"Eye"},{"issue":"4","key":"bib31","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/0014-4835(90)90140-P","article-title":"Light transmission of the cornea in whole human eyes","volume":"50","author":"Beems","year":"1990","journal-title":"Exp Eye Res"},{"issue":"6","key":"bib32","first-page":"776","article-title":"Transmission of the ocular media","volume":"1","author":"Boettner","year":"1962","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"bib33","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1016\/j.bpj.2012.02.023","article-title":"Ultraviolet light transmission through the human corneal stroma is reduced in the periphery","volume":"102","author":"Doutch","year":"2012","journal-title":"Biophys J"},{"issue":"3","key":"bib34","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1097\/01.ico.0000148312.01805.53","article-title":"White-to-white corneal diameter: normal values in healthy humans obtained with the Orbscan II topography system","volume":"24","author":"R\u00fcfer","year":"2005","journal-title":"Cornea"},{"issue":"2","key":"bib35","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S0039-6257(97)00024-6","article-title":"Keratoprostheses: advancing toward a true artificial cornea","volume":"42","author":"Hicks","year":"1997","journal-title":"Surv Ophthalmol"},{"issue":"4","key":"bib36","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1167\/iovs.06-0815","article-title":"In vivo three-dimensional high-resolution imaging of rodent retina with spectral-domain optical coherence tomography","volume":"48","author":"Ruggeri","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib37","doi-asserted-by":"publisher","first-page":"172","DOI":"10.18240\/ijo","article-title":"Ultraviolet light exposure and its penetrance through the eye in a porcine model","volume":"16","author":"Fukuoka","year":"2023","journal-title":"Int J Ophthalmol"},{"issue":"6","key":"bib38","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/0002-9394(86)90400-9","article-title":"The spectra, classification, and rationale of ultraviolet-protective intraocular lenses","volume":"102","author":"Mainster","year":"1986","journal-title":"Am J Ophthalmol"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"770780","DOI":"10.3389\/fmed.2021.770780","article-title":"Artificial cornea: past, current, and future directions","volume":"8","author":"Holland","year":"2021","journal-title":"Front Med"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/vision.2022.8.issue-1","article-title":"The Boston keratoprosthesis-the first 50\u00a0years: some reminiscences","volume":"8","author":"Dohlman","year":"2022","journal-title":"Annu Rev Vis Sci"},{"key":"bib41","first-page":"S0008-4182(23)00166-7","article-title":"Review of clinical trials addressing the Boston Keratoprosthesis","author":"Milad","year":"2023","journal-title":"Can J Ophthalmol"},{"issue":"11","key":"bib42","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1097\/ICO.0000000000000557","article-title":"Periprosthetic tissue loss in patients with idiopathic vitreous inflammation after the Boston keratoprosthesis","volume":"34","author":"Grassi","year":"2015","journal-title":"Cornea"},{"issue":"5","key":"bib43","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1097\/00003226-200307000-00007","article-title":"Histopathology of explanted collar button keratoprostheses: a clinicopathologic correlation","volume":"22","author":"Dudenhoefer","year":"2003","journal-title":"Cornea"},{"issue":"5","key":"bib44","doi-asserted-by":"publisher","first-page":"283","DOI":"10.4103\/0970-258X.261189","article-title":"Eye donation and eye banking in India","volume":"31","author":"Gupta","year":"2018","journal-title":"Natl Med J India"},{"key":"bib3","article-title":"Cornea transplantation","volume-title":"StatPearls","author":"Maghsoudlou","year":"2022"},{"key":"bib6","author":"Eye Bank Association of America"},{"key":"bib7","author":"Eye Bank Association of America"},{"key":"bib17","author":"Chodosh"}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2793684","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T15:31:16Z","timestamp":1716391876000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2793684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,22]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.13.5.19","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5,22]]}}}