{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:06:59Z","timestamp":1791209219303,"version":"4.1.0"},"reference-count":54,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"10","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2026,10,5]]},"DOI":"10.1167\/tvst.15.10.1","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:30:33Z","timestamp":1791207033000},"page":"1","source":"Crossref","is-referenced-by-count":0,"title":["Detailed Analysis of Intraretinal Layers and Their Correlation to Brain Structures in Normal Healthy Aging"],"prefix":"10.1167","volume":"15","author":[{"given":"Jack Anthony","family":"Cipolla","sequence":"first","affiliation":[{"name":"University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovana Rosa","family":"Gameiro","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA"},{"name":"Department of Ophthalmology and Visual Sciences, Federal University of Sao Paulo \u2013 EPM\/UNIFESP, Sao Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Tackett","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Aguirre","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradip","family":"Pattany","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Biostatistics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA"},{"name":"Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Detre","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1136\/jnnp-2011-301628","article-title":"Retinal pathology as biomarker for cognitive impairment and Alzheimer's disease","volume":"83","author":"Ikram","year":"2012","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"bib2","doi-asserted-by":"publisher","first-page":"2040622319882205","DOI":"10.1177\/2040622319882205","article-title":"Retinal correlates of neurological disorders","volume":"10","author":"Yap","year":"2019","journal-title":"Ther Adv Chronic Dis."},{"key":"bib3","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/j.1469-7580.2005.00395.x","article-title":"Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures","volume":"206","author":"Patton","year":"2005","journal-title":"J Anat."},{"key":"bib4","doi-asserted-by":"publisher","first-page":"8503859","DOI":"10.1155\/2016\/8503859","article-title":"Optical coherence tomography as a biomarker for diagnosis, progression, and prognosis of neurodegenerative diseases","volume":"2016","author":"Satue","year":"2016","journal-title":"J Ophthalmol."},{"key":"bib5","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1097\/WCO.0b013e328334e99b","article-title":"Optical coherence tomography of the retina: applications in neurology","volume":"23","author":"Jindahra","year":"2010","journal-title":"Curr Opin Neurol."},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.3233\/JAD-180070","article-title":"Visualization of focal thinning of the ganglion cell-inner plexiform layer in patients with mild cognitive impairment and Alzheimer's disease","volume":"64","author":"Shao","year":"2018","journal-title":"J Alzheimers Dis."},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1167\/iovs.18-25809","article-title":"Visual function and disability are associated with focal thickness reduction of the ganglion cell-inner plexiform layer in patients with multiple sclerosis","volume":"60","author":"Shi","year":"2019","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"bib8","doi-asserted-by":"publisher","first-page":"3295","DOI":"10.1523\/JNEUROSCI.23-08-03295.2003","article-title":"Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain","volume":"23","author":"Resnick","year":"2003","journal-title":"J Neurosci."},{"key":"bib9","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1515\/REVNEURO.2010.21.3.187","article-title":"Structural brain changes in aging: courses, causes and cognitive consequences","volume":"21","author":"Fjell","year":"2010","journal-title":"Rev Neurosci."},{"key":"bib10","doi-asserted-by":"publisher","first-page":"3034","DOI":"10.21037\/qims-21-860","article-title":"Age-related focal thinning of the ganglion cell-inner plexiform layer in a healthy population","volume":"12","author":"Deng","year":"2022","journal-title":"Quant Imaging Med Surg."},{"key":"bib11","doi-asserted-by":"publisher","first-page":"5134","DOI":"10.1167\/iovs.14-14303","article-title":"Age-associated changes in the retinal nerve fiber layer and optic nerve head","volume":"55","author":"Patel","year":"2014","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"bib12","doi-asserted-by":"publisher","first-page":"1014359","DOI":"10.3389\/fneur.2022.1014359","article-title":"Retinal thickness changes in different subfields reflect the volume change of cerebral white matter hyperintensity","volume":"13","author":"Lv","year":"2022","journal-title":"Front Neurol."},{"key":"bib13","doi-asserted-by":"publisher","first-page":"743","DOI":"10.3233\/JAD-210533","article-title":"Association of brain volume and retinal thickness in the early stages of Alzheimer's disease","volume":"91","author":"Mathew","year":"2023","journal-title":"J Alzheimers Dis."},{"key":"bib14","doi-asserted-by":"publisher","first-page":"6064","DOI":"10.1038\/s41467-024-50309-w","article-title":"Eye-brain connections revealed by multimodal retinal and brain imaging genetics","volume":"15","author":"Zhao","year":"2024","journal-title":"Nat Commun."},{"key":"bib15","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1111\/ene.14706","article-title":"Relationships between retinal layer thickness and brain volumes in the UK Biobank cohort","volume":"28","author":"Chua","year":"2021","journal-title":"Eur J Neurol."},{"key":"bib16","doi-asserted-by":"publisher","first-page":"e16288","DOI":"10.1111\/ene.16288","article-title":"Structural correlations between brain magnetic resonance image-derived phenotypes and retinal neuroanatomy","volume":"31","author":"Sun","year":"2024","journal-title":"Eur J Neurol."},{"key":"bib17","doi-asserted-by":"publisher","first-page":"4722","DOI":"10.1002\/hbm.26412","article-title":"Association of retinal nerve layers thickness and brain imaging in healthy young subjects from the i-Share-Bordeaux study","volume":"44","author":"Lima Reboucas","year":"2023","journal-title":"Hum Brain Mapp."},{"key":"bib18","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s13195-022-01008-5","article-title":"The relationship between retinal layers and brain areas in asymptomatic first-degree relatives of sporadic forms of Alzheimer's disease: an exploratory analysis","volume":"14","author":"Lopez-Cuenca","year":"2022","journal-title":"Alzheimers Res Ther."},{"key":"bib19","doi-asserted-by":"publisher","first-page":"9562","DOI":"10.1038\/s41598-022-13662-8","article-title":"Neuroimaging and cognitive correlates of retinal optical coherence tomography (OCT) measures at late middle age in a twin sample","volume":"12","author":"Moran","year":"2022","journal-title":"Sci Rep."},{"key":"bib20","doi-asserted-by":"publisher","first-page":"3069","DOI":"10.2147\/OPTH.S383770","article-title":"Multi-center repeatability of macular capillary perfusion density using optical coherence tomography angiography","volume":"16","author":"Jiang","year":"2022","journal-title":"Clin Ophthalmol."},{"key":"bib21","doi-asserted-by":"publisher","first-page":"3905","DOI":"10.1364\/BOE.7.003905","article-title":"Evaluation of artifact reduction in optical coherence tomography angiography with real-time tracking and motion correction technology","volume":"7","author":"Camino","year":"2016","journal-title":"Biomed Opt Express."},{"key":"bib22","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1080\/02713683.2025.2527755","article-title":"Characterizing retinal mitochondrial function and its relations to intraretinal thicknesses in healthy adults","volume":"50","author":"Kim","year":"2025","journal-title":"Curr Eye Res."},{"key":"bib23","doi-asserted-by":"publisher","first-page":"4477","DOI":"10.1093\/cercor\/bhab101","article-title":"Individual-specific areal-level parcellations improve functional connectivity prediction of behavior","volume":"31","author":"Kong","year":"2021","journal-title":"Cereb Cortex."},{"key":"bib24","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1152\/jn.00338.2011","article-title":"The organization of the human cerebral cortex estimated by intrinsic functional connectivity","volume":"106","author":"Yeo","year":"2011","journal-title":"J Neurophysiol."},{"key":"bib25","first-page":"1","article-title":"Advanced normalization tools (ANTS)","volume":"2","author":"Avants","year":"2009","journal-title":"The Insight J."},{"key":"bib26","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1016\/j.neuroimage.2008.12.016","article-title":"Registration based cortical thickness measurement","volume":"45","author":"Das","year":"2009","journal-title":"Neuroimage."},{"key":"bib27","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3389\/fnagi.2017.00225","article-title":"Cortical surface thickness in the middle-aged brain with white matter hyperintense lesions","volume":"9","author":"Zhuang","year":"2017","journal-title":"Front Aging Neurosci."},{"key":"bib28","doi-asserted-by":"publisher","first-page":"3095","DOI":"10.1093\/cercor\/bhx179","article-title":"Local-global parcellation of the human cerebral cortex from intrinsic functional connectivity MRI","volume":"28","author":"Schaefer","year":"2018","journal-title":"Cereb Cortex."},{"key":"bib29","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate - a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J Roy Stat Soc B."},{"key":"bib30","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1016\/j.neuroimage.2005.02.042","article-title":"Age- and sex-related effects on the neuroanatomy of healthy elderly","volume":"26","author":"Lemaitre","year":"2005","journal-title":"Neuroimage."},{"key":"bib31","doi-asserted-by":"publisher","first-page":"3804","DOI":"10.1167\/iovs.17-21460","article-title":"Age-related alterations in the retinal microvasculature, microcirculation, and microstructure","volume":"58","author":"Wei","year":"2017","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"bib32","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1167\/iovs.18-25864","article-title":"Age-related alterations in retinal tissue perfusion and volumetric vessel density","volume":"60","author":"Lin","year":"2019","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"bib33","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0008-4182(04)80054-1","article-title":"Age-related changes in the human retina","volume":"39","author":"Cavallotti","year":"2004","journal-title":"Can J Ophthalmol."},{"key":"bib34","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1136\/pgmj.2005.036665","article-title":"Ageing and the brain","volume":"82","author":"Peters","year":"2006","journal-title":"Postgrad Med J."},{"key":"bib35","doi-asserted-by":"publisher","first-page":"931536","DOI":"10.3389\/fnagi.2022.931536","article-title":"Normal aging induces changes in the brain and neurodegeneration progress: review of the structural, biochemical, metabolic, cellular, and molecular changes","volume":"14","author":"Lee","year":"2022","journal-title":"Front Aging Neurosci."},{"key":"bib36","doi-asserted-by":"publisher","first-page":"8769","DOI":"10.1167\/iovs.11-8388","article-title":"Effects of age, sex, and axial length on the three-dimensional profile of normal macular layer structures","volume":"52","author":"Ooto","year":"2011","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"bib37","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.2147\/OPTH.S137223","article-title":"Alteration of retinal layers in healthy subjects over 60 years of age until nonagenarians","volume":"11","author":"Altay","year":"2017","journal-title":"Clin Ophthalmol."},{"key":"bib38","doi-asserted-by":"publisher","first-page":"213343","DOI":"10.1016\/j.bioadv.2023.213343","article-title":"Mechanobiological implications of age-related remodelling in the outer retina","volume":"147","author":"Piskova","year":"2023","journal-title":"Biomater Adv."},{"key":"bib39","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s12264-022-00969-9","article-title":"Mechanisms underlying brain aging under normal and pathological conditions","volume":"39","author":"Jin","year":"2023","journal-title":"Neurosci Bull."},{"key":"bib40","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1006\/nimg.2001.0786","article-title":"A voxel-based morphometric study of ageing in 465 normal adult human brains","volume":"14","author":"Good","year":"2001","journal-title":"Neuroimage."},{"key":"bib41","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1148\/radiology.216.3.r00au37672","article-title":"Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteers","volume":"216","author":"Courchesne","year":"2000","journal-title":"Radiology."},{"key":"bib42","doi-asserted-by":"publisher","first-page":"360","DOI":"10.3389\/fnagi.2019.00360","article-title":"Is the retina a mirror of the aging brain? Aging of neural retina layers and primary visual cortex across the lifespan","volume":"11","author":"Jorge","year":"2019","journal-title":"Front Aging Neurosci."},{"key":"bib43","doi-asserted-by":"publisher","first-page":"e0182404","DOI":"10.1371\/journal.pone.0182404","article-title":"Segmented inner plexiform layer thickness as a potential biomarker to evaluate open-angle glaucoma: dendritic degeneration of retinal ganglion cell","volume":"12","author":"Kim","year":"2017","journal-title":"PLoS One."},{"key":"bib44","doi-asserted-by":"publisher","first-page":"904175","DOI":"10.3389\/fncel.2022.904175","article-title":"The detrimental effects of progression of retinal degeneration in the visual cortex","volume":"16","author":"Bhattacharyya","year":"2022","journal-title":"Front Cell Neurosci."},{"key":"bib45","doi-asserted-by":"publisher","first-page":"e5441","DOI":"10.1097\/MD.0000000000005441","article-title":"Effect of age and sex on retinal layer thickness and volume in normal eyes","volume":"95","author":"Won","year":"2016","journal-title":"Medicine (Baltimore)."},{"key":"bib46","doi-asserted-by":"publisher","first-page":"4934","DOI":"10.1167\/iovs.13-11913","article-title":"Effect of age on individual retinal layer thickness in normal eyes as measured with spectral-domain optical coherence tomography","volume":"54","author":"Demirkaya","year":"2013","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"bib47","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1177\/11206721211028035","article-title":"How do intracranial tumors associated with visual pathways affect quadrant and sectoral based optical coherence tomography measurements: the effect of intracranial tumors on RNFL and GC-IPL thickness","volume":"32","author":"Ozcan","year":"2022","journal-title":"Eur J Ophthalmol."},{"key":"bib48","doi-asserted-by":"publisher","first-page":"101092","DOI":"10.1016\/j.preteyeres.2022.101092","article-title":"Non-vasogenic cystoid maculopathies","volume":"91","author":"Gaudric","year":"2022","journal-title":"Prog Retin Eye Res."},{"key":"bib49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15548627.2015.1100356","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)","volume":"12","author":"Klionsky","year":"2016","journal-title":"Autophagy."},{"key":"bib50","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1097\/IAE.0000000000000527","article-title":"Directional optical coherence tomography provides accurate outer nuclear layer and Henle fiber layer measurements","volume":"35","author":"Lujan","year":"2015","journal-title":"Retina."},{"key":"bib51","doi-asserted-by":"publisher","first-page":"31804","DOI":"10.1038\/s41598-025-16008-2","article-title":"Association of retinal layer thickness with brain volume and cortical thickness in older adults","volume":"15","author":"Han","year":"2025","journal-title":"Sci Rep."},{"key":"bib52","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1016\/j.ophtha.2007.12.004","article-title":"Optical coherence tomography measurements and analysis methods in optical coherence tomography studies of diabetic macular edema","volume":"115","author":"Browning","year":"2008","journal-title":"Ophthalmology."},{"key":"bib53","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1001\/archopht.125.5.619","article-title":"Optimal optical coherence tomography-based measures in the diagnosis of clinically significant macular edema: retinal volume vs foveal thickness","volume":"125","author":"Campbell","year":"2007","journal-title":"Arch Ophthalmol."},{"key":"bib54","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1016\/j.neuroimage.2009.12.028","article-title":"Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies","volume":"53","author":"Winkler","year":"2010","journal-title":"Neuroimage."}],"container-title":["Translational Vision Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/tvst.arvojournals.org\/article.aspx?doi=10.1167\/tvst.15.10.1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:30:34Z","timestamp":1791207034000},"score":1,"resource":{"primary":{"URL":"http:\/\/tvst.arvojournals.org\/article.aspx?doi=10.1167\/tvst.15.10.1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,5]]},"references-count":54,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,5]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.15.10.1","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10,5]]}}}