{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:02:02Z","timestamp":1772164922106,"version":"3.50.1"},"reference-count":26,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"4","license":[{"start":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T00:00:00Z","timestamp":1564099200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2019,7,26]]},"DOI":"10.1167\/tvst.8.4.10","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T14:30:31Z","timestamp":1564151431000},"page":"10","source":"Crossref","is-referenced-by-count":6,"title":["Quantification of Double Stranded DNA Breaks and Telomere Length as Proxies for Corneal Damage and Replicative Stress in Human Keratoconus Corneas"],"prefix":"10.1167","volume":"8","author":[{"given":"Robert P. L.","family":"Wisse","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University Medical Center Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas J. W.","family":"Kuiper","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Medical Center Utrecht, The Netherlands"},{"name":"Ophthalmo-Immunology group, Laboratory of Translational Immunology, Department of Immunology, University Medical Center Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy R. D.","family":"Radstake","sequence":"additional","affiliation":[{"name":"Department of Rheumatology & Clinical Immunology, Laboratory of Translational Immunology, Department of Immunology, University Medical Center Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasper C. A.","family":"Broen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology & Clinical Immunology, Laboratory of Translational Immunology, Department of Immunology, University Medical Center Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27","reference":[{"key":"i2164-2591-8-4-10-b01","doi-asserted-by":"crossref","unstructured":"Rabinowitz\n\t\t\t\t\t\t\tYS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tKeratoconus.\n\t\t\t\t\tSurv Ophthalmol.\n\t\t\t\t\t1998;\n\t\t\t\t\t42:\n\t\t\t\t\t297\u2013319.","DOI":"10.1016\/S0039-6257(97)00119-7"},{"key":"i2164-2591-8-4-10-b02","doi-asserted-by":"crossref","unstructured":"Bawazeer\n\t\t\t\t\t\t\tAM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHodge\n\t\t\t\t\t\t\tWG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLorimer\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAtopy and keratoconus: a multivariate analysis.\n\t\t\t\t\tBr J Ophthalmol.\n\t\t\t\t\t2000;\n\t\t\t\t\t84:\n\t\t\t\t\t834\u2013836.","DOI":"10.1136\/bjo.84.8.834"},{"key":"i2164-2591-8-4-10-b03","doi-asserted-by":"crossref","unstructured":"Jafri\n\t\t\t\t\t\t\tB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLichter\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tStulting\n\t\t\t\t\t\t\tRD.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAsymmetric keratoconus attributed to eye rubbing.\n\t\t\t\t\tCornea.\n\t\t\t\t\t2004;\n\t\t\t\t\t23:\n\t\t\t\t\t560\u2013564.","DOI":"10.1097\/01.ico.0000121711.58571.8d"},{"key":"i2164-2591-8-4-10-b04","doi-asserted-by":"crossref","unstructured":"Karamichos\n\t\t\t\t\t\t\tD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHutcheon\n\t\t\t\t\t\t\tAE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRich\n\t\t\t\t\t\t\tCB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTrinkaus-Randall\n\t\t\t\t\t\t\tV,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAsara\n\t\t\t\t\t\t\tJM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZieske\n\t\t\t\t\t\t\tJD.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tIn vitro model suggests oxidative stress involved in keratoconus disease.\n\t\t\t\t\tSci Rep.\n\t\t\t\t\t2014;\n\t\t\t\t\t4:\n\t\t\t\t\t4608.","DOI":"10.1038\/srep04608"},{"key":"i2164-2591-8-4-10-b05","doi-asserted-by":"crossref","unstructured":"Parker\n\t\t\t\t\t\t\tJS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tvan Dijk\n\t\t\t\t\t\t\tK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMelles\n\t\t\t\t\t\t\tGR.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tTreatment options for advanced keratoconus: a review.\n\t\t\t\t\tSurv Ophthalmol.\n\t\t\t\t\t2015;\n\t\t\t\t\t60:\n\t\t\t\t\t459\u2013480.","DOI":"10.1016\/j.survophthal.2015.02.004"},{"key":"i2164-2591-8-4-10-b06","doi-asserted-by":"crossref","unstructured":"Atilano\n\t\t\t\t\t\t\tSR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCoskun\n\t\t\t\t\t\t\tP,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChwa\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tAccumulation of mitochondrial DNA damage in keratoconus corneas.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2005;\n\t\t\t\t\t46:\n\t\t\t\t\t1256\u20131263.","DOI":"10.1167\/iovs.04-1395"},{"key":"i2164-2591-8-4-10-b07","doi-asserted-by":"crossref","unstructured":"Buddi\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLin\n\t\t\t\t\t\t\tB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAtilano\n\t\t\t\t\t\t\tSR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZorapapel\n\t\t\t\t\t\t\tNC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKenney\n\t\t\t\t\t\t\tMC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBrown\n\t\t\t\t\t\t\tDJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tEvidence of oxidative stress in human corneal diseases.\n\t\t\t\t\tJ Histochem Cytochem.\n\t\t\t\t\t2002;\n\t\t\t\t\t50:\n\t\t\t\t\t341\u2013351.","DOI":"10.1177\/002215540205000306"},{"key":"i2164-2591-8-4-10-b08","doi-asserted-by":"crossref","unstructured":"Lombardo\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPucci\n\t\t\t\t\t\t\tG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBarberi\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLombardo\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tInteraction of ultraviolet light with the cornea: clinical implications for corneal crosslinking.\n\t\t\t\t\tJ Cataract Refract Surg.\n\t\t\t\t\t2015;\n\t\t\t\t\t41:\n\t\t\t\t\t446\u2013459.","DOI":"10.1016\/j.jcrs.2014.12.013"},{"key":"i2164-2591-8-4-10-b09","unstructured":"Behndig\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKarlsson\n\t\t\t\t\t\t\tK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJohansson\n\t\t\t\t\t\t\tBO,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBrannstrom\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMarklund\n\t\t\t\t\t\t\tSL.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tSuperoxide dismutase isoenzymes in the normal and diseased human cornea.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2001;\n\t\t\t\t\t42:\n\t\t\t\t\t2293\u20132296."},{"key":"i2164-2591-8-4-10-b10","doi-asserted-by":"crossref","unstructured":"Gondhowiardjo\n\t\t\t\t\t\t\tTD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tvan Haeringen\n\t\t\t\t\t\t\tNJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVolker-Dieben\n\t\t\t\t\t\t\tHJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tAnalysis of corneal aldehyde dehydrogenase patterns in pathologic corneas.\n\t\t\t\t\tCornea.\n\t\t\t\t\t1993;\n\t\t\t\t\t12:\n\t\t\t\t\t146\u2013154.","DOI":"10.1097\/00003226-199303000-00010"},{"key":"i2164-2591-8-4-10-b11","doi-asserted-by":"crossref","unstructured":"Kenney\n\t\t\t\t\t\t\tMC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChwa\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAtilano\n\t\t\t\t\t\t\tSR,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tIncreased levels of catalase and cathepsin V\/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2005;\n\t\t\t\t\t46:\n\t\t\t\t\t823\u2013832.","DOI":"10.1167\/iovs.04-0549"},{"key":"i2164-2591-8-4-10-b12","doi-asserted-by":"crossref","unstructured":"Flores\n\t\t\t\t\t\t\tI,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBenetti\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBlasco\n\t\t\t\t\t\t\tMA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tTelomerase regulation and stem cell behaviour.\n\t\t\t\t\tCurr Opin Cell Biol.\n\t\t\t\t\t2006;\n\t\t\t\t\t18:\n\t\t\t\t\t254\u2013260.","DOI":"10.1016\/j.ceb.2006.03.003"},{"key":"i2164-2591-8-4-10-b13","doi-asserted-by":"crossref","unstructured":"Englander\n\t\t\t\t\t\t\tEW,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHoward\n\t\t\t\t\t\t\tBH.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAlu-mediated detection of DNA damage in the human genome.\n\t\t\t\t\tMutat Res.\n\t\t\t\t\t1997;\n\t\t\t\t\t385:\n\t\t\t\t\t31\u201339.","DOI":"10.1016\/S0921-8777(97)00036-0"},{"key":"i2164-2591-8-4-10-b14","doi-asserted-by":"crossref","unstructured":"Wang\n\t\t\t\t\t\t\tG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHallberg\n\t\t\t\t\t\t\tLM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSaphier\n\t\t\t\t\t\t\tE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEnglander\n\t\t\t\t\t\t\tEW,\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tShort interspersed DNA element-mediated detection of UVB-induced DNA damage and repair in the mouse genome, in vitro, and in vivo in skin.\n\t\t\t\t\tMutat Res.\n\t\t\t\t\t1999;\n\t\t\t\t\t433:\n\t\t\t\t\t147\u2013157.","DOI":"10.1016\/S0921-8777(99)00007-5"},{"key":"i2164-2591-8-4-10-b15","doi-asserted-by":"crossref","unstructured":"Morales\n\t\t\t\t\t\t\tME,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWhite\n\t\t\t\t\t\t\tTB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tStreva\n\t\t\t\t\t\t\tVA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDeFreece\n\t\t\t\t\t\t\tCB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHedges\n\t\t\t\t\t\t\tDJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDeininger\n\t\t\t\t\t\t\tPL.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tThe contribution of alu elements to mutagenic DNA double-strand break repair.\n\t\t\t\t\tPLoS Genet.\n\t\t\t\t\t2015;\n\t\t\t\t\t11:\n\t\t\t\t\te1005016.","DOI":"10.1371\/journal.pgen.1005016"},{"key":"i2164-2591-8-4-10-b16","doi-asserted-by":"crossref","unstructured":"Cardelli\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAlu\n\t\t\t\t\t\t\tPCR.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tMethods Mol Biol.\n\t\t\t\t\t2011;\n\t\t\t\t\t687:\n\t\t\t\t\t221\u2013229.","DOI":"10.1007\/978-1-60761-944-4_15"},{"key":"i2164-2591-8-4-10-b17","doi-asserted-by":"crossref","unstructured":"Cook\n\t\t\t\t\t\t\tGW,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKonkel\n\t\t\t\t\t\t\tMK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWalker\n\t\t\t\t\t\t\tJA,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tA comparison of 100 human genes using an alu element-based instability model.\n\t\t\t\t\tPLoS One.\n\t\t\t\t\t2013;\n\t\t\t\t\t3:\n\t\t\t\t\te65188.","DOI":"10.1371\/journal.pone.0065188"},{"key":"i2164-2591-8-4-10-b18","doi-asserted-by":"crossref","unstructured":"O'Callaghan\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDhillon\n\t\t\t\t\t\t\tV,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tThomas\n\t\t\t\t\t\t\tP,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFenech\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tA quantitative real-time PCR method for absolute TL.\n\t\t\t\t\tBiotechniques.\n\t\t\t\t\t2008;\n\t\t\t\t\t44:\n\t\t\t\t\t807\u2013809.","DOI":"10.2144\/000112761"},{"key":"i2164-2591-8-4-10-b19","doi-asserted-by":"crossref","unstructured":"Wojcik\n\t\t\t\t\t\t\tKA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKaminska\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBlasiak\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSzaflik\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSzaflik\n\t\t\t\t\t\t\tJP.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tOxidative stress in the pathogenesis of keratoconus and Fuchs endothelial corneal dystrophy.\n\t\t\t\t\tInt J Mol Sci.\n\t\t\t\t\t2013;\n\t\t\t\t\t23:\n\t\t\t\t\t19294\u201319308.","DOI":"10.3390\/ijms140919294"},{"key":"i2164-2591-8-4-10-b20","doi-asserted-by":"crossref","unstructured":"Galbiati\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBeaus\u00e9jour\n\t\t\t\t\t\t\tC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\td'Adda di Fagagna\n\t\t\t\t\t\t\tF.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tA novel single-cell method provides direct evidence of persistent DNA damage in senescent cells and aged mammalian tissues.\n\t\t\t\t\tAging Cell.\n\t\t\t\t\t2017;\n\t\t\t\t\t16:\n\t\t\t\t\t422\u2013427.","DOI":"10.1111\/acel.12573"},{"key":"i2164-2591-8-4-10-b21","doi-asserted-by":"crossref","unstructured":"Atilano\n\t\t\t\t\t\t\tSR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChwa\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKim\n\t\t\t\t\t\t\tDW,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tHydrogen peroxide causes mitochondrial DNA damage in corneal epithelial cells.\n\t\t\t\t\tCornea.\n\t\t\t\t\t2009;\n\t\t\t\t\t28:\n\t\t\t\t\t426\u2013433.","DOI":"10.1097\/ICO.0b013e31818c2c55"},{"key":"i2164-2591-8-4-10-b22","doi-asserted-by":"crossref","unstructured":"Di Girolamo\n\t\t\t\t\t\t\tN.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tMoving epithelia: tracking the fate of mammalian limbal epithelial stem cells.\n\t\t\t\t\tProg Retin Eye Res.\n\t\t\t\t\t2015;\n\t\t\t\t\t48:\n\t\t\t\t\t203\u2013225","DOI":"10.1016\/j.preteyeres.2015.04.002"},{"key":"i2164-2591-8-4-10-b23","doi-asserted-by":"crossref","unstructured":"Mallet\n\t\t\t\t\t\t\tJD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDorr\n\t\t\t\t\t\t\tMM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDrigeard Desgarnier\n\t\t\t\t\t\t\tMC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBastien\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGendron\n\t\t\t\t\t\t\tSP,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRochette\n\t\t\t\t\t\t\tPJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tFaster DNA repair of ultraviolet-induced cyclobutane pyrimidine dimers and lower sensitivity to apoptosis in human corneal epithelial cells than in epidermal keratinocytes.\n\t\t\t\t\tPLoS One.\n\t\t\t\t\t2016;\n\t\t\t\t\t11:\n\t\t\t\t\te0162212.","DOI":"10.1371\/journal.pone.0162212"},{"key":"i2164-2591-8-4-10-b24","doi-asserted-by":"crossref","unstructured":"Wisse\n\t\t\t\t\t\t\tRPL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKuiper\n\t\t\t\t\t\t\tJJW,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGans\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tImhof\n\t\t\t\t\t\t\tSM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRadstake\n\t\t\t\t\t\t\tTRD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVan der Lelij\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tCytokine expression in keratoconus and its corneal microenvironment: a systematic review.\n\t\t\t\t\tOcul Surf.\n\t\t\t\t\t2015;\n\t\t\t\t\t13:\n\t\t\t\t\t272\u2013283.","DOI":"10.1016\/j.jtos.2015.04.006"},{"key":"i2164-2591-8-4-10-b25","doi-asserted-by":"crossref","unstructured":"Silverman\n\t\t\t\t\t\t\tRH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tUrs\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRoychoudhury\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tArcher\n\t\t\t\t\t\t\tTJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGobbe\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tReinstein\n\t\t\t\t\t\t\tDZ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tEpithelial remodeling as basis for machine-based identification of keratoconus.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2014;\n\t\t\t\t\t55:\n\t\t\t\t\t1580\u20131587.","DOI":"10.1167\/iovs.13-12578"},{"key":"i2164-2591-8-4-10-b26","doi-asserted-by":"crossref","unstructured":"Krumeich\n\t\t\t\t\t\t\tJH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBrand-Saberi\n\t\t\t\t\t\t\tB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChankiewitz\n\t\t\t\t\t\t\tV,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChankiewitz\n\t\t\t\t\t\t\tE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGuthoff\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tInduction of neoplasia after deep anterior lamellar keratoplasty in a CXL-treated cornea.\n\t\t\t\t\tCornea\n\t\t\t\t\t2014;\n\t\t\t\t\t33:\n\t\t\t\t\t313\u2013316.","DOI":"10.1097\/ICO.0000000000000047"}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2740078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T14:30:40Z","timestamp":1564151440000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2740078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,26]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.8.4.10","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/244871","asserted-by":"object"}]},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7,26]]}}}