{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T13:46:28Z","timestamp":1774705588990,"version":"3.50.1"},"reference-count":47,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"8","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2024,8,12]]},"DOI":"10.1167\/tvst.13.8.21","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T15:31:01Z","timestamp":1723476661000},"page":"21","source":"Crossref","is-referenced-by-count":4,"title":["Identification of Optic Nerve\u2013Related Biomarkers in Primary Open-Angle Glaucoma Based on Comprehensive Bioinformatics and Mendelian Randomization"],"prefix":"10.1167","volume":"13","author":[{"given":"Sijie","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zixuan","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, China"},{"name":"Bengbu Medical University, Bengbu, Anhui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiqin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziqing","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchen","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27","reference":[{"issue":"10108","key":"bib1","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1016\/S0140-6736(17)31469-1","article-title":"Glaucoma","volume":"390","author":"Jonas","year":"2017","journal-title":"Lancet"},{"issue":"5","key":"bib2","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.4103\/IJO.IJO_2570_22","article-title":"Molecular genetics of primary open-angle glaucoma","volume":"71","author":"Yadav","year":"2023","journal-title":"Indian J Ophthalmol"},{"issue":"11","key":"bib3","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s00347-020-01251-x","article-title":"Risk factors for open-angle glaucoma and recommendations for glaucoma screening","volume":"117","author":"Schuster","year":"2020","journal-title":"Ophthalmologe"},{"issue":"1","key":"bib4","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s12886-020-01365-5","article-title":"Identification of lncRNA\u2013miRNA\u2013mRNA regulatory network associated with primary open angle glaucoma","volume":"20","author":"Zhou","year":"2020","journal-title":"BMC Ophthalmol"},{"issue":"3","key":"bib5","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1111\/ceo.2011.39.issue-3","article-title":"Vascular risk factors in glaucoma: a review","volume":"39","author":"Yanagi","year":"2011","journal-title":"Clin Exp Ophthalmol"},{"issue":"4","key":"bib6","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1093\/gerona\/glad005","article-title":"Bioinformatics strategies for the analysis and integration of large-scale multiomics data","volume":"78","author":"Tesi","year":"2023","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1146\/bioeng.2002.4.issue-1","article-title":"DNA microarray technology: devices, systems, and applications","volume":"4","author":"Heller","year":"2002","journal-title":"Annu Rev BioMed Eng"},{"issue":"3","key":"bib8","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/nrg1809","article-title":"Microarray technology: beyond transcript profiling and genotype analysis","volume":"7","author":"Hoheisel","year":"2006","journal-title":"Nat Rev Genet"},{"issue":"1","key":"bib9","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.copbio.2012.09.004","article-title":"Transcriptome analysis using next-generation sequencing","volume":"24","author":"Mutz","year":"2013","journal-title":"Curr Opin Biotechnol"},{"key":"bib10","doi-asserted-by":"crossref","first-page":"6896390","DOI":"10.1155\/2017\/6896390","article-title":"Gene expression profiling of the optic nerve head of patients with primary open-angle glaucoma","volume":"2017","author":"Wang","year":"2017","journal-title":"J Ophthalmol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"109668","DOI":"10.1016\/j.exer.2023.109668","article-title":"Gender-specific lncRNA\u2013miRNA\u2013mRNA regulatory network to reveal potential genes for primary open-angle glaucoma","volume":"236","author":"Chen","year":"2023","journal-title":"Exp Eye Res"},{"issue":"11-12","key":"bib12","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1007\/s10495-022-01746-9","article-title":"A ZFP42\/MARK2 regulatory network reduces the damage of retinal ganglion cells in glaucoma: a study based on GEO dataset and in vitro experiments","volume":"27","author":"Yin","year":"2022","journal-title":"Apoptosis"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"4851","DOI":"10.1093\/bioinformatics\/btz469","article-title":"PhenoScanner V2: an expanded tool for searching human genotype\u2013phenotype associations","volume":"35","author":"Kamat","year":"2019","journal-title":"Bioinformatics"},{"issue":"R1","key":"bib14","doi-asserted-by":"publisher","first-page":"R89","DOI":"10.1093\/hmg\/ddu328","article-title":"Mendelian randomization: genetic anchors for causal inference in epidemiological studies","volume":"23","author":"Davey Smith","year":"2014","journal-title":"Hum Mol Genet"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"1227138","DOI":"10.3389\/fimmu.2023.1227138","article-title":"Causal association between common rheumatic diseases and glaucoma: a Mendelian randomization study","volume":"14","author":"Meng","year":"2023","journal-title":"Front Immunol"},{"issue":"7","key":"bib16","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"bib17","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1214\/16-AOAS920","article-title":"Robust hyperparameter estimation protects against hypervariable genes and improves power to detect differential expression","volume":"10","author":"Phipson","year":"2016","journal-title":"Ann Appl Stat"},{"issue":"3","key":"bib18","first-page":"100141","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb)"},{"issue":"5","key":"bib19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v039.i05","article-title":"Regularization paths for Cox's proportional hazards model via coordinate descent","volume":"39","author":"Simon","year":"2011","journal-title":"J Stat Softw"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v106.i01","article-title":"Elastic net regularization paths for all generalized linear models","volume":"106","author":"Tay","year":"2023","journal-title":"J Stat Softw"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinformatics"},{"issue":"6","key":"bib22","doi-asserted-by":"publisher","first-page":"2072","DOI":"10.1167\/iovs.19-26585","article-title":"Effects of salidroside on trabecular meshwork cell extracellular matrix expression and mouse intraocular pressure","volume":"60","author":"Fan","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"52","DOI":"10.2174\/1874364101004010052","article-title":"Aqueous humor dynamics: a review","volume":"4","author":"Goel","year":"2010","journal-title":"Open Ophthalmol J"},{"issue":"1","key":"bib24","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1023\/B:INTE.0000018524.48581.79","article-title":"The aqueous levels of TGF-beta2 in patients with glaucoma","volume":"25","author":"Ozcan","year":"2004","journal-title":"Int Ophthalmol"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.exer.2013.10.017","article-title":"Smad3 is necessary for transforming growth factor-beta2 induced ocular hypertension in mice","volume":"116","author":"McDowell","year":"2013","journal-title":"Exp Eye Res"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.arr.2016.05.012","article-title":"From DNA damage to functional changes of the trabecular meshwork in aging and glaucoma","volume":"29","author":"Sacc\u00e0","year":"2016","journal-title":"Ageing Res Rev"},{"issue":"9","key":"bib27","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1016\/j.cellsig.2007.04.009","article-title":"Oxyl radicals, redox-sensitive signalling cascades and antioxidants","volume":"19","author":"Genestra","year":"2007","journal-title":"Cell Signal"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"857812","DOI":"10.3389\/fimmu.2022.857812","article-title":"Targeting differential roles of tumor necrosis factor receptors as a therapeutic strategy for glaucoma","volume":"13","author":"Lambuk","year":"2022","journal-title":"Front Immunol"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.exer.2017.02.014","article-title":"Lasker\/IRRF initiative on astrocytes and glaucomatous neurodegeneration participants. Neuroinflammation in glaucoma: a new opportunity","volume":"157","author":"Williams","year":"2017","journal-title":"Exp Eye Res"},{"key":"bib30","doi-asserted-by":"crossref","first-page":"553","DOI":"10.2147\/OPTH.S19453","article-title":"Tumor necrosis factor-alpha (TNF-a) levels in aqueous humor of primary open angle glaucoma","volume":"5","author":"Balaiya","year":"2011","journal-title":"Clin Ophthalmol"},{"issue":"1","key":"bib31","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1186\/s12974-021-02315-8","article-title":"TRPV4-induced M\u00fcller cell gliosis and TNF-a elevation-mediated retinal ganglion cell apoptosis in glaucomatous rats via JAK2\/STAT3\/NF-?B pathway","volume":"18","author":"Li","year":"2021","journal-title":"J Neuroinflammation"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"100998","DOI":"10.1016\/j.preteyeres.2021.100998","article-title":"Molecular regulation of neuroinflammation in glaucoma: current knowledge and the ongoing search for new treatment targets","volume":"87","author":"Tezel","year":"2021","journal-title":"Prog Retin Eye Res"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"100916","DOI":"10.1016\/j.preteyeres.2020.100916","article-title":"Inflammation in glaucoma: from the back to the front of the eye, and beyond","volume":"83","author":"Baudouin","year":"2020","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"bib34","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1167\/iovs.04-0860","article-title":"Expression of acute-phase response proteins in retinal M\u00fcller cells in diabetes","volume":"46","author":"Gerhardinger","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib35","doi-asserted-by":"publisher","first-page":"2599","DOI":"10.1167\/iovs.12-11175","article-title":"Innate immune network in the retina activated by optic nerve crush","volume":"54","author":"Templeton","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib36","first-page":"1205","article-title":"Role of M\u00fcller glia in neuroprotection and regeneration in the retina","volume":"18","author":"Garcia","year":"2003","journal-title":"Histol Histopathol"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2015.06.003","article-title":"Glia\u2013neuron interactions in the mammalian retina","volume":"51","author":"Vecino","year":"2016","journal-title":"Prog Retin Eye Res"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/1471-2202-14-36","article-title":"Plasticity-related gene 3 promotes neurite shaft protrusion","volume":"14","author":"Velmans","year":"2013","journal-title":"BMC Neurosci"},{"issue":"21","key":"bib39","doi-asserted-by":"publisher","first-page":"13007","DOI":"10.3390\/ijms232113007","article-title":"PRG3 and PRG5 C-termini: important players in early neuronal differentiation","volume":"23","author":"Brandt","year":"2022","journal-title":"Int J Mol Sci"},{"key":"bib40","doi-asserted-by":"crossref","DOI":"10.1038\/s41380-022-01703-7","article-title":"Microglia homeostasis mediated by epigenetic ARID1A regulates neural progenitor cells response and leads to autism-like behaviors [published online ahead of print July 20, 2022]","author":"Su","year":"2022","journal-title":"Mol Psychiatry"},{"issue":"4","key":"bib41","doi-asserted-by":"publisher","first-page":"e95758","DOI":"10.1371\/journal.pone.0095758","article-title":"E50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy","volume":"9","author":"Chalasani","year":"2014","journal-title":"PLoS One"},{"issue":"10","key":"bib42","doi-asserted-by":"publisher","first-page":"e834","DOI":"10.1097\/IJG.0000000000000453","article-title":"Increased global DNA methylation and decreased TGF\u00df1 promoter methylation in glaucomatous lamina cribrosa cells","volume":"25","author":"McDonnell","year":"2016","journal-title":"J Glaucoma"},{"issue":"4","key":"bib43","doi-asserted-by":"publisher","first-page":"e0153354","DOI":"10.1371\/journal.pone.0153354","article-title":"Hypoxia-induced changes in DNA methylation alter RASAL1 and TGF\u00df1 expression in human trabecular meshwork cells","volume":"11","author":"McDonnell","year":"2016","journal-title":"PLoS One"},{"issue":"8","key":"bib44","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.tig.2007.05.008","article-title":"Epigenetics and aging: the targets and the marks","volume":"23","author":"Fraga","year":"2007","journal-title":"Trends Genet"},{"issue":"6","key":"bib45","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/s41576-018-0004-3","article-title":"DNA methylation-based biomarkers and the epigenetic clock theory of ageing","volume":"19","author":"Horvath","year":"2018","journal-title":"Nat Rev Genet"},{"issue":"4","key":"bib46","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1016\/j.ymthe.2020.12.030","article-title":"TET-dependent GDF7 hypomethylation impairs aqueous humor outflow and serves as a potential therapeutic target in glaucoma","volume":"29","author":"Wan","year":"2021","journal-title":"Mol Ther"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"e75244","DOI":"10.7554\/eLife.75244","article-title":"Genetic loci and metabolic states associated with murine epigenetic aging","volume":"11","author":"Mozhui","year":"2022","journal-title":"eLife"}],"container-title":["Translational Vision Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2800679","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T15:31:08Z","timestamp":1723476668000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2800679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,12]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.13.8.21","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8,12]]}}}