{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T23:07:05Z","timestamp":1776899225397,"version":"3.51.2"},"reference-count":38,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"8","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2024,8,12]]},"DOI":"10.1167\/tvst.13.8.19","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T15:30:56Z","timestamp":1723476656000},"page":"19","source":"Crossref","is-referenced-by-count":6,"title":["Subthreshold Micropulse Laser Versus Oral Spironolactone in Chronic Central Serous Chorioretinopathy: A Quasi-Randomized Controlled Trial"],"prefix":"10.1167","volume":"13","author":[{"given":"Sheng","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China"},{"name":"Research Laboratory of Macular Disease, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China"},{"name":"Research Laboratory of Macular Disease, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China"},{"name":"Research Laboratory of Macular Disease, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meixia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China"},{"name":"Research Laboratory of Macular Disease, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"100770","DOI":"10.1016\/j.preteyeres.2019.07.003","article-title":"Central serous chorioretinopathy: towards an evidence-based treatment guideline","volume":"73","author":"van Rijssen","year":"2019","journal-title":"Prog Retin Eye Res"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1111\/aos.2008.86.issue-2","article-title":"Central serous chorioretinopathy","volume":"86","author":"Wang","year":"2008","journal-title":"Acta Ophthalmol"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.survophthal.2012.07.004","article-title":"Central serous chorioretinopathy: update on pathophysiology and treatment","volume":"58","author":"Nicholson","year":"2013","journal-title":"Surv Ophthalmol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1097\/00006982-200202000-00004","article-title":"Factors associated with reduced visual acuity during long-term follow-up of patients with idiopathic central serous chorioretinopathy","volume":"22","author":"Loo","year":"2002","journal-title":"Retina"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1016\/j.ophtha.2018.04.021","article-title":"Half-dose photodynamic therapy versus high-density subthreshold micropulse laser treatment in patients with chronic central serous chorioretinopathy: the PLACE Trial","volume":"125","author":"van Dijk","year":"2018","journal-title":"Ophthalmology"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1136\/bjo.2010.182121","article-title":"Comparative study of patients with central serous chorioretinopathy undergoing focal laser photocoagulation or photodynamic therapy","volume":"95","author":"Lim","year":"2011","journal-title":"Br J Ophthalmol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"4604567","DOI":"10.1155\/2020\/4604567","article-title":"Comparison of 532?nm micropulse green laser versus continuous-wave 532?nm green laser in chronic central serous chorioretinopathy: long-term follow-up","volume":"2020","author":"Piasecka","year":"2020","journal-title":"J Ophthalmol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"e0184112","DOI":"10.1371\/journal.pone.0184112","article-title":"Subthreshold 577\u00a0nm micropulse laser treatment for central serous chorioretinopathy","volume":"12","author":"Maruko","year":"2017","journal-title":"PLoS One"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1136\/bjophthalmol-2017-311291","article-title":"Yellow (577\u00a0nm) micropulse laser versus half-dose verteporfin photodynamic therapy in eyes with chronic central serous chorioretinopathy: results of the Pan-American Collaborative Retina Study (PACORES) Group","volume":"102","author":"Roca","year":"2018","journal-title":"Br J Ophthalmol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"e610","DOI":"10.1111\/aos.2017.95.issue-7","article-title":"Eplerenone for chronic central serous chorioretinopathy\u2014a randomized controlled prospective study","volume":"95","author":"Schwartz","year":"2017","journal-title":"Acta Ophthalmol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/S0140-6736(19)32981-2","article-title":"Eplerenone for chronic central serous chorioretinopathy in patients with active, previously untreated disease for more than 4 months (VICI): a randomised, double-blind, placebo-controlled trial","volume":"395","author":"Lotery","year":"2020","journal-title":"Lancet"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1038\/s41433-020-01338-4","article-title":"Efficacy and safety of the mineralocorticoid receptor antagonist treatment for central serous chorioretinopathy: a systematic review and meta-analysis","volume":"35","author":"Duan","year":"2021","journal-title":"Eye (Lond)"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"3306","DOI":"10.1038\/s41433-023-02509-9","article-title":"Randomized controlled trials in central serous chorioretinopathy: a review","volume":"37","author":"Singh","year":"2023","journal-title":"Eye (Lond)"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.survophthal.2023.03.001","article-title":"Comparing interventions for chronic central serous chorioretinopathy: a network meta-analysis","volume":"68","author":"You","year":"2023","journal-title":"Surv Ophthalmol"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/j.oret.2020.07.026","article-title":"Multimodal imaging-based central serous chorioretinopathy classification","volume":"4","author":"Chhablani","year":"2020","journal-title":"Ophthalmol Retina"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1038\/s41433-019-0692-8","article-title":"Efficacy and safety of subthreshold micropulse laser compared with threshold conventional laser in central serous chorioretinopathy","volume":"34","author":"Sun","year":"2020","journal-title":"Eye (Lond)"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.ajo.2020.02.003","article-title":"Quantification of choriocapillaris with Phansalkar local thresholding: pitfalls to avoid","volume":"213","author":"Chu","year":"2020","journal-title":"Am J Ophthalmol"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"824239","DOI":"10.3389\/fmed.2021.824239","article-title":"Changes in the foveal outer nuclear layer of central serous chorioretinopathy patients over the disease course and their response to photodynamic therapy","volume":"8","author":"Deng","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1007\/s10103-019-02721-8","article-title":"A pilot prospective study of 577-nm yellow subthreshold micropulse laser treatment with two different power settings for acute central serous chorioretinopathy","volume":"34","author":"Zhou","year":"2019","journal-title":"Lasers Med Sci"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/0002-9394(83)90265-9","article-title":"Direct, indirect, and sham laser photocoagulation in the management of central serous chorioretinopathy","volume":"95","author":"Robertson","year":"1983","journal-title":"Am J Ophthalmol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.preteyeres.2015.05.003","article-title":"Central serous chorioretinopathy: recent findings and new physiopathology hypothesis","volume":"48","author":"Daruich","year":"2015","journal-title":"Prog Retin Eye Res"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1016\/S0140-6736(20)32327-8","article-title":"Eplerenone for chronic central serous chorioretinopathy","volume":"396","author":"Stanescu-Segall","year":"2020","journal-title":"Lancet"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"3445","DOI":"10.1038\/s41433-020-01325-9","article-title":"Current perspectives on the use of eplerenone for chronic central serous chorioretinopathy","volume":"35","author":"Xia","year":"2021","journal-title":"Eye (Lond)"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"729792","DOI":"10.1155\/2015\/729792","article-title":"Sublethal photothermal stimulation with a micropulse laser induces heat shock protein expression in ARPE-19 cells","volume":"2015","author":"Inagaki","year":"2015","journal-title":"J Ophthalmol"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/cxo.12818","article-title":"Subthreshold diode micropulse laser versus observation in acute central serous chorioretinopathy","volume":"102","author":"Arora","year":"2019","journal-title":"Clin Exp Optom"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/WCO.0000000000000284","article-title":"Corticosteroids and the retina: a role for the mineralocorticoid receptor","volume":"29","author":"Behar-Cohen","year":"2016","journal-title":"Curr Opin Neurol"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1007\/s00417-010-1338-5","article-title":"Thickness of photoreceptor layers in polypoidal choroidal vasculopathy and central serous chorioretinopathy","volume":"248","author":"Ooto","year":"2010","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1080\/08820538.2020.1809682","article-title":"Subthreshold micro-pulse yellow laser and eplerenone drug therapy in chronic central serous chorio-retinopathy patients: a comparative study","volume":"35","author":"Vignesh","year":"2020","journal-title":"Semin Ophthalmol"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1007\/s00417-016-3373-3","article-title":"Clinical experience with eplerenone to treat chronic central serous chorioretinopathy","volume":"254","author":"Cakir","year":"2016","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"16621","DOI":"10.1038\/s41598-020-73959-4","article-title":"Predictive factors of selective mineralocorticoid receptor antagonist treatment in chronic central serous chorioretinopathy","volume":"10","author":"Gergely","year":"2020","journal-title":"Sci Rep"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1172\/JCI61427","article-title":"Mineralocorticoid receptor is involved in rat and human ocular chorioretinopathy","volume":"122","author":"Zhao","year":"2012","journal-title":"J Clin Invest"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1038\/s41433-022-02091-6","article-title":"Choroidal modifications assessed by means of choroidal vascularity index after oral eplerenone treatment in chronic central serous chorioretinopathy","volume":"37","author":"Toto","year":"2023","journal-title":"Eye (Lond)"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"3405","DOI":"10.1096\/fsb2.v24.9","article-title":"The neuroretina is a novel mineralocorticoid target: aldosterone up-regulates ion and water channels in M\u00fcller glial cells","volume":"24","author":"Zhao","year":"2010","journal-title":"FASEB J"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"e1375","DOI":"10.1111\/aos.v99.8","article-title":"Effect of eplerenone on choroidal blood flow changes during isometric exercise in patients with chronic central serous chorioretinopathy","volume":"99","author":"Gallice","year":"2021","journal-title":"Acta Ophthalmol"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.ajo.2019.01.014","article-title":"Optical coherence tomography angiography quantitative assessment of choriocapillaris blood flow in central serous chorioretinopathy","volume":"201","author":"Rochepeau","year":"2019","journal-title":"Am J Ophthalmol"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s00417-018-4179-2","article-title":"Choriocapillaris flow features and choroidal vasculature in the fellow eyes of patients with acute central serous chorioretinopathy","volume":"257","author":"Yun","year":"2019","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1001\/jama.1965.03090020077026","article-title":"Spironolactone therapy and gynecomastia","volume":"193","author":"Clark","year":"1965","journal-title":"JAMA"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.1111\/bcp.v88.6","article-title":"Eplerenone repurposing in management of chorioretinopathy: mechanism, nanomedicine-based delivery applications and future trends","volume":"88","author":"Abdelhakeem","year":"2022","journal-title":"Br J Clin Pharmacol"}],"container-title":["Translational Vision Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2800681","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T15:31:00Z","timestamp":1723476660000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2800681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,12]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.13.8.19","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8,12]]}}}