{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T03:56:14Z","timestamp":1772078174461,"version":"3.50.1"},"reference-count":43,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"8","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2024,8,13]]},"DOI":"10.1167\/tvst.13.8.24","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T15:30:53Z","timestamp":1723563053000},"page":"24","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Topic Delivery of an Inhibitor of Serine Racemase on Laser-Induced Choroidal Vasculopathy"],"prefix":"10.1167","volume":"13","author":[{"given":"Simin","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Optometry, and Visual Science; Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Optometry, and Visual Science; Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dehuan","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Optometry, and Visual Science; Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaifan","family":"Pei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Optometry, and Visual Science; Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Optometry, and Visual Science; Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Gong","sequence":"additional","affiliation":[{"name":"PriMed Non-human Primate Research Center of Sichuan PriMed Shines Bio-tech., Ltd., Ya'an, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Zeng","sequence":"additional","affiliation":[{"name":"PriMed Non-human Primate Research Center of Sichuan PriMed Shines Bio-tech., Ltd., Ya'an, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimei","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Optometry, and Visual Science; Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengzhou","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Optometry, and Visual Science; Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.ophtha.2012.10.036","article-title":"Clinical classification of age-related macular degeneration","volume":"120","author":"Ferris","year":"2013","journal-title":"Ophthalmology"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.neuron.2012.06.018","article-title":"Mechanisms of age-related macular degeneration","volume":"75","author":"Ambati","year":"2012","journal-title":"Neuron"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"2537","DOI":"10.1016\/j.ophtha.2012.09.006","article-title":"Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration","volume":"119","author":"Heier","year":"2012","journal-title":"Ophthalmology"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1056\/NEJMoa054481","article-title":"Ranibizumab for neovascular age-related macular degeneration","volume":"355","author":"Rosenfeld","year":"2006","journal-title":"N Engl J Med"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"4926","DOI":"10.1073\/pnas.97.9.4926","article-title":"D-serine is an endogenous ligand for the glycine site of the-methyl-D-aspartate receptor","volume":"97","author":"Mothet","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"14486","DOI":"10.1523\/JNEUROSCI.5034-08.2008","article-title":"NMDA- and beta-amyloid1-42-induced neurotoxicity is attenuated in serine racemase knock-out mice","volume":"28","author":"Inoue","year":"2008","journal-title":"J Neurosci"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1523\/JNEUROSCI.4297-09.2010","article-title":"Serine racemase deletion protects against cerebral ischemia and excitotoxicity","volume":"30","author":"Mustafa","year":"2010","journal-title":"J Neurosci"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.exer.2018.06.017","article-title":"Loss-of-function mutation of serine racemase attenuates retinal ganglion cell loss in diabetic mice","volume":"175","author":"Jiang","year":"2018","journal-title":"Exp Eye Res"},{"issue":"1","key":"bib9","doi-asserted-by":"publisher","first-page":"e0190864","DOI":"10.1371\/journal.pone.0190864","article-title":"Serine racemase deletion attenuates neurodegeneration and microvascular damage in diabetic retinopathy","volume":"13","author":"Ozaki","year":"2018","journal-title":"PLoS One"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1007\/s00125-020-05333-y","article-title":"Overexpression of D-amino acid oxidase prevents retinal neurovascular pathologies in diabetic rats","volume":"64","author":"Jiang","year":"2021","journal-title":"Diabetologia"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/sj.onc.1201201","article-title":"Induction of vascular endothelial growth factor by nitric oxide in human glioblastoma and hepatocellular carcinoma cells","volume":"15","author":"Chin","year":"1997","journal-title":"Oncogene"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1161\/01.ATV.20.3.659","article-title":"Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells","volume":"20","author":"Dulak","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1002\/jcp.v191:1","article-title":"Nitric oxide is proangiogenic in the retina and choroid","volume":"191","author":"Ando","year":"2002","journal-title":"J Cell Physiol"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1124\/mol.62.3.539","article-title":"Blockade of nitric-oxide synthase reduces choroidal neovascularization","volume":"62","author":"Ando","year":"2002","journal-title":"Mol Pharmacol"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1111\/jnc.2017.143.issue-3","article-title":"Serine racemase deficiency attenuates choroidal neovascularization and reduces nitric oxide and VEGF levels by retinal pigment epithelial cells","volume":"143","author":"Jiang","year":"2017","journal-title":"J Neurochem"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"3736","DOI":"10.1016\/j.bmc.2017.05.011","article-title":"A novel serine racemase inhibitor suppresses neuronal over-activation in vivo","volume":"25","author":"Mori","year":"2017","journal-title":"Bioorg Med Chem"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.exer.2019.03.018","article-title":"Intravenous injection of l-aspartic acid beta-hydroxamate attenuates choroidal neovascularization via anti-VEGF and anti-inflammation","volume":"182","author":"Wu","year":"2019","journal-title":"Exp Eye Res"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"108446","DOI":"10.1016\/j.exer.2021.108446","article-title":"Repurposing bortezomib for choroidal neovascularization treatment via antagonizing VEGF-A and PDGF-D mediated signaling","volume":"204","author":"Liu","year":"2021","journal-title":"Exp Eye Res"},{"issue":"7","key":"bib19","doi-asserted-by":"publisher","first-page":"e0132643","DOI":"10.1371\/journal.pone.0132643","article-title":"Optimization of an image-guided laser-induced choroidal neovascularization model in mice","volume":"10","author":"Gong","year":"2015","journal-title":"Plos One"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"6525","DOI":"10.1167\/iovs.14-15067","article-title":"Reliability of the mouse model of choroidal neovascularization induced by laser photocoagulation","volume":"55","author":"Poor","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1038\/nprot.2013.135","article-title":"Laser-induced choroidal neovascularization model to study age-related macular degeneration in mice","volume":"8","author":"Lambert","year":"2013","journal-title":"Nat Protoc"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"3813","DOI":"10.2147\/DDDT","article-title":"Comparing the efficacy of an anti-human VEGF-A neutralizing antibody versus bevacizumab on a laser-induced choroidal neovascularization (CNV) rhesus monkey model","volume":"13","author":"Olvera-Monta\u00f1o","year":"2019","journal-title":"Drug Des Devel Ther"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/labinvest.3780409","article-title":"Preclinical evaluation of a phosphorothioate oligonucleotide in the retina of rhesus monkey","volume":"82","author":"Shen","year":"2002","journal-title":"Lab Invest"},{"key":"bib24","first-page":"567","article-title":"Experimental choroidal neovascularization induced by laser in the eyes of rhesus monkeys","volume":"39","author":"Zhang","year":"2008","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"issue":"1","key":"bib25","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1001\/archopht.118.1.78","article-title":"Angiography of fluoresceinated anti-vascular endothelial growth factor antibody and dextrans in experimental choroidal neovascularization","volume":"118","author":"Tolentino","year":"2000","journal-title":"Arch Ophthalmol"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1001\/archopht.120.3.338","article-title":"Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment","volume":"120","author":"Krzystolik","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"4738","DOI":"10.1167\/iovs.09-4890","article-title":"Relative contribution of VEGF and TNF-alpha in the cynomolgus laser-induced CNV model: comparing the efficacy of bevacizumab, adalimumab, and ESBA105","volume":"51","author":"Lichtlen","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s00417-008-0936-y","article-title":"Are intravitreal bevacizumab and ranibizumab effective in a rat model of choroidal neovascularization?","volume":"247","author":"Lu","year":"2009","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1167\/iovs.07-1175","article-title":"Interaction between bevacizumab and murine VEGF-A: a reassessment","volume":"49","author":"Yu","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"134","DOI":"10.3390\/pharmaceutics14010134","article-title":"Topical drug delivery to the posterior segment of the eye","volume":"14","author":"Loscher","year":"2022","journal-title":"Pharmaceutics"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.jconrel.2020.07.031","article-title":"Intravitreal hydrogels for sustained release of therapeutic proteins","volume":"326","author":"Ilochonwu","year":"2020","journal-title":"J Control Release"},{"issue":"4","key":"bib32","first-page":"149","article-title":"New ophthalmic drug delivery systems","volume":"44","author":"Castro-Balado","year":"2020","journal-title":"Farm Hosp"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.2147\/OPTH","article-title":"Systemic side effects of eye drops: a pharmacokinetic perspective","volume":"10","author":"Farkouh","year":"2016","journal-title":"Clin Ophthalmol"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1089\/jop.1987.3.177","article-title":"Systemic side effects from ophthalmic timolol and their prevention","volume":"3","author":"Fraunfelder","year":"1987","journal-title":"J Ocul Pharmacol"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1001\/archophthalmol.2009.27","article-title":"Suppression and regression of choroidal neovascularization by the multitargeted kinase inhibitor pazopanib","volume":"127","author":"Takahashi","year":"2009","journal-title":"Arch Ophthalmol"},{"issue":"1-3","key":"bib36","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ejphar.2011.05.016","article-title":"Anti-angiogenic effects of the receptor tyrosine kinase inhibitor, pazopanib, on choroidal neovascularization in rats","volume":"666","author":"Yafai","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.ophtha.2014.09.036","article-title":"Clinical evaluation of pazopanib eye drops versus ranibizumab intravitreal injections in subjects with neovascular age-related macular degeneration","volume":"122","author":"Csaky","year":"2015","journal-title":"Ophthalmology"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"101113","DOI":"10.1016\/j.preteyeres.2022.101113","article-title":"Towards a better understanding of non-exudative choroidal and macular neovascularization","volume":"92","author":"Sacconi","year":"2023","journal-title":"Prog Retin Eye Res"},{"issue":"6","key":"bib39","doi-asserted-by":"publisher","first-page":"e0217805","DOI":"10.1371\/journal.pone.0217805","article-title":"Progression of subclinical choroidal neovascularization in age-related macular degeneration","volume":"14","author":"Heiferman","year":"2019","journal-title":"PLoS One"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1111\/jnc.2008.104.issue-4","article-title":"Serine racemase expression and D-serine content are developmentally regulated in neuronal ganglion cells of the retina","volume":"104","author":"Dun","year":"2008","journal-title":"J Neurochem"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"6789","DOI":"10.1073\/pnas.1237052100","article-title":"D-serine and serine racemase are present in the vertebrate retina and contribute to the physiological activation of NMDA receptors","volume":"100","author":"Stevens","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"140447","DOI":"10.1016\/j.bbapap.2020.140447","article-title":"TGFbeta1-Smad3 signaling mediates the formation of a stable serine racemase dimer in microglia","volume":"1868","author":"Beltran-Castillo","year":"2020","journal-title":"Biochim Biophys Acta Proteins Proteom"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"3149","DOI":"10.1073\/pnas.1215929110","article-title":"Astrocyte-induced cortical vasodilation is mediated by D-serine and endothelial nitric oxide synthase","volume":"110","author":"Stobart","year":"2013","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Translational Vision Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2800685","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T15:30:58Z","timestamp":1723563058000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2800685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,13]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.13.8.24","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8,13]]}}}