{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T03:25:46Z","timestamp":1770261946923,"version":"3.49.0"},"reference-count":44,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"2","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2026,2,4]]},"DOI":"10.1167\/tvst.15.2.5","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T13:30:56Z","timestamp":1770211856000},"page":"5","source":"Crossref","is-referenced-by-count":0,"title":["Visual Acuity Provides a More Meaningful Measure of Vision-Related Functioning Than Mesopic Microperimetry in Age-Related Macular Degeneration Patients: A Cross-Sectional Study"],"prefix":"10.1167","volume":"15","author":[{"given":"Francesco","family":"Cinque","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen A. A. H.","family":"Pas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"de Breuk","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Heesterbeek","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline C. W.","family":"Klaver","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands"},{"name":"Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands"},{"name":"Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands"},{"name":"Institute of Molecular and Clinical Ophthalmology, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carel B.","family":"Hoyng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yara T. E.","family":"Lechanteur","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline M.","family":"van Heugten","sequence":"additional","affiliation":[{"name":"Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, the Netherlands; Limburg Brain Injury Center, Maastricht University, Maastricht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1016\/j.ophtha.2017.05.035","article-title":"Prevalence of age-related macular degeneration in Europe: the past and the future","volume":"124","author":"Colijn","year":"2017","journal-title":"Ophthalmology"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"15326","DOI":"10.1038\/s41598-019-51769-7","article-title":"Association of vision-related quality of life with visual function in age-related macular degeneration","volume":"9","author":"Pondorfer","year":"2019","journal-title":"Sci Rep"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1016\/S0161-6420(01)00754-0","article-title":"Depression, visual acuity, comorbidity, and disability associated with age-related macular degeneration","volume":"108","author":"Brody","year":"2001","journal-title":"Ophthalmology"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"3456","DOI":"10.1167\/iovs.17-22339","article-title":"Report from the NEI\/FDA endpoints workshop on age-related macular degeneration and inherited retinal diseases","volume":"58","author":"Csaky","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1159\/000515148","article-title":"Clinical perspectives and trends: microperimetry as a trial endpoint in retinal disease","volume":"244","author":"Yang","year":"2021","journal-title":"Ophthalmologica"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"100907","DOI":"10.1016\/j.preteyeres.2020.100907","article-title":"Fundus-controlled perimetry (microperimetry): application as outcome measure in clinical trials","volume":"82","author":"Pfau","year":"2021","journal-title":"Prog Retin Eye Res"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1167\/tvst.8.1.7","article-title":"Mesopic and dark-adapted two-color fundus-controlled perimetry in choroidal neovascularization secondary to age-related macular degeneration","volume":"8","author":"von der Emde","year":"2019","journal-title":"Transl Vis Sci Technol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"Bio61","DOI":"10.1167\/iovs.16-21210","article-title":"Combined fundus autofluorescence and near infrared reflectance as prognostic biomarkers for visual acuity in foveal-sparing geographic atrophy","volume":"58","author":"Lindner","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1016\/j.ophtha.2017.06.032","article-title":"Optical coherence tomography predictors of risk for progression to non-neovascular atrophic age-related macular degeneration","volume":"124","author":"Sleiman","year":"2017","journal-title":"Ophthalmology"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.oret.2020.01.019","article-title":"Visual function decline resulting from geographic atrophy: results from the Chroma and Spectri phase 3 trials","volume":"4","author":"Heier","year":"2020","journal-title":"Ophthalmol Retina"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.survophthal.2019.01.014","article-title":"Microperimetry for geographic atrophy secondary to age-related macular degeneration","volume":"64","author":"Csaky","year":"2019","journal-title":"Surv Ophthalmol"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.ajo.2016.05.007","article-title":"Retinal sensitivity at the junctional zone of eyes with geographic atrophy due to age-related macular degeneration","volume":"168","author":"Hariri","year":"2016","journal-title":"Am J Ophthalmol"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1167\/iovs.10-6075","article-title":"Changes in retinal sensitivity in geographic atrophy progression as measured by microperimetry","volume":"52","author":"Meleth","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1097\/IAE.0000000000002337","article-title":"Mesopic and dark-adapted two-color fundus-controlled perimetry in geographic atrophy secondary to age-related macular degeneration","volume":"40","author":"Pfau","year":"2020","journal-title":"Retina"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/S0896-1549(03)00013-0","article-title":"Visual acuity and its measurement","volume":"16","author":"Kniestedt","year":"2003","journal-title":"Ophthalmol Clin North Am"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.preteyeres.2013.01.005","article-title":"Adaptation of the central retina for high acuity vision: cones, the fovea and the avascular zone","volume":"35","author":"Provis","year":"2013","journal-title":"Prog Retin Eye Res"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1001\/jamaophthalmol.2014.5963","article-title":"Longitudinal changes in microperimetry and low luminance visual acuity in age-related macular degeneration","volume":"133","author":"Wu","year":"2015","journal-title":"JAMA Ophthalmol"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.ajo.2018.02.012","article-title":"Visual function metrics in early and intermediate dry age-related macular degeneration for use as clinical trial endpoints","volume":"189","author":"Cocce","year":"2018","journal-title":"Am J Ophthalmol"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"2973","DOI":"10.1002\/sim.5403","article-title":"Biomarkers and surrogate endpoints in clinical trials","volume":"31","author":"Fleming","year":"2012","journal-title":"Stat Med"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.ajo.2010.09.020","article-title":"Vision-specific quality-of-life research: a need to improve the quality","volume":"151","author":"Lamoureux","year":"2011","journal-title":"Am J Ophthalmol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s12955-019-1158-1","article-title":"Vision-related quality of life considering both eyes: results from the German population-based Gutenberg Health Study (GHS)","volume":"17","author":"Nickels","year":"2019","journal-title":"Health Qual Life Outcomes"},{"key":"bib22","first-page":"1226","article-title":"ETDRS-Fast: implementing psychophysical adaptive methods to standardized visual acuity measurement with ETDRS charts","volume":"42","author":"Camparini","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/0002-9394(82)90197-0","article-title":"New visual acuity charts for clinical research","volume":"94","author":"Ferris","year":"1982","journal-title":"Am J Ophthalmol"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/S0161-6420(13)38009-9","article-title":"Early Treatment Diabetic Retinopathy Study design and baseline patient characteristics: ETDRS report number 7","volume":"98","year":"1991","journal-title":"Ophthalmology"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1001\/archopht.119.7.1050","article-title":"Development of the 25-item National Eye Institute Visual Function Questionnaire","volume":"119","author":"Mangione","year":"2001","journal-title":"Arch Ophthalmol"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1111\/ceo.12907","article-title":"Effects of pupil dilation on MAIA microperimetry","volume":"45","author":"Han","year":"2017","journal-title":"Clin Exp Ophthalmol"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.jcrs.2009.11.019","article-title":"Remediating serious flaws in the National Eye Institute Visual Function Questionnaire","volume":"36","author":"Pesudovs","year":"2010","journal-title":"J Cataract Refract Surg"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s12955-017-0732-7","article-title":"The National Eye Institute 25-Item Visual Function Questionnaire (NEI VFQ-25) \u2013 reference data from the German population-based Gutenberg Health Study (GHS)","volume":"15","author":"Nickels","year":"2017","journal-title":"Health Qual Life Outcomes"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.survophthal.2016.12.011","article-title":"Assessment of patient-reported outcomes in retinal diseases: a systematic review","volume":"62","author":"Prem Senthil","year":"2017","journal-title":"Surv Ophthalmol"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"9","DOI":"10.2147\/PROM.S162802","article-title":"The use of patient-reported outcome research in modern ophthalmology: impact on clinical trials and routine clinical practice","volume":"10","author":"Braithwaite","year":"2019","journal-title":"Patient Relat Outcome Meas"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1167\/tvst.5.6.6","article-title":"Reference clinical database for fixation stability metrics in normal subjects measured with the MAIA microperimeter","volume":"5","author":"Morales","year":"2016","journal-title":"Transl Vis Sci Technol"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1016\/S0161-6420(91)32186-9","article-title":"The Wisconsin age-related maculopathy grading system","volume":"98","author":"Klein","year":"1991","journal-title":"Ophthalmology"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1016\/S0161-6420(03)00501-3","article-title":"Grading of age-related maculopathy for epidemiological studies: is digital imaging as good as 35-mm film?","volume":"110","author":"van Leeuwen","year":"2003","journal-title":"Ophthalmology"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"607","DOI":"10.5301\/ejo.5000930","article-title":"Normal values for microperimetry with the MAIA microperimeter: sensitivity and fixation analysis in healthy adults and children","volume":"27","author":"Molina-Mart\u00edn","year":"2017","journal-title":"Eur J Ophthalmol"},{"key":"bib35","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.2147\/OPTH.S64200","article-title":"The impact of a better-seeing eye and a worse-seeing eye on vision-related quality of life","volume":"8","author":"Hirneiss","year":"2014","journal-title":"Clin Ophthalmol"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1167\/iovs.06-0361","article-title":"The Impact of Vision Impairment Questionnaire: an assessment of its domain structure using confirmatory factor analysis and Rasch analysis","volume":"48","author":"Lamoureux","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"AMD152","DOI":"10.1167\/iovs.18-23878","article-title":"Retest reliability of mesopic and dark-adapted microperimetry in patients with intermediate age-related macular degeneration and age-matched controls","volume":"59","author":"Welker","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1038\/eye.2016.107","article-title":"Variation in rod and cone density from the fovea to the mid-periphery in healthy human retinas using adaptive optics scanning laser ophthalmoscopy","volume":"30","author":"Wells-Gray","year":"2016","journal-title":"Eye"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.oret.2019.03.010","article-title":"Longitudinal study of visual function in dry age-related macular degeneration at 12 months","volume":"3","author":"Hsu","year":"2019","journal-title":"Ophthalmol Retina"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"100351","DOI":"10.1016\/j.xops.2023.100351","article-title":"Macular sensitivity endpoints in geographic atrophy: exploratory analysis of Chroma and Spectri Clinical trials","volume":"4","author":"Chang","year":"2024","journal-title":"Ophthalmol Sci"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1080\/08164622.2021.2023477","article-title":"Scotopic microperimetry: evolution, applications and future directions","volume":"105","author":"Taylor","year":"2022","journal-title":"Clin Exp Optom"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1016\/j.socscimed.2007.11.037","article-title":"Declines in late-life disability: The role of early- and mid-life factors","volume":"66","author":"Freedman","year":"2008","journal-title":"Soc Sci Med"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1167\/tvst.11.4.5","article-title":"Calibration of the Dutch EyeQ to measure vision related quality of life in patients with exudative retinal diseases","volume":"11","author":"Rausch-Koster","year":"2022","journal-title":"Transl Vis Sci Technol"},{"key":"bib43","doi-asserted-by":"crossref","first-page":"xxiii,830","DOI":"10.1007\/978-0-230-36355-7","volume-title":"Serious stats: a guide to advanced statistics for the behavioral sciences","author":"Baguley","year":"2012"}],"container-title":["Translational Vision Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/tvst.arvojournals.org\/article.aspx?doi=10.1167\/tvst.15.2.5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T13:30:57Z","timestamp":1770211857000},"score":1,"resource":{"primary":{"URL":"http:\/\/tvst.arvojournals.org\/article.aspx?doi=10.1167\/tvst.15.2.5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,4]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,2]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.15.2.5","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,4]]}}}