{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:31:56Z","timestamp":1792495916547,"version":"4.5.0"},"reference-count":29,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"12","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trans. Vis. Sci. Tech."],"published-print":{"date-parts":[[2020,11,17]]},"DOI":"10.1167\/tvst.9.12.23","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T15:31:07Z","timestamp":1605627067000},"page":"23","source":"Crossref","is-referenced-by-count":40,"title":["Novel Extranasal Tear Stimulation: Pivotal Study Results"],"prefix":"10.1167","volume":"9","author":[{"given":"Marco H.","family":"Ji","sequence":"first","affiliation":[{"name":"Horngren Family Vitreoretinal Center, Byers Eye Institute, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, USA"},{"name":"Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darius M.","family":"Moshfeghi","sequence":"additional","affiliation":[{"name":"Horngren Family Vitreoretinal Center, Byers Eye Institute, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Periman","sequence":"additional","affiliation":[{"name":"Evergreen Eye Center, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kading","sequence":"additional","affiliation":[{"name":"Specialty Eyecare Group, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Matossian","sequence":"additional","affiliation":[{"name":"Matossian Eye Associates, Pennington, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Walman","sequence":"additional","affiliation":[{"name":"Arizona Eye Specialists, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Markham","sequence":"additional","affiliation":[{"name":"M&M Eye Institute, Prescott, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy","family":"Mu","sequence":"additional","affiliation":[{"name":"NV Eye Surgery, Las Vegas, NV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Jayaram","sequence":"additional","affiliation":[{"name":"Mid-Peninsula Ophthalmology Medical Group, Menlo Park, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gertner","sequence":"additional","affiliation":[{"name":"Olympic Ophthalmics, Inc., Issaquah, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Karpecki","sequence":"additional","affiliation":[{"name":"Kentucky Eye Institute, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil J.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Mid-Peninsula Ophthalmology Medical Group, Menlo Park, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"6","key":"bib1","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1001\/archophthalmol.2009.103","article-title":"Prevalence of dry eye disease among US men: estimates from the Physicians\u2019 Health Studies","volume":"127","author":"Schaumberg","year":"2009","journal-title":"Arch Ophthalmol"},{"issue":"2","key":"bib2","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0002-9394(03)00218-6","article-title":"Prevalence of dry eye syndrome among US women","volume":"136","author":"Schaumberg","year":"2003","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"bib3","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1542-0124(12)70081-2","article-title":"The definition and classification of dry eye disease: report of the definition and classification subcommittee of the International Dry Eye WorkShop (2007)","volume":"5","author":"Lemp","year":"2007","journal-title":"Ocul Surf"},{"issue":"14","key":"bib4","doi-asserted-by":"crossref","first-page":"DES7","DOI":"10.1167\/iovs.17-23475","article-title":"Definition and diagnostic criteria of dry eye disease: historical overview and future directions","volume":"59","author":"Shimazaki","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"bib5","doi-asserted-by":"crossref","first-page":"e0184296","DOI":"10.1371\/journal.pone.0184296","article-title":"Relation of accommodative microfluctuation with dry eye symptoms in short tear break-up time dry eye","volume":"12","author":"Kaido","year":"2017","journal-title":"PLoS One"},{"issue":"6","key":"bib6","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/00003226-199711000-00008","article-title":"Nasolacrimal stimulation of aqueous tear production","volume":"16","author":"Gupta","year":"1997","journal-title":"Cornea"},{"issue":"2","key":"bib7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/IIO.0000000000000163","article-title":"Intranasal tear neurostimulation: an emerging concept in the treatment of dry eye","volume":"57","author":"Gumus","year":"2017","journal-title":"Int Ophthalmol Clin"},{"key":"bib8","first-page":"795","article-title":"A nonrandomized, open-label study to evaluate the effect of nasal stimulation on tear production in subjects with dry eye disease","volume":"10","author":"Friedman","year":"2016","journal-title":"Clin Ophthalmol"},{"issue":"10","key":"bib9","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1097\/ICO.0b013e3181814cff","article-title":"Meibomian gland diagnostic expressibility: correlation with dry eye symptoms and gland location","volume":"27","author":"Korb","year":"2008","journal-title":"Cornea"},{"issue":"1","key":"bib11","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1001\/archophthalmol.2009.356","article-title":"Minimal clinically important difference for the ocular surface disease index","volume":"128","author":"Miller","year":"2010","journal-title":"Arch Ophthalmol"},{"issue":"3","key":"bib12","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1109\/TBME.2013.2244890","article-title":"Neuromodulation for brain disorders: challenges and opportunities","volume":"60","author":"Johnson","year":"2013","journal-title":"IEEE Trans Biomed Eng"},{"issue":"7444","key":"bib13","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/496159a","article-title":"A jump-start for electroceuticals","volume":"496","author":"Famm","year":"2013","journal-title":"Nature"},{"issue":"3","key":"bib14","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s11916-013-0397-9","article-title":"New horizons in neuromodulation","volume":"18","author":"Gofeld","year":"2014","journal-title":"Curr Pain Headache Rep"},{"issue":"5","key":"bib15","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s11916-014-0412-9","article-title":"Peripheral neuromodulation: a review","volume":"18","author":"Goroszeniuk","year":"2014","journal-title":"Curr Pain Headache Rep"},{"issue":"4","key":"bib16","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.ucl.2013.07.002","article-title":"Electrical and mechanical office-based neuromodulation","volume":"40","author":"Kacker","year":"2013","journal-title":"Urol Clin North Am"},{"key":"bib17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fneng.2014.00027","article-title":"Neuromodulation: present and emerging methods","volume":"7","author":"Luan","year":"2014","journal-title":"Front Neuroeng"},{"key":"bib18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/B978-0-444-53497-2.00004-8","article-title":"Deep brain stimulation: how does it work?","volume":"116","author":"Agnesi","year":"2013","journal-title":"Handb Clin Neurol"},{"key":"bib19","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ajo.2017.03.002","article-title":"Randomized controlled crossover trial comparing the impact of sham or intranasal tear neurostimulation on conjunctival goblet cell degranulation","volume":"177","author":"Gumus","year":"2017","journal-title":"Am J Ophthalmol"},{"issue":"8","key":"bib20","first-page":"2673","article-title":"Effect of intranasal neurostimulation on tear protein content in patients with dry eye","volume":"58","author":"Woodward","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"bib21","first-page":"2694","article-title":"In vivo confocal microscopy demonstrates intranasal neurostimulation-induced goblet cell alterations in patients with dry eye disease","volume":"58","author":"Dieckmann","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"bib22","first-page":"2693","article-title":"Tear total lipid concentration in patients with dry eye following intranasal neurostimulation","volume":"58","author":"Green","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"bib23","first-page":"2692","article-title":"Quantitation of tear production by tear meniscus height following acute use of the intranasal tear neurostimulator","volume":"58","author":"Orrick","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"bib24","first-page":"2235","article-title":"Intranasal neurostimulator induces morphologial changes in meibomian glands in patients with dry eye disease","volume":"58","author":"Pondelis","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"bib25","first-page":"4387","article-title":"Effect of the intranasal tear neurostimulator on meibomian glands","volume":"58","author":"Watson","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib26","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.jtos.2018.11.009","article-title":"Characterization of tear production in subjects with dry eye disease during intranasal tear neurostimulation: results from two pivotal clinical trials","volume":"17","author":"Sheppard","year":"2019","journal-title":"Ocul Surf"},{"issue":"1","key":"bib27","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1167\/iovs.18-23984","article-title":"Randomized, controlled, double-masked, multicenter, pilot study evaluating safety and efficacy of intranasal neurostimulation for dry eye disease","volume":"60","author":"Cohn","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib28","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1097\/ICO.0b013e318225415a","article-title":"Distribution of aqueous-deficient and evaporative dry eye in a clinic-based patient cohort: a retrospective study","volume":"31","author":"Lemp","year":"2012","journal-title":"Cornea"},{"issue":"4","key":"bib29","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1097\/ICO.0b013e318239aaea","article-title":"A new system, the LipiFlow, for the treatment of meibomian gland dysfunction","volume":"31","author":"Lane","year":"2012","journal-title":"Cornea"},{"key":"bib10","volume-title":"Gray's Anatomy","author":"Standring","year":"2016","edition":"41st ed."}],"container-title":["Translational Vision Science & Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2771969","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T15:31:29Z","timestamp":1605627089000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvst.arvojournals.org\/article.aspx?articleid=2771969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,17]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,11,2]]}},"URL":"https:\/\/doi.org\/10.1167\/tvst.9.12.23","relation":{},"ISSN":["2164-2591"],"issn-type":[{"value":"2164-2591","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11,17]]}}}