{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:17:06Z","timestamp":1789906626825,"version":"4.0.1"},"reference-count":36,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"8","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2024,8,5]]},"DOI":"10.1167\/tvst.13.8.8","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T16:31:07Z","timestamp":1722875467000},"page":"8","source":"Crossref","is-referenced-by-count":4,"title":["Identification of the Metabolic Signature of Aging Retina"],"prefix":"10.1167","volume":"13","author":[{"given":"Wan","family":"Mu","sequence":"first","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Han","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Tong","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Ben","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mudi","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Ren","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Huang","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Li","sequence":"additional","affiliation":[{"name":"The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumiao","family":"Li","sequence":"additional","affiliation":[{"name":"The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1146\/vision.2021.7.issue-1","article-title":"Aging of the retina: molecular and metabolic turbulences and potential interventions","volume":"7","author":"Campello","year":"2021","journal-title":"Annu Rev Vis Sci"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"16003","DOI":"10.1038\/npjamd.2016.3","article-title":"A glimpse at the aging eye","volume":"2","author":"Lin","year":"2016","journal-title":"NPJ Aging Mech Dis"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.preteyeres.2018.10.003","article-title":"Immune regulation in the aging retina","volume":"69","author":"Chen","year":"2019","journal-title":"Prog Retin Eye Res"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"101779","DOI":"10.1016\/j.redox.2020.101779","article-title":"Oxidative stress in the light-exposed retina and its implication in age-related macular degeneration","volume":"37","author":"Ozawa","year":"2020","journal-title":"Redox Biol"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"E4472","DOI":"10.1073\/pnas.1702302114","article-title":"Involvement of a gut-retina axis in protection against dietary glycemia-induced age-related macular degeneration","volume":"114","author":"Rowan","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"464","DOI":"10.3390\/cells9020464","article-title":"Characterizing the retinal phenotype in the high-fat diet and western diet mouse models of prediabetes","volume":"9","author":"Asare-Bediako","year":"2020","journal-title":"Cells"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"895147","DOI":"10.1155\/2013\/895147","article-title":"Smoking and age-related macular degeneration: review and update","volume":"2013","author":"Velilla","year":"2013","journal-title":"J Ophthalmol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"107525","DOI":"10.1016\/j.celrep.2020.107525","article-title":"Genome-wide profiling identifies DNA methylation signatures of aging in rod photoreceptors associated with alterations in energy metabolism","volume":"31","author":"Corso-D\u00edaz","year":"2020","journal-title":"Cell Rep"},{"key":"bib9","first-page":"1570","article-title":"Metabolome profiling in aging studies","volume":"11","author":"Balashova","year":"2022","journal-title":"Biology (Basel)"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.preteyeres.2018.11.002","article-title":"Metabolomics in the study of retinal health and disease","volume":"69","author":"La\u00edns","year":"2019","journal-title":"Prog Retin Eye Res"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/nrm.2016.25","article-title":"Metabolomics: beyond biomarkers and towards mechanisms","volume":"17","author":"Johnson","year":"2016","journal-title":"Nat Rev Mol Cell Biol"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"e2200130","DOI":"10.1002\/smtd.v6.7","article-title":"Precise metabolomics reveals a diversity of aging-associated metabolic features","volume":"6","author":"Tian","year":"2022","journal-title":"Small Methods"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1038\/nprot.2009.191","article-title":"Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo","volume":"4","author":"Debacq-Chainiaux","year":"2009","journal-title":"Nat Protoc"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"4992","DOI":"10.1158\/0008-5472.CAN-13-0308","article-title":"Metabolic characterization of hepatocellular carcinoma using nontargeted tissue metabolomics","volume":"73","author":"Huang","year":"2013","journal-title":"Cancer Res"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.medj.2023.06.010","article-title":"Determining a multimodal aging clock in a cohort of Chinese women","volume":"4","author":"Li","year":"2023","journal-title":"Med"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.plipres.2011.02.004","article-title":"Mechanisms of glycerophospholipid homeostasis in mammalian cells","volume":"50","author":"Hermansson","year":"2011","journal-title":"Prog Lipid Res"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.3390\/ijms20051149","article-title":"An updated review of lysophosphatidylcholine metabolism in human diseases","volume":"20","author":"Law","year":"2019","journal-title":"Int J Mol Sci"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1146\/physiol.2019.81.issue-1","article-title":"Phospholipid remodeling in physiology and disease","volume":"81","author":"Wang","year":"2019","journal-title":"Annu Rev Physiol"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3390\/ijms22010175","article-title":"Whole blood metabolomics in aging research","volume":"22","author":"Kondoh","year":"2020","journal-title":"Int J Mol Sci"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.neurobiolaging.2018.07.024","article-title":"Metabolic signature of the aging eye in mice","volume":"71","author":"Wang","year":"2018","journal-title":"Neurobiol Aging"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3389\/fmolb.2018.00029","article-title":"A three-ring circus: metabolism of the three proteogenic aromatic amino acids and their role in the health of plants and animals","volume":"5","author":"Parthasarathy","year":"2018","journal-title":"Front Mol Biosci"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1194\/jlr.R046094","article-title":"Diversity and function of membrane glycerophospholipids generated by the remodeling pathway in mammalian cells","volume":"55","author":"Hishikawa","year":"2014","journal-title":"J Lipid Res"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.ophtha.2017.08.008","article-title":"Human plasma metabolomics study across all stages of age-related macular degeneration identifies potential lipid biomarkers","volume":"125","author":"La\u00edns","year":"2018","journal-title":"Ophthalmology"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"101085","DOI":"10.1016\/j.xcrm.2023.101085","article-title":"Integrating genetics and metabolomics from multi-ethnic and multi-fluid data reveals putative mechanisms for age-related macular degeneration","volume":"4","author":"Han","year":"2023","journal-title":"Cell Rep Med"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.neurobiolaging.2013.08.001","article-title":"Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease","volume":"35","author":"Whiley","year":"2014","journal-title":"Neurobiol Aging"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.plipres.2011.06.001","article-title":"Glycerophospholipids and glycerophospholipid-derived lipid mediators: a complex meshwork in Alzheimer's disease pathology","volume":"50","author":"Frisardi","year":"2011","journal-title":"Prog Lipid Res"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"2591","DOI":"10.3390\/cells10102591","article-title":"Lipid profiling of Alzheimer's disease brain highlights enrichment in glycerol(phospho)lipid, and sphingolipid metabolism","volume":"10","author":"Akyol","year":"2021","journal-title":"Cells"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"3472","DOI":"10.1093\/brain\/awac176","article-title":"Lipid pathway dysfunction is prevalent in patients with Parkinson's disease","volume":"145","author":"Galper","year":"2022","journal-title":"Brain"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"829425","DOI":"10.3389\/fimmu.2022.829425","article-title":"Comprehensive metabolic profiling of inflammation indicated key roles of glycerophospholipid and arginine metabolism in coronary artery disease","volume":"13","author":"Zhu","year":"2022","journal-title":"Front Immunol"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"E1060","DOI":"10.1210\/jc.2012-4132","article-title":"Metabolic signature shift in type 2 diabetes mellitus revealed by mass spectrometry-based metabolomics","volume":"98","author":"Xu","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"e1056","DOI":"10.1002\/ctm2.v12.9","article-title":"Sphingosine 1-phosphate lyase facilitates cancer progression through converting sphingolipids to glycerophospholipids","volume":"12","author":"Uranbileg","year":"2022","journal-title":"Clin Transl Med"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3109\/10409238.2012.735643","article-title":"The role of phosphatidylcholine and choline metabolites to cell proliferation and survival","volume":"48","author":"Ridgway","year":"2013","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.cell.2019.10.005","article-title":"Cellular senescence: defining a path forward","volume":"179","author":"Gorgoulis","year":"2019","journal-title":"Cell"},{"key":"bib34","first-page":"31","article-title":"Mitochondrial dysfunction in the aging retina","volume":"8","author":"Eells","year":"2019","journal-title":"Biology (Basel)"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/bs.ircmb.2015.10.001","article-title":"Phosphatidylethanolamine metabolism in health and disease","volume":"321","author":"Calzada","year":"2016","journal-title":"Int Rev Cell Mol Biol"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/cdd.2014.219","article-title":"Phosphatidylethanolamine positively regulates autophagy and longevity","volume":"22","author":"Rockenfeller","year":"2015","journal-title":"Cell Death Differ"}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2800649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T16:31:13Z","timestamp":1722875473000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2800649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,5]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.13.8.8","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8,5]]}}}