{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:54:16Z","timestamp":1781790856945,"version":"3.54.5"},"reference-count":74,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"6","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2026,6,18]]},"DOI":"10.1167\/tvst.15.6.23","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:30:38Z","timestamp":1781789438000},"page":"23","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic Potential of miR-196a in Protecting Corneal Endothelial Cells From Senescence Through Mitochondrial and TGF-\u03b2 Signaling Modulation"],"prefix":"10.1167","volume":"15","author":[{"given":"Hye-Jin","family":"Son","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Republic of Korea"},{"name":"Hallym BioEyeTech Research Center, Hallym University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyeong Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Republic of Korea"},{"name":"Hallym BioEyeTech Research Center, Hallym University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunkyoung","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Republic of Korea"},{"name":"Hallym BioEyeTech Research Center, Hallym University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Bo","family":"Noh","sequence":"additional","affiliation":[{"name":"Hallym BioEyeTech Research Center, Hallym University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Sun","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Republic of Korea"},{"name":"Hallym BioEyeTech Research Center, Hallym University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Hee","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Republic of Korea"},{"name":"Hallym BioEyeTech Research Center, Hallym University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Joo","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Republic of Korea"},{"name":"Hallym BioEyeTech Research Center, Hallym University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"pt 3","key":"bib1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/eye.1990.53","article-title":"The corneal endothelium","volume":"4","author":"Tuft","year":"1990","journal-title":"Eye (Lond)"},{"issue":"1","key":"bib2","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S1350-9462(02)00059-9","article-title":"Identity and regulation of ion transport mechanisms in the corneal endothelium","volume":"22","author":"Bonanno","year":"2003","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"bib3","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.exer.2011.06.004","article-title":"Molecular mechanisms underlying the corneal endothelial pump","volume":"95","author":"Bonanno","year":"2012","journal-title":"Exp Eye Res"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"108495","DOI":"10.1016\/j.exer.2021.108495","article-title":"Diseases of the corneal endothelium","volume":"205","author":"Jeang","year":"2021","journal-title":"Exp Eye Res"},{"key":"bib5","first-page":"2515841418815802","article-title":"Corneal endothelial cell dysfunction: etiologies and management","volume":"10","author":"Feizi","year":"2018","journal-title":"Ther Adv Ophthalmol"},{"issue":"11","key":"bib6","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1097\/ICO.0000000000002687","article-title":"New therapies for corneal endothelial diseases: 2020 and beyond","volume":"40","author":"Soh","year":"2021","journal-title":"Cornea"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of microRNA biogenesis, mechanisms of actions, and circulation","volume":"9","author":"O'Brien","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"key":"bib8","first-page":"1815","article-title":"MicroRNA profile comparison of the corneal endothelia of young and old mice: implications for senescence of the corneal endothelium","volume":"19","author":"Zhao","year":"2013","journal-title":"Mol Vis"},{"issue":"14","key":"bib9","doi-asserted-by":"publisher","first-page":"11490","DOI":"10.3390\/ijms241411490","article-title":"Inhibiting miR-195-5p induces proliferation of human corneal endothelial cells","volume":"24","author":"Parekh","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"1","key":"bib10","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/j.1582-4934.2010.01219.x","article-title":"MicroRNA-196: critical roles and clinical applications in development and cancer","volume":"15","author":"Chen","year":"2011","journal-title":"J Cell Mol Med"},{"issue":"1","key":"bib11","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.brainresbull.2008.12.009","article-title":"Misexpression of miR-196a induces eye anomaly in Xenopus laevis","volume":"79","author":"Qiu","year":"2009","journal-title":"Brain Res Bull"},{"issue":"15","key":"bib12","doi-asserted-by":"publisher","first-page":"4254","DOI":"10.7150\/ijbs.60805","article-title":"MicroRNA-196a promotes renal cancer cell migration and invasion by targeting BRAM1 to regulate SMAD and MAPK signaling pathways","volume":"17","author":"Cui","year":"2021","journal-title":"Int J Biol Sci"},{"issue":"11","key":"bib13","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.3390\/antiox9111085","article-title":"SIRT1 activation using CRISPR\/dCas9 promotes regeneration of human corneal endothelial cells through inhibiting senescence","volume":"9","author":"Joo","year":"2020","journal-title":"Antioxidants (Basel)"},{"issue":"12","key":"bib14","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1002\/stem.2915","article-title":"SOX2 activation using CRISPR\/dCas9 promotes wound healing in corneal endothelial cells","volume":"36","author":"Chang","year":"2018","journal-title":"Stem Cells"},{"issue":"6","key":"bib15","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1016\/j.cell.2017.10.008","article-title":"Force triggers YAP nuclear entry by regulating transport across nuclear pores","volume":"171","author":"Elosegui-Artola","year":"2017","journal-title":"Cell"},{"issue":"8","key":"bib16","doi-asserted-by":"publisher","first-page":"R90","DOI":"10.1186\/gb-2010-11-8-r90","article-title":"Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites","volume":"11","author":"Betel","year":"2010","journal-title":"Genome Biol"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"e05005","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs","volume":"4","author":"Agarwal","year":"2015","journal-title":"Elife"},{"issue":"6","key":"bib18","doi-asserted-by":"publisher","first-page":"2408","DOI":"10.1167\/iovs.05-0745","article-title":"Antibody blockade of junctional adhesion molecule-A in rabbit corneal endothelial tight junctions produces corneal swelling","volume":"47","author":"Mandell","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib19","doi-asserted-by":"publisher","first-page":"9361","DOI":"10.1038\/s41598-023-36567-6","article-title":"A single-cell RNA-seq analysis unravels the heterogeneity of primary cultured human corneal endothelial cells","volume":"13","author":"Catala","year":"2023","journal-title":"Sci Rep"},{"issue":"4","key":"bib20","doi-asserted-by":"publisher","first-page":"3674","DOI":"10.3390\/ijms24043674","article-title":"Basic methods of cell cycle analysis","volume":"24","author":"Ligasova","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"2","key":"bib21","first-page":"665","article-title":"Nestin structure and predicted function in cellular cytoskeletal organisation","volume":"20","author":"Michalczyk","year":"2005","journal-title":"Histol Histopathol"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"645593","DOI":"10.3389\/fcell.2021.645593","article-title":"Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype","volume":"9","author":"Kumari","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"11","key":"bib23","doi-asserted-by":"publisher","first-page":"a011338","DOI":"10.1101\/cshperspect.a011338","article-title":"Mitochondrial quality control mediated by PINK1 and parkin: links to parkinsonism","volume":"4","author":"Narendra","year":"2012","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"1","key":"bib24","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/cdd.2017.172","article-title":"Cell cycle arrest through indirect transcriptional repression by p53: i have a DREAM","volume":"25","author":"Engeland","year":"2018","journal-title":"Cell Death Differ"},{"issue":"12","key":"bib25","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1212\/WNL.0000000000207779","article-title":"What is the role of the Rho-ROCK pathway in neurologic disorders?","volume":"101","author":"Benarroch","year":"2023","journal-title":"Neurology"},{"issue":"13","key":"bib26","doi-asserted-by":"publisher","first-page":"3468","DOI":"10.3390\/cancers15133468","article-title":"The Hippo pathway effectors YAP\/TAZ-TEAD oncoproteins as emerging therapeutic targets in the tumor microenvironment","volume":"15","author":"Mokhtari","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"1","key":"bib27","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1128\/MMBR.00031-10","article-title":"Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases","volume":"75","author":"Cargnello","year":"2011","journal-title":"Microbiol Mol Biol Rev"},{"issue":"7","key":"bib28","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/nmeth.2489","article-title":"MicroRNA target site identification by integrating sequence and binding information","volume":"10","author":"Majoros","year":"2013","journal-title":"Nat Methods"},{"issue":"2","key":"bib29","doi-asserted-by":"publisher","first-page":"G196","DOI":"10.1152\/ajpgi.00077.2014","article-title":"Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration","volume":"307","author":"Grijalva","year":"2014","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"11","key":"bib30","doi-asserted-by":"publisher","first-page":"7610","DOI":"10.1167\/iovs.14-14980","article-title":"Cell surface markers of functional phenotypic corneal endothelial cells","volume":"55","author":"Okumura","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"29047","DOI":"10.1038\/srep29047","article-title":"3D map of the human corneal endothelial cell","volume":"6","author":"He","year":"2016","journal-title":"Sci Rep"},{"issue":"23","key":"bib32","doi-asserted-by":"publisher","first-page":"3682","DOI":"10.3390\/ani13233682","article-title":"miR-196a promotes proliferation of mammary epithelial cells by targeting CDKN1B","volume":"13","author":"Chen","year":"2023","journal-title":"Animals (Basel)"},{"issue":"3","key":"bib33","first-page":"2461","article-title":"MicroRNA-196a overexpression promotes cell proliferation and inhibits cell apoptosis through PTEN\/Akt\/FOXO1 pathway","volume":"8","author":"Shang","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"issue":"5","key":"bib34","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1038\/bjc.2013.829","article-title":"MicroRNA-196a promotes cervical cancer proliferation through the regulation of FOXO1 and p27Kip1","volume":"110","author":"Hou","year":"2014","journal-title":"Br J Cancer"},{"issue":"8","key":"bib35","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1369\/jhc.2010.955609","article-title":"The neural stem\/progenitor cell marker nestin is expressed in proliferative endothelial cells, but not in mature vasculature","volume":"58","author":"Suzuki","year":"2010","journal-title":"J Histochem Cytochem"},{"issue":"11","key":"bib36","doi-asserted-by":"publisher","first-page":"4200","DOI":"10.1167\/iovs.05-0691","article-title":"Fate maps of neural crest and mesoderm in the mammalian eye","volume":"46","author":"Gage","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib37","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/j.exer.2011.07.009","article-title":"Overview of cytochrome P450 1B1 gene mutations in patients with primary congenital glaucoma","volume":"93","author":"Li","year":"2011","journal-title":"Exp Eye Res"},{"issue":"19\u201320","key":"bib38","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1007\/s00018-004-4144-6","article-title":"Nestin expression\u2014a property of multi-lineage progenitor cells?","volume":"61","author":"Wiese","year":"2004","journal-title":"Cell Mol Life Sci"},{"issue":"2","key":"bib39","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/nrm2621","article-title":"MicroRNAs: key regulators of stem cells","volume":"10","author":"Gangaraju","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.ab.2017.07.009","article-title":"Mitochondrial membrane potential","volume":"552","author":"Zorova","year":"2018","journal-title":"Anal Biochem"},{"issue":"pt 4","key":"bib41","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1242\/jcs.093849","article-title":"PINK1- and parkin-mediated mitophagy at a glance","volume":"125","author":"Jin","year":"2012","journal-title":"J Cell Sci"},{"issue":"1","key":"bib42","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/s41392-023-01503-7","article-title":"The mitophagy pathway and its implications in human diseases","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct Target Ther"},{"issue":"4","key":"bib43","doi-asserted-by":"publisher","first-page":"e89303","DOI":"10.1172\/jci.insight.89303","article-title":"Mitophagy and mitochondrial biogenesis in atrial tissue of patients undergoing heart surgery with cardiopulmonary bypass","volume":"2","author":"Andres","year":"2017","journal-title":"JCI Insight"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.neulet.2018.04.004","article-title":"Multiple pathways for mitophagy: a neurodegenerative conundrum for Parkinson's disease","volume":"697","author":"Chu","year":"2019","journal-title":"Neurosci Lett"},{"issue":"4","key":"bib45","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1007\/s00018-015-2087-8","article-title":"Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy","volume":"73","author":"Hamacher-Brady","year":"2016","journal-title":"Cell Mol Life Sci"},{"issue":"12","key":"bib46","doi-asserted-by":"publisher","first-page":"4182","DOI":"10.1080\/15548627.2021.1907167","article-title":"The role of mitophagy in the regulation of mitochondrial energetic status in neurons","volume":"17","author":"Han","year":"2021","journal-title":"Autophagy"},{"issue":"5","key":"bib47","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1038\/s41418-022-00988-z","article-title":"Cell cycle regulation: p53-p21-RB signaling","volume":"29","author":"Engeland","year":"2022","journal-title":"Cell Death Differ"},{"issue":"1","key":"bib48","doi-asserted-by":"publisher","first-page":"2280","DOI":"10.1038\/s41467-021-22655-6","article-title":"Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis","volume":"12","author":"Wei","year":"2021","journal-title":"Nat Commun"},{"issue":"1","key":"bib49","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/s41392-023-01347-1","article-title":"Targeting p53 pathways: mechanisms, structures, and advances in therapy","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct Target Ther"},{"issue":"12","key":"bib50","doi-asserted-by":"publisher","first-page":"102704","DOI":"10.1016\/j.jbc.2022.102704","article-title":"The interaction between E3 ubiquitin ligase parkin and mitophagy receptor PHB2 links inner mitochondrial membrane ubiquitination to efficient mitophagy","volume":"298","author":"Sun","year":"2022","journal-title":"J Biol Chem"},{"issue":"9","key":"bib51","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1161\/CIRCRESAHA.112.265819","article-title":"Mitochondria and mitophagy: the yin and yang of cell death control","volume":"111","author":"Kubli","year":"2012","journal-title":"Circ Res"},{"issue":"1","key":"bib52","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1038\/s41467-025-56631-1","article-title":"The autophagy component LC3 regulates lymphocyte adhesion via LFA1 transport in response to outside-in signaling","volume":"16","author":"Kondo","year":"2025","journal-title":"Nat Commun"},{"issue":"12","key":"bib53","doi-asserted-by":"publisher","first-page":"2985","DOI":"10.1080\/15548627.2022.2062111","article-title":"LC3 subfamily in cardiolipin-mediated mitophagy: a comparison of the LC3A, LC3B and LC3C homologs","volume":"18","author":"Iriondo","year":"2022","journal-title":"Autophagy"},{"issue":"1","key":"bib54","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/cdd.2012.81","article-title":"The pathways of mitophagy for quality control and clearance of mitochondria","volume":"20","author":"Ashrafi","year":"2013","journal-title":"Cell Death Differ"},{"issue":"2","key":"bib55","doi-asserted-by":"publisher","first-page":"e483","DOI":"10.1038\/cddis.2013.10","article-title":"Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment","volume":"4","author":"Shi","year":"2013","journal-title":"Cell Death Dis"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3389\/fimmu.2012.00307","article-title":"PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures","volume":"3","author":"Leshner","year":"2012","journal-title":"Front Immunol"},{"issue":"3","key":"bib57","doi-asserted-by":"publisher","first-page":"568","DOI":"10.3892\/etm.2022.11505","article-title":"PAD4 silencing inhibits inflammation whilst promoting trophoblast cell invasion and migration by inactivating the NEMO\/NF-kappaB pathway","volume":"24","author":"Zeng","year":"2022","journal-title":"Exp Ther Med"},{"issue":"3","key":"bib58","doi-asserted-by":"publisher","first-page":"113926","DOI":"10.1016\/j.celrep.2024.113926","article-title":"The Hippo signaling pathway in development and regeneration","volume":"43","author":"Zhong","year":"2024","journal-title":"Cell Rep"},{"issue":"3","key":"bib59","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1158\/2159-8290.CD-20-0706","article-title":"Machine-learning and chemicogenomics approach defines and predicts cross-talk of Hippo and MAPK pathways","volume":"11","author":"Pham","year":"2021","journal-title":"Cancer Discov"},{"issue":"20","key":"bib60","doi-asserted-by":"publisher","first-page":"5002","DOI":"10.3390\/ijms20205002","article-title":"TGF-beta signaling in cellular senescence and aging-related pathology","volume":"20","author":"Tominaga","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"2","key":"bib61","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/bcr43","article-title":"Transforming growth factor-beta and breast cancer: cell cycle arrest by transforming growth factor-beta and its disruption in cancer","volume":"2","author":"Donovan","year":"2000","journal-title":"Breast Cancer Res"},{"issue":"13","key":"bib62","doi-asserted-by":"publisher","first-page":"e158447","DOI":"10.1172\/JCI158447","article-title":"Mitochondrial dysfunction in cell senescence and aging","volume":"132","author":"Miwa","year":"2022","journal-title":"J Clin Invest"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.ebiom.2017.03.020","article-title":"Mitochondria in cell senescence: is mitophagy the weakest link?","volume":"21","author":"Korolchuk","year":"2017","journal-title":"EBioMedicine"},{"issue":"10","key":"bib64","doi-asserted-by":"publisher","first-page":"F1477","DOI":"10.1152\/ajprenal.00182.2013","article-title":"TGF-beta1 stimulates mitochondrial oxidative phosphorylation and generation of reactive oxygen species in cultured mouse podocytes, mediated in part by the mTOR pathway","volume":"305","author":"Abe","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"890823","DOI":"10.3389\/fnagi.2022.890823","article-title":"PINK1\/parkin pathway activation for mitochondrial quality control\u2014which is the best molecular target for therapy?","volume":"14","author":"Silvian","year":"2022","journal-title":"Front Aging Neurosci"},{"issue":"23","key":"bib66","doi-asserted-by":"publisher","first-page":"8844","DOI":"10.1158\/0008-5472.CAN-08-4401","article-title":"Autophagy is activated by TGF-beta and potentiates TGF-beta-mediated growth inhibition in human hepatocellular carcinoma cells","volume":"69","author":"Kiyono","year":"2009","journal-title":"Cancer Res"},{"issue":"3","key":"bib67","doi-asserted-by":"publisher","first-page":"e1696","DOI":"10.1038\/cddis.2015.36","article-title":"Autophagy is a regulator of TGF-beta1-induced fibrogenesis in primary human atrial myofibroblasts","volume":"6","author":"Ghavami","year":"2015","journal-title":"Cell Death Dis"},{"issue":"3","key":"bib68","doi-asserted-by":"publisher","first-page":"420","DOI":"10.3390\/biom10030420","article-title":"Role of p53 in the regulation of cellular senescence","volume":"10","author":"Mijit","year":"2020","journal-title":"Biomolecules"},{"issue":"1","key":"bib69","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/s41392-023-01705-z","article-title":"Targeting the RAS\/RAF\/MAPK pathway for cancer therapy: from mechanism to clinical studies","volume":"8","author":"Bahar","year":"2023","journal-title":"Signal Transduct Target Ther"},{"issue":"3","key":"bib70","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1177\/1947601911407328","article-title":"The ERK cascade: distinct functions within various subcellular organelles","volume":"2","author":"Wortzel","year":"2011","journal-title":"Genes Cancer"},{"issue":"6","key":"bib71","doi-asserted-by":"publisher","first-page":"2749","DOI":"10.1167\/iovs.15-18826","article-title":"Novel identity and functional markers for human corneal endothelial cells","volume":"57","author":"Bartakova","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib72","doi-asserted-by":"publisher","first-page":"4438","DOI":"10.1038\/s41598-018-22821-9","article-title":"TGF-beta1 promotes cell barrier function upon maturation of corneal endothelial cells","volume":"8","author":"Beaulieu Leclerc","year":"2018","journal-title":"Sci Rep"},{"issue":"1","key":"bib73","doi-asserted-by":"publisher","first-page":"6801","DOI":"10.1038\/s41598-017-06924-3","article-title":"Activation of TGF-beta signaling induces cell death via the unfolded protein response in Fuchs endothelial corneal dystrophy","volume":"7","author":"Okumura","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"bib74","doi-asserted-by":"publisher","first-page":"9655","DOI":"10.1038\/s41598-023-36808-8","article-title":"A ROCK inhibitor suppresses the transforming growth factor-beta-2-induced endothelial-mesenchymal transition in Schlemm's canal endothelial cells","volume":"13","author":"Fujimoto","year":"2023","journal-title":"Sci Rep"}],"container-title":["Translational Vision Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/tvst.arvojournals.org\/article.aspx?doi=10.1167\/tvst.15.6.23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:30:40Z","timestamp":1781789440000},"score":1,"resource":{"primary":{"URL":"http:\/\/tvst.arvojournals.org\/article.aspx?doi=10.1167\/tvst.15.6.23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,18]]},"references-count":74,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.15.6.23","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,18]]}}}