{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:03:35Z","timestamp":1788876215783,"version":"build-2803163510"},"reference-count":28,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"5","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2025,5,28]]},"DOI":"10.1167\/tvst.14.5.27","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T14:30:27Z","timestamp":1748442627000},"page":"27","source":"Crossref","is-referenced-by-count":5,"title":["Perifoveal Choriocapillaris Flow Deficits Associated With Cerebrospinal Fluid A\u03b2<sub>42<\/sub>\/tau in Presymptomatic Alzheimer's Disease"],"prefix":"10.1167","volume":"14","author":[{"given":"Jane W.","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Corradetti","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA"},{"name":"Doheny Eye Institute, Pasadena, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Analytical Biochemistry Core, Huntington Medical Research Institute, Pasadena, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Astraea","sequence":"additional","affiliation":[{"name":"Analytical Biochemistry Core, Huntington Medical Research Institute, Pasadena, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghong","family":"Arakaki","sequence":"additional","affiliation":[{"name":"Cognition and Brain Integration Lab, Huntington Medical Research Institute, Pasadena, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred N.","family":"Fonteh","sequence":"additional","affiliation":[{"name":"Biomarker and Neuro-Mechanism Lab, Huntington Medical Research Institute, Pasadena, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid M.","family":"Suchy-Dicey","sequence":"additional","affiliation":[{"name":"Huntington Medical Research Institute, Pasadena, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SriniVas","family":"Sadda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA"},{"name":"Doheny Eye Institute, Pasadena, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/S0301-0082(00)00068-X","article-title":"Cerebral microvascular pathology in aging and Alzheimer's disease","volume":"64","author":"Farkas","year":"2001","journal-title":"Prog Neurobiol"},{"issue":"4","key":"bib2","doi-asserted-by":"publisher","first-page":"e0266974","DOI":"10.1371\/journal.pone.0266974","article-title":"Retinal biomarkers of cerebral small vessel disease: a systematic review","volume":"17","author":"Biffi","year":"2022","journal-title":"PLoS One"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/j.1469-7580.2005.00395.x","article-title":"Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures","volume":"206","author":"Patton","year":"2005","journal-title":"J Anat"},{"issue":"12","key":"bib4","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/nrn3114","article-title":"Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders","volume":"12","author":"Zlokovic","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"2991","DOI":"10.1038\/s41433-020-01298-9","article-title":"Progression of choriocapillaris flow deficits in clinically stable intermediate age-related macular degeneration","volume":"35","author":"Tiosano","year":"2021","journal-title":"Eye (Lond)"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1167\/iovs.65.1.47","article-title":"Choriocapillaris and retinal vascular alterations in presymptomatic Alzheimer's disease","volume":"65","author":"Corradetti","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"e79378","DOI":"10.1371\/journal.pone.0079378","article-title":"Executive function changes before memory in preclinical Alzheimer's pathology: a prospective, cross-sectional, case control study","volume":"8","author":"Harrington","year":"2013","journal-title":"PLoS One"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.jalz.2013.12.025","article-title":"Aggregate effects of vascular risk factors on cerebrovascular changes in autopsy-confirmed Alzheimer's disease","volume":"11","author":"Bangen","year":"2015","journal-title":"Alzheimers Dement"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"595","DOI":"10.3233\/JAD-2012-111697","article-title":"Antemortem pulse pressure elevation predicts cerebrovascular disease in autopsy-confirmed Alzheimer's disease","volume":"30","author":"Nation","year":"2012","journal-title":"J Alzheimers Dis"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1364\/OL.35.001467","article-title":"Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiography","volume":"35","author":"Wang","year":"2010","journal-title":"Opt Lett"},{"issue":"8","key":"bib11","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1167\/iovs.65.8.40","article-title":"Choriocapillaris impairment, visual function, and distance to fovea in aging and age-related macular degeneration: ALSTAR2 baseline","volume":"65","author":"Kar","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1167\/iovs.65.1.47","article-title":"Choriocapillaris and retinal vascular alterations in presymptomatic Alzheimer's disease","volume":"65","author":"Corradetti","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/s41433-023-02788-2","article-title":"Impact of slab selection on the relationship between choriocapillaris flow deficits and enlargement rate of geographic atrophy","volume":"38","author":"Alagorie","year":"2024","journal-title":"Eye (Lond)"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.ajo.2022.07.015","article-title":"Pentosan polysulfate sodium-associated maculopathy: early detection using OCT angiography and choriocapillaris flow deficit analysis","volume":"244","author":"Fogel Levin","year":"2022","journal-title":"Am J Ophthalmol"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"2991","DOI":"10.1038\/s41433-020-01298-9","article-title":"Progression of choriocapillaris flow deficits in clinically stable intermediate age-related macular degeneration","volume":"35","author":"Tiosano","year":"2021","journal-title":"Eye (Lond)"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"2887","DOI":"10.1007\/s00417-021-05167-3","article-title":"Topography of choriocapillaris flow deficit predicts development of neovascularization or atrophy in age-related macular degeneration","volume":"259","author":"Corvi","year":"2021","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"16","key":"bib17","doi-asserted-by":"publisher","first-page":"e93621","DOI":"10.1172\/jci.insight.93621","article-title":"Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer's disease","volume":"2","author":"Koronyo","year":"2017","journal-title":"JCI Insight"},{"issue":"Suppl 1","key":"bib18","doi-asserted-by":"crossref","first-page":"S204","DOI":"10.1016\/j.neuroimage.2010.06.020","article-title":"Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model","volume":"54","author":"Koronyo-Hamaoui","year":"2011","journal-title":"Neuroimage"},{"issue":"1","key":"bib19","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1167\/iovs.13-12888","article-title":"Ocular changes in TgF344-AD rat model of Alzheimer's disease","volume":"55","author":"Tsai","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"6017","DOI":"10.1007\/s12035-019-1479-4","article-title":"Upregulation of proteolytic pathways and altered protein biosynthesis underlie retinal pathology in a mouse model of Alzheimer's disease","volume":"56","author":"Mirzaei","year":"2019","journal-title":"Mol Neurobiol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"4185","DOI":"10.1002\/alz.13871","article-title":"Choriocapillaris reduction accurately discriminates against early-onset Alzheimer's disease","volume":"20","author":"Kwapong","year":"2024","journal-title":"Alzheimers Dement"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"656750","DOI":"10.3389\/fnagi.2021.656750","article-title":"Choriocapillaris changes are correlated with disease duration and MoCA score in early-onset dementia","volume":"13","author":"Zhang","year":"2021","journal-title":"Front Aging Neurosci"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"eaaz2387","DOI":"10.1126\/sciadv.aaz2387","article-title":"Abeta deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer's disease","volume":"6","author":"Mattsson-Carlgren","year":"2020","journal-title":"Sci Adv"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/s43587-023-00405-1","article-title":"Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau pathologies","volume":"3","author":"Montoliu-Gaya","year":"2023","journal-title":"Nat Aging"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1001\/jamaneurol.2022.4485","article-title":"Association of phosphorylated tau biomarkers with amyloid positron emission tomography vs tau positron emission tomography","volume":"80","author":"Therriault","year":"2023","journal-title":"JAMA Neurol"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1093\/brain\/awad042","article-title":"Predicting amyloid PET and tau PET stages with plasma biomarkers","volume":"146","author":"Jack","year":"2023","journal-title":"Brain"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1038\/s41591-024-02869-z","article-title":"Highly accurate blood test for Alzheimer's disease is similar or superior to clinical cerebrospinal fluid tests","volume":"30","author":"Barthelemy","year":"2024","journal-title":"Nat Med"},{"key":"bib28","first-page":"85","article-title":"Advances in blood biomarkers for Alzheimer's disease: ultra-sensitive detection technologies and impact on clinical diagnosis","volume":"14","author":"Zhang","year":"2024","journal-title":"Degener Neurol Neuromuscul Dis"}],"container-title":["Translational Vision Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2803036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T14:30:28Z","timestamp":1748442628000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2803036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,28]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.14.5.27","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5,28]]}}}