{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:04:25Z","timestamp":1789844665142,"version":"4.0.1"},"reference-count":45,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"4","license":[{"start":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2019,7,3]]},"DOI":"10.1167\/tvst.8.4.4","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T14:38:18Z","timestamp":1562164698000},"page":"4","source":"Crossref","is-referenced-by-count":25,"title":["Optical Coherence Tomography Angiography Evaluation of Conjunctival Vessels During Filtering Surgery"],"prefix":"10.1167","volume":"8","author":[{"given":"St\u00e9phanie","family":"Hayek","sequence":"first","affiliation":[{"name":"Department of Ophthalmology III, Quinze-Vingts Hospital, Paris, France"},{"name":"Quinze-Vingts Hospital, DHU Sight Restore, INSERM-DHOS CIC, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Labb\u00e9","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology III, Quinze-Vingts Hospital, Paris, France"},{"name":"Quinze-Vingts Hospital, DHU Sight Restore, INSERM-DHOS CIC, Paris, France."},{"name":"INSERM, U968, Paris, France"},{"name":"Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06, Paris, France"},{"name":"CNRS, UMR 7210, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Brasnu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology III, Quinze-Vingts Hospital, Paris, France"},{"name":"Quinze-Vingts Hospital, DHU Sight Restore, INSERM-DHOS CIC, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Hamard","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology III, Quinze-Vingts Hospital, Paris, France"},{"name":"Quinze-Vingts Hospital, DHU Sight Restore, INSERM-DHOS CIC, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Baudouin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology III, Quinze-Vingts Hospital, Paris, France"},{"name":"Quinze-Vingts Hospital, DHU Sight Restore, INSERM-DHOS CIC, Paris, France."},{"name":"INSERM, U968, Paris, France"},{"name":"Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06, Paris, France"},{"name":"CNRS, UMR 7210, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i2164-2591-8-4-4-b01","doi-asserted-by":"crossref","unstructured":"Joseph JP, Miller MH, Hitchings RA. Wound healing as a barrier to successful filtration surgery. Eye (Lond). 1988; (suppl 2): S113\u2013123.","DOI":"10.1038\/eye.1988.138"},{"key":"i2164-2591-8-4-4-b02","doi-asserted-by":"crossref","unstructured":"Richter CU, Shingleton BJ, Bellows AR, et al. The development of encapsulated filtering blebs. Ophthalmology. 1988; 95: 1163\u20131168.","DOI":"10.1016\/S0161-6420(88)33041-1"},{"key":"i2164-2591-8-4-4-b03","doi-asserted-by":"crossref","unstructured":"Picht G, Grehn F. Classification of filtering blebs in trabeculectomy: biomicroscopy and functionality. Curr Opin Ophthalmol. 1998; 9: 2\u20138.","DOI":"10.1097\/00055735-199804000-00002"},{"key":"i2164-2591-8-4-4-b04","doi-asserted-by":"crossref","unstructured":"Cantor LB, Mantravadi A, WuDunn D, et al. Morphologic classification of filtering blebs after glaucoma filtration surgery: the Indiana Bleb Appearance Grading Scale. J Glaucoma. 2003; 12: 266\u2013271.","DOI":"10.1097\/00061198-200306000-00015"},{"key":"i2164-2591-8-4-4-b05","doi-asserted-by":"crossref","unstructured":"Wells AP, Crowston JG, Marks J, et al. A pilot study of a system for grading of drainage blebs after glaucoma surgery. J Glaucoma. 2004; 13: 454\u2013460.","DOI":"10.1097\/00061198-200412000-00005"},{"key":"i2164-2591-8-4-4-b06","doi-asserted-by":"crossref","unstructured":"Yamamoto T, Sakuma T, Kitazawa Y. An ultrasound biomicroscopic study of filtering blebs after mitomycin C trabeculectomy. Ophthalmology. 1995; 102: 1770\u20131776.","DOI":"10.1016\/S0161-6420(95)30795-6"},{"key":"i2164-2591-8-4-4-b07","doi-asserted-by":"crossref","unstructured":"Labb\u00e9 A, Dupas B, Hamard P, et al. In vivo confocal microscopy study of blebs after filtering surgery. Ophthalmology. 2005; 112: 1979.","DOI":"10.1016\/j.ophtha.2005.05.021"},{"key":"i2164-2591-8-4-4-b08","doi-asserted-by":"crossref","unstructured":"Leung CK, Yick DW, Kwong YY, et al. Analysis of bleb morphology after trabeculectomy with Visante anterior segment optical coherence tomography. Br J Ophthalmol. 2007; 91: 340\u2013344.","DOI":"10.1136\/bjo.2006.100321"},{"key":"i2164-2591-8-4-4-b09","doi-asserted-by":"crossref","unstructured":"Labb\u00e9 A, Hamard P, Iordanidou V, et al. Utility of the Visante OCT in the follow-up of glaucoma surgery. J Fr Ophtalmol. 2007; 30: 225\u2013231.","DOI":"10.1016\/S0181-5512(07)89582-9"},{"key":"i2164-2591-8-4-4-b10","doi-asserted-by":"crossref","unstructured":"Meziani L, Tahiri Joutei Hassani R, El Sanharawi M, et al. Evaluation of blebs after filtering surgery with en-face anterior-segment optical coherence tomography: a pilot study. J Glaucoma. 2016; 25: 550\u2013558.","DOI":"10.1097\/IJG.0000000000000319"},{"key":"i2164-2591-8-4-4-b11","doi-asserted-by":"crossref","unstructured":"Kim M, Lee C, Payne R, et al. Angiogenesis in glaucoma filtration surgery and neovascular glaucoma: a review. Surv Ophthalmol. 2015; 60: 524\u2013535.","DOI":"10.1016\/j.survophthal.2015.04.003"},{"key":"i2164-2591-8-4-4-b12","doi-asserted-by":"crossref","unstructured":"Sacu S, Rainer G, Findl O, et al. Correlation between the early morphological appearance of filtering blebs and outcome of trabeculectomy with mitomycin C. J Glaucoma. 2003; 12: 430\u2013435.","DOI":"10.1097\/00061198-200310000-00006"},{"key":"i2164-2591-8-4-4-b13","unstructured":"Marks J, Clarke JCK, Peto T. Postoperative increased bleb vascularity persists for over one year and has implications for intraocular pressure control. Invest Ophthalmol Vis Sci. 2004; 45: U377\u2013U377."},{"key":"i2164-2591-8-4-4-b14","doi-asserted-by":"crossref","unstructured":"Messmer EM, Zapp DM, Mackert MJ, et al. In vivo confocal microscopy of filtering blebs after trabeculectomy. Arch Ophthalmol. 2006; 124: 1095\u20131103.","DOI":"10.1001\/archopht.124.8.1095"},{"key":"i2164-2591-8-4-4-b15","unstructured":"Zeng K, Huang L, Lai M, et al. Correlation between morphologic appearance and function of filtering bleb in vivo. Eye Sci. 2011; 26: 201\u2013207."},{"key":"i2164-2591-8-4-4-b16","doi-asserted-by":"crossref","unstructured":"Caglar C, Karpuzoglu N, Batur M, et al. In vivo confocal microscopy and biomicroscopy of filtering blebs after trabeculectomy. J Glaucoma. 2016; 25: 377\u2013383.","DOI":"10.1097\/IJG.0000000000000377"},{"key":"i2164-2591-8-4-4-b17","doi-asserted-by":"crossref","unstructured":"Chew PT, Watson PG, Chee CK. Vascular changes over trabeculectomy blebs. Eye (Lond). 1994; 8: 389\u2013393.","DOI":"10.1038\/eye.1994.92"},{"key":"i2164-2591-8-4-4-b18","doi-asserted-by":"crossref","unstructured":"Alsagoff Z, Chew PT, Chee CK, et al. Indocyanine green anterior segment angiography for studying conjunctival vascular changes after trabeculectomy. Clin Exp Ophthalmol. 2001; 29: 22\u201326.","DOI":"10.1046\/j.1442-9071.2001.00365.x"},{"key":"i2164-2591-8-4-4-b19","doi-asserted-by":"crossref","unstructured":"Sambhav K, Grover S, Chalam KV. The application of optical coherence tomography angiography in retinal diseases. Surv Ophthalmol. 2017; 62: 838\u2013866.","DOI":"10.1016\/j.survophthal.2017.05.006"},{"key":"i2164-2591-8-4-4-b20","doi-asserted-by":"crossref","unstructured":"Ang M, Cai Y, MacPhee B, et al. Optical coherence tomography angiography and indocyanine green angiography for corneal vascularisation. Br J Ophthalmol. 2016; 100: 1557\u20131563.","DOI":"10.1136\/bjophthalmol-2015-307706"},{"key":"i2164-2591-8-4-4-b21","doi-asserted-by":"crossref","unstructured":"Ang M, Cai Y, Shahipasand S, et al. En face optical coherence tomography angiography for corneal neovascularisation. Br J Ophthalmol. 2016; 100: 616\u2013621.","DOI":"10.1136\/bjophthalmol-2015-307338"},{"key":"i2164-2591-8-4-4-b22","doi-asserted-by":"crossref","unstructured":"Cai Y, Alio Del Barrio JL, Wilkins MR, et al. Serial optical coherence tomography angiography for corneal vascularization. Graefes Arch Clin Exp Ophthalmol. 2017; 255: 135\u2013139.","DOI":"10.1007\/s00417-016-3505-9"},{"key":"i2164-2591-8-4-4-b23","doi-asserted-by":"crossref","unstructured":"Yin X, Cai Q, Song R, et al. Relationship between filtering bleb vascularization and surgical outcomes after trabeculectomy: an optical coherence tomography angiography study [ published online ahead of print September 12, 2018]. Graefes Arch Clin Exp Ophthalmol. https:\/\/doi.org\/10.1007\/s00417-018-4136-0.","DOI":"10.1007\/s00417-018-4136-0"},{"key":"i2164-2591-8-4-4-b24","doi-asserted-by":"crossref","unstructured":"Jia Y, Tan O, Tokayer J, et al. Split-spectrum amplitude-decorrelation angiography with optical coherence tomography. Opt Express. 2012; 20: 4710\u20134725.","DOI":"10.1364\/OE.20.004710"},{"key":"i2164-2591-8-4-4-b25","doi-asserted-by":"crossref","unstructured":"Ridler T, Calvard S. Picture thresholding using an iterative selection method. IEEE Trans Syst Man Cybern Syst. 1978; 8: 630\u2013632.","DOI":"10.1109\/TSMC.1978.4310039"},{"key":"i2164-2591-8-4-4-b26","doi-asserted-by":"crossref","unstructured":"Zhang T, Suen C. A fast parallel algorithm for thinning digital patterns. Commun ACM. 1984; 27: 236\u2013239.","DOI":"10.1145\/357994.358023"},{"key":"i2164-2591-8-4-4-b27","doi-asserted-by":"crossref","unstructured":"Kirwan JF, Lockwood AJ, Shah P, et al. Trabeculectomy in the 21st century: a multicenter analysis. Ophthalmology. 2013; 120: 2532\u20132539.","DOI":"10.1016\/j.ophtha.2013.07.049"},{"key":"i2164-2591-8-4-4-b28","doi-asserted-by":"crossref","unstructured":"Shingleton BJ. Management of the failing glaucoma filter. Ophthalmic Surg Lasers. 1996; 27: 445\u2013451.","DOI":"10.3928\/1542-8877-19960601-09"},{"key":"i2164-2591-8-4-4-b29","doi-asserted-by":"crossref","unstructured":"Agnifili L, Fasanella V, Mastropasqua R, et al. In vivo goblet cell density as a potential indicator of glaucoma filtration surgery outcome. Invest Ophthalmol Vis Sci. 2016; 57: 2898\u20132905.","DOI":"10.1167\/iovs.16-19257"},{"key":"i2164-2591-8-4-4-b30","doi-asserted-by":"crossref","unstructured":"Mastropasqua R, Fasanella V, Brescia L, et al. In vivo confocal imaging of the conjunctiva as a predictive tool for the glaucoma filtration surgery outcome. Invest Ophthalmol Vis Sci. 2017; 58: BIO114\u2013BIO120.","DOI":"10.1167\/iovs.17-21795"},{"key":"i2164-2591-8-4-4-b31","doi-asserted-by":"crossref","unstructured":"Seet L-F, Finger SN, Chu SWL, et al. Novel insight into the inflammatory and cellular responses following experimental glaucoma surgery: a roadmap for inhibiting fibrosis. Curr Mol Med. 2013; 13: 911\u2013928.","DOI":"10.2174\/15665240113139990021"},{"key":"i2164-2591-8-4-4-b32","doi-asserted-by":"crossref","unstructured":"Cheng J-W, Cheng S-W, Wei R-L, et al. Anti-vascular endothelial growth factor for control of wound healing in glaucoma surgery. Cochrane Database Syst Rev. 2016: CD009782.","DOI":"10.1002\/14651858.CD009782.pub2"},{"key":"i2164-2591-8-4-4-b33","doi-asserted-by":"crossref","unstructured":"Lopilly Park H-Y, Kim JH, Ahn MD, et al. Level of vascular endothelial growth factor in Tenon tissue and results of glaucoma surgery. Arch Ophthalmol. 2012; 130: 685\u2013689.","DOI":"10.1001\/archophthalmol.2011.2799"},{"key":"i2164-2591-8-4-4-b34","doi-asserted-by":"crossref","unstructured":"Bouhenni RA, Al Jadaan I, Rassavong H, et al. Lymphatic and blood vessel density in human conjunctiva after glaucoma filtration surgery. J Glaucoma. 2016; 25: 35\u201338.","DOI":"10.1097\/IJG.0000000000000199"},{"key":"i2164-2591-8-4-4-b35","unstructured":"Baudouin C. Mechanisms of failure in glaucoma filtering surgery: a consequence of antiglaucomatous drugs? Int J Clin Pharmacol Res. 1996; 16: 29\u201341."},{"key":"i2164-2591-8-4-4-b36","doi-asserted-by":"crossref","unstructured":"Baudouin C, Labb\u00e9 A, Liang H, et al. Preservatives in eyedrops: the good, the bad and the ugly. Prog Retin Eye Res. 2010; 29: 312\u2013334.","DOI":"10.1016\/j.preteyeres.2010.03.001"},{"key":"i2164-2591-8-4-4-b37","doi-asserted-by":"crossref","unstructured":"Warcoin E, Clouzeau C, Roubeix C, et al. Hyperosmolarity and benzalkonium chloride differently stimulate inflammatory markers in conjunctiva-derived epithelial cells in vitro. Ophthalmic Res. 2017; 58: 40\u201348.","DOI":"10.1159\/000448117"},{"key":"i2164-2591-8-4-4-b38","doi-asserted-by":"crossref","unstructured":"Aptel F, Denis P, Baudouin C. Managing treatment side effects: the respective roles of the active ingredient and the preservative. J Fr Ophtalmol. 2011; 34: 409\u2013412.","DOI":"10.1016\/j.jfo.2010.12.005"},{"key":"i2164-2591-8-4-4-b39","unstructured":"Lumigan [package insert]. Irvine, CA: Allergan, Inc; 2001."},{"key":"i2164-2591-8-4-4-b40","unstructured":"Travatan [package insert]. Fort Worth, TX: Alcon Pharmaceuticals; 2001."},{"key":"i2164-2591-8-4-4-b41","unstructured":"Xalatan [package insert]. Kalamazoo, MI: Pharmacia & Upjohn; 2000."},{"key":"i2164-2591-8-4-4-b42","doi-asserted-by":"crossref","unstructured":"Hamacher T, Airaksinen J, Saarela V, et al. Efficacy and safety levels of preserved and preservative-free tafluprost are equivalent in patients with glaucoma or ocular hypertension: results from a pharmacodynamics analysis. Acta Ophthalmol Suppl. 2008; 242: 14\u201319.","DOI":"10.1111\/j.1755-3768.2008.01381.x"},{"key":"i2164-2591-8-4-4-b43","unstructured":"Rayes A, Or\u00e9fice F, Rocha H. Distribui\u00e7\u00e3o da rede linf\u00e1tica da conjuntiva bulbar humana normal, estudada atrav\u00e9s de inje\u00e7\u00f5es conjuntivais de azul de tripan a 1%. Arq Bras Oftalmol. 1980; 435: 188\u2013200."},{"key":"i2164-2591-8-4-4-b44","doi-asserted-by":"crossref","unstructured":"Freitas-Neto CA, Costa RA, Kombo N, et al. Subconjunctival indocyanine green identifies lymphatic vessels. JAMA Ophthalmol. 2015; 133: 102\u2013104.","DOI":"10.1001\/jamaophthalmol.2014.3944"},{"key":"i2164-2591-8-4-4-b45","doi-asserted-by":"crossref","unstructured":"Guo W, Zhu Y, Yu PK, et al. Quantitative study of the topographic distribution of conjunctival lymphatic vessels in the monkey. Exp Eye Res. 2012; 94: 90\u201397.","DOI":"10.1016\/j.exer.2011.11.011"}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/tvst.arvojournals.org\/article.aspx?articleid=2737756","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T21:32:44Z","timestamp":1663882364000},"score":1,"resource":{"primary":{"URL":"http:\/\/tvst.arvojournals.org\/article.aspx?doi=10.1167\/tvst.8.4.4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,3]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.8.4.4","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7,3]]}}}