{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T12:49:07Z","timestamp":1782737347654,"version":"3.54.5"},"reference-count":46,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"6","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2026,6,29]]},"DOI":"10.1167\/tvst.15.6.37","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T12:31:37Z","timestamp":1782736297000},"page":"37","source":"Crossref","is-referenced-by-count":0,"title":["Deep-ZOMA: A Deep Learning-Based Approach for Automated Morphometric Analysis of Zebrafish Larvae Ocular Structures"],"prefix":"10.1167","volume":"15","author":[{"given":"Youyuan","family":"Zhuang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China"},{"name":"Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Dai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China"},{"name":"Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China"},{"name":"Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiyuan","family":"Ding","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China"},{"name":"Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhe","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China"},{"name":"Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruowen","family":"Qiu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China"},{"name":"Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen Ji","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China"},{"name":"Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyuan","family":"Fang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China"},{"name":"Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Qu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China"},{"name":"Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Su","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China"},{"name":"Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"5387","DOI":"10.3390\/ijms24065387","article-title":"An overview towards zebrafish larvae as a model for ocular diseases","volume":"24","author":"Rosa","year":"2023","journal-title":"Int J Mol Sci"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/eye.2016.198","article-title":"The zebrafish eye-a paradigm for investigating human ocular genetics","volume":"31","author":"Richardson","year":"2017","journal-title":"Eye"},{"issue":"1","key":"bib3","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/jdb9010010","article-title":"Metabolism in the zebrafish retina","volume":"9","author":"Jaroszynska","year":"2021","journal-title":"J Dev Biol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3389\/fcell.2018.00075","article-title":"Versatile genome engineering techniques advance human ocular disease researches in zebrafish","volume":"6","author":"Zheng","year":"2018","journal-title":"Front Cell Dev Biol"},{"issue":"18","key":"bib5","doi-asserted-by":"publisher","first-page":"10001","DOI":"10.3390\/ijms221810001","article-title":"Mechanistic insights into axenfeld-rieger syndrome from zebrafish foxc1 and pitx2 mutants","volume":"22","author":"French","year":"2021","journal-title":"Int J Mol Sci"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/bph.13279","article-title":"High glucose-induced changes in hyaloid-retinal vessels during early ocular development of zebrafish: a short-term animal model of diabetic retinopathy","volume":"173","author":"Jung","year":"2016","journal-title":"Br J Pharmacol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"550","DOI":"10.3390\/genes11050550","article-title":"Role of GUCA1C in primary congenital glaucoma and in the retina: Functional evaluation in zebrafish","volume":"11","author":"Morales-C\u00e1mara","year":"2020","journal-title":"Genes"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"2214","DOI":"10.3390\/cells9102214","article-title":"Progressive photoreceptor dysfunction and age-related macular degeneration-like features in rp1l1 mutant zebrafish","volume":"9","author":"Noel","year":"2020","journal-title":"Cells"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.ajhg.2019.06.015","article-title":"De novo missense variants in WDR37 cause a severe multisystemic syndrome","volume":"105","author":"Reis","year":"2019","journal-title":"Am J Hum Genet"},{"key":"bib10","first-page":"587","article-title":"Targeted disruption of the endogenous zebrafish rhodopsin locus as models of rapid rod photoreceptor degeneration","volume":"24","author":"Zelinka","year":"2018","journal-title":"Mol Vis"},{"issue":"5","key":"bib11","doi-asserted-by":"publisher","first-page":"165724","DOI":"10.1016\/j.bbadis.2020.165724","article-title":"Knockout of DNase1l1l abrogates lens denucleation process and causes cataract in zebrafish","volume":"1866","author":"Zhang","year":"2020","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"1","key":"bib12","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41525-024-00391-2","article-title":"Whole genome sequencing enables new genetic diagnosis for inherited retinal diseases by identifying pathogenic variants","volume":"9","author":"Liu","year":"2024","journal-title":"NPJ Genom Med"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"104161","DOI":"10.1016\/j.ebiom.2022.104161","article-title":"Genome-wide association meta-analysis of 88,250 individuals highlights pleiotropic mechanisms of five ocular diseases in UK Biobank","volume":"82","author":"Xue","year":"2022","journal-title":"EBioMedicine"},{"issue":"1","key":"bib14","doi-asserted-by":"publisher","first-page":"6703","DOI":"10.1038\/s41467-024-50580-x","article-title":"Exome-wide association study identifies KDELR3 mutations in extreme myopia","volume":"15","author":"Yuan","year":"2024","journal-title":"Nat Commun"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s40123-024-01043-5","article-title":"Nonclinical similarity of the biosimilar candidate abp 938 with aflibercept reference product","volume":"14","author":"Seo","year":"2025","journal-title":"Ophthalmol Ther"},{"issue":"13","key":"bib16","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1167\/iovs.65.13.11","article-title":"Quercetin alleviates scleral remodeling through inhibiting the PERK-EIF2a axis in experiment myopia","volume":"65","author":"Zhang","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1186\/s12974-024-03279-1","article-title":"m6A-methylase METTL3 promotes retinal angiogenesis through modulation of metabolic reprogramming in RPE cells","volume":"21","author":"Zhou","year":"2024","journal-title":"J Neuroinflamm"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1080\/08820538.2024.2403436","article-title":"Diagnosing cataracts in the digital age: a survey on ai, metaverse, and digital twin applications","volume":"39","author":"Jones","year":"2024","journal-title":"Semin Ophthalmol"},{"issue":"1","key":"bib19","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1186\/s12913-024-11776-5","article-title":"Vision rehabilitation workforce in Italy: a country-level analysis","volume":"24","author":"Amore","year":"2024","journal-title":"BMC Health Serv Res"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1097\/WNO.0000000000002205","article-title":"AI in neuro-ophthalmology: current practice and future opportunities","volume":"44","author":"Kenney","year":"2024","journal-title":"J Neuroophthalmol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"224","DOI":"10.4103\/ojo.ojo_167_23","article-title":"Profile and risk factors of sight-threatening retinopathy of prematurity: Experience from SNCU in North India","volume":"17","author":"Nayyar","year":"2024","journal-title":"Oman J Ophthalmol"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1097\/IAE.0000000000003977","article-title":"Artificial intelligence for optical coherence tomography angiography-based disease activity prediction in age-related macular degeneration","volume":"44","author":"Heinke","year":"2024","journal-title":"Retina"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"18127","DOI":"10.1021\/acs.est.3c00593","article-title":"Deep learning-enabled morphometric analysis for toxicity screening using zebrafish larvae","volume":"57","author":"Dong","year":"2023","journal-title":"Environ Sci Technol"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"275","DOI":"10.12688\/wellcomeopenres.18313.1","article-title":"Automated staging of zebrafish embryos using machine learning","volume":"7","author":"Jones","year":"2022","journal-title":"Wellcome Open Res"},{"issue":"10","key":"bib25","doi-asserted-by":"publisher","first-page":"e202200098","DOI":"10.1002\/jbio.202200098","article-title":"Morphological characteristics of zebrafish's yolk sac for malformation based on orthogonal-polarization-gating optical coherence tomography","volume":"15","author":"Li","year":"2022","journal-title":"J Biophotonics"},{"issue":"4","key":"bib26","doi-asserted-by":"publisher","first-page":"72","DOI":"10.3390\/inventions4040072","article-title":"ZF-AutoML: an easy machine-learning-based method to detect anomalies in fluorescent-labelled zebrafish","volume":"4","author":"Sawaki","year":"2019","journal-title":"Inventions"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.neuroscience.2025.01.048","article-title":"Development and applications of a machine learning model for an in-depth analysis of pentylenetetrazol-induced seizure-like behaviors in adult zebrafish","volume":"568","author":"Fontana","year":"2025","journal-title":"Neuroscience"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"663","DOI":"10.3390\/biology14060663","article-title":"A deep learning approach to measure visual function in zebrafish","volume":"14","author":"Patil","year":"2025","journal-title":"Biology"},{"issue":"1","key":"bib29","doi-asserted-by":"publisher","first-page":"8580","DOI":"10.1038\/s41598-025-86351-x","article-title":"Zebrafish identification with deep CNN and ViT architectures using a rolling training window","volume":"15","author":"Puchalla","year":"2025","journal-title":"Sci Rep"},{"issue":"1","key":"bib30","doi-asserted-by":"publisher","first-page":"e0202377","DOI":"10.1371\/journal.pone.0202377","article-title":"Deep learning image recognition enables efficient genome editing in zebrafish by automated injections","volume":"14","author":"Cordero-Maldonado","year":"2019","journal-title":"PloS One"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev Dyn"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1177\/0049124120914948","article-title":"Methodological issues when interpreting changes in social phenomena over time: perceptions of relative difference, absolute difference, and time distance","volume":"52","author":"Prevodnik","year":"2023","journal-title":"Sociol Methods Res"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s12880-015-0068-x","article-title":"Metrics for evaluating 3D medical image segmentation: analysis, selection, and tool","volume":"15","author":"Taha","year":"2015","journal-title":"BMC Med Imaging"},{"issue":"8476","key":"bib34","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","article-title":"Statistical methods for assessing agreement between two methods of clinical measurement","volume":"1","author":"Bland","year":"1986","journal-title":"Lancet"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jcm.2016.02.012","article-title":"A guideline of selecting and reporting intraclass correlation coefficients for reliability research","volume":"15","author":"Koo","year":"2016","journal-title":"J Chiropr Med"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"9613","DOI":"10.3390\/ijms25179613","article-title":"Slc4a7 regulates retina development in zebrafish","volume":"25","author":"Zhuang","year":"2024","journal-title":"Int J Mol Sci"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1097\/ICU.0000000000000645","article-title":"Primary angle closure glaucoma genomic associations and disease mechanism","volume":"31","author":"Liu","year":"2020","journal-title":"Curr Opin Ophthalmol"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"3814","DOI":"10.3390\/jcm9123814","article-title":"Anterior chamber angle assessment techniques: a review","volume":"9","author":"Riva","year":"2020","journal-title":"J Clin Med"},{"issue":"1","key":"bib39","doi-asserted-by":"publisher","first-page":"6840","DOI":"10.1038\/s41598-021-86185-3","article-title":"Quantitative comparison of corneal surface areas in keratoconus and normal eyes","volume":"11","author":"Crahay","year":"2021","journal-title":"Sci Rep"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1097\/ICO.0000000000000840","article-title":"Comparison of corneal diameter and anterior chamber depth measurements using 4 different devices","volume":"35","author":"Shajari","year":"2016","journal-title":"Cornea"},{"issue":"1","key":"bib41","doi-asserted-by":"publisher","first-page":"11744","DOI":"10.1038\/s41598-025-95819-9","article-title":"Applying deep learning for style transfer in digital art: enhancing creative expression through neural networks","volume":"15","author":"Zhang","year":"2025","journal-title":"Sci Rep"},{"issue":"18","key":"bib42","doi-asserted-by":"publisher","first-page":"6030","DOI":"10.3390\/s24186030","article-title":"RSE-YOLOv8: an algorithm for underwater biological target detection","volume":"24","author":"Song","year":"2024","journal-title":"Sensors"},{"issue":"15","key":"bib43","doi-asserted-by":"publisher","first-page":"5059","DOI":"10.3390\/s24155059","article-title":"Improved YOLOv8 algorithm for water surface object detection","volume":"24","author":"Wang","year":"2024","journal-title":"Sensors"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1023\/A:1007379606734","article-title":"Multitask Learning","volume":"28","author":"Caruana","year":"1997","journal-title":"Mach Learn"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/s41592-020-01008-z","article-title":"nnU-Net: a self-configuring method for deep learning-based biomedical image segmentation","volume":"18","author":"Isensee","year":"2021","journal-title":"Nat Methods"},{"key":"bib46","first-page":"3614","article-title":"Multi-task learning for dense prediction tasks: a survey","volume":"44","author":"Vandenhende","year":"2022","journal-title":"IEEE Trans Pattern Anal Mach Intell"}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/tvst.arvojournals.org\/article.aspx?doi=10.1167\/tvst.15.6.37","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T12:31:38Z","timestamp":1782736298000},"score":1,"resource":{"primary":{"URL":"http:\/\/tvst.arvojournals.org\/article.aspx?doi=10.1167\/tvst.15.6.37"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.15.6.37","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,29]]}}}