{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:25:25Z","timestamp":1784690725073,"version":"3.55.0"},"reference-count":44,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"1","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2025,1,9]]},"DOI":"10.1167\/tvst.14.1.7","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T16:00:56Z","timestamp":1736438456000},"page":"7","source":"Crossref","is-referenced-by-count":4,"title":["Pulsed Ultrasound-Mediated Drug Delivery Enhancement Through Human Sclera"],"prefix":"10.1167","volume":"14","author":[{"given":"Shuqi","family":"You","sequence":"first","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China"},{"name":"Department of Ophthalmology, Children's Hospital of Fudan University, National Children\u2019s Medical Center, Shanghai, China"},{"name":"NHC Key Laboratory of Myopia (Fudan University); Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suqian","family":"Wu","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China"},{"name":"NHC Key Laboratory of Myopia (Fudan University); Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shicheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai Acoustics Laboratory, Chinese Academy of Science, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, USA"},{"name":"Emory Eye Center, Emory University, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China"},{"name":"NHC Key Laboratory of Myopia (Fudan University); Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangwu","family":"Chen","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China"},{"name":"NHC Key Laboratory of Myopia (Fudan University); Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Acoustics Laboratory, Chinese Academy of Science, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Xia","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China"},{"name":"NHC Key Laboratory of Myopia (Fudan University); Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Xiong","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China"},{"name":"NHC Key Laboratory of Myopia (Fudan University); Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongsheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Advanced Ultrasonic Technology of National Innovation Center Par Excellence, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofen","family":"Mo","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China"},{"name":"NHC Key Laboratory of Myopia (Fudan University); Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"2","key":"bib1","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/S2214-109X(13)70145-1","article-title":"Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis","volume":"2","author":"Wong","year":"2014","journal-title":"Lancet Glob Health"},{"issue":"11","key":"bib2","first-page":"844","article-title":"Global data on visual impairment in the year 2002","volume":"82","author":"Resnikoff","year":"2004","journal-title":"Bull World Health Organ"},{"issue":"1\u20132","key":"bib3","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.ijpharm.2016.11.053","article-title":"Pharmaceutical technology can turn a traditional drug, dexamethasone into a first-line ocular medicine. A global perspective and future trends","volume":"516","author":"Villanueva","year":"2017","journal-title":"Int J Pharm"},{"issue":"5","key":"bib4","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1038\/eye.2014.13","article-title":"A review of anti-VEGF agents for proliferative diabetic retinopathy","volume":"28","author":"Osaadon","year":"2014","journal-title":"Eye"},{"issue":"5\u20136","key":"bib5","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3109\/08820538.2014.962167","article-title":"Complications of intravitreal injections in patients with diabetes","volume":"29","author":"Shikari","year":"2014","journal-title":"Semin Ophthalmol"},{"issue":"3","key":"bib6","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3341\/kjo.2017.0081","article-title":"Factors associated with pain following intravitreal injections","volume":"32","author":"Shin","year":"2018","journal-title":"Korean J Ophthalmol"},{"issue":"4","key":"bib7","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/j.survophthal.2021.12.002","article-title":"Efficacy and safety of intravitreal and periocular injection of corticosteroids in noninfectious uveitis: a systematic review","volume":"67","author":"Jos\u00e9-Vieira","year":"2022","journal-title":"Surv Ophthalmol"},{"issue":"4","key":"bib8","doi-asserted-by":"publisher","first-page":"323","DOI":"10.5935\/0004-2749.20180063","article-title":"Effects of sub-Tenon's triamcinolone injections in patients with uveitis","volume":"81","author":"Ferreira","year":"2018","journal-title":"Arq Bras Oftalmol"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"101389","DOI":"10.1016\/j.jddst.2019.101389","article-title":"Target strategies for drug delivery bypassing ocular barriers","volume":"55","author":"Suri","year":"2020","journal-title":"J Drug Deliv Sci Technol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.addr.2017.09.008","article-title":"Overcoming ocular drug delivery barriers through the use of physical forces","volume":"126","author":"Huang","year":"2018","journal-title":"Adv Drug Deliv Rev"},{"issue":"4","key":"bib11","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/s11095-018-2368-7","article-title":"Formulation stabilization and disaggregation of bevacizumab, ranibizumab and aflibercept in dilute solutions","volume":"35","author":"Giannos","year":"2018","journal-title":"Pharm Res"},{"issue":"6","key":"bib12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11095-018-2392-7","article-title":"Photokinetic drug delivery: near infrared (NIR) induced permeation enhancement of bevacizumab, ranibizumab and aflibercept through human sclera","volume":"35","author":"Giannos","year":"2018","journal-title":"Pharm Res"},{"issue":"5225","key":"bib13","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1126\/science.7638603","article-title":"Ultrasound-mediated transdermal protein delivery","volume":"269","author":"Mitragotri","year":"1995","journal-title":"Science"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.addr.2014.01.008","article-title":"Ultrasound-mediated blood-brain barrier disruption for targeted drug delivery in the central nervous system","volume":"72","author":"Aryal","year":"2014","journal-title":"Adv Drug Deliv Rev"},{"issue":"1","key":"bib15","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.jconrel.2012.06.012","article-title":"The kinetics of blood brain barrier permeability and targeted doxorubicin delivery into brain induced by focused ultrasound","volume":"162","author":"Park","year":"2012","journal-title":"J Control Release"},{"issue":"15","key":"bib16","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/S1359-6446(04)03170-8","article-title":"Ultrasound and transdermal drug delivery","volume":"9","author":"Lavon","year":"2004","journal-title":"Drug Discov Today"},{"issue":"1\u20132","key":"bib17","first-page":"16","article-title":"Ultrasound-enhanced intrascleral delivery of protein","volume":"401","author":"Chi","year":"2010","journal-title":"Int J Pharm"},{"issue":"1","key":"bib18","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.ejpb.2014.04.011","article-title":"A novel technology using transscleral ultrasound to deliver protein loaded nanoparticles","volume":"88","author":"Huang","year":"2014","journal-title":"Eur J Pharm Biopharm"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.ejps.2017.01.016","article-title":"Ultrasound-enhanced penetration through sclera depends on frequency of sonication and size of macromolecules","volume":"100","author":"Chau","year":"2017","journal-title":"Eur J Pharm Sci"},{"issue":"6","key":"bib20","doi-asserted-by":"publisher","first-page":"4358","DOI":"10.1167\/iovs.13-11978","article-title":"Ultrasound-mediated transscleral delivery of macromolecules to the posterior segment of rabbit eye in vivo","volume":"54","author":"Suen","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"14","key":"bib21","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1167\/tvst.10.14.2","article-title":"Feasibility of therapeutic ultrasound application in topical scleral delivery of avastin","volume":"10","author":"Almogbil","year":"2021","journal-title":"Transl Vis Sci Technol"},{"issue":"5","key":"bib22","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1080\/165019701750419608","article-title":"Therapeutic ultrasound: temperature increase at different depths by different modes in a human cadaver","volume":"33","author":"Cambier","year":"2001","journal-title":"J Rehabil Med"},{"issue":"11","key":"bib23","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.1007\/s11095-008-9684-2","article-title":"Can ultrasound solve the transport barrier of the neural retina??","volume":"25","author":"Peeters","year":"2008","journal-title":"Pharm Res"},{"issue":"8","key":"bib24","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/S1470-2045(18)30332-2","article-title":"Safety and feasibility of ultrasound-triggered targeted drug delivery of doxorubicin from thermosensitive liposomes in liver tumours (TARDOX): a single-centre, open-label, phase 1 trial","volume":"19","author":"Lyon","year":"2018","journal-title":"Lancet Oncol"},{"issue":"9","key":"bib25","first-page":"1893","article-title":"Human scleral permeability. Effects of age, cryotherapy, transscleral diode laser, and surgical thinning","volume":"36","author":"Olsen","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"bib26","doi-asserted-by":"publisher","first-page":"2650","DOI":"10.1016\/j.ultrasmedbio.2016.07.013","article-title":"Examination of effects of low-frequency ultrasound on scleral permeability and collagen network","volume":"42","author":"Suen","year":"2016","journal-title":"Ultrasound Med Biol"},{"issue":"1\u20132","key":"bib27","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ijpharm.2009.12.046","article-title":"Iontophoretic transport of charged macromolecules across human sclera","volume":"388","author":"Chopra","year":"2010","journal-title":"Int J Pharm"},{"key":"bib28","first-page":"9","article-title":"Acoustic bubble detection - 1. The detection of stable gas bodies","author":"Leighton","year":"1994;7","journal-title":"J Environ Eng (New York)."},{"issue":"6","key":"bib29","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1016\/j.ultrasmedbio.2013.12.032","article-title":"Contribution of inertial cavitation in the enhancement of in vitro transscleral drug delivery","volume":"40","author":"Razavi","year":"2014","journal-title":"Ultrasound Med Biol"},{"issue":"11","key":"bib30","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.3109\/02713683.2014.980006","article-title":"Transsclera drug delivery by pulsed high-intensity focused ultrasound (HIFU): an ex vivo study","volume":"40","author":"Murugappan","year":"2015","journal-title":"Curr Eye Res"},{"key":"bib31","first-page":"259","article-title":"Porcine sclera as a model of human sclera for in vitro transport experiments: histology, SEM, and comparative permeability","volume":"15","author":"Nicoli","year":"2009","journal-title":"Mol Vis"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1242\/jcs.74.1.95","article-title":"The ultrastructural organization of proteoglycans and collagen in human and rabbit scleral matrix","volume":"74","author":"Young","year":"1985","journal-title":"J Cell Sci"},{"issue":"1","key":"bib33","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.exer.2012.03.004","article-title":"Intraocular distribution of melanin in human, monkey, rabbit, minipig and dog eyes","volume":"98","author":"Durairaj","year":"2012","journal-title":"Exp Eye Res"},{"issue":"10","key":"bib34","first-page":"3162","article-title":"880 kHz ultrasound treatment for drug delivery to the vitreous humor","volume":"10","author":"Lamy","year":"2018","journal-title":"Am J Transl Res"},{"issue":"6","key":"bib35","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/j.ultrasmedbio.2017.01.013","article-title":"A model for porosity changes occurring during ultrasound-enhanced transcorneal drug delivery","volume":"43","author":"Hariharan","year":"2017","journal-title":"Ultrasound Med Biol"},{"issue":"2","key":"bib36","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1089\/jop.2022.0114","article-title":"Pulsed ultrasound-mediated enhancement on transscleral and transconjunctival fluorescein sodium delivery to rabbit eye in vivo","volume":"39","author":"You","year":"2023","journal-title":"J Ocul Pharmacol Ther"},{"issue":"3","key":"bib37","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/S0014-4835(03)00212-4","article-title":"Scleral structure, organisation and disease. A review","volume":"78","author":"Watson","year":"2004","journal-title":"Exp Eye Res"},{"issue":"1","key":"bib38","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1002\/aic.690440123","article-title":"Fiber matrix model of sclera and corneal stroma for drug delivery to the eye","volume":"44","author":"Edwards","year":"1998","journal-title":"Aiche J"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.addr.2013.11.008","article-title":"Understanding ultrasound induced sonoporation: definitions and underlying mechanisms","volume":"72","author":"Lentacker","year":"2014","journal-title":"Adv Drug Deliv Rev"},{"issue":"4","key":"bib41","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.ultrasmedbio.2012.11.010","article-title":"Ultrasound-enhanced delivery of antibiotics and anti-inflammatory drugs into the eye","volume":"39","author":"Nabili","year":"2013","journal-title":"Ultrasound Med Biol"},{"issue":"1","key":"bib42","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/BF00385934","article-title":"Thresholds for rectified diffusion and acoustic microstreaming by bubbles in biological tissue","volume":"38","author":"Lewin","year":"1982","journal-title":"Appl Sci Res"},{"issue":"1","key":"bib43","doi-asserted-by":"publisher","first-page":"15532","DOI":"10.1038\/s41598-019-52069-w","article-title":"Ultrasound-assisted gatifloxacin delivery in mouse cornea, in vivo","volume":"9","author":"Jegal","year":"2019","journal-title":"Sci Rep"},{"issue":"1","key":"bib44","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1006\/exer.1993.1004","article-title":"Heat shock response and thermal resistance in cultured human retinal pigment epithelium","volume":"56","author":"Wakakura","year":"1993","journal-title":"Exp Eye Res"},{"key":"bib39","article-title":"Acoustic cavitation and bubble dynamics","volume-title":"Ultrasound: Its Chemical, Physical, and Biological Effects","author":"Atchley","year":"1988"}],"container-title":["Translational Vision Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2802445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T16:01:03Z","timestamp":1736438463000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2802445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,9]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,2]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.14.1.7","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1,9]]}}}