{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:50:12Z","timestamp":1790628612749,"version":"4.1.0"},"reference-count":29,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"DOI":"10.1167\/tvst.15.5.2","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T12:30:50Z","timestamp":1777638650000},"page":"2","source":"Crossref","is-referenced-by-count":1,"title":["Targeting Circadian Rhythm Disruption in Glaucoma: PTGDS Mediates Trabecular Meshwork Fibrosis and Is Therapeutically Targeted by Aprepitant"],"prefix":"10.1167","volume":"15","author":[{"given":"Hongzhi","family":"Yuan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong Province, People's Republic of China"},{"name":"Department of Ophthalmology, the Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, Guangdong Province, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Che","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong Province, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong Province, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Cai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong Province, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Tzu","family":"Ping","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong Province, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoran","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong Province, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangfan","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong Province, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"issue":"16","key":"bib1","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1001\/jama.2023.16311","article-title":"What is glaucoma?","volume":"330","author":"Voelker","year":"2023","journal-title":"JAMA"},{"issue":"3","key":"bib2","doi-asserted-by":"publisher","first-page":"418","DOI":"10.3390\/medicina61030418","article-title":"Impact of physiological and psychological stress on glaucoma development and progression: a narrative review","volume":"61","author":"Isserow","year":"2025","journal-title":"Medicina (Kaunas)"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1136\/bjo-2025-327650","article-title":"Psychological comorbidity in glaucoma: prevalence and impact of anxiety and depression","volume":"109","author":"Rokohl","year":"2025","journal-title":"Br J Ophthalmol"},{"issue":"15","key":"bib4","doi-asserted-by":"publisher","first-page":"3065","DOI":"10.1038\/s41433-023-02471-6","article-title":"Obstructive sleep apnoea and glaucoma: a systematic review and meta-analysis","volume":"37","author":"Cheong","year":"2023","journal-title":"Eye (Lond)"},{"issue":"6","key":"bib5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1167\/iovs.61.6.7","article-title":"Intra-subject variability and diurnal cycle of ocular perfusion pressure as characterized by continuous telemetry in nonhuman primates","volume":"61","author":"Wilson","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"bib6","doi-asserted-by":"publisher","first-page":"e0225754","DOI":"10.1371\/journal.pone.0225754","article-title":"Diurnal variations of amplitude of accommodation in different age groups","volume":"14","author":"Park","year":"2019","journal-title":"PLoS One"},{"issue":"2","key":"bib7","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.survophthal.2019.09.004","article-title":"Review of the measurement and management of 24-hour intraocular pressure in patients with glaucoma","volume":"65","author":"Mansouri","year":"2020","journal-title":"Surv Ophthalmol"},{"issue":"4","key":"bib8","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.ophtha.2015.11.020","article-title":"Visual field change and 24-hour IOP-related profile with a contact lens sensor in treated glaucoma patients","volume":"123","author":"De Moraes","year":"2016","journal-title":"Ophthalmology"},{"issue":"1","key":"bib9","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3390\/ijms22010359","article-title":"Disruption of 24-hour rhythm in intraocular pressure correlates with retinal ganglion cell loss in glaucoma","volume":"22","author":"Neroev","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"12","key":"bib10","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1167\/iovs.66.12.48","article-title":"Small extracellular vesicle treatment of trabecular meshwork fibrosis: 2D\/3D in vitro and in vivo analyses","volume":"66","author":"Jiang","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"bib11","doi-asserted-by":"publisher","first-page":"3469","DOI":"10.1111\/jcmm.15032","article-title":"AQP1 suppression by ATF4 triggers trabecular meshwork tissue remodelling in ET-1-induced POAG","volume":"24","author":"Zhao","year":"2020","journal-title":"J Cell Mol Med"},{"issue":"3","key":"bib12","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1167\/iovs.66.3.48","article-title":"Fibrosis-related gene and protein expression in normal and glaucomatous trabecular meshwork cells","volume":"66","author":"Yang","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib13","doi-asserted-by":"publisher","first-page":"4877","DOI":"10.1038\/s41467-021-25181-7","article-title":"GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans","volume":"12","author":"Nair","year":"2021","journal-title":"Nat Commun"},{"issue":"22","key":"bib14","doi-asserted-by":"publisher","first-page":"e174836","DOI":"10.1172\/jci.insight.174836","article-title":"Effects of SIPA1L1 on trabecular meshwork extracellular matrix protein accumulation and cellular phagocytosis in POAG","volume":"9","author":"Xu","year":"2024","journal-title":"JCI Insight"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"115340","DOI":"10.1016\/j.bcp.2022.115340","article-title":"AZD6738 decreases intraocular pressure and inhibits fibrotic response in trabecular meshwork through CHK1\/P53 pathway","volume":"206","author":"Huang","year":"2022","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"bib16","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1186\/s12964-024-01614-w","article-title":"DEC1 is involved in circadian rhythm disruption-exacerbated pulmonary fibrosis","volume":"22","author":"Chen","year":"2024","journal-title":"Cell Commun Signal"},{"issue":"1","key":"bib17","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.1038\/s41467-021-23050-x","article-title":"Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis","volume":"12","author":"Yoshida","year":"2021","journal-title":"Nat Commun"},{"issue":"3","key":"bib18","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1167\/iovs.16-21154","article-title":"Modulation of circadian rhythms affects corneal epithelium renewal and repair in mice","volume":"58","author":"Xue","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"bib19","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.3390\/antiox11081516","article-title":"Redox homeostasis in ocular tissues: circadian regulation of glutathione in the lens?","volume":"11","author":"Lim","year":"2022","journal-title":"Antioxidants (Basel)"},{"issue":"5","key":"bib20","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1093\/biolre\/ioaf030","article-title":"Melatonin modulated GPX5 and PTGDS expression in Bactrian camel epididymis mainly via receptor MT1\u2020","volume":"112","author":"Zhao","year":"2025","journal-title":"Biol Reprod"},{"issue":"10","key":"bib21","doi-asserted-by":"publisher","first-page":"5551","DOI":"10.1093\/rheumatology\/keaf276","article-title":"Targeting PTGDS inhibits pro-inflammatory fibroblasts associated with skin fibrosis in systemic sclerosis","volume":"64","author":"Fang","year":"2025","journal-title":"Rheumatology (Oxford)"},{"issue":"5","key":"bib22","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1167\/iovs.66.5.31","article-title":"Single-cell RNA sequencing of the primary visual cortex in mice with optic nerve injury","volume":"66","author":"Li","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"bib23","doi-asserted-by":"publisher","first-page":"3805","DOI":"10.1007\/s00417-021-05279-w","article-title":"The potential role of long noncoding RNAs in primary open-angle glaucoma","volume":"259","author":"Zhang","year":"2021","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"9","key":"bib24","doi-asserted-by":"publisher","first-page":"6382","DOI":"10.1167\/iovs.13-12128","article-title":"Gene expression profile in human trabecular meshwork from patients with primary open-angle glaucoma","volume":"54","author":"Liu","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"23","key":"bib25","doi-asserted-by":"publisher","first-page":"25153","DOI":"10.18632\/aging.203733","article-title":"A circadian rhythm-related gene signature associated with tumor immunity, cisplatin efficacy, and prognosis in bladder cancer","volume":"13","author":"Zhou","year":"2021","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"bib26","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s12974-017-0868-8","article-title":"GlyCAM1 negatively regulates monocyte entry into the optic nerve head and contributes to radiation-based protection in glaucoma","volume":"14","author":"Williams","year":"2017","journal-title":"J Neuroinflammation"},{"issue":"1","key":"bib27","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s13024-018-0303-3","article-title":"Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA\/2J glaucoma","volume":"14","author":"Williams","year":"2019","journal-title":"Mol Neurodegener"},{"issue":"21","key":"bib28","doi-asserted-by":"publisher","first-page":"15936","DOI":"10.3390\/ijms242115936","article-title":"The repurposing of non-peptide neurokinin-1 receptor antagonists as antitumor drugs: an urgent challenge for aprepitant","volume":"24","author":"Cove\u00f1as","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"2","key":"bib29","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1167\/tvst.13.2.9","article-title":"Aprepitant restores corneal sensitivity and reduces pain in DED","volume":"13","author":"Bonelli","year":"2024","journal-title":"Transl Vis Sci Technol"}],"container-title":["Translational Vision Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/tvst.arvojournals.org\/article.aspx?doi=10.1167\/tvst.15.5.2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T14:30:38Z","timestamp":1781706638000},"score":1,"resource":{"primary":{"URL":"http:\/\/tvst.arvojournals.org\/article.aspx?doi=10.1167\/tvst.15.5.2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.15.5.2","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,1]]}}}