{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T17:29:44Z","timestamp":1794245384912,"version":"4.9.0"},"reference-count":32,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"2","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2025,2,25]]},"DOI":"10.1167\/tvst.14.2.24","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T15:59:19Z","timestamp":1740499159000},"page":"24","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of Serum and Aqueous Humor Neurofilament Light Chain as Markers of Neurodegeneration in Glaucoma"],"prefix":"10.1167","volume":"14","author":[{"given":"Jonathan B.","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani","family":"El Helwe","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henisk","family":"Falah","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno L.","family":"Hammerschlag","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A.","family":"Schultz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Baldwin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixi","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan A.","family":"Vasan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin","family":"Meeker","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silas L.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Kivis\u00e4kk","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sol\u00e1-Del Valle","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milica A.","family":"Margeta","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"1","key":"bib1","doi-asserted-by":"publisher","first-page":"e053805","DOI":"10.1136\/bmjopen-2021-053805","article-title":"Time trends, associations and prevalence of blindness and vision loss due to glaucoma: an analysis of observational data from the Global Burden of Disease Study 2017","volume":"12","author":"Sun","year":"2022","journal-title":"BMJ Open"},{"issue":"18","key":"bib2","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The pathophysiology and treatment of glaucoma: a review","volume":"311","author":"Weinreb","year":"2014","journal-title":"JAMA"},{"issue":"Suppl 1","key":"bib3","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.survophthal.2008.08.006","article-title":"Risk factors for glaucoma onset and progression","volume":"53","author":"Coleman","year":"2008","journal-title":"Surv Ophthalmol"},{"issue":"2","key":"bib4","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.ogla.2022.08.017","article-title":"Comparison of 10-2 and 24-2 perimetry to diagnose glaucoma using OCT as an independent reference standard","volume":"6","author":"Onyekaba","year":"2023","journal-title":"Ophthalmol Glaucoma"},{"issue":"Suppl 2","key":"bib5","doi-asserted-by":"publisher","first-page":"ii15","DOI":"10.1136\/bjophthalmol-2013-304326","article-title":"OCT for glaucoma diagnosis, screening and detection of glaucoma progression","volume":"98","author":"Bussel","year":"2014","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"bib6","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.molmed.2017.11.004","article-title":"Monitoring neurodegeneration in glaucoma: therapeutic implications","volume":"24","author":"Ban","year":"2018","journal-title":"Trends Mol Med"},{"issue":"4","key":"bib7","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1097\/IIO.0000000000000285","article-title":"Imaging retinal ganglion cell death and dysfunction in glaucoma","volume":"59","author":"Liu","year":"2019","journal-title":"Int Ophthalmol Clin"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"100976","DOI":"10.1016\/j.preteyeres.2021.100976","article-title":"Detecting retinal cell stress and apoptosis with DARC: progression from lab to clinic","volume":"86","author":"Cordeiro","year":"2022","journal-title":"Prog Retin Eye Res"},{"issue":"7","key":"bib9","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1080\/14737159.2020.1758067","article-title":"A CNN-aided method to predict glaucoma progression using DARC (detection of apoptosing retinal cells)","volume":"20","author":"Normando","year":"2020","journal-title":"Expert Rev Mol Diagn"},{"issue":"2","key":"bib10","doi-asserted-by":"publisher","first-page":"e88855","DOI":"10.1371\/journal.pone.0088855","article-title":"Single-cell resolution imaging of retinal ganglion cell apoptosis in vivo using a cell-penetrating caspase-activatable peptide probe","volume":"9","author":"Qiu","year":"2014","journal-title":"PLoS One"},{"issue":"7","key":"bib11","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1097\/IJG.0000000000000980","article-title":"Noninvasive detection of mitochondrial dysfunction in ocular hypertension and primary open-angle glaucoma","volume":"27","author":"Geyman","year":"2018","journal-title":"J Glaucoma"},{"issue":"4","key":"bib12","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.ogla.2021.12.006","article-title":"Mitochondrial dysfunction in primary open-angle glaucoma characterized by flavoprotein fluorescence at the optic nerve head","volume":"5","author":"Zhou","year":"2022","journal-title":"Ophthalmol Glaucoma"},{"issue":"2","key":"bib13","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/s41591-018-0304-3","article-title":"Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease","volume":"25","author":"Preische","year":"2019","journal-title":"Nat Med"},{"issue":"22","key":"bib14","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1212\/WNL.0000000000001642","article-title":"Neurofilament light chain: a prognostic biomarker in amyotrophic lateral sclerosis","volume":"84","author":"Lu","year":"2015","journal-title":"Neurology"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"104970","DOI":"10.1016\/j.ebiom.2024.104970","article-title":"Guidance for use of neurofilament light chain as a cerebrospinal fluid and blood biomarker in multiple sclerosis management","volume":"101","author":"Freedman","year":"2024","journal-title":"EBioMedicine"},{"issue":"10","key":"bib16","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1136\/bjo-2021-320828","article-title":"Neurofilament light chain: a new marker for neuronal decay in the anterior chamber fluid of patients with glaucoma","volume":"107","author":"Woltsche","year":"2023","journal-title":"Br J Ophthalmol"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.2147\/OPTH.S438358","article-title":"Neurofilament light chain in aqueous humor as a marker of neurodegeneration in glaucoma","volume":"17","author":"Lin","year":"2023","journal-title":"Clin Ophthalmol"},{"issue":"5","key":"bib18","doi-asserted-by":"publisher","first-page":"100517","DOI":"10.1016\/j.xops.2024.100517","article-title":"Using electronic health record data to determine the safety of aqueous humor liquid biopsies for molecular analyses","volume":"4","author":"Wolf","year":"2024","journal-title":"Ophthalmol Sci"},{"issue":"3","key":"bib19","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"issue":"6","key":"bib21","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/nbt.1641","article-title":"Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations","volume":"28","author":"Rissin","year":"2010","journal-title":"Nat Biotechnol"},{"issue":"1","key":"bib22","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/s41433-023-02650-5","article-title":"Improving glaucoma staging in clinical practice by combining the ICD-10 glaucoma severity classification system and optical coherence tomography","volume":"38","author":"Leshno","year":"2024","journal-title":"Eye (Lond)"},{"issue":"2","key":"bib23","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1080\/09286586.2016.1259636","article-title":"Tutorial on biostatistics: linear regression analysis of continuous correlated eye data","volume":"24","author":"Ying","year":"2017","journal-title":"Ophthalmic Epidemiol"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"8344","DOI":"10.1038\/srep08344","article-title":"Generation of retinal ganglion cells with functional axons from human induced pluripotent stem cells","volume":"5","author":"Tanaka","year":"2015","journal-title":"Sci Rep"},{"issue":"1-2","key":"bib25","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/S0006-8993(02)04052-0","article-title":"Rat retinal ganglion cell loss caused by kainate, NMDA and ischemia correlates with a reduction in mRNA and protein of Thy-1 and neurofilament light","volume":"963","author":"Chidlow","year":"2003","journal-title":"Brain Res"},{"issue":"11","key":"bib26","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1167\/tvst.12.11.9","article-title":"Correlation of aqueous, vitreous, and serum protein levels in patients with retinal diseases","volume":"12","author":"Wilson","year":"2023","journal-title":"Transl Vis Sci Technol"},{"issue":"11","key":"bib27","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1002\/mds.28206","article-title":"Validation of serum neurofilament light chain as a biomarker of Parkinson's disease progression","volume":"35","author":"Mollenhauer","year":"2020","journal-title":"Mov Disord"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"689938","DOI":"10.3389\/fnins.2021.689938","article-title":"Neurofilament proteins as biomarkers to monitor neurological diseases and the efficacy of therapies","volume":"15","author":"Yuan","year":"2021","journal-title":"Front Neurosci"},{"issue":"6","key":"bib29","doi-asserted-by":"crossref","first-page":"e610","DOI":"10.1212\/WNL.0000000000009983","article-title":"Neurofilament light as a biomarker in traumatic brain injury","volume":"95","author":"Shahim","year":"2020","journal-title":"Neurology"},{"issue":"10","key":"bib30","doi-asserted-by":"publisher","first-page":"e1007","DOI":"10.1212\/WNL.0000000000007032","article-title":"Blood neurofilament light chain as a biomarker of MS disease activity and treatment response","volume":"92","author":"Kuhle","year":"2019","journal-title":"Neurology"},{"issue":"2","key":"bib32","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1002\/alz.12404","article-title":"Characterizing plasma NfL in a community-dwelling multi-ethnic cohort: results from the HABLE study","volume":"18","author":"O'Bryant","year":"2022","journal-title":"Alzheimers Dement"},{"key":"bib20","volume-title":"Pwr: Basic Functions for Power Analysis","author":"Champely","year":"2020"},{"key":"bib31","author":"Pessuti"}],"container-title":["Translational Vision Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2802630","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T15:59:24Z","timestamp":1740499164000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2802630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,25]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2,3]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.14.2.24","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2,25]]}}}