{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T03:36:47Z","timestamp":1770262607768,"version":"3.49.0"},"reference-count":37,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"2","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2026,2,4]]},"DOI":"10.1167\/tvst.15.2.4","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T13:30:56Z","timestamp":1770211856000},"page":"4","source":"Crossref","is-referenced-by-count":0,"title":["Increased Erythrocyte Osmotic Fragility as a Risk Factor for Predicting Glaucoma"],"prefix":"10.1167","volume":"15","author":[{"given":"Jialiang","family":"Yang","sequence":"first","affiliation":[{"name":"Genetic Diseases Key Laboratory of Sichuan Province and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Yang","sequence":"additional","affiliation":[{"name":"Genetic Diseases Key Laboratory of Sichuan Province and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kecheng","family":"Li","sequence":"additional","affiliation":[{"name":"Genetic Diseases Key Laboratory of Sichuan Province and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junming","family":"Gu","sequence":"additional","affiliation":[{"name":"Medical Information Center, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yilian","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Hao","sequence":"additional","affiliation":[{"name":"Genetic Diseases Key Laboratory of Sichuan Province and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Gong","sequence":"additional","affiliation":[{"name":"Genetic Diseases Key Laboratory of Sichuan Province and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, People's Republic of China"},{"name":"Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houbin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Genetic Diseases Key Laboratory of Sichuan Province and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, People's Republic of China"},{"name":"Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1016\/S0140-6736(23)01289-8","article-title":"Glaucoma: now and beyond","volume":"402","author":"Jayaram","year":"2023","journal-title":"Lancet."},{"key":"bib2","doi-asserted-by":"publisher","first-page":"4598","DOI":"10.1167\/iovs.18-25085","article-title":"Mitochondrial DNA variation and disease susceptibility in primary open-angle glaucoma","volume":"59","author":"Singh","year":"2018","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"bib3","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1001\/jama.2020.21899","article-title":"Glaucoma in adults-screening, diagnosis, and management: a review","volume":"325","author":"Stein","year":"2021","journal-title":"JAMA."},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1001\/jama.2023.16311","article-title":"What is glaucoma?","volume":"330","author":"Voelker","year":"2023","journal-title":"JAMA."},{"key":"bib5","doi-asserted-by":"publisher","first-page":"101191","DOI":"10.1016\/j.preteyeres.2023.101191","article-title":"Familial normal tension glaucoma genetics","volume":"96","author":"Fox","year":"2023","journal-title":"Prog Retin Eye Res."},{"key":"bib6","doi-asserted-by":"publisher","first-page":"381","DOI":"10.3389\/fimmu.2019.00381","article-title":"Autoantibody biomarker discovery in primary open angle glaucoma using serological proteome analysis (SERPA)","volume":"10","author":"Beutgen","year":"2019","journal-title":"Front Immunol."},{"key":"bib7","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.mito.2021.10.008","article-title":"Blood biomarkers for assessment of mitochondrial dysfunction: an expert review","volume":"62","author":"Hubens","year":"2022","journal-title":"Mitochondrion."},{"key":"bib8","doi-asserted-by":"publisher","first-page":"2362","DOI":"10.1038\/s41591-024-03068-6","article-title":"Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss","volume":"30","author":"Petriti","year":"2024","journal-title":"Nat Med."},{"key":"bib9","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.exer.2008.07.011","article-title":"Oxidative injury to blood vessels and glia of the pre-laminar optic nerve head in human glaucoma","volume":"87","author":"Feilchenfeld","year":"2008","journal-title":"Exp Eye Res."},{"key":"bib10","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.mrrev.2005.11.001","article-title":"The role of oxidative stress in glaucoma","volume":"612","author":"Izzotti","year":"2006","journal-title":"Mutat Res."},{"key":"bib11","doi-asserted-by":"publisher","first-page":"612422","DOI":"10.3389\/fneur.2020.612422","article-title":"The role of neuroinflammation in glaucoma: an update on molecular mechanisms and new therapeutic options","volume":"11","author":"Rolle","year":"2020","journal-title":"Front Neurol."},{"key":"bib13","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1515\/CCLM.2000.104","article-title":"Antioxidant status, erythrocyte membrane lipid peroxidation and osmotic fragility in malignant lymphoma patients","volume":"38","author":"Abou-Seif","year":"2000","journal-title":"Clin Chem Lab Med."},{"key":"bib14","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1089\/ars.2016.6954","article-title":"Red blood cell function and dysfunction: redox regulation, nitric oxide metabolism, anemia","volume":"26","author":"Kuhn","year":"2017","journal-title":"Antioxid Redox Signal."},{"key":"bib15","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.3390\/biom13081262","article-title":"Oxidative stress in healthy and pathological red blood cells","volume":"13","author":"Orrico","year":"2023","journal-title":"Biomolecules."},{"key":"bib16","doi-asserted-by":"publisher","first-page":"7027","DOI":"10.3390\/ijms25137027","article-title":"Mild systemic inflammation increases erythrocyte fragility","volume":"25","author":"Stuart","year":"2024","journal-title":"Int J Mol Sci."},{"key":"bib17","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/vcp.12155","article-title":"Increases in beta-lipoproteins in hyperlipidemic and dyslipidemic dogs are associated with increased erythrocyte osmotic fragility","volume":"43","author":"Behling-Kelly","year":"2014","journal-title":"Vet Clin Pathol."},{"key":"bib18","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1182\/blood.2023022052","article-title":"Regulation of kynurenine metabolism by blood donor genetics and biology impacts red cell hemolysis in vitro and in vivo","volume":"143","author":"Nemkov","year":"2024","journal-title":"Blood."},{"key":"bib19","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1016\/j.ebiom.2015.09.049","article-title":"Low red blood cell vitamin C concentrations induce red blood cell fragility: a link to diabetes via glucose, glucose transporters, and dehydroascorbic acid","volume":"2","author":"Tu","year":"2015","journal-title":"EBioMedicine."},{"key":"bib20","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0960-0760(02)00266-2","article-title":"Binding of ovarian steroids to erythrocytes in patients with sickle cell disease; effects on cell sickling and osmotic fragility","volume":"84","author":"Yoong","year":"2003","journal-title":"J Steroid Biochem Mol Biol."},{"key":"bib21","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1007\/s12020-009-9251-6","article-title":"Erythrocyte osmotic fragility and lipid peroxidation in experimental hyperthyroidism","volume":"36","author":"Y\u00fccel","year":"2009","journal-title":"Endocrine."},{"key":"bib22","doi-asserted-by":"publisher","first-page":"3939","DOI":"10.1182\/blood-2008-07-161166","article-title":"Red cell membrane: past, present, and future","volume":"112","author":"Mohandas","year":"2008","journal-title":"Blood."},{"key":"bib23","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/1040-8428(90)90020-S","article-title":"rheology","volume":"10","author":"Shiga","year":"1990","journal-title":"Crit Rev Oncol Hematol."},{"key":"bib24","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.jaci.2022.02.029","article-title":"Prognostic factors for polyp recurrence in chronic rhinosinusitis with nasal polyps","volume":"150","author":"Bai","year":"2022","journal-title":"J Allergy Clin Immunol."},{"key":"bib25","doi-asserted-by":"publisher","first-page":"105948","DOI":"10.1016\/j.ijsu.2021.105948","article-title":"Evaluation and analysis of incidence and risk factors of lower extremity venous thrombosis after urologic surgeries: a prospective two-center cohort study using LASSO-logistic regression","volume":"89","author":"Tang","year":"2021","journal-title":"Int J Surg."},{"key":"bib26","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1097\/JS9.0000000000000726","article-title":"Normalization weighted combination scores re-evaluate TNM staging of gastric cancer: a retrospective cohort study based on a multicenter database","volume":"110","author":"Wu","year":"2024","journal-title":"Int J Surg."},{"key":"bib27","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1097\/JS9.0000000000000808","article-title":"Prediction models of surgical site infection after gastrointestinal surgery: a nationwide prospective cohort study","volume":"110","author":"Yang","year":"2024","journal-title":"Int J Surg."},{"key":"bib28","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.3390\/ijms21062036","article-title":"The predictive value of salt sensitivity and osmotic fragility in the development of cerebral small vessel disease","volume":"21","author":"Dobrynina","year":"2020","journal-title":"Int J Mol Sci."},{"key":"bib29","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/j.2517-6161.1996.tb02080.x","article-title":"Regression shrinkage and selection via the lasso","volume":"58","author":"Tibshiranit","year":"1996","journal-title":"J Royal Stat Soc."},{"key":"bib30","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1002\/(SICI)1097-0258(19970228)16:4&lt;385::AID-SIM380&gt;3.0.CO;2-3","article-title":"The lasso method for variable selection in the Cox model","volume":"16","author":"Tibshiranit","year":"1997","journal-title":"Stat Med."},{"key":"bib31","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.tins.2023.06.005","article-title":"Blood-brain crosstalk: the roles of neutrophils, platelets, and neutrophil extracellular traps in neuropathologies","volume":"46","author":"Chou","year":"2023","journal-title":"Trends Neurosci."},{"key":"bib32","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.jbspin.2011.12.008","article-title":"The neutrophil and systemic inflammation","volume":"79","author":"Gougerot-Pocidalo","year":"2012","journal-title":"Joint Bone Spine."},{"key":"bib33","doi-asserted-by":"publisher","first-page":"773","DOI":"10.4143\/crt.2020.974","article-title":"LASSO-based machine learning algorithm for prediction of lymph node metastasis in T1 colorectal cancer","volume":"53","author":"Kang","year":"2021","journal-title":"Cancer Res Treat."},{"key":"bib34","doi-asserted-by":"publisher","first-page":"e37265","DOI":"10.1097\/MD.0000000000037265","article-title":"Red blood cells as biomarkers and mediators in complications of diabetes mellitus: a review","volume":"103","author":"Obeagu","year":"2024","journal-title":"Medicine."},{"key":"bib35","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.preteyeres.2013.07.001","article-title":"Retinal ganglion cells: energetics, compartmentation, axonal transport, cytoskeletons and vulnerability","volume":"36","author":"Yu","year":"2013","journal-title":"Prog Retin Eye Res."},{"key":"bib36","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/0002-9394(76)90299-3","article-title":"Ghost cells as a cause of glaucoma","volume":"81","author":"Campbell","year":"1976","journal-title":"Am J Ophthalmol."},{"key":"bib37","first-page":"893","article-title":"The production and mechanism of ghost cell glaucoma in the cat and primate","volume":"26","author":"Lambrou","year":"1985","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"bib12","first-page":"580","article-title":"Role of oxidative stress enzymes in open-angle glaucoma","volume-title":"Eye (Lond).","author":"Yildirim","year":"2005"}],"container-title":["Translational Vision Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/tvst.arvojournals.org\/article.aspx?doi=10.1167\/tvst.15.2.4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T13:31:00Z","timestamp":1770211860000},"score":1,"resource":{"primary":{"URL":"http:\/\/tvst.arvojournals.org\/article.aspx?doi=10.1167\/tvst.15.2.4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,4]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,2]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.15.2.4","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,4]]}}}