{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:56:23Z","timestamp":1781528183663,"version":"3.54.1"},"reference-count":36,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"6","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2026,6,15]]},"DOI":"10.1167\/tvst.15.6.18","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:30:52Z","timestamp":1781526652000},"page":"18","source":"Crossref","is-referenced-by-count":0,"title":["Intrinsic Capacity, Polygenic Risk Score, and Risk of Glaucoma"],"prefix":"10.1167","volume":"15","author":[{"given":"Jia-Yan","family":"Kai","sequence":"first","affiliation":[{"name":"School of Public Health, Suzhou Medical College of Soochow University, Suzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Yi","family":"Gong","sequence":"additional","affiliation":[{"name":"School of Public Health, Suzhou Medical College of Soochow University, Suzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hui","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Public Health, Suzhou Medical College of Soochow University, Suzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Xuan","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Public Health, Suzhou Medical College of Soochow University, Suzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan-Lin","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health, Suzhou Medical College of Soochow University, Suzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaofu","family":"Ke","sequence":"additional","affiliation":[{"name":"School of Public Health, Suzhou Medical College of Soochow University, Suzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Wei","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Public Health, Suzhou Medical College of Soochow University, Suzhou, People's Republic of China"},{"name":"https:\/\/orcid.org\/0000-0003-3362-4613"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"10108","key":"bib1","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1016\/S0140-6736(17)31469-1","article-title":"Glaucoma","volume":"390","author":"Jonas","year":"2017","journal-title":"Lancet"},{"issue":"11","key":"bib2","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"bib3","doi-asserted-by":"crossref","first-page":"j3889","DOI":"10.1136\/bmj.j3889","article-title":"Glaucoma and intraocular pressure in EPIC-Norfolk Eye Study: cross sectional study","volume":"358","author":"Chan","year":"2017","journal-title":"BMJ"},{"issue":"10","key":"bib4","first-page":"2251","article-title":"Risk factors for late presentation in chronic glaucoma","volume":"40","author":"Fraser","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"18","key":"bib5","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The pathophysiology and treatment of glaucoma: a review","volume":"311","author":"Weinreb","year":"2014","journal-title":"JAMA"},{"issue":"5","key":"bib6","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1038\/s41433-018-0042-2","article-title":"Normal tension glaucoma: review of current understanding and mechanisms of the pathogenesis","volume":"32","author":"Killer","year":"2018","journal-title":"Eye (Lond)"},{"issue":"12","key":"bib7","doi-asserted-by":"publisher","first-page":"2102","DOI":"10.1016\/j.clintera.2004.12.007","article-title":"Gold standard medical therapy for glaucoma: defining the criteria identifying measures for an evidence-based analysis","volume":"26","author":"Obstbaum","year":"2004","journal-title":"Clin Ther"},{"issue":"10033","key":"bib8","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1016\/S0140-6736(15)00516-4","article-title":"The World report on ageing and health: a policy framework for healthy ageing","volume":"387","author":"Beard","year":"2016","journal-title":"Lancet"},{"issue":"12","key":"bib9","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1093\/gerona\/gly011","article-title":"Evidence for the domains supporting the construct of intrinsic capacity","volume":"73","author":"Cesari","year":"2018","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"12","key":"bib10","doi-asserted-by":"publisher","first-page":"e209452","DOI":"10.1212\/WNL.0000000000209452","article-title":"Intrinsic capacity, polygenic risk score, APOE genotype, and risk of dementia: a prospective cohort study based on the UK Biobank","volume":"102","author":"Sun","year":"2024","journal-title":"Neurology"},{"issue":"5","key":"bib11","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1002\/jcsm.13283","article-title":"Association of intrinsic capacity with incidence and mortality of cardiovascular disease: Prospective study in UK Biobank","volume":"14","author":"Ram\u00edrez-V\u00e9lez","year":"2023","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"143","DOI":"10.2147\/NSS.S439274","article-title":"Investigating the causal relationship between sleep behaviors and primary open-angle glaucoma: a bidirectional two-sample mendelian randomization study","volume":"16","author":"Zhang","year":"2024","journal-title":"Nat Sci Sleep"},{"issue":"11","key":"bib13","doi-asserted-by":"publisher","first-page":"e063676","DOI":"10.1136\/bmjopen-2022-063676","article-title":"Association of sleep behaviour and pattern with the risk of glaucoma: a prospective cohort study in the UK Biobank","volume":"12","author":"Sun","year":"2022","journal-title":"BMJ Open"},{"issue":"2","key":"bib14","doi-asserted-by":"publisher","first-page":"339","DOI":"10.5664\/jcsm.10334","article-title":"Long-term effects of obstructive sleep apnea and its treatment on open-angle glaucoma: a big-data cohort study","volume":"19","author":"Lee","year":"2023","journal-title":"J Clin Sleep Med"},{"issue":"7","key":"bib15","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.3390\/jcm8071078","article-title":"Relationships between hearing loss and the prevalences of cataract, glaucoma, diabetic retinopathy, and age-related macular degeneration in Korea","volume":"8","author":"Kim","year":"2019","journal-title":"J Clin Med"},{"issue":"9822","key":"bib16","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1016\/S0140-6736(12)60404-8","article-title":"What makes UK Biobank special?","volume":"379","author":"Collins","year":"2012","journal-title":"Lancet"},{"issue":"3","key":"bib17","doi-asserted-by":"publisher","first-page":"e1001779","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med"},{"issue":"9990","key":"bib18","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/S0140-6736(14)62000-6","article-title":"Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study","volume":"386","author":"Leong","year":"2015","journal-title":"Lancet"},{"issue":"9","key":"bib19","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1007\/s12603-020-1503-4","article-title":"In the quest of a standard index of intrinsic capacity. A critical literature review","volume":"24","author":"Gonzalez-Bautista","year":"2020","journal-title":"J Nutr Health Aging"},{"issue":"2","key":"bib20","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1038\/s41588-019-0556-y","article-title":"Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression","volume":"52","author":"Craig","year":"2020","journal-title":"Nat Genet"},{"issue":"7726","key":"bib21","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","article-title":"The UK Biobank resource with deep phenotyping and genomic data","volume":"562","author":"Bycroft","year":"2018","journal-title":"Nature"},{"issue":"1","key":"bib22","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1097\/WOX.0b013e3182439613","article-title":"Oxidative stress and antioxidant defense","volume":"5","author":"Birben","year":"2012","journal-title":"World Allergy Organ J"},{"issue":"1","key":"bib23","doi-asserted-by":"publisher","first-page":"e13710","DOI":"10.1002\/jcsm.13710","article-title":"A natural autophagy activator castanea crenata flower alleviates skeletal muscle ageing","volume":"16","author":"Park","year":"2025","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"12","key":"bib24","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.3390\/antiox10121948","article-title":"Role of oxidative stress in ocular diseases associated with retinal ganglion cells degeneration","volume":"10","author":"Kang","year":"2021","journal-title":"Antioxidants (Basel)"},{"issue":"2","key":"bib25","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1097\/ICU.0000000000000354","article-title":"Lamina cribrosa in glaucoma","volume":"28","author":"Downs","year":"2017","journal-title":"Curr Opin Ophthalmol"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"108683","DOI":"10.1016\/j.exer.2021.108683","article-title":"Resveratrol attenuates retinal ganglion cell loss in a mouse model of retinal ischemia reperfusion injury via multiple pathways","volume":"209:","author":"Ji","year":"2021","journal-title":"Exp Eye Res"},{"key":"bib27","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.gerinurse.2023.12.005","article-title":"Gait speed assessment as a prognostic tool for morbidity and mortality in vulnerable older adult patients following vascular surgery","volume":"56:","author":"DR","year":"2024","journal-title":"Geriatr Nurs"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.bbi.2024.12.007","article-title":"Blood biomarker signatures for slow gait speed in older adults: an explainable machine learning approach","volume":"124","author":"G\u00f6k\u00e7e","year":"2025","journal-title":"Brain Behav Immun"},{"issue":"3","key":"bib29","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1167\/iovs.03-0469","article-title":"Posterior ciliary artery circulation in health and disease: the Weisenfeld lecture","volume":"45","author":"Hayreh","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib30","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/S1350-9462(02)00008-3","article-title":"The impact of ocular blood flow in glaucoma","volume":"21","author":"Flammer","year":"2002","journal-title":"Prog Retin Eye Res"},{"issue":"10","key":"bib31","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1016\/j.ophtha.2014.04.016","article-title":"Nocturnal systemic hypotension increases the risk of glaucoma progression","volume":"121","author":"Charlson","year":"2014","journal-title":"Ophthalmology"},{"issue":"28","key":"bib32","doi-asserted-by":"publisher","first-page":"e11377","DOI":"10.1097\/MD.0000000000011377","article-title":"Migraine as a risk factor for primary open angle glaucoma: a systematic review and meta-analysis","volume":"97","author":"Xu","year":"2018","journal-title":"Medicine (Baltimore)"},{"issue":"8","key":"bib33","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1007\/s11011-024-01393-w","article-title":"Stress, hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-gonadal axis, and aggression","volume":"39","author":"Mbiydzenyuy","year":"2024","journal-title":"Metab Brain Dis"},{"issue":"1","key":"bib34","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1167\/iovs.11-8434","article-title":"Multiplex cytokine analysis of aqueous humor in eyes with primary open-angle glaucoma, exfoliation glaucoma, and cataract","volume":"53","author":"Takai","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib35","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/cns.13569","article-title":"Peripheral inflammation and blood-brain barrier disruption: effects and mechanisms","volume":"27","author":"Huang","year":"2021","journal-title":"CNS Neurosci Ther"},{"issue":"2","key":"bib36","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.ogla.2021.08.003","article-title":"The prevalence of autoimmune diseases in patients with primary open-angle glaucoma undergoing ophthalmic surgeries","volume":"5","author":"Lorenzo","year":"2022","journal-title":"Ophthalmol Glaucoma"}],"container-title":["Translational Vision Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/tvst.arvojournals.org\/article.aspx?doi=10.1167\/tvst.15.6.18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:30:53Z","timestamp":1781526653000},"score":1,"resource":{"primary":{"URL":"http:\/\/tvst.arvojournals.org\/article.aspx?doi=10.1167\/tvst.15.6.18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,15]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.15.6.18","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,15]]}}}