{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:08:48Z","timestamp":1788973728265,"version":"build-2803163510"},"reference-count":43,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"11","license":[{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2020,10,14]]},"DOI":"10.1167\/tvst.9.11.15","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T15:04:44Z","timestamp":1602687884000},"page":"15","source":"Crossref","is-referenced-by-count":9,"title":["VEGF Trap<sub>R1R2<\/sub> Suspended in the Semifluorinated Alkane F6H8 Inhibits Inflammatory Corneal Hem- and Lymphangiogenesis"],"prefix":"10.1167","volume":"9","author":[{"given":"Viet Nhat Hung","family":"Le","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Germany"},{"name":"Department of Ophthalmology, Hue University of Medicine and Pharmacy, Hue University, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Hos","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Germany"},{"name":"Center for Molecular Medicine Cologne (CMMC), University of Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Germany"},{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madlen","family":"Witt","sequence":"additional","affiliation":[{"name":"Novaliq GmbH, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Barkovskiy","sequence":"additional","affiliation":[{"name":"Novaliq GmbH, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Bock","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Cursiefen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Germany"},{"name":"Center for Molecular Medicine Cologne (CMMC), University of Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1080\/08820530500509358","article-title":"Angiogenesis and lymphangiogenesis-implications for corneal immunity","volume":"21","author":"Dana","year":"2006","journal-title":"Semin Ophthalmol"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1097\/00007890-199906270-00001","article-title":"The immune privilege of corneal allografts","volume":"67","author":"Niederkorn","year":"1999","journal-title":"Transplantation"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1097\/01.tp.0000285489.91595.13","article-title":"The immunobiology of corneal transplantation","volume":"84","author":"Williams","year":"2007","journal-title":"Transplantation"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1097\/00003226-200304000-00021","article-title":"Corneal lymphangiogenesis: evidence, mechanisms, and implications for corneal transplant immunology","volume":"22","author":"Cursiefen","year":"2003","journal-title":"Cornea"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1016\/j.ophtha.2010.01.039","article-title":"Corneal neovascularization as a risk factor for graft failure and rejection after keratoplasty: an evidence-based meta-analysis","volume":"117","author":"Bachmann","year":"2010","journal-title":"Ophthalmology"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"535","DOI":"10.4049\/jimmunol.0903180","article-title":"Cutting edge: lymphatic vessels, not blood vessels, primarily mediate immune rejections after transplantation","volume":"184","author":"Dietrich","year":"2010","journal-title":"J Immunol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1001\/archophthalmol.2010.124","article-title":"Evidence of corneal lymphangiogenesis in dry eye disease: a potential link to adaptive immunity?","volume":"128","author":"Goyal","year":"2010","journal-title":"Arch Ophthalmol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"3140","DOI":"10.1167\/iovs.14-16186","article-title":"Involvement of corneal lymphangiogenesis in a mouse model of allergic eye disease","volume":"56","author":"Lee","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s00417-007-0684-4","article-title":"Bevacizumab (Avastin) eye drops inhibit corneal neovascularization","volume":"246","author":"Bock","year":"2008","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"2666","DOI":"10.1167\/iovs.03-1380","article-title":"Inhibition of hemangiogenesis and lymphangiogenesis after normal-risk corneal transplantation by neutralizing VEGF promotes graft survival","volume":"45","author":"Cursiefen","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"bib11","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1097\/ICO.0b013e3182775f8d","article-title":"Topical ranibizumab as a treatment of corneal neovascularization","volume":"32","author":"Ferrari","year":"2013","journal-title":"Cornea"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1001\/archophthalmol.2011.266","article-title":"Blockade of prolymphangiogenic vascular endothelial growth factor C in dry eye disease","volume":"130","author":"Goyal","year":"2012","journal-title":"Arch Ophthalmol"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"e452","DOI":"10.1097\/TXD.0000000000000894","article-title":"Risk of corneal graft rejection after high-risk keratoplasty following fine-needle vessel coagulation of corneal neovascularization combined with bevacizumab: a pilot study","volume":"5","author":"Hos","year":"2019","journal-title":"Transplant Direct"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.1111\/ajt.2018.18.issue-12","article-title":"UV light crosslinking regresses mature corneal blood and lymphatic vessels and promotes subsequent high-risk corneal transplant survival","volume":"18","author":"Hou","year":"2018","journal-title":"Am J Transplant"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"5707","DOI":"10.1038\/s41598-018-24037-3","article-title":"Fine needle-diathermy regresses pathological corneal (lymph)angiogenesis and promotes high-risk corneal transplant survival","volume":"8","author":"Le","year":"2018","journal-title":"Sci Rep"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1136\/bjophthalmol-2013-303729","article-title":"Long-term outcomes of fine needle diathermy for established corneal neovascularisation","volume":"98","author":"Trikha","year":"2014","journal-title":"Br J Ophthalmol"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/nrc2403","article-title":"VEGF-targeted therapy: mechanisms of anti-tumour activity","volume":"8","author":"Ellis","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1172\/JCI20465","article-title":"VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment","volume":"113","author":"Cursiefen","year":"2004","journal-title":"J Clin Invest"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.1167\/iovs.06-0570","article-title":"Bevacizumab as a potent inhibitor of inflammatory corneal angiogenesis and lymphangiogenesis","volume":"48","author":"Bock","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib20","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/j.1755-3768.2012.02525.x","article-title":"Topical Ranibizumab inhibits inflammatory corneal hem- and lymphangiogenesis","volume":"92","author":"Bucher","year":"2014","journal-title":"Acta Ophthalmol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1167\/iovs.07-1314","article-title":"Inflammatory corneal (lymph)angiogenesis is blocked by VEGFR-tyrosine kinase inhibitor ZK 261991, resulting in improved graft survival after corneal transplantation","volume":"49","author":"Hos","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"5778","DOI":"10.1167\/iovs.10-6816","article-title":"Blockade of insulin receptor substrate-1 inhibits corneal lymphangiogenesis","volume":"52","author":"Hos","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"11393","DOI":"10.1073\/pnas.172398299","article-title":"VEGF-Trap: a VEGF blocker with potent antitumor effects","volume":"99","author":"Holash","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"2446","DOI":"10.1111\/ajt.v19.9","article-title":"Local VEGF-A blockade modulates the microenvironment of the corneal graft bed","volume":"19","author":"Salabarria","year":"2019","journal-title":"Am J Transplant"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1177\/112067210001000301","article-title":"Semifluorinated alkanes A new class of compounds with outstanding properties for use in ophthalmology","volume":"10","author":"Meinert","year":"2000","journal-title":"Eur J Ophthalmol"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1089\/jop.2017.0042","article-title":"Semifluorinated alkane eye drops for treatment of dry eye disease due to meibomian gland disease","volume":"33","author":"Steven","year":"2017","journal-title":"J Ocul Pharmacol Ther"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.ejpb.2014.05.009","article-title":"Semifluorinated alkanes as a liquid drug carrier system for topical ocular drug delivery","volume":"88","author":"Dutescu","year":"2014","journal-title":"Eur J Pharm Biopharm"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1089\/jop.2015.0048","article-title":"Semifluorinated alkane eye drops for treatment of dry eye disease\u2013a prospective, multicenter noninterventional study","volume":"31","author":"Steven","year":"2015","journal-title":"J Ocul Pharmacol Ther"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.ijpharm.2018.01.019","article-title":"Semifluorinated alkane based systems for enhanced corneal penetration of poorly soluble drugs","volume":"538","author":"Agarwal","year":"2018","journal-title":"Int J Pharm"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.ejpb.2019.06.008","article-title":"Topical semifluorinated alkane-based azithromycin suspension for the management of ocular infections","volume":"142","author":"Agarwal","year":"2019","journal-title":"Eur J Pharm Biopharm"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.exer.2008.08.007","article-title":"Improved semiautomatic method for morphometry of angiogenesis and lymphangiogenesis in corneal flatmounts","volume":"87","author":"Bock","year":"2008","journal-title":"Exp Eye Res"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.semcdb.2014.11.003","article-title":"Antilymphangiogenic therapy to promote transplant survival and to reduce cancer metastasis: what can we learn from the eye?","volume":"38","author":"Hos","year":"2015","journal-title":"Semin Cell Dev Biol"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.ajpath.2015.09.012","article-title":"IL-10 Indirectly regulates corneal lymphangiogenesis and resolution of inflammation via macrophages","volume":"186","author":"Hos","year":"2016","journal-title":"Am J Pathol"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1007\/s00417-016-3572-y","article-title":"A semifluorinated alkane (F4H5) as novel carrier for cyclosporine A: a promising therapeutic and prophylactic option for topical treatment of dry eye","volume":"255","author":"Gehlsen","year":"2017","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.ophtha.2019.01.024","article-title":"A clinical phase II study to assess efficacy, safety, and tolerability of waterfree cyclosporine formulation for treatment of dry eye disease","volume":"126","author":"Wirta","year":"2019","journal-title":"Ophthalmology"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"8718","DOI":"10.1167\/iovs.11-7871","article-title":"Corneal penetration of topical and subconjunctival bevacizumab","volume":"52","author":"Dastjerdi","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1097\/01.ICL.00000117256.77329.06","article-title":"Subjective symptom of eye dryness and lifestyle factors with corneal neovascularization in contact lens wearers","volume":"30","author":"Nomura","year":"2004","journal-title":"Eye Contact Lens"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.jtos.2019.11.008","article-title":"Neurotrophic keratitis: Frequency, etiologies, clinical management and outcomes","volume":"18","author":"Saad","year":"2020","journal-title":"Ocul Surf."},{"key":"bib43","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1167\/iovs.09-3886","article-title":"An in vivo confocal microscopy and impression cytology analysis of goblet cells in patients with chemical burns","volume":"51","author":"Le","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib31","article-title":"Stabilized Antibody Compositions","author":"Guenther","year":"2015"},{"key":"bib32","article-title":"Stabilised protein compositions based on semifluorinated alkanes","author":"Guenther","year":"2013"},{"key":"bib38","article-title":"A randomized, double-masked, vehicle-controlled phase 2b\/3 trial to evaluate cyclosporine A for the treatment of dry-eye disease","volume-title":"Paper presented at ASCRS Annual Meeting. 2019","author":"Sheppard","year":"2019"},{"key":"bib40","article-title":"Randomized double-masked, saline-controlled phase 2 trial to evaluate perfluorohexyloctane for treatment of dry-eye disease","volume-title":"Paper presented at ASCRS Annual Meeting. 2019","author":"Tauber","year":"2019"}],"container-title":["Translational Vision Science &amp; Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2770912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T15:04:46Z","timestamp":1602687886000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2770912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,14]]},"references-count":43,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,10,1]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.9.11.15","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10,14]]}}}