{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T14:36:35Z","timestamp":1767710195691,"version":"3.48.0"},"reference-count":34,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"1","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2026,1,6]]},"DOI":"10.1167\/tvst.15.1.7","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T14:30:46Z","timestamp":1767709846000},"page":"7","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondria-Related Gene\n                    <i>BDH1<\/i>\n                    Implicated in Myopia Risk via Methylation-Regulated Expression: An Integrative Summary-Data Mendelian Randomization Study"],"prefix":"10.1167","volume":"15","author":[{"given":"Shiming","family":"Peng","sequence":"first","affiliation":[{"name":"Shenzhen Eye Hospital, Shenzhen Eye Institute, Jinan University, Shenzhen, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Deng","sequence":"additional","affiliation":[{"name":"Shenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, Shenzhen, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengyang","family":"Tao","sequence":"additional","affiliation":[{"name":"Shenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, Shenzhen, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Shenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, Shenzhen, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zefeng","family":"Kang","sequence":"additional","affiliation":[{"name":"Eye Hospital, China Academy of Chinese Medical Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27","reference":[{"issue":"1","key":"bib1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41572-020-00231-4","article-title":"Myopia","volume":"6","author":"Baird","year":"2020","journal-title":"Nat Rev Dis Primers"},{"issue":"5","key":"bib2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1167\/iovs.62.5.2","article-title":"IMI impact of myopia","volume":"62","author":"Sankaridurg","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib3","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.preteyeres.2017.09.004","article-title":"The epidemics of myopia: aetiology and prevention","volume":"62","author":"Morgan","year":"2018","journal-title":"Prog Retin Eye Res"},{"issue":"8","key":"bib4","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.neurol.2020.10.008","article-title":"Headache associated with refractive errors: characteristics and risk factors","volume":"177","author":"Lajmi","year":"2021","journal-title":"Rev Neurol (Paris)"},{"issue":"4","key":"bib5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1167\/iovs.61.4.49","article-title":"The complications of myopia: a review and meta-analysis","volume":"61","author":"Haarman","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib6","first-page":"4960852","article-title":"Update on myopia risk factors and microenvironmental changes","volume":"2019","author":"Coviltir","year":"2019","journal-title":"J Ophthalmol"},{"issue":"3","key":"bib7","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3390\/children9030382","article-title":"Myopia genetics and heredity","volume":"9","author":"Wang","year":"2022","journal-title":"Children"},{"key":"bib8","doi-asserted-by":"crossref","first-page":"101156","DOI":"10.1016\/j.preteyeres.2022.101156","article-title":"Myopia: histology, clinical features, and potential implications for the etiology of axial elongation","volume":"96","author":"Jonas","year":"2023","journal-title":"Prog Retin Eye Res"},{"key":"bib9","doi-asserted-by":"crossref","first-page":"654445","DOI":"10.3389\/fphar.2021.654445","article-title":"ATP and adenosine in the retina and retinal diseases","volume":"12","author":"Ye","year":"2021","journal-title":"Front Pharmacol"},{"issue":"1","key":"bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/cddiscovery.2016.34","article-title":"Mitochondria mediates caspase-dependent and independent retinal cell death in Staphylococcus aureus endophthalmitis","volume":"2","author":"Singh","year":"2016","journal-title":"Cell Death Discov"},{"key":"bib12","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.neuroscience.2019.02.026","article-title":"Early diabetes induces changes in mitochondrial physiology of inner retinal neurons","volume":"406","author":"Haider","year":"2019","journal-title":"Neuroscience"},{"key":"bib13","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1007\/s00018-016-2318-7","article-title":"Metabolic and redox signaling in the retina","volume":"74","author":"L\u00e9veillard","year":"2017","journal-title":"Cell Mol Life Sci"},{"issue":"5","key":"bib14","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s00438-023-02036-y","article-title":"Association of mitochondrial DNA variation with high myopia in a Han Chinese population","volume":"298","author":"Xing","year":"2023","journal-title":"Mol Genet Genomics"},{"issue":"12","key":"bib15","doi-asserted-by":"crossref","first-page":"2400269","DOI":"10.1002\/adbi.202400269","article-title":"Electroacupuncture slows experimental myopia progression by improving retinal mitochondrial function: a study based on single-cell RNA sequencing","volume":"8","author":"Hao","year":"2024","journal-title":"Adv Biol (Weinh)"},{"issue":"12","key":"bib16","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1038\/s41433-023-02523-x","article-title":"Mitochondria and the eye\u2014manifestations of mitochondrial diseases and their management","volume":"37","author":"Chen","year":"2023","journal-title":"Eye"},{"issue":"5","key":"bib17","doi-asserted-by":"crossref","first-page":"e426","DOI":"10.1002\/cpz1.426","article-title":"Molecular quantitative trait locus mapping in human complex diseases","volume":"2","author":"Olayinka","year":"2022","journal-title":"Curr Protoc"},{"issue":"1","key":"bib18","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.1038\/s41467-019-10936-0","article-title":"Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits","volume":"10","author":"Porcu","year":"2019","journal-title":"Nat Commun"},{"issue":"9","key":"bib19","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1038\/s41588-018-0184-y","article-title":"Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies","volume":"50","author":"Zhou","year":"2018","journal-title":"Nat Genet"},{"issue":"1","key":"bib20","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/s41467-018-03371-0","article-title":"Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits","volume":"9","author":"Wu","year":"2018","journal-title":"Nat Commun"},{"issue":"9","key":"bib21","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/s41588-021-00913-z","article-title":"Large-scale cis-and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression","volume":"53","author":"V\u00f5sa","year":"2021","journal-title":"Nat Genet"},{"issue":"6569","key":"bib22","doi-asserted-by":"crossref","first-page":"eabj1541","DOI":"10.1126\/science.abj1541","article-title":"Mapping the proteo-genomic convergence of human diseases","volume":"374","author":"Pietzner","year":"2021","journal-title":"Science"},{"issue":"5","key":"bib23","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ng.3538","article-title":"Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets","volume":"48","author":"Zhu","year":"2016","journal-title":"Nat Genet"},{"issue":"5","key":"bib24","doi-asserted-by":"crossref","first-page":"e1004383","DOI":"10.1371\/journal.pgen.1004383","article-title":"Bayesian test for colocalisation between pairs of genetic association studies using summary statistics","volume":"10","author":"Giambartolomei","year":"2014","journal-title":"PLoS Genet"},{"issue":"12","key":"bib25","doi-asserted-by":"crossref","first-page":"e627","DOI":"10.1002\/cpz1.627","article-title":"Bayesian genetic colocalization test of two traits using coloc","volume":"2","author":"Rasooly","year":"2022","journal-title":"Curr Protoc"},{"issue":"5","key":"bib26","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.ajhg.2022.04.001","article-title":"Combining evidence from Mendelian randomization and colocalization: review and comparison of approaches","volume":"109","author":"Zuber","year":"2022","journal-title":"Am J Human Genet"},{"issue":"5","key":"bib27","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ng.3538","article-title":"Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets","volume":"48","author":"Zhu","year":"2016","journal-title":"Nat Genet"},{"issue":"1","key":"bib28","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s13059-024-03218-6","article-title":"DNA methylation patterns of transcription factor binding regions characterize their functional and evolutionary contexts","volume":"25","author":"Rimoldi","year":"2024","journal-title":"Genome Biol"},{"key":"bib29","doi-asserted-by":"crossref","first-page":"101269","DOI":"10.1016\/j.molmet.2021.101269","article-title":"Diminished ketone interconversion, hepatic TCA cycle flux, and glucose production in D-\u00df-hydroxybutyrate dehydrogenase hepatocyte-deficient mice","volume":"53","author":"Stagg","year":"2021","journal-title":"Mol Metab"},{"issue":"11","key":"bib30","doi-asserted-by":"crossref","first-page":"e21098","DOI":"10.1016\/j.heliyon.2023.e21098","article-title":"\u00df-Hydroxybutyrate as an epigenetic modifier: underlying mechanisms and implications","volume":"9","author":"He","year":"2023","journal-title":"Heliyon"},{"issue":"1","key":"bib31","first-page":"750637","article-title":"Oxidative stress in myopia","volume":"2015","author":"Francisco","year":"2015","journal-title":"Oxid Med Cell Longev"},{"key":"bib32","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1007\/s00439-014-1468-7","article-title":"Hypothesis-independent pathway analysis implicates GABA and acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma","volume":"133","author":"Bailey","year":"2014","journal-title":"Hum Genet"},{"key":"bib33","doi-asserted-by":"crossref","first-page":"1112996","DOI":"10.3389\/fmed.2023.1112996","article-title":"Evidence of vascular involvement in myopia: a review","volume":"10","author":"Benavente-Perez","year":"2023","journal-title":"Front Med"},{"key":"bib10","first-page":"790","volume-title":"Oxidative stress and inflammation in retinal degeneration","author":"Jadeja","year":"2021"},{"volume-title":"In Situ Synthesis of Ketone Bodies by Retinal Endothelial Cells Promotes Pathological Angiogenesis in Proliferative Retinopathy.","year":"2021","author":"Yang","key":"bib34"}],"container-title":["Translational Vision Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2811317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T14:30:51Z","timestamp":1767709851000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2811317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,6]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,5]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.15.1.7","relation":{},"ISSN":["2164-2591"],"issn-type":[{"type":"print","value":"2164-2591"}],"subject":[],"published":{"date-parts":[[2026,1,6]]}}}