{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:05:31Z","timestamp":1789441531594,"version":"build-2803163510"},"reference-count":37,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"7","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2025,7,28]]},"DOI":"10.1167\/tvst.14.7.23","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T13:30:37Z","timestamp":1753709437000},"page":"23","source":"Crossref","is-referenced-by-count":6,"title":["Identification of Matrix Metalloproteinase 3 as a Potential Biomarker for Dry Eye Disease"],"prefix":"10.1167","volume":"14","author":[{"given":"Xichen","family":"Wan","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Brain Function and Disorders, Fudan University, Shanghai, China"},{"name":"NHC Key Laboratory of Myopia and Related Eye Diseases, Shanghai, China"},{"name":"Shanghai Key Laboratory of Rare Disease Gene Editing and Cell Therapy; Shanghai Engineering Research Center of Synthetic Immunology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingrui","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Brain Function and Disorders, Fudan University, Shanghai, China"},{"name":"NHC Key Laboratory of Myopia and Related Eye Diseases, Shanghai, China"},{"name":"Shanghai Key Laboratory of Rare Disease Gene Editing and Cell Therapy; Shanghai Engineering Research Center of Synthetic Immunology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changchang","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Brain Function and Disorders, Fudan University, Shanghai, China"},{"name":"NHC Key Laboratory of Myopia and Related Eye Diseases, Shanghai, China"},{"name":"Shanghai Key Laboratory of Rare Disease Gene Editing and Cell Therapy; Shanghai Engineering Research Center of Synthetic Immunology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiteng","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Brain Function and Disorders, Fudan University, Shanghai, China"},{"name":"NHC Key Laboratory of Myopia and Related Eye Diseases, Shanghai, China"},{"name":"Shanghai Key Laboratory of Rare Disease Gene Editing and Cell Therapy; Shanghai Engineering Research Center of Synthetic Immunology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Brain Function and Disorders, Fudan University, Shanghai, China"},{"name":"NHC Key Laboratory of Myopia and Related Eye Diseases, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Brain Function and Disorders, Fudan University, Shanghai, China"},{"name":"NHC Key Laboratory of Myopia and Related Eye Diseases, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xujiao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Brain Function and Disorders, Fudan University, Shanghai, China"},{"name":"NHC Key Laboratory of Myopia and Related Eye Diseases, Shanghai, China"},{"name":"Shanghai Key Laboratory of Rare Disease Gene Editing and Cell Therapy; Shanghai Engineering Research Center of Synthetic Immunology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihua","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Brain Function and Disorders, Fudan University, Shanghai, China"},{"name":"NHC Key Laboratory of Myopia and Related Eye Diseases, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Brain Function and Disorders, Fudan University, Shanghai, China"},{"name":"NHC Key Laboratory of Myopia and Related Eye Diseases, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institutes of Biomedical Sciences of Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhujian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Eye & ENT Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxu","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Brain Function and Disorders, Fudan University, Shanghai, China"},{"name":"NHC Key Laboratory of Myopia and Related Eye Diseases, Shanghai, China"},{"name":"Shanghai Key Laboratory of Rare Disease Gene Editing and Cell Therapy; Shanghai Engineering Research Center of Synthetic Immunology, Shanghai, China"},{"name":"Department of Ophthalmology, Children's Hospital of Fudan University, National Pediatric Medical Center of China, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"3","key":"bib1","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","article-title":"TFOS DEWS II Epidemiology Report","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul Surf"},{"issue":"3","key":"bib2","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II Definition and Classification Report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul Surf"},{"issue":"23","key":"bib3","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1056\/NEJMra1407936","article-title":"Dry eye","volume":"378","author":"Clayton","year":"2018","journal-title":"N Engl J Med"},{"issue":"7","key":"bib4","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1016\/j.ophtha.2015.02.037","article-title":"Comparison of two questionnaires for dry eye symptom assessment: the Ocular Surface Disease Index and the Symptom Assessment in Dry Eye","volume":"122","author":"Amparo","year":"2015","journal-title":"Ophthalmology"},{"issue":"3","key":"bib5","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1124\/pharmrev.121.000349","article-title":"Matrix metalloproteinases: from molecular mechanisms to physiology, pathophysiology, and pharmacology","volume":"74","author":"de Almeida","year":"2022","journal-title":"Pharmacol Rev"},{"issue":"3","key":"bib6","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.jtos.2017.05.001","article-title":"TFOS DEWS II Diagnostic Methodology Report","volume":"15","author":"Wolffsohn","year":"2017","journal-title":"Ocul Surf"},{"issue":"1","key":"bib7","doi-asserted-by":"publisher","first-page":"2228192","DOI":"10.1080\/07853890.2023.2228192","article-title":"Comparison of matrix metallopeptidase-9 expression following cyclosporine and diquafosol treatment in dry eye","volume":"55","author":"So","year":"2023","journal-title":"Ann Med"},{"issue":"2","key":"bib8","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.jtos.2015.10.004","article-title":"The matrix metalloproteinase 9 point-of-care test in dry eye","volume":"14","author":"Lanza","year":"2016","journal-title":"Ocul Surf"},{"issue":"12","key":"bib9","doi-asserted-by":"publisher","first-page":"4302","DOI":"10.1167\/iovs.04-0299","article-title":"Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells","volume":"45","author":"Li","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.2147\/DDDT.S309648","article-title":"Topical delivery of levocarnitine to the cornea and anterior eye by thermosensitive in-situ gel for dry eye disease","volume":"15","author":"Ma","year":"2021","journal-title":"Drug Des Dev Ther"},{"issue":"11","key":"bib11","doi-asserted-by":"publisher","first-page":"2506","DOI":"10.1002\/jcp.25364","article-title":"MMP-8 is critical for dexamethasone therapy in alkali-burned corneas under dry eye conditions","volume":"231","author":"Bian","year":"2016","journal-title":"J Cell Physiol"},{"key":"bib12","first-page":"1243","article-title":"Osmoprotectants suppress the production and activity of matrix metalloproteinases induced by hyperosmolarity in primary human corneal epithelial cells","volume":"20","author":"Deng","year":"2014","journal-title":"Mol Vis"},{"issue":"11","key":"bib13","doi-asserted-by":"publisher","first-page":"2300","DOI":"10.1016\/j.ophtha.2016.07.028","article-title":"Matrix metalloproteinase 9 testing in dry eye disease using a commercially available point-of-care immunoassay","volume":"123","author":"Messmer","year":"2016","journal-title":"Ophthalmology"},{"issue":"3","key":"bib14","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1097\/ICO.0000000000001042","article-title":"Reversibility of gland dropout and significance of eyelid hygiene treatment in meibomian gland dysfunction","volume":"36","author":"Yin","year":"2017","journal-title":"Cornea"},{"issue":"8","key":"bib15","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1080\/08820538.2023.2211149","article-title":"Matrix metalloproteinases in glaucoma: an updated overview","volume":"38","author":"Zhang","year":"2023","journal-title":"Semin Ophthalmol"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"113938","DOI":"10.1016\/j.jep.2021.113938","article-title":"Tectona grandis leaf extract ameliorates hepatic fibrosis: modulation of TGF-\u00df\/Smad signaling pathway and upregulating MMP3\/TIMP1 ratio","volume":"272","author":"Tariq","year":"2021","journal-title":"J Ethnopharmacol"},{"issue":"2","key":"bib17","first-page":"240","article-title":"Dry eye: an inflammatory ocular disease","volume":"9","author":"Hessen","year":"2014","journal-title":"J Ophthalmic Vis Res"},{"issue":"4","key":"bib18","doi-asserted-by":"publisher","first-page":"e12987","DOI":"10.1111\/hel.12987","article-title":"Induction of MMP-3 and MMP-9 expression during Helicobacter pylori infection via MAPK signaling pathways","volume":"28","author":"Karayiannis","year":"2023","journal-title":"Helicobacter"},{"issue":"1","key":"bib19","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.ophtha.2014.07.048","article-title":"Matrix metalloproteinase 9 and transglutaminase 2 expression at the ocular surface in patients with different forms of dry eye disease","volume":"122","author":"Aragona","year":"2015","journal-title":"Ophthalmology"},{"issue":"17","key":"bib20","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1177\/15353702211012417","article-title":"Inflammatory response and matrix metalloproteinases in chronic kidney failure: modulation by adropin and spexin","volume":"246","author":"Yazgan","year":"2021","journal-title":"Exp Biol Med (Maywood)"},{"issue":"4","key":"bib21","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.berh.2019.01.006","article-title":"MMP3 is a reliable marker for disease activity, radiological monitoring, disease outcome predictability, and therapeutic response in rheumatoid arthritis","volume":"32","author":"Lerner","year":"2018","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"8","key":"bib22","doi-asserted-by":"publisher","first-page":"3375","DOI":"10.1167\/iovs.18-24013","article-title":"0.005% preservative-free latanoprost induces dry eye-like ocular surface damage via promotion of inflammation in mice","volume":"59","author":"Yang","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib23","doi-asserted-by":"publisher","first-page":"683","DOI":"10.18240\/ijo.2022.05.01","article-title":"Hyperosmolarity disrupts tight junction via TNF-a\/MMP pathway in primary human corneal epithelial cells","volume":"15","author":"Zhang","year":"2022","journal-title":"Int J Ophthalmol"},{"issue":"7","key":"bib24","doi-asserted-by":"publisher","first-page":"e43","DOI":"10.1016\/j.ophtha.2012.03.017","article-title":"Immunomodulatory effect of the topical ophthalmic Janus kinase inhibitor tofacitinib (CP-690,550) in patients with dry eye disease","volume":"119","author":"Huang","year":"2012","journal-title":"Ophthalmology"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"155081","DOI":"10.1016\/j.phymed.2023.155081","article-title":"Berberine ameliorate inflammation and apoptosis via modulating PI3K\/AKT\/NF?B and MAPK pathway on dry eye","volume":"121","author":"Han","year":"2023","journal-title":"Phytomedicine"},{"issue":"12","key":"bib26","doi-asserted-by":"publisher","first-page":"3776","DOI":"10.1167\/iovs.19-26928","article-title":"Therapeutic effects of STAT3 inhibition on experimental murine dry eye","volume":"60","author":"Qu","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"bib27","doi-asserted-by":"publisher","first-page":"4898","DOI":"10.1167\/iovs.17-22240","article-title":"Therapeutic effect of MK2 inhibitor on experimental murine dry eye","volume":"58","author":"Wu","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib28","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1097\/ACI.0000000000000307","article-title":"Tear film assessments for the diagnosis of dry eye","volume":"16","author":"Dohlman","year":"2016","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"4","key":"bib29","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.4103\/IJO.IJO_2981_22","article-title":"Tear biomarkers in dry eye disease: progress in the last decade","volume":"71","author":"Kumar","year":"2023","journal-title":"Indian J Ophthalmol"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.exer.2019.04.023","article-title":"Corneal autophagy and ocular surface inflammation: a new perspective in dry eye","volume":"184","author":"Ma","year":"2019","journal-title":"Exp Eye Res"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"952038","DOI":"10.3389\/fnagi.2022.952038","article-title":"Predictive value of longitudinal changes of serum matrix metalloproteinase-9 and brain-derived neurotrophic factor in acute ischemic stroke","volume":"14","author":"Li","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"bib32","first-page":"1503","article-title":"Temporal and quantitative analysis of expression of metalloproteinases (MMPs) and their endogenous inhibitors in atherosclerotic lesions","volume":"23","author":"Yu","year":"2008","journal-title":"Histol Histopathol"},{"issue":"1","key":"bib33","doi-asserted-by":"publisher","first-page":"e007983","DOI":"10.1136\/jitc-2023-007983","article-title":"Sulforaphane activates CD8(+) T cells antitumor response through IL-12RB2\/MMP3\/FasL-induced MDSCs apoptosis","volume":"12","author":"Liu","year":"2024","journal-title":"J Immunother Cancer"},{"issue":"4","key":"bib34","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.2353\/ajpath.2006.060005","article-title":"Matrix metalloproteinase 3 is present in the cell nucleus and is involved in apoptosis","volume":"169","author":"Si-Tayeb","year":"2006","journal-title":"Am J Pathol"},{"issue":"5","key":"bib35","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1007\/s11064-015-1800-1","article-title":"Inhibiting matrix metalloproteinase 3 ameliorates neuronal loss in the ganglion cell layer of rats in retinal ischemia\/reperfusion","volume":"41","author":"Hu","year":"2016","journal-title":"Neurochem Res"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.archoralbio.2010.08.017","article-title":"Anti-M(3) muscarinic cholinergic autoantibodies from patients with primary Sj\u00f6gren's syndrome trigger production of matrix metalloproteinase-3 (MMP-3) and prostaglandin E(2) (PGE(2)) from the submandibular glands","volume":"56","author":"Reina","year":"2011","journal-title":"Arch Oral Biol"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"989","DOI":"10.3899\/jrheum.080733","article-title":"Autoantibody and biopsy grading are associated with expression of ICAM-1, MMP-3, and TRAIL in salivary gland mononuclear cells of Chinese patients with Sjogren's syndrome","volume":"36","author":"Chen","year":"2009","journal-title":"J Rheumatol"}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2810444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T13:30:38Z","timestamp":1753709438000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2810444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,28]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.14.7.23","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7,28]]}}}