{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T18:26:38Z","timestamp":1783103198854,"version":"3.54.6"},"reference-count":94,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"9","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2025,9,8]]},"DOI":"10.1167\/tvst.14.9.11","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T12:30:45Z","timestamp":1757334645000},"page":"11","source":"Crossref","is-referenced-by-count":1,"title":["P2X4 Receptor Antagonist Ameliorates Ocular Pain in Rats After Lacrimal Gland Removal"],"prefix":"10.1167","volume":"14","author":[{"given":"Minjie","family":"Chen","sequence":"first","affiliation":[{"name":"Wilmer Eye Institute, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"B\u00e4urle","sequence":"additional","affiliation":[{"name":"Bayer AG, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Karlstetter","sequence":"additional","affiliation":[{"name":"Bayer AG, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianni","family":"Simmons","sequence":"additional","affiliation":[{"name":"Wilmer Eye Institute, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Seo","sequence":"additional","affiliation":[{"name":"Wilmer Eye Institute, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel C.","family":"Yiu","sequence":"additional","affiliation":[{"name":"Wilmer Eye Institute, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"100842","DOI":"10.1016\/j.preteyeres.2020.100842","article-title":"Advances in the diagnosis and treatment of dry eye","volume":"78","author":"Kojima","year":"2020","journal-title":"Prog Retin Eye Res"},{"issue":"3","key":"bib2","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.sjopt.2014.06.002","article-title":"Dry eye disease: a review of diagnostic approaches and treatments","volume":"28","author":"Lin","year":"2014","journal-title":"Saudi J Ophthalmol"},{"issue":"1-2","key":"bib3","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3109\/08820538.2015.1114853","article-title":"Understanding neuropathic corneal pain\u2014gaps and current therapeutic approaches","volume":"31","author":"Goyal","year":"2016","journal-title":"Semin Ophthalmol"},{"issue":"3","key":"bib4","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1097\/ICO.0000000000003193","article-title":"Novel treatments for chronic ocular surface pain","volume":"42","author":"Mangwani-Mordani","year":"2023","journal-title":"Cornea"},{"issue":"11","key":"bib5","doi-asserted-by":"publisher","first-page":"S34","DOI":"10.1016\/j.ophtha.2017.08.004","article-title":"Neuropathic corneal pain: approaches for management","volume":"124","author":"Dieckmann","year":"2017","journal-title":"Ophthalmology"},{"issue":"14","key":"bib6","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1080\/14656566.2017.1372748","article-title":"Lifitegrast for the treatment of dry eye disease in adults","volume":"18","author":"Donnenfeld","year":"2017","journal-title":"Expert Opin Pharmacother"},{"issue":"4","key":"bib7","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1089\/jop.2012.0102","article-title":"Corneal inflammation is inhibited by the LFA-1 antagonist, lifitegrast (SAR 1118)","volume":"29","author":"Sun","year":"2013","journal-title":"J Ocul Pharmacol Ther"},{"issue":"12","key":"bib8","doi-asserted-by":"publisher","first-page":"e0167200","DOI":"10.1371\/journal.pone.0167200","article-title":"Loss of TRPV4 function suppresses inflammatory fibrosis induced by alkali-burning mouse corneas","volume":"11","author":"Okada","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"bib9","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.pain.2010.03.024","article-title":"Prolonged analgesic response of cornea to topical resiniferatoxin, a potent TRPV1 agonist","volume":"149","author":"Bates","year":"2010","journal-title":"Pain"},{"issue":"3","key":"bib10","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1167\/tvst.12.3.7","article-title":"Topical ocular TRPV1 antagonist SAF312 (libvatrep) for postoperative pain after photorefractive keratectomy","volume":"12","author":"Thompson","year":"2023","journal-title":"Transl Vis Sci Technol"},{"issue":"8","key":"bib11","first-page":"722","article-title":"In-vitro and In-vivo pharmacology of SAF312 as a TRPV1 inhibitor for ocular surface pain","volume":"62","author":"Medley","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"173","DOI":"10.3389\/fphar.2017.00173","article-title":"Gabapentin attenuates ocular inflammation: in vitro and in vivo studies","volume":"8","author":"Anfuso","year":"2017","journal-title":"Front Pharmacol"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"4187","DOI":"10.2147\/OPTH.S279051","article-title":"A Review of the mechanism of action of cyclosporine a: the role of cyclosporine A in dry eye disease and recent formulation developments","volume":"14","author":"Periman","year":"2020","journal-title":"Clin Ophthalmol"},{"issue":"6","key":"bib14","doi-asserted-by":"publisher","first-page":"2736","DOI":"10.1167\/iovs.08-1880","article-title":"Neurologic evaluation of acute lacrimomimetic effect of cyclosporine in an experimental rabbit dry eye model","volume":"50","author":"Toshida","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib15","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1089\/jop.2008.0138","article-title":"Long-term topical cyclosporine treatment improves tear production and reduces keratoconjunctivitis in rabbits with induced autoimmune dacryoadenitis","volume":"25","author":"Thomas","year":"2009","journal-title":"J Ocul Pharmacol Ther"},{"issue":"1","key":"bib16","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.2147\/OPTH.S30261","article-title":"PERSIST: physician's evaluation of Restasis\u00ae satisfaction in second trial of topical cyclosporine ophthalmic emulsion 0.05% for dry eye: a retrospective review","volume":"6","author":"Mah","year":"2012","journal-title":"Clin Ophthalmol"},{"issue":"8","key":"bib17","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1080\/14728222.2022.2122438","article-title":"Neuropathic ocular surface pain: emerging drug targets and therapeutic implications","volume":"26","author":"Patel","year":"2022","journal-title":"Expert Opin Ther Targets"},{"issue":"1","key":"bib18","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1136\/bjophthalmol-2014-306280","article-title":"Ocular neuropathic pain","volume":"100","author":"Rosenthal","year":"2016","journal-title":"Br J Ophthalmol"},{"issue":"3","key":"bib19","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.jcrs.2010.12.037","article-title":"Anatomy and physiology of the cornea","volume":"37","author":"DelMonte","year":"2011","journal-title":"J Cataract Refract Surg"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/bs.pmbts.2015.04.001","article-title":"Overview of the cornea: structure, function, and development","volume":"134","author":"Eghrari","year":"2015","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"5","key":"bib21","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S0014-4835(03)00050-2","article-title":"Corneal nerves: structure, contents and function","volume":"76","author":"M\u00fcller","year":"2003","journal-title":"Exp Eye Res"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"3242649","DOI":"10.1155\/2017\/3242649","article-title":"Corneal nerve fiber structure, its role in corneal function, and its changes in corneal diseases","volume":"2017","author":"Eguchi","year":"2017","journal-title":"Biomed Res Int"},{"issue":"1","key":"bib23","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s11302-021-09839-x","article-title":"Purinergic receptors mediate endothelial dysfunction and participate in atherosclerosis","volume":"19","author":"Wu","year":"2023","journal-title":"Purinergic Signal"},{"issue":"8","key":"bib24","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1248\/bpb.b22-00234","article-title":"Effects of NP-1815-PX, a P2X4 receptor antagonist, on contractions in guinea pig tracheal and bronchial smooth muscles","volume":"45","author":"Obara","year":"2022","journal-title":"Biol Pharm Bull"},{"issue":"21","key":"bib25","doi-asserted-by":"publisher","first-page":"4992","DOI":"10.1111\/bph.15928","article-title":"Ionotropic P2X4 and P2X7 receptors in the regulation of ion transport across rat colon","volume":"179","author":"Ballout","year":"2022","journal-title":"Br J Pharmacol"},{"issue":"9","key":"bib26","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1007\/s11255-018-1948-0","article-title":"Elevated hydrostatic pressure stimulates ATP release which mediates activation of the NLRP3 inflammasome via P2X4 in rat urothelial cells","volume":"50","author":"Dunton","year":"2018","journal-title":"Int Urol Nephrol"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"176941","DOI":"10.1016\/j.ejphar.2024.176941","article-title":"Purinergic control of apical ion conductance by luminal ATP in rat colonic epithelium","volume":"982","author":"Ballout","year":"2024","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"bib28","first-page":"73","article-title":"P2X4 receptor mediates macrophage infiltration leading to endometriotic cyst epithelium proliferation and hyperalgesia in mouse model","volume":"6","author":"Nagata","year":"2024","journal-title":"F S Sci"},{"issue":"8","key":"bib29","doi-asserted-by":"publisher","first-page":"3583","DOI":"10.1172\/JCI120972","article-title":"Purinergic P2X4 receptors and mitochondrial ATP production regulate T cell migration","volume":"128","author":"Ledderose","year":"2018","journal-title":"J Clin Invest"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.coph.2019.02.001","article-title":"Role of the P2X4 receptor in neuropathic pain","volume":"47","author":"Inoue","year":"2019","journal-title":"Curr Opin Pharmacol"},{"issue":"8","key":"bib31","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1097\/WNR.0b013e32833980b2","article-title":"P2X4 receptor expression in a rat model of trigeminal neuropathic pain","volume":"21","author":"Nakai","year":"2010","journal-title":"NeuroReport"},{"issue":"13","key":"bib32","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1097\/WNR.0b013e3283568a29","article-title":"Expression of P2X1 and P2X4 receptors in rat trigeminal ganglion neurons","volume":"23","author":"Kuroda","year":"2012","journal-title":"NeuroReport"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/1744-8069-5-28","article-title":"Behavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronic pain assays","volume":"5","author":"Tsuda","year":"2009","journal-title":"Mol Pain"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"645834","DOI":"10.3389\/fimmu.2021.645834","article-title":"Structural and functional features of the P2X4 receptor: an immunological perspective","volume":"12","author":"Kanellopoulos","year":"2021","journal-title":"Front Immunol"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"191","DOI":"10.3389\/fncel.2013.00191","article-title":"P2X4 receptors and neuropathic pain","volume":"7","author":"Tsuda","year":"2013","journal-title":"Front Cell Neurosci"},{"issue":"4","key":"bib36","doi-asserted-by":"publisher","first-page":"549561","DOI":"10.1007\/s11302-021-09822-6","article-title":"Mechanisms of ATP release in pain: role of pannexin and connexin channels","volume":"17","author":"Mu\u00f1oz","year":"2021","journal-title":"Purinergic Signal"},{"key":"bib37","doi-asserted-by":"crossref","DOI":"10.1007\/s11302-023-09972-9","article-title":"Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation","author":"Qu","year":"2023","journal-title":"Purinergic Signal"},{"issue":"10","key":"bib38","doi-asserted-by":"publisher","first-page":"3099","DOI":"10.1007\/s11064-023-03969-x","article-title":"Intrathecal injection of botulinum toxin type A has an analgesic effect in male rats CCI model by inhibiting the activation of spinal P2X4R","volume":"48","author":"Zhou","year":"2023","journal-title":"Neurochem Res"},{"issue":"10","key":"bib39","doi-asserted-by":"publisher","first-page":"e0165189","DOI":"10.1371\/journal.pone.0165189","article-title":"Duloxetine inhibits microglial P2X4 receptor function and alleviates neuropathic pain after peripheral nerve injury","volume":"11","author":"Yamashita","year":"2016","journal-title":"PLoS One"},{"issue":"5","key":"bib40","doi-asserted-by":"publisher","first-page":"3347","DOI":"10.1167\/iovs.15-16717","article-title":"Corneal sensitivity following lacrimal gland excision in the rat","volume":"56","author":"Meng","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"109005","DOI":"10.1016\/j.exer.2022.109005","article-title":"Evidence for a phenotypic switch in corneal afferents after lacrimal gland excision","volume":"218","author":"Sullivan","year":"2022","journal-title":"Exp Eye Res"},{"key":"bib42","first-page":"150","article-title":"Precise longitudinal monitoring of corneal change through in vivo confocal microscopy in a rat dry eye disease model","volume":"30","author":"Chen","year":"2024","journal-title":"Mol Vis"},{"issue":"4","key":"bib43","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.exer.2009.12.010","article-title":"Anatomy of the human corneal innervation","volume":"90","author":"Marfurt","year":"2010","journal-title":"Exp Eye Res"},{"issue":"7","key":"bib44","doi-asserted-by":"publisher","first-page":"e0180175","DOI":"10.1371\/journal.pone.0180175","article-title":"Diagnostic utility of corneal confocal microscopy and intra-epidermal nerve fibre density in diabetic neuropathy","volume":"12","author":"Alam","year":"2017","journal-title":"PLoS One"},{"issue":"5","key":"bib45","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.bj.2017.06.010","article-title":"P2X4: a fast and sensitive purinergic receptor","volume":"40","author":"Suurv\u00e4li","year":"2017","journal-title":"Biomed J"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"291","DOI":"10.3389\/fphar.2017.00291","article-title":"P2X4 receptor function in the nervous system and current breakthroughs in pharmacology","volume":"8","author":"Stokes","year":"2017","journal-title":"Front Pharmacol"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"109614","DOI":"10.1016\/j.exer.2023.109614","article-title":"Purinergic 2X4 (P2X4), but not P2X7, receptors increase cytosolic [Ca2+] and stimulate mucin secretion in rat conjunctival goblet cells to maintain ocular surface health","volume":"235","author":"Fjaervoll","year":"2023","journal-title":"Exp Eye Res"},{"issue":"6","key":"bib48","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1007\/s13346-016-0339-2","article-title":"A comprehensive insight on ocular pharmacokinetics","volume":"6","author":"Agrahari","year":"2016","journal-title":"Drug Deliv Transl Res"},{"issue":"8","key":"bib49","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1016\/j.drudis.2019.02.001","article-title":"Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties","volume":"24","author":"Subrizi","year":"2019","journal-title":"Drug Discov Today"},{"issue":"16","key":"bib50","doi-asserted-by":"publisher","first-page":"13025","DOI":"10.3390\/ijms241613025","article-title":"Cyclosporine A decreases dryness-induced hyperexcitability of corneal cold-sensitive nerve terminals","volume":"24","author":"Gyenes","year":"2023","journal-title":"Int J Mol Sci"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"831307","DOI":"10.3389\/fmed.2022.831307","article-title":"Semiautomated and automated quantitative analysis of corneal sub-basal nerves in patients with DED with ocular pain using IVCM","volume":"9","author":"Zhang","year":"2022","journal-title":"Front Med (Lausanne)"},{"issue":"3","key":"bib53","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1111\/cxo.12887","article-title":"Corneal confocal microscopy: ready for prime time","volume":"103","author":"Petropoulos","year":"2020","journal-title":"Clin Exp Optom"},{"issue":"14","key":"bib54","doi-asserted-by":"publisher","first-page":"DES41","DOI":"10.1167\/iovs.17-23602","article-title":"Application of in vivo confocal microscopy in dry eye disease","volume":"59","author":"Matsumoto","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib55","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jtos.2016.09.004","article-title":"In vivo confocal microscopy of corneal nerves in health and disease","volume":"15","author":"Cruzat","year":"2017","journal-title":"Ocul Surf"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"725363","DOI":"10.3389\/fpain.2021.725363","article-title":"Corneal confocal microscopy to image small nerve fiber degeneration: ophthalmology meets neurology","volume":"2","author":"Petropoulos","year":"2021","journal-title":"Front Pain Res (Lausanne)"},{"issue":"5","key":"bib57","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.ajo.2006.06.057","article-title":"Epithelial dendritic cell distribution in normal and inflamed human cornea: in vivo confocal microscopy study","volume":"142","author":"Mastropasqua","year":"2006","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"bib58","doi-asserted-by":"publisher","first-page":"247","DOI":"10.2165\/00003088-200544030-00003","article-title":"Ocular pharmacokinetics and safety of ciclosporin, a novel topical treatment for dry eye","volume":"44","author":"Tang-Liu","year":"2005","journal-title":"Clin Pharmacokinet"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.ejpb.2017.03.006","article-title":"Cyclosporine A delivery to the eye: a comprehensive review of academic and industrial efforts","volume":"117","author":"Lallemand","year":"2017","journal-title":"Eur J Pharm Biopharm"},{"issue":"7","key":"bib60","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1089\/jop.2018.0106","article-title":"Ocular distribution of cyclosporine following topical administration of OTX-101 in New Zealand White rabbits","volume":"35","author":"Weiss","year":"2019","journal-title":"J Ocul Pharmacol Ther"},{"issue":"1","key":"bib61","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s10194-019-0963-6","article-title":"Behavioral and cognitive animal models in headache research","volume":"20","author":"Vuralli","year":"2019","journal-title":"J Headache Pain"},{"issue":"4","key":"bib62","doi-asserted-by":"publisher","first-page":"e664","DOI":"10.1097\/PR9.0000000000000664","article-title":"Acute hyperalgesia and delayed dry eye after corneal abrasion injury","volume":"3","author":"Hegarty","year":"2018","journal-title":"Pain Rep"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.preteyeres.2018.11.005","article-title":"Corneal pain and experimental model development","volume":"71","author":"McKay","year":"2019","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"bib64","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1167\/iovs.63.1.7","article-title":"Pathogenic mechanism of dry eye-induced chronic ocular pain and a mechanism-based therapeutic approach","volume":"63","author":"Tei","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib65","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1097\/j.pain.0000000000001419","article-title":"Dual enkephalinase inhibitor PL265: a novel topical treatment to alleviate corneal pain and inflammation","volume":"160","author":"Reaux-Le Goazigo","year":"2019","journal-title":"Pain"},{"issue":"6","key":"bib66","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1097\/j.pain.0000000000003141","article-title":"An experimental model for primary neuropathic corneal pain induced by long ciliary nerve ligation in rats","volume":"165","author":"Wu","year":"2024","journal-title":"Pain"},{"issue":"14","key":"bib67","doi-asserted-by":"publisher","first-page":"11021","DOI":"10.1074\/jbc.M008392200","article-title":"Ligand-induced dynamic membrane changes and cell deletion conferred by vanilloid receptor 1","volume":"276","author":"Olah","year":"2001","journal-title":"J Biol Chem"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"598678","DOI":"10.3389\/fncel.2020.598678","article-title":"Chronic tear deficiency sensitizes transient receptor potential vanilloid 1-mediated responses in corneal sensory nerves","volume":"14","author":"Masuoka","year":"2020","journal-title":"Front Cell Neurosci"},{"issue":"7","key":"bib69","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1093\/brain\/awaf044","article-title":"Novel insight into TRPV1-induced mitochondrial dysfunction in neuropathic pain","volume":"148","author":"Awad-Igbaria","year":"2015","journal-title":"Brain"},{"issue":"6","key":"bib70","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1523\/JNEUROSCI.1726-18.2018","article-title":"The immunosuppressant macrolide tacrolimus activates cold-sensing TRPM8 channels","volume":"39","author":"Arcas","year":"2019","journal-title":"J Neurosci"},{"issue":"1","key":"bib71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms8150","article-title":"TRPM8 is a neuronal osmosensor that regulates eye blinking in mice","volume":"6","author":"Quallo","year":"2015","journal-title":"Nat Commun"},{"issue":"2","key":"bib72","doi-asserted-by":"publisher","first-page":"250","DOI":"10.3390\/jcm10020250","article-title":"Topical TRPM8 agonist for relieving neuropathic ocular pain in patients with dry eye: a pilot study","volume":"10","author":"Yoon","year":"2021","journal-title":"J Clin Med"},{"issue":"7","key":"bib73","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/d41573-025-00106-x","article-title":"FDA approves first-in-class TRPM8 ion channel agonist for dry eye disease","volume":"24","author":"Mullard","year":"2025","journal-title":"Nat Rev Drug Discov"},{"issue":"5","key":"bib74","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1038\/eye.2017.3","article-title":"Corneal confocal scanning laser microscopy in patients with dry eye disease treated with topical cyclosporine","volume":"31","author":"Iaccheri","year":"2017","journal-title":"Eye (Lond)"},{"issue":"1","key":"bib75","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s11302-022-09851-9","article-title":"Targeting purinergic receptors to attenuate inflammation of dry eye","volume":"19","author":"Wang","year":"2022","journal-title":"Purinergic Signal"},{"key":"bib76","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/978-3-031-55529-9","article-title":"Microglia in neuropathic pain","volume":"37","author":"Inoue","year":"2024","journal-title":"Adv Neurobiol"},{"issue":"7","key":"bib77","doi-asserted-by":"publisher","first-page":"476","DOI":"10.3390\/cells14070476","article-title":"BDNF signaling and pain modulation","volume":"14","author":"Mazzitelli","year":"2025","journal-title":"Cells"},{"issue":"5","key":"bib78","doi-asserted-by":"publisher","first-page":"539","DOI":"10.3390\/biom14050539","article-title":"Brain-derived neurotrophic factor, nociception, and pain","volume":"14","author":"Merighi","year":"2024","journal-title":"Biomolecules"},{"key":"bib79","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.neulet.2013.08.037","article-title":"The known knowns of microglia-neuronal signalling in neuropathic pain","volume":"557","author":"Beggs","year":"2013","journal-title":"Neurosci Lett"},{"key":"bib80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ynpai.2017.04.001","article-title":"Spinal mechanisms of neuropathic pain: is there a P2X4-BDNF controversy?","volume":"1","author":"Malcangio","year":"2017","journal-title":"Neurobiol Pain"},{"issue":"1","key":"bib81","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s11302-021-09801-x","article-title":"Purinergic signaling: a potential therapeutic target for depression and chronic pain","volume":"19","author":"Zou","year":"2023","journal-title":"Purinergic Signal"},{"issue":"7","key":"bib82","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1007\/s11064-010-0160-0","article-title":"Chronic administration of cyclosporine a changes expression of BDNF and TrkB in rat hippocampus and midbrain","volume":"35","author":"Chen","year":"2010","journal-title":"Neurochem Res"},{"issue":"6","key":"bib83","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1159\/000150445","article-title":"Inflammatory markers in the tears of patients with ocular surface disease","volume":"40","author":"Acera","year":"2008","journal-title":"Ophthalmic Res"},{"issue":"6","key":"bib84","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1590\/S0004-27492008000700017","article-title":"Rationale for anti-inflammatory therapy in dry eye syndrome","volume":"71","author":"de Paiva","year":"2009","journal-title":"Arq Bras Oftalmol"},{"key":"bib85","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.exer.2014.08.009","article-title":"Purines in the eye: recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, M\u00fcller cells, lens, trabecular meshwork, cornea and lacrimal gland","volume":"127","author":"Sanderson","year":"2014","journal-title":"Exp Eye Res"},{"issue":"8","key":"bib86","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1089\/jop.2016.0009","article-title":"Purinergic signaling in corneal wound healing: a tale of 2 receptors","volume":"32","author":"Minns","year":"2016","journal-title":"J Ocul Pharmacol Ther"},{"issue":"2","key":"bib87","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1096\/fj.09-138883","article-title":"The P2X7 purinergic receptor: from physiology to neurological disorders","volume":"24","author":"Skaper","year":"2010","journal-title":"FASEB J"},{"key":"bib88","doi-asserted-by":"publisher","first-page":"10555","DOI":"10.1038\/ncomms10555","article-title":"Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1\u00df secretion in response to ATP","volume":"7","author":"Karmakar","year":"2016","journal-title":"Nat Commun"},{"issue":"17","key":"bib89","doi-asserted-by":"publisher","first-page":"2415341","DOI":"10.1002\/advs.202415341","article-title":"M6A modified miR-31-5p suppresses M1 macrophage polarization and autoimmune dry eye by targeting P2RX7","volume":"12","author":"Zhao","year":"2025","journal-title":"Adv Sci"},{"key":"bib90","doi-asserted-by":"publisher","first-page":"1463767","DOI":"10.3389\/fimmu.2024.1463767","article-title":"Linarine inhibits inflammatory responses in dry eye disease mice by modulating purinergic receptors","volume":"15","author":"Liu","year":"2024","journal-title":"Front Immunol"},{"issue":"2","key":"bib91","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.ajpath.2015.10.006","article-title":"Purinoreceptor P2X7 regulation of Ca2+ mobilization and cytoskeletal rearrangement is required for corneal reepithelialization after injury","volume":"186","author":"Minns","year":"2016","journal-title":"Am J Pathol"},{"key":"bib92","doi-asserted-by":"publisher","first-page":"886721","DOI":"10.3389\/fcell.2022.886721","article-title":"Age dependent changes in corneal epithelial cell signaling","volume":"10","author":"Segars","year":"2022","journal-title":"Front Cell Dev Biol"},{"issue":"4","key":"bib93","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1080\/09687680802050385","article-title":"Assembly and trafficking of P2X purinergic receptors (Review)","volume":"25","author":"Murrell-Lagnado","year":"2008","journal-title":"Mol Membr Biol"},{"key":"bib94","doi-asserted-by":"publisher","first-page":"860","DOI":"10.3389\/fphar.2017.00860","article-title":"Interaction of purinergic P2X4 and P2X7 receptor subunits","volume":"8","author":"Schneider","year":"2017","journal-title":"Front Pharmacol"},{"key":"bib52","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/978-3-030-16638-0_12","article-title":"vivo confocal scanning laser microscopy","volume-title":"High Resolution Imaging in Microscopy and Ophthalmology","author":"Stachs","year":"2019"}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2810793","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T12:30:55Z","timestamp":1757334655000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2810793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,8]]},"references-count":94,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9,2]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.14.9.11","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,8]]}}}