{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:25:36Z","timestamp":1779891936568,"version":"3.53.1"},"reference-count":43,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"5","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2025,5,8]]},"DOI":"10.1167\/tvst.14.5.12","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T16:30:55Z","timestamp":1746721855000},"page":"12","source":"Crossref","is-referenced-by-count":1,"title":["Advancing Toward a World Without Vision Loss From Diabetes: Insights From The Mary Tyler Moore Vision Initiative Symposium 2024 on Curing Vision Loss From Diabetes"],"prefix":"10.1167","volume":"14","author":[{"given":"Ward","family":"Fickweiler","sequence":"first","affiliation":[{"name":"Beetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA"},{"name":"Department of Ophthalmology, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantina","family":"Sampani","sequence":"additional","affiliation":[{"name":"Beetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA"},{"name":"Department of Medicine, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorene S.","family":"Markel","sequence":"additional","affiliation":[{"name":"Mary Tyler Moore Vision Initiative, Greenwich, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Robert","family":"Levine","sequence":"additional","affiliation":[{"name":"Mary Tyler Moore Vision Initiative, Greenwich, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer K.","family":"Sun","sequence":"additional","affiliation":[{"name":"Beetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA"},{"name":"Department of Ophthalmology, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Gardner","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"11","key":"bib1","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1167\/tvst.12.11.33","article-title":"Report From the 2022 Mary Tyler Moore Vision Initiative Diabetic Retinal Disease Clinical Endpoints Workshop","volume":"12","author":"Levine","year":"2023","journal-title":"Transl Vis Sci Technol"},{"issue":"4","key":"bib2","doi-asserted-by":"publisher","first-page":"100494","DOI":"10.1016\/j.xops.2024.100494","article-title":"Role of systemic factors in improving the prognosis of diabetic retinal disease and predicting response to diabetic retinopathy treatment","volume":"4","author":"Mellor","year":"2024","journal-title":"Ophthalmol Sci"},{"issue":"5","key":"bib3","doi-asserted-by":"publisher","first-page":"100519","DOI":"10.1016\/j.xops.2024.100519","article-title":"Visual function measurements in eyes with diabetic retinopathy: an expert opinion on available measures","volume":"4","author":"Glassman","year":"2024","journal-title":"Ophthalmol Sci"},{"issue":"5","key":"bib4","doi-asserted-by":"publisher","first-page":"100521","DOI":"10.1016\/j.xops.2024.100521","article-title":"Rationale of basic and cellular mechanisms considered in updating the staging system for diabetic retinal disease","volume":"4","author":"Hartnett","year":"2024","journal-title":"Ophthalmol Sci"},{"issue":"3","key":"bib5","doi-asserted-by":"publisher","first-page":"100449","DOI":"10.1016\/j.xops.2023.100449","article-title":"Imaging modalities for assessing the vascular component of diabetic retinal disease: review and consensus for an updated staging system","volume":"4","author":"Tan","year":"2024","journal-title":"Ophthalmol Sci"},{"issue":"3","key":"bib6","doi-asserted-by":"publisher","first-page":"100420","DOI":"10.1016\/j.xops.2023.100420","article-title":"A new approach to staging diabetic eye disease: staging of diabetic retinal neurodegeneration and diabetic macular edema","volume":"4","author":"Channa","year":"2024","journal-title":"Ophthalmol Sci"},{"issue":"2","key":"bib7","doi-asserted-by":"publisher","first-page":"100378","DOI":"10.1016\/j.xops.2023.100378","article-title":"Measuring quality of life in diabetic retinal disease: a narrative review of available patient-reported outcome measures","volume":"4","author":"Vujosevic","year":"2024","journal-title":"Ophthalmol Sci"},{"issue":"10","key":"bib8","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1167\/tvst.13.10.4","article-title":"Data harmonization, standardization, and collaboration for diabetic retinal disease (DRD) research: report from the 2024 Mary Tyler Moore Vision Initiative Workshop on Data","volume":"13","author":"Domalpally","year":"2024","journal-title":"Transl Vis Sci Technol"},{"issue":"11","key":"bib9","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1001\/jamaophthalmol.2024.3877","article-title":"Diabetic retinopathy in youths - a potentially unappreciated public health catastrophe","volume":"142","author":"Rosenthal","year":"2024","journal-title":"JAMA Ophthalmol"},{"issue":"4","key":"bib10","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.ophtha.2020.10.008","article-title":"Updating the staging system for diabetic retinal disease","volume":"128","author":"Sun","year":"2021","journal-title":"Ophthalmology"},{"issue":"4","key":"bib11","doi-asserted-by":"publisher","first-page":"e084574","DOI":"10.1136\/bmjopen-2024-084574","article-title":"Artificial intelligence-based prediction of diabetic retinopathy evolution (EviRed): protocol for a prospective cohort","volume":"14","author":"Tadayoni","year":"2024","journal-title":"BMJ Open"},{"issue":"22","key":"bib12","doi-asserted-by":"publisher","first-page":"6024","DOI":"10.1182\/blood-2010-10-311589","article-title":"Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A","volume":"117","author":"Joyal","year":"2011","journal-title":"Blood"},{"issue":"11","key":"bib13","doi-asserted-by":"publisher","first-page":"4807","DOI":"10.1172\/JCI76492","article-title":"Neuropilin-1 mediates myeloid cell chemoattraction and influences retinal neuroimmune crosstalk","volume":"124","author":"Dejda","year":"2014","journal-title":"J Clin Invest"},{"issue":"4","key":"bib14","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.cmet.2013.09.003","article-title":"Neuron-derived semaphorin 3A is an early inducer of vascular permeability in diabetic retinopathy via neuropilin-1","volume":"18","author":"Cerani","year":"2013","journal-title":"Cell Metab"},{"issue":"362","key":"bib15","doi-asserted-by":"publisher","first-page":"362ra144","DOI":"10.1126\/scitranslmed.aaf9440","article-title":"Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy","volume":"8","author":"Oubaha","year":"2016","journal-title":"Sci Transl Med"},{"issue":"2","key":"bib16","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s41580-020-00314-w","article-title":"Cellular senescence in ageing: from mechanisms to therapeutic opportunities","volume":"22","author":"Di Micco","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"bib17","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.cmet.2021.01.011","article-title":"Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition","volume":"33","author":"Crespo-Garcia","year":"2021","journal-title":"Cell Metab"},{"issue":"2","key":"bib18","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/s41591-024-02802-4","article-title":"Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results","volume":"30","author":"Crespo-Garcia","year":"2024","journal-title":"Nat Med"},{"issue":"2","key":"bib19","doi-asserted-by":"publisher","first-page":"e9","DOI":"10.1016\/j.ophtha.2021.10.001","article-title":"Collaborative Community on Ophthalmic Imaging Executive Committee. The collaborative community on ophthalmic imaging: accelerating global innovation and clinical utility","volume":"129","author":"Blumenkranz","year":"2022","journal-title":"Ophthalmology"},{"issue":"22","key":"bib20","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1001\/jama.2017.18152","article-title":"Development and validation of a deep learning system for diabetic retinopathy and related eye diseases using retinal images from multiethnic populations with diabetes","volume":"318","author":"Ting","year":"2017","journal-title":"JAMA"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41746-018-0040-6","article-title":"Pivotal trial of an autonomous AI-based diagnostic system for detection of diabetic retinopathy in primary care offices","volume":"1","author":"Abramoff","year":"2018","journal-title":"NPJ Digit Med"},{"issue":"5","key":"bib22","doi-asserted-by":"publisher","first-page":"e240","DOI":"10.1016\/S2589-7500(20)30060-1","article-title":"Artificial intelligence for teleophthalmology-based diabetic retinopathy screening in a national programme: an economic analysis modelling study","volume":"2","author":"Xie","year":"2020","journal-title":"Lancet Digit Health"},{"issue":"4","key":"bib23","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.ophtha.2020.10.008","article-title":"Updating the staging system for diabetic retinal disease","volume":"128","author":"Sun","year":"2021","journal-title":"Ophthalmology"},{"issue":"6","key":"bib24","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1001\/jama.2010.1111","article-title":"Prevalence of diabetic retinopathy in the United States, 2005-2008","volume":"304","author":"Zhang","year":"2010","journal-title":"JAMA"},{"issue":"4","key":"bib25","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1097\/IAE.0000000000003730","article-title":"Defining \u201cstrong\u201d versus \u201cweak\u201d response to antivascular endothelial growth factor treatment for center-involved diabetic macular edema","volume":"43","author":"Sun","year":"2023","journal-title":"Retina"},{"issue":"11","key":"bib26","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1016\/j.ophtha.2021.04.027","article-title":"Global prevalence of diabetic retinopathy and projection of burden through 2045: systematic review and meta-analysis","volume":"128","author":"Teo","year":"2021","journal-title":"Ophthalmology"},{"issue":"8","key":"bib27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1001\/jama.2021.9883","article-title":"Trends in prevalence of diabetes and control of risk factors in diabetes among US adults, 1999\u20132018","volume":"326","author":"Wang","year":"2021","journal-title":"JAMA"},{"issue":"5","key":"bib28","doi-asserted-by":"publisher","first-page":"956","DOI":"10.2337\/dc17-2524","article-title":"Changes in health insurance coverage under the Affordable Care Act: a national sample of U.S. adults with diabetes, 2009 and 2016","volume":"41","author":"Casagrande","year":"2018","journal-title":"Diabetes Care"},{"issue":"3","key":"bib29","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/S0161-6420(00)00600-X","article-title":"Patterns of adherence to diabetes vision care guidelines: baseline findings from the Diabetic Retinopathy Awareness Program","volume":"108","author":"Schoenfeld","year":"2001","journal-title":"Ophthalmology"},{"issue":"9","key":"bib30","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1001\/jamaophthalmol.2013.4694","article-title":"Socioeconomic disparity in use of eye care services among US adults with age-related eye diseases: National Health Interview Survey, 2002 and 2008","volume":"131","author":"Zhang","year":"2013","journal-title":"JAMA Ophthalmol"},{"issue":"12","key":"bib31","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.47102\/annals-acadmedsg.V38N12p1048","article-title":"Lack of awareness amongst community patients with diabetes and diabetic retinopathy: the Singapore Malay eye study","volume":"38","author":"Huang","year":"2009","journal-title":"Ann Acad Med Singap"},{"issue":"2","key":"bib32","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1001\/jamaophthalmol.2013.6426","article-title":"Underuse of the health care system by persons with diabetes mellitus and diabetic macular edema in the United States","volume":"132","author":"Bressler","year":"2014","journal-title":"JAMA Ophthalmol"},{"issue":"13","key":"bib33","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1167\/tvst.9.13.23","article-title":"Gait in elderly glaucoma: impact of lighting conditions, changes in lighting, and fear of falling","volume":"9","author":"Bicket","year":"2020","journal-title":"Transl Vis Sci Technol"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"101118","DOI":"10.1016\/j.eclinm.2021.101118","article-title":"Unraveling the concepts of distress, burnout, and depression in type 1 diabetes: a scoping review","volume":"40","author":"Kiriella","year":"2021","journal-title":"EClinicalMedicine"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.ajo.2020.12.001","article-title":"The Michigan Vision-Related Anxiety Questionnaire: a psychosocial outcomes measure for inherited retinal degenerations","volume":"225","author":"Lacy","year":"2021","journal-title":"Am J Ophthalmol"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.ajo.2020.08.032","article-title":"The Michigan Retinal Degeneration Questionnaire: a patient-reported outcome instrument for inherited retinal degenerations","volume":"222","author":"Lacy","year":"2021","journal-title":"Am J Ophthalmol"},{"issue":"8","key":"bib37","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1016\/j.jval.2011.06.013","article-title":"Content validity\u2013establishing and reporting the evidence in newly developed patient-reported outcomes (PRO) instruments for medical product evaluation: ISPOR PRO Good Research Practices Task Force report: part 2\u2013assessing respondent understanding","volume":"14","author":"Patrick","year":"2011","journal-title":"Value Health"},{"issue":"8","key":"bib38","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.jval.2011.06.014","article-title":"Content validity\u2013establishing and reporting the evidence in newly developed patient-reported outcomes (PRO) instruments for medical product evaluation: ISPOR PRO good research practices task force report: part 1\u2013eliciting concepts for a new PRO instrument","volume":"14","author":"Patrick","year":"2011","journal-title":"Value Health"},{"issue":"7","key":"bib39","first-page":"697-F0222\u20130697\u2013F0222","article-title":"Vitreous biopsy device and potential change in practice patterns in patients with infectious and non-infectious uveitis","volume":"63","author":"Weber","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"939","DOI":"10.2147\/OPTH.S292527","article-title":"A virtual reality orientation and mobility test for inherited retinal degenerations: testing a proof-of-concept after gene therapy","volume":"15","author":"Aleman","year":"2021","journal-title":"Clin Ophthalmol"},{"issue":"5","key":"bib42","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1111\/aos.16601","article-title":"Correlations between the Michigan Retinal Degeneration Questionnaire and visual function parameters in patients with retinitis pigmentosa","volume":"102","author":"Karuntu","year":"2024","journal-title":"Acta Ophthalmol"},{"issue":"10","key":"bib43","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1167\/tvst.13.10.15","article-title":"Endpoints and design for clinical trials in USH2A-related retinal degeneration: results and recommendations from the RUSH2A Natural History Study","volume":"13","author":"Maguire","year":"2024","journal-title":"Transl Vis Sci Technol"},{"key":"bib40","author":"Lauro"}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2802972","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T16:30:56Z","timestamp":1746721856000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2802972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,8]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.14.5.12","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5,8]]}}}