{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T11:50:18Z","timestamp":1789213818673,"version":"build-2803163510"},"reference-count":42,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"9","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2025,9,4]]},"DOI":"10.1167\/tvst.14.9.9","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:30:40Z","timestamp":1756992640000},"page":"9","source":"Crossref","is-referenced-by-count":1,"title":["Tissue Architecture Modulates Compositional and Structural Properties of Corneal Myofibroblast-Derived Matrix"],"prefix":"10.1167","volume":"14","author":[{"given":"Antonios","family":"Giannopoulos","sequence":"first","affiliation":[{"name":"Department of Medical and Translational Biology, Ume\u00e5 University, Ume\u00e5, Sweden"},{"name":"Department of Community Medicine and Rehabilitation, Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludvig J.","family":"Backman","sequence":"additional","affiliation":[{"name":"Department of Medical and Translational Biology, Ume\u00e5 University, Ume\u00e5, Sweden"},{"name":"Department of Community Medicine and Rehabilitation, Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Danielson","sequence":"additional","affiliation":[{"name":"Department of Medical and Translational Biology, Ume\u00e5 University, Ume\u00e5, Sweden"},{"name":"Department of Clinical Sciences, Ophthalmology, Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"3","key":"bib1","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.exer.2010.06.021","article-title":"The molecular basis of corneal transparency","volume":"91","author":"Hassell","year":"2010","journal-title":"Exp Eye Res"},{"issue":"10","key":"bib2","doi-asserted-by":"publisher","first-page":"2607","DOI":"10.1002\/dvdy.21579","article-title":"Development of the corneal stroma, and the collagen\u2013proteoglycan associations that help define its structure and function","volume":"237","author":"Quantock","year":"2008","journal-title":"Dev Dyn"},{"issue":"s1","key":"bib3","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/j.1463-5224.2009.00742.x","article-title":"Meet the corneal myofibroblast: the role of myofibroblast transformation in corneal wound healing and pathology","volume":"12","author":"Myrna","year":"2009","journal-title":"Vet Ophthalmol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"609653","DOI":"10.3389\/fbioe.2020.609653","article-title":"Mechanical and physical regulation of fibroblast\u2013myofibroblast transition: from cellular mechanoresponse to tissue pathology","volume":"8","author":"D'Urso","year":"2020","journal-title":"Front Bioeng Biotechnol"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"108272","DOI":"10.1016\/j.exer.2020.108272","article-title":"Corneal myofibroblasts and fibrosis","volume":"201","author":"Wilson","year":"2020","journal-title":"Exp Eye Res"},{"issue":"5","key":"bib6","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nrm809","article-title":"Myofibroblasts and mechano-regulation of connective tissue remodelling","volume":"3","author":"Tomasek","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.exer.2015.07.009","article-title":"Myofibroblasts","volume":"142","author":"Hinz","year":"2016","journal-title":"Exp Eye Res"},{"issue":"5","key":"bib8","doi-asserted-by":"publisher","first-page":"1601238","DOI":"10.1002\/adhm.201601238","article-title":"Surface topography and mechanical strain promote keratocyte phenotype and extracellular matrix formation in a biomimetic 3D corneal model","volume":"6","author":"Zhang","year":"2017","journal-title":"Adv Healthc Mater"},{"issue":"11","key":"bib9","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1016\/j.biomaterials.2004.04.037","article-title":"Nanofiber alignment and direction of mechanical strain affect the ECM production of human ACL fibroblast","volume":"26","author":"Lee","year":"2005","journal-title":"Biomaterials"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.matbio.2017.06.002","article-title":"Tissue alignment enhances remodeling potential of tendon-derived cells \u2013 lessons from a novel microtissue model of tendon scarring","volume":"65","author":"Foolen","year":"2018","journal-title":"Matrix Biol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.actbio.2018.03.004","article-title":"Substrate fiber alignment mediates tendon cell response to inflammatory signaling","volume":"71","author":"Schoenenberger","year":"2018","journal-title":"Acta Biomater"},{"issue":"22","key":"bib12","doi-asserted-by":"publisher","first-page":"e2301353","DOI":"10.1002\/advs.202301353","article-title":"Collagen fibril orientation instructs fibroblast differentiation via cell contractility","volume":"10","author":"Sapudom","year":"2023","journal-title":"Adv Sci (Weinh)"},{"issue":"3","key":"bib13","first-page":"377","article-title":"Role of fibronectin and fibrinogen in healing of corneal epithelial scrape wounds","volume":"30","author":"Phan","year":"1989","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.matbio.2017.04.003","article-title":"The provisional matrix: setting the stage for tissue repair outcomes","volume":"60\u201361","author":"Barker","year":"2017","journal-title":"Matrix Biol"},{"issue":"7","key":"bib15","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1242\/jcs.110.7.861","article-title":"Fibronectin provides a conduit for fibroblast transmigration from collagenous stroma into fibrin clot provisional matrix","volume":"110","author":"Greiling","year":"1997","journal-title":"J Cell Sci"},{"issue":"7","key":"bib16","doi-asserted-by":"publisher","first-page":"e0134157","DOI":"10.1371\/journal.pone.0134157","article-title":"Expression profiles of neuropeptides, neurotransmitters, and their receptors in human keratocytes in vitro and in situ","volume":"10","author":"Sloniecka","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"bib17","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1006\/excr.1996.0065","article-title":"In vitro fibroplasia: matrix contraction, cell growth, and collagen production of fibroblasts cultured in fibrin gels","volume":"223","author":"Tuan","year":"1996","journal-title":"Exp Cell Res"},{"issue":"18","key":"bib18","doi-asserted-by":"publisher","first-page":"4889","DOI":"10.1016\/j.biomaterials.2010.02.062","article-title":"The initiation of embryonic-like collagen fibrillogenesis by adult human tendon fibroblasts when cultured under tension","volume":"31","author":"Bayer","year":"2010","journal-title":"Biomaterials"},{"issue":"13","key":"bib19","doi-asserted-by":"publisher","first-page":"7307","DOI":"10.1073\/pnas.111150598","article-title":"Corneal collagen fibril structure in three dimensions: structural insights into fibril assembly, mechanical properties, and tissue organization","volume":"98","author":"Holmes","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"bib20","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1167\/iovs.09-3860","article-title":"Human corneal fibrosis: an in vitro model","volume":"51","author":"Karamichos","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib21","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s12551-009-0011-x","article-title":"Corneal collagen\u2014its role in maintaining corneal shape and transparency","volume":"1","author":"Meek","year":"2009","journal-title":"Biophys Rev"},{"issue":"3","key":"bib22","doi-asserted-by":"publisher","first-page":"662","DOI":"10.3390\/cells10030662","article-title":"Collagen assembly at the cell surface: dogmas revisited","volume":"10","author":"Musiime","year":"2021","journal-title":"Cells"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"100079","DOI":"10.1016\/j.mbplus.2021.100079","article-title":"Collagen fibril assembly: new approaches to unanswered questions","volume":"12","author":"Revell","year":"2021","journal-title":"Matrix Biol Plus"},{"issue":"23","key":"bib24","doi-asserted-by":"publisher","first-page":"4096","DOI":"10.1242\/jcs.091363","article-title":"Collagen V is a dominant regulator of collagen fibrillogenesis: dysfunctional regulation of structure and function in a corneal-stroma-specific Col5a1-null mouse model","volume":"124","author":"Sun","year":"2011","journal-title":"J Cell Sci"},{"issue":"1","key":"bib25","doi-asserted-by":"publisher","first-page":"13555","DOI":"10.1038\/srep13555","article-title":"Chick tendon fibroblast transcriptome and shape depend on whether the cell has made its own collagen matrix","volume":"5","author":"Yeung","year":"2015","journal-title":"Sci Rep"},{"issue":"3","key":"bib26","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S0968-4328(00)00043-3","article-title":"Type V collagen: heterotypic type I\/V collagen interactions in the regulation of fibril assembly","volume":"32","author":"Birk","year":"2001","journal-title":"Micron"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.exer.2014.08.001","article-title":"Regulation of corneal stroma extracellular matrix assembly","volume":"133","author":"Chen","year":"2015","journal-title":"Exp Eye Res"},{"issue":"9","key":"bib28","first-page":"1749","article-title":"Human corneal fibrillogenesis. Collagen V structural analysis and fibrillar assembly by stromal fibroblasts in culture","volume":"37","author":"Ruggiero","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib29","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1242\/jcs.95.4.649","article-title":"Collagen fibrillogenesis in vitro: interaction of types I and V collagen regulates fibril diameter","volume":"95","author":"Birk","year":"1990","journal-title":"J Cell Sci"},{"issue":"2","key":"bib30","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1167\/iovs.05-0771","article-title":"Structural abnormalities of the cornea and lid resulting from collagen V mutations","volume":"47","author":"Segev","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib31","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/jcb.20024","article-title":"Reduced type I collagen utilization: a pathogenic mechanism in COL5A1 haplo-insufficient Ehlers\u2013Danlos syndrome","volume":"92","author":"Wenstrup","year":"2004","journal-title":"J Cell Biochem"},{"issue":"8","key":"bib32","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1091\/mbc.E20-08-0533","article-title":"Fibronectin fibril alignment is established upon initiation of extracellular matrix assembly","volume":"32","author":"Garrison","year":"2021","journal-title":"Mol Biol Cell"},{"issue":"23\u201324","key":"bib33","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1089\/ten.tea.2020.0332","article-title":"Extracellular matrix alignment directs provisional matrix assembly and three dimensional fibrous tissue closure","volume":"27","author":"Das","year":"2021","journal-title":"Tissue Eng Part A"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.matbio.2017.06.001","article-title":"Fibroblast-fibronectin patterning and network formation in 3D fibrin matrices","volume":"64","author":"Miron-Mendoza","year":"2017","journal-title":"Matrix Biol"},{"issue":"4","key":"bib35","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1016\/j.matt.2024.01.023","article-title":"Tension in the ranks: cooperative cell contractions drive force-dependent collagen assembly in human fibroblast culture","volume":"7","author":"Silverman","year":"2024","journal-title":"Matter"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.matbio.2017.08.004","article-title":"Decorin and biglycan are necessary for maintaining collagen fibril structure, fiber realignment, and mechanical properties of mature tendons","volume":"64","author":"Robinson","year":"2017","journal-title":"Matrix Biol"},{"issue":"2","key":"bib37","doi-asserted-by":"publisher","first-page":"e0147948","DOI":"10.1371\/journal.pone.0147948","article-title":"Role of decorin core protein in collagen organisation in congenital stromal corneal dystrophy (CSCD)","volume":"11","author":"Kamma-Lorger","year":"2016","journal-title":"PLoS One"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"108933","DOI":"10.1016\/j.exer.2022.108933","article-title":"Decorin regulates collagen fibrillogenesis during corneal wound healing in mouse in vivo","volume":"216","author":"Gupta","year":"2022","journal-title":"Exp Eye Res"},{"issue":"23","key":"bib39","doi-asserted-by":"publisher","first-page":"4321","DOI":"10.1242\/jcs.190546","article-title":"Tenascin-C at a glance","volume":"129","author":"Midwood","year":"2016","journal-title":"J Cell Sci"},{"issue":"10","key":"bib40","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1016\/j.ajpath.2020.06.008","article-title":"Tenascin-C induces phenotypic changes in fibroblasts to myofibroblasts with high contractility through the integrin av\u00df1\/transforming growth factor \u00df\/SMAD signaling axis in human breast cancer","volume":"190","author":"Katoh","year":"2020","journal-title":"Am J Pathol"},{"issue":"4","key":"bib41","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1091\/mbc.5.4.439","article-title":"The extracellular matrix ligands fibronectin and tenascin collaborate in regulating collagenase gene expression in fibroblasts","volume":"5","author":"Tremble","year":"1994","journal-title":"Mol Biol Cell"},{"issue":"2","key":"bib42","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/labinvest.2012.157","article-title":"Impaired cornea wound healing in a tenascin C-deficient mouse model","volume":"93","author":"Sumioka","year":"2013","journal-title":"Lab Invest"}],"container-title":["Translational Vision Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2810780","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:30:41Z","timestamp":1756992641000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2810780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,4]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9,2]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.14.9.9","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,4]]}}}