{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T13:04:40Z","timestamp":1780059880522,"version":"3.54.0"},"reference-count":37,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"8","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2025,8,19]]},"DOI":"10.1167\/tvst.14.8.21","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T15:01:15Z","timestamp":1755615675000},"page":"21","source":"Crossref","is-referenced-by-count":2,"title":["OBM1701 Alleviates Choroidal Neovascularization in Experimental Animals Via Suppressing the Expression of HIF-1\u03b1 in Retinal Pigment Epithelial Cells"],"prefix":"10.1167","volume":"14","author":[{"given":"Shu-I","family":"Yeh","sequence":"first","affiliation":[{"name":"Department of Medicine, Mackay Medical College, New Taipei City, Taiwan"},{"name":"Department of Ophthalmology, Mackay Memorial Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Chuan","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Mackay Memorial Hospital, New Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Wen","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Mackay Memorial Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Show-Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchong","family":"Ou","sequence":"additional","affiliation":[{"name":"Oculus BioMed Limited, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeou-Ping","family":"Tsao","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mackay Medical College, New Taipei City, Taiwan"},{"name":"Department of Ophthalmology, Mackay Memorial Hospital, Taipei, Taiwan"},{"name":"Department of Medical Research, Mackay Memorial Hospital, New Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.preteyeres.2010.05.003","article-title":"Animal models of choroidal and retinal neovascularization","volume":"29","author":"Grossniklaus","year":"2010","journal-title":"Prog Retin Eye Res"},{"key":"bib2","doi-asserted-by":"crossref","first-page":"8941057","DOI":"10.1155\/2020\/8941057","article-title":"Pigment Epithelium-Derived Factor as a Possible Treatment Agent for Choroidal Neovascularization","volume":"2020","author":"Xi","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.mcna.2021.01.003","article-title":"Age-Related Macular Degeneration","volume":"105","author":"Thomas","year":"2021","journal-title":"Med Clin North Am"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1111\/j.1444-0938.2007.00152.x","article-title":"Age-related maculopathy in the light of ischaemia","volume":"90","author":"Feigl","year":"2007","journal-title":"Clin Exp Optom"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"6197","DOI":"10.1167\/iovs.11-8936","article-title":"Impacts of hypoxia-inducible factor-1 knockout in the retinal pigment epithelium on choroidal neovascularization","volume":"53","author":"Lin","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib6","first-page":"3158","article-title":"VEGF is major stimulator in model of choroidal neovascularization","volume":"41","author":"Kwak","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.3390\/jcm9051522","article-title":"Comparative safety of bevacizumab, ranibizumab, and aflibercept for treatment of neovascular age-related macular degeneration (AMD): a systematic review and network meta-analysis of direct comparative studies","volume":"9","author":"Plyukhova","year":"2020","journal-title":"J Clin Med"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"100906","DOI":"10.1016\/j.preteyeres.2020.100906","article-title":"Incomplete response to Anti-VEGF therapy in neovascular AMD: exploring disease mechanisms and therapeutic opportunities","volume":"82","author":"Mettu","year":"2021","journal-title":"Prog Retin Eye Res"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/S0002-9394(02)01549-0","article-title":"Pigment epithelium-derived factor is deficient in the vitreous of patients with choroidal neovascularization due to age-related macular degeneration","volume":"134","author":"Holekamp","year":"2002","journal-title":"Am J Ophthalmol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/jcp.1114","article-title":"Pigment epithelium-derived factor inhibits retinal and choroidal neovascularization","volume":"188","author":"Mori","year":"2001","journal-title":"J Cell Physiol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.omtn.2019.01.012","article-title":"Suppression of choroidal neovascularization by AAV-based dual-acting antiangiogenic gene therapy","volume":"16","author":"Askou","year":"2019","journal-title":"Mol Ther Nucleic Acids"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1167\/iovs.09-4455","article-title":"Effects of human recombinant PEDF protein and PEDF-derived peptide 34-mer on choroidal neovascularization","volume":"51","author":"Amaral","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib13","doi-asserted-by":"publisher","first-page":"C456","DOI":"10.1152\/ajpcell.00259.2017","article-title":"PEDF expression affects the oxidative and inflammatory state of choroidal endothelial cells","volume":"314","author":"Farnoodian","year":"2018","journal-title":"Am J Physiol Cell Physiol"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"42846","DOI":"10.1038\/srep42846","article-title":"PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy","volume":"7","author":"Gao","year":"2017","journal-title":"Sci Rep"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s12886-022-02295-0","article-title":"A short peptide derived from pigment epithelial-derived factor exhibits an angioinhibitory effect","volume":"22","author":"Ho","year":"2022","journal-title":"BMC Ophthalmol"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.exer.2014.05.003","article-title":"A detailed three-step protocol for live imaging of intracellular traffic in polarized primary porcine RPE monolayers","volume":"124","author":"Toops","year":"2014","journal-title":"Exp Eye Res"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1080\/02713683.2023.2259636","article-title":"A novel primary porcine retinal pigment epithelium cell model with preserved properties","volume":"49","author":"Zhou","year":"2024","journal-title":"Curr Eye Res"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/s41467-018-08125-6","article-title":"Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration","volume":"10","author":"Zhao","year":"2019","journal-title":"Nat Commun"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"2599","DOI":"10.1167\/iovs.07-1508","article-title":"Increased choroidal neovascularization following laser induction in mice lacking lysyl oxidase-like 1","volume":"49","author":"Yu","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"109743","DOI":"10.1016\/j.exer.2023.109743","article-title":"Short peptides derived from pigment epithelium-derived factor attenuate retinal ischemia reperfusion injury through inhibition of apoptosis and inflammatory response in rats","volume":"238","author":"Sun","year":"2024","journal-title":"Exp Eye Res"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"4857","DOI":"10.1007\/s11033-011-1281-5","article-title":"Identification of valid housekeeping genes for quantitative RT-PCR analysis of cardiosphere-derived cells preconditioned under hypoxia or with prolyl-4-hydroxylase inhibitors","volume":"39","author":"Tan","year":"2012","journal-title":"Mol Biol Rep"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"30273","DOI":"10.1074\/jbc.M804196200","article-title":"15-deoxy-Delta(12,14)-prostaglandin J2 induces vascular endothelial cell apoptosis through the sequential activation of MAPKS and p53","volume":"283","author":"Ho","year":"2008","journal-title":"J Biol Chem"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s12896-014-0112-x","article-title":"PHDs inhibitor DMOG promotes the vascularization process in the AV loop by HIF-1a up-regulation and the preliminary discussion on its kinetics in rat","volume":"14","author":"Yuan","year":"2014","journal-title":"BMC Biotechnol"},{"key":"bib24","first-page":"1112","article-title":"Inhibition of choroidal neovascularization by lentivirus-mediated PEDF gene transfer in rats","volume":"9","author":"Yu","year":"2016","journal-title":"Int J Ophthalmol"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"107798","DOI":"10.1016\/j.exer.2019.107798","article-title":"Novel anti-angiogenic PEDF-derived small peptides mitigate choroidal neovascularization","volume":"188","author":"Sheibani","year":"2019","journal-title":"Exp Eye Res"},{"issue":"50","key":"bib26","doi-asserted-by":"publisher","first-page":"e2302845120","DOI":"10.1073\/pnas.2302845120","article-title":"Pathologic vs. protective roles of hypoxia-inducible factor 1 in RPE and photoreceptors in wet vs. dry age-related macular degeneration","volume":"120","author":"Babapoor-Farrokhran","year":"2023","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"5395","DOI":"10.1111\/febs.16928","article-title":"Neutrophil extracellular traps boost laser-induced mouse choroidal neovascularization through the activation of the choroidal endothelial cell TLR4\/HIF-1a pathway","volume":"290","author":"Zeng","year":"2023","journal-title":"FEBS J"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1002\/jcb.22072","article-title":"Characterization of PEDF: a multi-functional serpin family protein","volume":"106","author":"Filleur","year":"2009","journal-title":"J Cell Biochem"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.exer.2005.05.007","article-title":"Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration","volume":"82","author":"Bhutto","year":"2006","journal-title":"Exp Eye Res"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1677\/jme.1.02008","article-title":"Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy","volume":"37","author":"Zhang","year":"2006","journal-title":"J Mol Endocrinol"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/s43856-025-00789-8","article-title":"H105A peptide eye drops promote photoreceptor survival in murine and human models of retinal degeneration","volume":"5","author":"Bernardo-Col\u00f3n","year":"2025","journal-title":"Commun Med (Lond)"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.mcn.2015.08.001","article-title":"Eye drop delivery of pigment epithelium-derived factor-34 promotes retinal ganglion cell neuroprotection and axon regeneration","volume":"68","author":"Vigneswara","year":"2015","journal-title":"Mol Cell Neurosci"},{"issue":"11","key":"bib33","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1167\/iovs.65.11.28","article-title":"Mathematical models of ocular drug delivery","volume":"65","author":"Sedeghi","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1006\/exer.2000.0907","article-title":"Quantitative image analysis of laser-induced choroidal neovascularization in rat","volume":"71","author":"Edelman","year":"2000","journal-title":"Exp Eye Res"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"5869","DOI":"10.3390\/molecules29245869","article-title":"Characterizing interactions between small peptides and dimethyl sulfoxide using infrared spectroscopy and computational methods","volume":"29","author":"Panuszko","year":"2024","journal-title":"Molecules"},{"issue":"3","key":"bib36","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3810\/psm.2011.09.1923","article-title":"Dimethyl sulfoxide: an effective penetration enhancer for topical administration of NSAIDs","volume":"39","author":"Marren","year":"2011","journal-title":"Phys Sportsmed"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1096\/fj.13-235440","article-title":"Unexpected low-dose toxicity of the universal solvent DMSO","volume":"28","author":"Galvao","year":"2014","journal-title":"FASEB J"}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2810697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T15:01:16Z","timestamp":1755615676000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2810697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,19]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.14.8.21","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8,19]]}}}