{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T22:13:15Z","timestamp":1767910395256,"version":"3.49.0"},"reference-count":52,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"7","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2025,7,7]]},"DOI":"10.1167\/tvst.14.7.4","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T13:30:32Z","timestamp":1751895032000},"page":"4","source":"Crossref","is-referenced-by-count":3,"title":["Investigating the Role of Autonomic Dysfunction in the Pathogenesis of Depression-Related Dry Eye"],"prefix":"10.1167","volume":"14","author":[{"given":"Dan","family":"Wang","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueni","family":"Ma","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Gao","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Qi","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenying","family":"Shang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruibo","family":"Yang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27","reference":[{"issue":"3","key":"bib1","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II definition and classification report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul Surf"},{"issue":"1","key":"bib2","doi-asserted-by":"publisher","first-page":"578","DOI":"10.3390\/ijms24010578","article-title":"Selected biomarkers of depression: what are the effects of cytokines and inflammation?","volume":"24","author":"Harsanyi","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"3","key":"bib3","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1097\/JCP.0000000000001382","article-title":"Dry those crying eyes: the role of depression and antidepressants in dry eye disease","volume":"41","author":"Rakofsky","year":"2021","journal-title":"J Clin Psychopharmacol"},{"issue":"4","key":"bib4","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1001\/jamaophthalmol.2022.0140","article-title":"Association between depression and severity of dry eye symptoms, signs, and inflammatory markers in the DREAM Study","volume":"140","author":"Zhou","year":"2022","journal-title":"JAMA Ophthalmol"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.jtos.2023.04.008","article-title":"TFOS Lifestyle: impact of lifestyle challenges on the ocular surface","volume":"28","author":"Galor","year":"2023","journal-title":"Ocul Surf"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jare.2024.03.015","article-title":"Decoding and reconstructing disease relations between dry eye and depression: a multimodal investigation comprising meta-analysis, genetic pathways and Mendelian randomization","volume":"69","author":"Chang","year":"2025","journal-title":"J Adv Res"},{"issue":"5","key":"bib7","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/s41433-023-02803-6","article-title":"Association of self-reported psychiatric and systemic risk factors in dry eye disease in adult Korean population","volume":"38","author":"Lim","year":"2024","journal-title":"Eye (Lond)"},{"issue":"6","key":"bib8","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1097\/ICO.0b013e3182261590","article-title":"Dry eye disease in patients with depressive and anxiety disorders in Shanghai","volume":"31","author":"Wen","year":"2012","journal-title":"Cornea"},{"issue":"5","key":"bib9","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1080\/02713683.2016.1236966","article-title":"Dry eye disease in patients with newly diagnosed depressive disorder","volume":"42","author":"Tiskaoglu","year":"2017","journal-title":"Curr Eye Res"},{"issue":"8","key":"bib10","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1097\/OPX.0b013e318181a947","article-title":"Long-term incidence of dry eye in an older population","volume":"85","author":"Moss","year":"2008","journal-title":"Optom Vis Sci"},{"issue":"2","key":"bib11","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.ajo.2012.02.009","article-title":"Depression, post-traumatic stress disorder, and dry eye syndrome: a study utilizing the national United States Veterans Affairs administrative database","volume":"154","author":"Galor","year":"2012","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"bib12","doi-asserted-by":"publisher","first-page":"343","DOI":"10.3109\/10253890.2015.1045868","article-title":"Autonomic dysfunction and heart rate variability in depression","volume":"18","author":"Sgoifo","year":"2015","journal-title":"Stress"},{"issue":"2","key":"bib13","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3390\/biom14020167","article-title":"Exploratory review of the Takotsubo syndrome and the possible role of the psychosocial stress response and inflammaging","volume":"14","author":"Frank","year":"2024","journal-title":"Biomolecules"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"108760","DOI":"10.1016\/j.exer.2021.108760","article-title":"Phenylephrine increases tear cathepsin S secretion in healthy murine lacrimal gland acinar cells through an alternative secretory pathway","volume":"211","author":"Fu","year":"2021","journal-title":"Exp Eye Res"},{"issue":"1","key":"bib15","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1002\/j.2040-4603.2015.tb00603.x","article-title":"Autonomic control of the eye","volume":"5","author":"McDougal","year":"2015","journal-title":"Compr Physiol"},{"issue":"1","key":"bib16","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3390\/vision6010006","article-title":"Ocular autonomic nervous system: an update from anatomy to physiological functions","volume":"6","author":"Wu","year":"2022","journal-title":"Vision (Basel)"},{"issue":"24","key":"bib17","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1016\/0024-3205(84)90423-5","article-title":"Stimulation of lacrimal secretion by sympathetic nerve impulses in the rabbit","volume":"34","author":"Tangkrisanavinont","year":"1984","journal-title":"Life Sci"},{"issue":"8","key":"bib18","doi-asserted-by":"publisher","first-page":"5720","DOI":"10.1167\/iovs.11-7358","article-title":"Interaction of alpha1D-adrenergic and P2X(7) receptors in the rat lacrimal gland and the effect on intracellular [Ca2+] and protein secretion","volume":"52","author":"Dartt","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib19","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/j.ajpath.2020.01.007","article-title":"Identification of lacrimal gland postganglionic innervation and its regulation of tear secretion","volume":"190","author":"Jin","year":"2020","journal-title":"Am J Pathol"},{"issue":"7","key":"bib20","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/j.ajpath.2023.03.015","article-title":"Hyperglycemia induces tear reduction and dry eye in diabetic mice through the norepinephrine-a(1) adrenergic receptor-mitochondrial impairment axis of lacrimal gland","volume":"193","author":"Zhang","year":"2023","journal-title":"Am J Pathol"},{"issue":"7","key":"bib21","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1111\/apt.15433","article-title":"Review article: the role of the autonomic nervous system in the pathogenesis and therapy of IBD","volume":"50","author":"Mogilevski","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"issue":"2","key":"bib22","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.advms.2017.03.003","article-title":"Pro-inflammatory cytokines associated with clinical severity of dry eye disease of patients with depression","volume":"62","author":"Mrugacz","year":"2017","journal-title":"Adv Med Sci"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.psyneuen.2017.10.005","article-title":"Omega-3 and omega-6 fatty acid levels in depressive and anxiety disorders","volume":"87","author":"Thesing","year":"2018","journal-title":"Psychoneuroendocrinology"},{"issue":"11","key":"bib24","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.18240\/ijo.2021.11.08","article-title":"Effects of dietary high dose DHA omega-3 supplement in dry eye with meibomian gland dysfunction","volume":"14","author":"Jo","year":"2021","journal-title":"Int J Ophthalmol"},{"issue":"1","key":"bib25","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1167\/iovs.18-25572","article-title":"Selective serotonin reuptake inhibitors aggravate depression-associated dry eye via activating the NF-?B pathway","volume":"60","author":"Zhang","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"984475","DOI":"10.3389\/fphar.2022.984475","article-title":"Acacetin protects against depression-associated dry eye disease by regulating ubiquitination of NLRP3 through gp78 signal","volume":"13","author":"Xie","year":"2022","journal-title":"Front Pharmacol"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"109486","DOI":"10.1016\/j.exer.2023.109486","article-title":"Administration of serotonin and norepinephrine reuptake inhibitors tends to have less ocular surface damage in a chronic stress-induced rat model of depression than selective serotonin reuptake inhibitors","volume":"231","author":"Zhao","year":"2023","journal-title":"Exp Eye Res"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1186\/1471-244X-13-187","article-title":"Altered cardiac autonomic nervous function in depression","volume":"13","author":"Wang","year":"2013","journal-title":"BMC Psychiatry"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"729","DOI":"10.3389\/fphys.2017.00729","article-title":"Xiao-Yao-San, a Chinese medicine formula, ameliorates chronic unpredictable mild stress induced polycystic ovary in rat","volume":"8","author":"Sun","year":"2017","journal-title":"Front Physiol"},{"issue":"3","key":"bib30","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s11010-021-04313-z","article-title":"Blueberry extract attenuates norepinephrine-induced oxidative stress and apoptosis in H9c2 cardiac cells","volume":"477","author":"T\u00fcrck","year":"2022","journal-title":"Mol Cell Biochem"},{"issue":"2","key":"bib31","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1002\/nau.23876","article-title":"Stress-induced autonomic dysregulation of mitochondrial function in the rat urothelium","volume":"38","author":"Kullmann","year":"2019","journal-title":"Neurourol Urodyn"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"e254646","DOI":"10.1590\/1519-6984.254646","article-title":"Alterations of serum biochemical parameters and tyrosine phosphorylation in kidney and liver of chronic stress-induced rats","volume":"84","author":"Khanthiyong","year":"2022","journal-title":"Braz J Biol"},{"issue":"3","key":"bib33","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1167\/iovs.63.3.3","article-title":"Obstructive sleep apnea affects lacrimal gland function","volume":"63","author":"Wang","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"bib34","doi-asserted-by":"publisher","first-page":"e11119","DOI":"10.1371\/journal.pone.0011119","article-title":"Lacrimal hypofunction as a new mechanism of dry eye in visual display terminal users","volume":"5","author":"Nakamura","year":"2010","journal-title":"PLoS One"},{"issue":"14","key":"bib35","doi-asserted-by":"publisher","first-page":"Des130","DOI":"10.1167\/iovs.17-23762","article-title":"Approach to dry eye in video display terminal workers (basic science)","volume":"59","author":"Nakamura","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib36","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s40610-015-0020-4","article-title":"Myoepithelial cells: their origin and function in lacrimal gland morphogenesis, homeostasis, and repair","volume":"1","author":"Makarenkova","year":"2015","journal-title":"Curr Mol Biol Rep"},{"issue":"Pt 3","key":"bib37","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1113\/jphysiol.2002.029686","article-title":"Autonomic nervous control of myoepithelial cells and secretion in submandibular gland of anaesthetized dogs","volume":"546","author":"Lung","year":"2003","journal-title":"J Physiol"},{"issue":"8","key":"bib38","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1038\/icb.2017.38","article-title":"CD8 T cells contribute to lacrimal gland pathology in the nonobese diabetic mouse model of Sj\u00f6gren syndrome","volume":"95","author":"Barr","year":"2017","journal-title":"Immunol Cell Biol"},{"issue":"12","key":"bib39","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1016\/j.ajpath.2020.09.002","article-title":"High-fat diet-induced functional and pathologic changes in lacrimal gland","volume":"190","author":"He","year":"2020","journal-title":"Am J Pathol"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.abb.2019.03.009","article-title":"Resveratrol and dimethyl fumarate ameliorate testicular dysfunction caused by chronic unpredictable mild stress-induced depression in rats","volume":"665","author":"Fahim","year":"2019","journal-title":"Arch Biochem Biophys"},{"key":"bib41","doi-asserted-by":"crossref","first-page":"780616","DOI":"10.1155\/2014\/780616","article-title":"A possible change process of inflammatory cytokines in the prolonged chronic stress and its ultimate implications for health","volume":"2014","author":"Tian","year":"2014","journal-title":"ScientificWorldJournal"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.physbeh.2016.03.017","article-title":"Chronic unpredictable mild stress generates oxidative stress and systemic inflammation in rats","volume":"161","author":"L\u00f3pez-L\u00f3pez","year":"2016","journal-title":"Physiol Behav"},{"key":"bib43","first-page":"101571","article-title":"A review on linking stress, depression, and insulin resistance via low-grade chronic inflammation","volume":"36","author":"Mehdi","year":"2023","journal-title":"Biochem Biophys Rep"},{"issue":"10","key":"bib44","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1097\/HJH.0b013e32833ca68c","article-title":"Oxidative stress and inflammatory mediators contribute to endothelial dysfunction in high-fat diet-induced obesity in mice","volume":"28","author":"Kobayasi","year":"2010","journal-title":"J Hypertens"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"109498","DOI":"10.1016\/j.exer.2023.109498","article-title":"Effect of PPAR? on oxidative stress in diabetes-related dry eye","volume":"231","author":"Wang","year":"2023","journal-title":"Exp Eye Res"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"102156","DOI":"10.1016\/j.redox.2021.102156","article-title":"Targeting mitochondria-inflammation circle by renal denervation reduces atheroprone endothelial phenotypes and atherosclerosis","volume":"47","author":"Li","year":"2021","journal-title":"Redox Biol"},{"issue":"2","key":"bib47","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s11064-016-2113-8","article-title":"Oxidative stress mediated hippocampal neuron apoptosis participated in carbon disulfide-induced rats cognitive dysfunction","volume":"42","author":"Wang","year":"2017","journal-title":"Neurochem Res"},{"issue":"1","key":"bib48","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s00394-023-03266-x","article-title":"Folic acid alleviated oxidative stress-induced telomere attrition and inhibited apoptosis of neurocytes in old rats","volume":"63","author":"Zhou","year":"2024","journal-title":"Eur J Nutr"},{"issue":"5","key":"bib49","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1016\/j.ajpath.2012.01.019","article-title":"Age-related dysfunction of the lacrimal gland and oxidative stress: evidence from the Cu,Zn-superoxide dismutase-1 (Sod1) knockout mice","volume":"180","author":"Kojima","year":"2012","journal-title":"Am J Pathol"},{"issue":"6","key":"bib50","doi-asserted-by":"publisher","first-page":"4348","DOI":"10.1002\/jcp.30175","article-title":"Endoplasmic reticulum stress and oxidative stress drive endothelial dysfunction induced by high selenium","volume":"236","author":"Zachariah","year":"2021","journal-title":"J Cell Physiol"},{"issue":"11\u201312","key":"bib51","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s10495-022-01770-9","article-title":"Orientin downregulating oxidative stress-mediated endoplasmic reticulum stress and mitochondrial dysfunction through AMPK\/SIRT1 pathway in rat nucleus pulposus cells in vitro and attenuated intervertebral disc degeneration in vivo","volume":"27","author":"Zhang","year":"2022","journal-title":"Apoptosis"},{"issue":"12","key":"bib52","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1038\/eye.2016.186","article-title":"Depression and anxiety in dry eye disease: a systematic review and meta-analysis","volume":"30","author":"Wan","year":"2016","journal-title":"Eye (Lond)"}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2809193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T13:30:33Z","timestamp":1751895033000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2809193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,7]]},"references-count":52,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.14.7.4","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7,7]]}}}